ATE229331T1 - Inhibitoren von metazoan-parasit-proteasen - Google Patents

Inhibitoren von metazoan-parasit-proteasen

Info

Publication number: ATE229331T1
Authority: AT; Austria
Prior art keywords: metazoan; parasite; pct; protease; metazoan parasite
Prior art date: 1992-09-11

Application number

AT93921592T

Other languages

English (en)

Inventor

Fred Ehrenkranz Cohen

James Hobson Mckerrow

Christine Sun Young Ring

Philip Jon Rosenthal

George Lommel Kenyon

Zhe Li

Original Assignee

Univ California

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-11

Filing date

1993-09-13

Publication date

2002-12-15

1993-09-13 Application filed by Univ California filed Critical Univ California

2002-12-15 Application granted granted Critical

2002-12-15 Publication of ATE229331T1 publication Critical patent/ATE229331T1/de

Links

241001465754 Metazoa Species 0.000 title abstract 8
244000045947 parasite Species 0.000 title abstract 7
108091005804 Peptidases Proteins 0.000 title abstract 4
239000004365 Protease Substances 0.000 title abstract 4
102000035195 Peptidases Human genes 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 3
229940124158 Protease/peptidase inhibitor Drugs 0.000 abstract 2
239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 2
230000002255 enzymatic effect Effects 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Quinoline Compounds (AREA)
Furan Compounds (AREA)
Pyrane Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

AT93921592T 1992-09-11 1993-09-13 Inhibitoren von metazoan-parasit-proteasen ATE229331T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US94392592A	1992-09-11	1992-09-11
PCT/US1993/008708 WO1994006280A1 (en)	1992-09-11	1993-09-13	Inhibitors of metazoan parasite proteases

Publications (1)

Publication Number	Publication Date
ATE229331T1 true ATE229331T1 (de)	2002-12-15

Family

ID=25480499

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93921592T ATE229331T1 (de)	1992-09-11	1993-09-13	Inhibitoren von metazoan-parasit-proteasen

Country Status (11)

Country	Link
US (1)	US5610192A (de)
EP (1)	EP0752813B1 (de)
JP (1)	JPH08502048A (de)
AT (1)	ATE229331T1 (de)
AU (1)	AU4923093A (de)
DE (1)	DE69332567T2 (de)
DK (1)	DK0752813T3 (de)
ES (1)	ES2183817T3 (de)
OA (1)	OA10132A (de)
PT (1)	PT752813E (de)
WO (1)	WO1994006280A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6419923B1 (en)	1991-02-12	2002-07-16	Heska Corporation	Filariid nematode cysteine protease proteins, and uses thereof
US5795768A (en) *	1991-02-12	1998-08-18	Heska Corporation	Filariid nematode cysteine protease proteins, nucleic acid molecules and uses thereof
US5739170A (en) *	1992-09-11	1998-04-14	The Regents Of The University Of California	Inhibitors of metazoan parasite proteases
EP0766693A4 (de) *	1994-05-26	2002-10-30	Heska Corp	Gene und proteine und parasitproteasen
US5863716A (en) *	1994-09-19	1999-01-26	The Leland Stanford Junior University Board Of Trustees	Treatment of plasmodium
US5936120A (en) *	1997-12-10	1999-08-10	University Of New Mexico	Deoxygossylic compounds
NZ505362A (en) *	1997-12-22	2004-12-24	Upjohn Co	4-hydroxyquinoline-3-carboxamides and -hydrazides useful as antiviral agents
SE9903894D0 (sv)	1999-10-28	1999-10-28	New Pharma Research Ab	Novel compounds
EP1130009A1 (de) *	2000-03-01	2001-09-05	Therascope AG	Erzeugung und Screenen einer dynamischen kombinatorischen Verbindungsbibliothek
CL2003001415A1 (es) *	2002-07-12	2005-01-07	Janssen Pharmaceutica Nv	Compuestos d derivados de naftil, quinolinil e isoquinolinil urea; composicion farmaceutica; y uso en el tratamiento y prevencion de condiciones de dolor y en el sibndrome del colon irritable y condiciones asociadas.
CA2527832A1 (en) *	2003-06-10	2004-12-23	F. Hoffmann-La Roche Ag	1.3.4-triaza-phenalene and 1,3,4,6-tetraazaphenalene derivatives
US20080039528A1 (en) *	2004-03-17	2008-02-14	Kansas State University Research Foundation	Zinc finger ejectors and methods of use thereof
WO2007104695A1 (en) *	2006-03-15	2007-09-20	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Quinolin-4-ylhydrazine derivatives as antimalarial agent
ES2660756T3 (es) *	2011-04-15	2018-03-26	National University Corporation Tottori University	Síntesis y análisis de nuevos compuestos capaces de inducir la diferenciación de célula madre mesenquimal humana en hepatocito
US9296716B2 (en) *	2011-11-23	2016-03-29	The Provost, Fellows, Foundation Scholars, & The Other Members Of Board, Of The College Of The Holy And Undiv. Trinity Of Queen Elizabeth Near Dublin	Androgen receptor ligands
EP2633855A1 (de)	2012-03-01	2013-09-04	Veterinärmedizinische Universität Wien	Proteaseinhibitoren zur Behandlung von Infektionen mit Trichomonas gallinae
US9889129B2 (en) *	2012-03-21	2018-02-13	Case Western Reserve University	Method of modulating ribonucleotide reductase
EP3151821A4 (de) *	2014-06-05	2017-12-13	The University of Kansas	Marmelin-analoga und verfahren zur verwendung in der krebsbehandlung
AU2015311598A1 (en)	2014-09-02	2017-03-16	Neoculi Pty Ltd	Methods for treating protozoan infections
CN105777578B (zh) *	2016-04-01	2017-12-29	西北师范大学	一种酰腙类氰根离子传感器分子及其合成及在含水体系中检测氰根离子的应用
CN107759489A (zh) *	2017-11-08	2018-03-06	海南医学院	一种苯甲酰肼衍生物p及其合成和应用
CN117946055A (zh) *	2024-01-25	2024-04-30	贵州医科大学	一种色烯芳基酰肼类衍生物及其制备方法和应用

1993
- 1993-09-13 WO PCT/US1993/008708 patent/WO1994006280A1/en not_active Ceased
- 1993-09-13 ES ES93921592T patent/ES2183817T3/es not_active Expired - Lifetime
- 1993-09-13 EP EP93921592A patent/EP0752813B1/de not_active Expired - Lifetime
- 1993-09-13 AT AT93921592T patent/ATE229331T1/de not_active IP Right Cessation
- 1993-09-13 DE DE69332567T patent/DE69332567T2/de not_active Expired - Fee Related
- 1993-09-13 AU AU49230/93A patent/AU4923093A/en not_active Abandoned
- 1993-09-13 US US08/387,760 patent/US5610192A/en not_active Expired - Fee Related
- 1993-09-13 JP JP6508279A patent/JPH08502048A/ja active Pending
- 1993-09-13 PT PT93921592T patent/PT752813E/pt unknown
- 1993-09-13 DK DK93921592T patent/DK0752813T3/da active
1995
- 1995-03-07 OA OA60620A patent/OA10132A/en unknown

Also Published As

Publication number	Publication date
AU4923093A (en)	1994-04-12
JPH08502048A (ja)	1996-03-05
US5610192A (en)	1997-03-11
EP0752813A1 (de)	1997-01-15
EP0752813B1 (de)	2002-12-11
EP0752813A4 (de)	1997-08-20
DE69332567D1 (de)	2003-01-23
PT752813E (pt)	2003-04-30
DE69332567T2 (de)	2003-04-17
WO1994006280A1 (en)	1994-03-31
DK0752813T3 (da)	2003-01-06
OA10132A (en)	1996-12-18
ES2183817T3 (es)	2003-04-01

Legal Events

Date

Code

Title

Description

2003-04-15

UEP

Publication of translation of european patent specification

Ref document number: 0752813

Country of ref document: EP

2005-06-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE229331T1 (de)	2002-12-15	Inhibitoren von metazoan-parasit-proteasen
AU7321598A (en)	1998-09-22	Use of cholinesterase inhibitors to treat disorders of attention
DE69924641D1 (de)	2005-05-12	Behandlung von asthma anhand von mek-inhibitoren
ATE150300T1 (de)	1997-04-15	Hemmung der tnf - bildung
EE9400341A (et)	1996-04-15	Kolesterooli biosünteesi inhibiitori ja kolesterooli absorptsiooni ß-laktaaminhibiitori kombinatsioon
GR3033667T3 (en)	2000-10-31	Use of non-steroidal cyclooxygenase inhibitors to treat elevated intraocular pressure
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