ATE229030T1 - S-(+)-adenosylmethionine und 3'-azido-2',3'- dideoxy-nukleosid-komplexe als potente inhibitoren von hiv-replikation - Google Patents

S-(+)-adenosylmethionine und 3'-azido-2',3'- dideoxy-nukleosid-komplexe als potente inhibitoren von hiv-replikation

Info

Publication number
ATE229030T1
ATE229030T1 AT97114113T AT97114113T ATE229030T1 AT E229030 T1 ATE229030 T1 AT E229030T1 AT 97114113 T AT97114113 T AT 97114113T AT 97114113 T AT97114113 T AT 97114113T AT E229030 T1 ATE229030 T1 AT E229030T1
Authority
AT
Austria
Prior art keywords
adenosylmethionine
azido
dideoxy
potent inhibitors
hiv replication
Prior art date
Application number
AT97114113T
Other languages
English (en)
Inventor
Kurt Dr Zimmermann
Henrich H Prof Dr Dr Paradies
Original Assignee
Symbio Herborn Group Gmbh & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symbio Herborn Group Gmbh & Co filed Critical Symbio Herborn Group Gmbh & Co
Application granted granted Critical
Publication of ATE229030T1 publication Critical patent/ATE229030T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT97114113T 1996-08-14 1997-08-14 S-(+)-adenosylmethionine und 3'-azido-2',3'- dideoxy-nukleosid-komplexe als potente inhibitoren von hiv-replikation ATE229030T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19632823A DE19632823C1 (de) 1996-08-14 1996-08-14 Komplexe zwischen S-(+)-Adenosylmethionin und 3'-Azido-2',3'-didesoxynucleosid als potente Inhibitoren der HIV-Replikation

Publications (1)

Publication Number Publication Date
ATE229030T1 true ATE229030T1 (de) 2002-12-15

Family

ID=7802653

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97114113T ATE229030T1 (de) 1996-08-14 1997-08-14 S-(+)-adenosylmethionine und 3'-azido-2',3'- dideoxy-nukleosid-komplexe als potente inhibitoren von hiv-replikation

Country Status (9)

Country Link
US (1) US6117849A (de)
EP (1) EP0827964B1 (de)
JP (1) JP3202179B2 (de)
AT (1) ATE229030T1 (de)
CA (1) CA2213099C (de)
DE (2) DE19632823C1 (de)
DK (1) DK0827964T3 (de)
ES (1) ES2188828T3 (de)
PT (1) PT827964E (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6759395B2 (en) * 2000-12-18 2004-07-06 Orchid Chemicals & Pharmaceuticals, Ltd. Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same
US6914052B2 (en) 2001-03-15 2005-07-05 The Trustees Of Boston College Selective anti-viral nucleoside chain terminators
ITMI20012462A1 (it) * 2001-11-22 2003-05-22 Gnosis Srl Processo per la preparazione di compresse comprendenti s-adenosilmetionina
DE60102938T2 (de) * 2001-12-12 2005-03-31 Chemistry & Health International B.V. Lagerstabile Granulate, die S-Adenosylmethionin enthalten, und Verfahren zu ihrer Herstellung
US20050272687A1 (en) * 2004-06-08 2005-12-08 Hebert Rolland F Stable S-adenosyl-l-methionine
US20090012036A1 (en) * 2005-05-24 2009-01-08 Hebert Rolland F Stable S-adenosyl-L-methionine
EA200800932A1 (ru) * 2005-09-26 2008-10-30 Фармассет, Инк. Модифицированные 4`-нуклеозиды в качестве противовирусных агентов
US20100004191A1 (en) * 2008-07-01 2010-01-07 Rolland F Hebert Compositions of S-adenosyl-L-methionine.
KR102186066B1 (ko) 2013-01-16 2020-12-04 허버트 샘-이 엘엘씨 S-아데노실-l-메티오닌의 안정한 인돌-3-프로피오네이트염
JP2020164521A (ja) * 2019-03-29 2020-10-08 国立大学法人 長崎大学 抗ウィルス薬

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2001976B (en) * 1977-08-03 1982-03-10 Yamasa Shoyu Kk S-adenosyl-l-methionine compositions and production thereof
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
US4880782A (en) * 1986-11-21 1989-11-14 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V. Method of treating viral infections in humans and compositions therefor
DE4005275A1 (de) * 1990-02-20 1991-08-22 Grundmann Ewald Verwendung von s-adenosylmethionin als mittel gegen virale infektionen durch retroviren
IT1243859B (it) * 1990-10-23 1994-06-28 Bioresearch Spa Composizioni farmaceutiche comprendenti associazioni fra sali di s-adenosil-l-metionina e acido 5-metil (o 5-formil)-tetraidrofolico per la terapia di complicanze neurologiche negli ammalati di aids.
DE19628514C1 (de) * 1996-07-05 1997-09-25 E Dr Grundmann Kombination von S-Adenosylmethionin und Azidothymidin zur Hemmung der HIV-Replikation

Also Published As

Publication number Publication date
CA2213099A1 (en) 1998-02-14
EP0827964A2 (de) 1998-03-11
PT827964E (pt) 2003-04-30
DE19632823C1 (de) 1997-11-20
DE69717568T2 (de) 2003-09-04
JP3202179B2 (ja) 2001-08-27
EP0827964B1 (de) 2002-12-04
EP0827964A3 (de) 1998-07-29
DK0827964T3 (da) 2003-03-17
DE69717568D1 (de) 2003-01-16
US6117849A (en) 2000-09-12
JPH10139795A (ja) 1998-05-26
CA2213099C (en) 2003-10-28
ES2188828T3 (es) 2003-07-01

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