ATE229001T1 - Zwischenprodukte verwendbar in der herstellung von enzym-inhibitoren - Google Patents

Zwischenprodukte verwendbar in der herstellung von enzym-inhibitoren

Info

Publication number: ATE229001T1
Authority: AT; Austria
Prior art keywords: production; enzyme inhibitors; intermediate products; products usable; protecting group
Prior art date: 1994-06-15

Application number

AT99116304T

Other languages

English (en)

Inventor

Karl Witold Franzmann

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-15

Filing date

1995-06-14

Publication date

2002-12-15

1995-05-15 Priority claimed from GBGB9509774.7A external-priority patent/GB9509774D0/en

1995-06-14 Application filed by Wellcome Found filed Critical Wellcome Found

2002-12-15 Application granted granted Critical

2002-12-15 Publication of ATE229001T1 publication Critical patent/ATE229001T1/de

Links

239000002532 enzyme inhibitor Substances 0.000 title 1
239000013067 intermediate product Substances 0.000 title 1
239000000543 intermediate Substances 0.000 abstract 2
125000006239 protecting group Chemical group 0.000 abstract 2
102000011779 Nitric Oxide Synthase Type II Human genes 0.000 abstract 1
108010076864 Nitric Oxide Synthase Type II Proteins 0.000 abstract 1
229940124639 Selective inhibitor Drugs 0.000 abstract 1
DFEXVBOMMIJOAW-UHFFFAOYSA-N carbamimidoylsulfonylmethanimidamide Chemical class NC(=N)S(=O)(=O)C(N)=N DFEXVBOMMIJOAW-UHFFFAOYSA-N 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Saccharide Compounds (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Steroid Compounds (AREA)

AT99116304T 1994-06-15 1995-06-14 Zwischenprodukte verwendbar in der herstellung von enzym-inhibitoren ATE229001T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
EP94304314		1994-06-15
GBGB9509774.7A GB9509774D0 (en)	1995-05-15	1995-05-15	Enzyme inhibitors
EP95924405A EP0765308B1 (de)	1994-06-15	1995-06-14	Enzymhemmer
EP99116304A EP0957087B1 (de)	1994-06-15	1995-06-14	Zwischenprodukte verwendbar in der Herstellung von Enzym-Inhibitoren

Publications (1)

Publication Number	Publication Date
ATE229001T1 true ATE229001T1 (de)	2002-12-15

Family

ID=26137155

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT99116304T ATE229001T1 (de)	1994-06-15	1995-06-14	Zwischenprodukte verwendbar in der herstellung von enzym-inhibitoren
AT95924405T ATE191470T1 (de)	1994-06-15	1995-06-14	Enzymhemmer

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT95924405T ATE191470T1 (de)	1994-06-15	1995-06-14	Enzymhemmer

Country Status (28)

Country	Link
US (2)	US5889056A (de)
EP (2)	EP0957087B1 (de)
JP (2)	JP2989010B2 (de)
KR (1)	KR100430207B1 (de)
CN (1)	CN1070849C (de)
AT (2)	ATE229001T1 (de)
AU (1)	AU692892B2 (de)
BR (1)	BR9507995A (de)
CA (1)	CA2192668A1 (de)
CY (2)	CY2238B1 (de)
DE (2)	DE69529101T2 (de)
DK (2)	DK0765308T3 (de)
ES (2)	ES2189322T3 (de)
FI (1)	FI965019A0 (de)
GR (1)	GR3033746T3 (de)
HU (1)	HUT77407A (de)
IL (2)	IL114142A (de)
IS (1)	IS4384A (de)
MX (1)	MX9606136A (de)
MY (1)	MY115437A (de)
NO (1)	NO308655B1 (de)
NZ (1)	NZ289157A (de)
PT (2)	PT765308E (de)
RU (1)	RU2162841C2 (de)
SI (2)	SI0765308T1 (de)
TW (1)	TW442453B (de)
WO (1)	WO1995034534A1 (de)
ZA (1)	ZA954940B (de)

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AU6605800A (en) *	1999-07-16	2001-02-05	Trega Biosciences, Inc.	Melanocortin receptor-3 ligands to treat sexual dysfunction
DK1265859T3 (da) *	2000-03-24	2006-05-01	Pharmacia Corp	Amidinoforbindelser der er nyttige som nitrogenoxidsyntaseinhibitorer
AR034120A1 (es) *	2000-04-13	2004-02-04	Pharmacia Corp	Compuesto derivado halogenado del acido 2-amino-4,5 heptenoico, composicion farmaceutica que lo comprende y el uso de dicho compuesto y dicha composicion en la fabricacion de un medicamento para inhibir o modular la sintesis de acido nitrico
GB0031179D0 (en) *	2000-12-21	2001-01-31	Glaxo Group Ltd	Nitric oxide synthase inhibitors
DE10111052A1 (de) *	2001-03-06	2002-09-12	Beiersdorf Ag	Verwendung von Substanzen, die verhindern, daß die NO-Synthase des warmblütigen Organismus ihre Wirkung entfaltet, zur Herstellung von kosmetischen oder dermatologischen Zubereitungen zur Steigerung der Ceramidbiosynthese
DE10111050A1 (de) *	2001-03-06	2002-09-12	Beiersdorf Ag	Verwendung von Substanzen, die verhindern, daß die NO-Synthase des warmblütigenOrganismus ihre Wirkung entfaltet, zur Herstellung von kosmetischewn oder dermatologischen Zubereitungen zur Behandlung und/oder Prophylaxe unerwünschter Hautpigmentierung
DE10111054A1 (de) *	2001-03-06	2002-09-12	Beiersdorf Ag	Verwendung von Substanzen, die verhindern, daß die NO-Synthese des warmblütigen Organismus ihre Wirkung entfaltet, zur Herstellung von kosmetischen oder dermatologischen Zubereitungen zur Stärkung der Barrierefunktion der Haut
DE10111049A1 (de) *	2001-03-06	2002-09-12	Beiersdorf Ag	Verwendung von Substanzen, die verhindern, daß die NO-Synthese des warmblütigen Organismus ihre Wirkung entfaltet, zur Herstellung von kosmetischen oder dermatologischen Zubereitungen, zur Prophylaxe und Behandlung von entzündlichen Hautzuständen und/oder zum Hautschutz bei empfindlich determinierter trockener Haut
US7012098B2 (en) *	2001-03-23	2006-03-14	Pharmacia Corporation	Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers
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TWI307630B (en)	2004-07-01	2009-03-21	Glaxo Group Ltd	Immunoglobulins
GB0418045D0 (en)	2004-08-12	2004-09-15	Glaxo Group Ltd	Compounds
EP1841780B1 (de)	2005-01-10	2011-07-27	Glaxo Group Limited	Androstan-17-alpha-carbonat-derivate zur verwendung bei der behandlung allergischer und entzündlicher zustände
UY29440A1 (es)	2005-03-25	2006-10-02	Glaxo Group Ltd	Nuevos compuestos
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DE102005047946A1 (de) *	2005-10-06	2007-05-03	Bayer Healthcare Ag	Verwendung von Aktivatoren der löslichen Guanylatzyklase zur Behandlung von akuten und chronischen Lungenkrankheiten
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MX2008013411A (es)	2006-04-20	2008-11-04	Glaxo Group Ltd	Nuevos compuestos.
GB0611587D0 (en)	2006-06-12	2006-07-19	Glaxo Group Ltd	Novel compounds
SI2046787T1 (sl)	2006-08-01	2011-07-29	Glaxo Group Ltd	Pirazolo(3,4-b)piridinske spojine in njihova uporaba kot PDE4 inhibitorji
US20080114021A1 (en) *	2006-11-09	2008-05-15	University Of Maryland Baltimore	Use Of 5,6-Dimethylxanthenone-4-Acetic Acid as an Antimicrobial Agent
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JP5791500B2 (ja)	2008-05-23	2015-10-07	パンミラファーマシューティカルズ，エルエルシー．	５−リポキシゲナーゼ活性化タンパク質阻害剤
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JP2012521764A (ja)	2009-03-27	2012-09-20	メルク・シャープ・エンド・ドーム・コーポレイション	低分子干渉核酸（ｓｉＮＡ）を用いた胸腺間質性リンパ球新生因子（ＴＳＬＰ）遺伝子発現のＲＮＡ干渉媒介性阻害
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JP2012521760A (ja)	2009-03-27	2012-09-20	メルク・シャープ・エンド・ドーム・コーポレイション	低分子干渉核酸（ｓｉＮＡ）を用いたアポトーシスシグナル調節キナーゼ１（ＡＳＫ１）遺伝子発現のＲＮＡ干渉媒介性阻害
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EP2512438B1 (de)	2009-12-16	2017-01-25	3M Innovative Properties Company	Formulierungen und verfahren zur steuerung der mdi-partikelgrössenfreisetzung
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US9657007B2 (en)	2013-09-22	2017-05-23	Calitor Sciences, Llc	Substituted aminopyrimidine compounds and methods of use
MX2016012574A (es)	2014-03-28	2017-09-26	Calitor Sciences Llc	Compuestos heteroarilo sustituidos y metodos de uso.
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1995
- 1995-06-14 EP EP99116304A patent/EP0957087B1/de not_active Expired - Lifetime
- 1995-06-14 AT AT99116304T patent/ATE229001T1/de not_active IP Right Cessation
- 1995-06-14 US US08/750,679 patent/US5889056A/en not_active Ceased
- 1995-06-14 DK DK95924405T patent/DK0765308T3/da active
- 1995-06-14 US US10/407,204 patent/USRE39576E1/en not_active Expired - Lifetime
- 1995-06-14 JP JP8501803A patent/JP2989010B2/ja not_active Expired - Lifetime
- 1995-06-14 NZ NZ289157A patent/NZ289157A/en not_active IP Right Cessation
- 1995-06-14 ES ES99116304T patent/ES2189322T3/es not_active Expired - Lifetime
- 1995-06-14 DK DK99116304T patent/DK0957087T3/da active
- 1995-06-14 HU HU9603454A patent/HUT77407A/hu unknown
- 1995-06-14 DE DE69529101T patent/DE69529101T2/de not_active Expired - Lifetime
- 1995-06-14 RU RU97100747/04A patent/RU2162841C2/ru not_active IP Right Cessation
- 1995-06-14 KR KR1019960707192A patent/KR100430207B1/ko not_active Expired - Fee Related
- 1995-06-14 SI SI9530412T patent/SI0765308T1/xx unknown
- 1995-06-14 BR BR9507995A patent/BR9507995A/pt not_active IP Right Cessation
- 1995-06-14 EP EP95924405A patent/EP0765308B1/de not_active Expired - Lifetime
- 1995-06-14 WO PCT/GB1995/001378 patent/WO1995034534A1/en not_active Ceased
- 1995-06-14 AU AU28917/95A patent/AU692892B2/en not_active Ceased
- 1995-06-14 ES ES95924405T patent/ES2145282T3/es not_active Expired - Lifetime
- 1995-06-14 PT PT95924405T patent/PT765308E/pt unknown
- 1995-06-14 CA CA002192668A patent/CA2192668A1/en not_active Abandoned
- 1995-06-14 AT AT95924405T patent/ATE191470T1/de not_active IP Right Cessation
- 1995-06-14 DE DE69516141T patent/DE69516141T2/de not_active Expired - Fee Related
- 1995-06-14 SI SI9530645T patent/SI0957087T1/xx unknown
- 1995-06-14 PT PT99116304T patent/PT957087E/pt unknown
- 1995-06-14 ZA ZA954940A patent/ZA954940B/xx unknown
- 1995-06-14 IL IL11414295A patent/IL114142A/xx not_active IP Right Cessation
- 1995-06-14 CN CN95194518A patent/CN1070849C/zh not_active Expired - Fee Related
- 1995-06-15 MY MYPI95001621A patent/MY115437A/en unknown
- 1995-07-15 TW TW084107349A patent/TW442453B/zh not_active IP Right Cessation
1996
- 1996-11-13 IS IS4384A patent/IS4384A/is unknown
- 1996-12-05 MX MX9606136A patent/MX9606136A/es not_active IP Right Cessation
- 1996-12-13 FI FI965019A patent/FI965019A0/fi not_active Application Discontinuation
- 1996-12-13 NO NO965379A patent/NO308655B1/no unknown
1999
- 1999-02-25 IL IL12871799A patent/IL128717A0/xx not_active IP Right Cessation
- 1999-06-07 JP JP16019399A patent/JP3614711B2/ja not_active Expired - Fee Related
2000
- 2000-06-22 GR GR20000401441T patent/GR3033746T3/el not_active IP Right Cessation
2001
- 2001-09-07 CY CY0100026A patent/CY2238B1/xx unknown
2004
- 2004-06-03 CY CY0400042A patent/CY2455B1/xx unknown

Also Published As

Publication number	Publication date
IL114142A0 (en)	1995-10-31
DK0957087T3 (da)	2003-03-24
DK0765308T3 (da)	2000-09-11
NO308655B1 (no)	2000-10-09
EP0765308A1 (de)	1997-04-02
FI965019A7 (fi)	1996-12-13
JP3614711B2 (ja)	2005-01-26
NO965379L (no)	1996-12-13
CN1155276A (zh)	1997-07-23
HU9603454D0 (en)	1997-02-28
DE69516141T2 (de)	2000-10-19
NO965379D0 (no)	1996-12-13
GR3033746T3 (en)	2000-10-31
EP0957087B1 (de)	2002-12-04
NZ289157A (en)	1998-03-25
DE69529101T2 (de)	2003-11-13
IL114142A (en)	2000-02-17
CN1070849C (zh)	2001-09-12
PT765308E (pt)	2000-09-29
EP0957087A3 (de)	2000-12-20
CY2238B1 (en)	2003-07-04
PT957087E (pt)	2003-04-30
ES2145282T3 (es)	2000-07-01
EP0957087A2 (de)	1999-11-17
IL128717A0 (en)	2000-01-31
WO1995034534A1 (en)	1995-12-21
ATE191470T1 (de)	2000-04-15
CA2192668A1 (en)	1995-12-21
USRE39576E1 (en)	2007-04-17
DE69529101D1 (de)	2003-01-16
RU2162841C2 (ru)	2001-02-10
ES2189322T3 (es)	2003-07-01
AU2891795A (en)	1996-01-05
MX9606136A (es)	1998-06-30
EP0765308B1 (de)	2000-04-05
JP2000026402A (ja)	2000-01-25
JP2989010B2 (ja)	1999-12-13
TW442453B (en)	2001-06-23
US5889056A (en)	1999-03-30
HK1003935A1 (en)	1998-11-13
ZA954940B (en)	1996-12-17
BR9507995A (pt)	1997-08-05
CY2455B1 (en)	2005-06-03
DE69516141D1 (de)	2000-05-11
IS4384A (is)	1996-11-13
SI0957087T1 (en)	2003-04-30
AU692892B2 (en)	1998-06-18
JPH10506371A (ja)	1998-06-23
HUT77407A (hu)	1998-04-28
FI965019A0 (fi)	1996-12-13
MY115437A (en)	2003-06-30
KR100430207B1 (ko)	2004-07-19
SI0765308T1 (sl)	2000-08-31

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