ATE229524T1 - Distamycin a analoga als antitumor- oder antivirale wirkstoffe - Google Patents

Distamycin a analoga als antitumor- oder antivirale wirkstoffe

Info

Publication number: ATE229524T1
Authority: AT; Austria
Prior art keywords: antitumor; analogas; distamycin; active ingredients; pct
Prior art date: 1994-08-08

Application number

AT95926927T

Other languages

English (en)

Inventor

Italo Beria

Enrico Pesenti

Laura Capolongo

Nicola Mongelli

Piergiovanni Baraldi

Original Assignee

Pharmacia Italia Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-08

Filing date

1995-07-18

Publication date

2002-12-15

1995-07-18 Application filed by Pharmacia Italia Spa filed Critical Pharmacia Italia Spa

2002-12-15 Application granted granted Critical

2002-12-15 Publication of ATE229524T1 publication Critical patent/ATE229524T1/de

Links

230000000259 anti-tumor effect Effects 0.000 title abstract 2
239000004480 active ingredient Substances 0.000 title 1
230000000840 anti-viral effect Effects 0.000 title 1
UPBAOYRENQEPJO-UHFFFAOYSA-N n-[5-[[5-[(3-amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-formamido-1-methylpyrrole-2-carboxamide Chemical compound CN1C=C(NC=O)C=C1C(=O)NC1=CN(C)C(C(=O)NC2=CN(C)C(C(=O)NCCC(N)=N)=C2)=C1 UPBAOYRENQEPJO-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
239000002246 antineoplastic agent Substances 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Gas Burners (AREA)
Pre-Mixing And Non-Premixing Gas Burner (AREA)
Nozzles For Spraying Of Liquid Fuel (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT95926927T 1994-08-08 1995-07-18 Distamycin a analoga als antitumor- oder antivirale wirkstoffe ATE229524T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB9416005A GB9416005D0 (en)	1994-08-08	1994-08-08	Peptidic compounds analogous to distamycin a and process for their preparation
PCT/EP1995/002814 WO1996005196A1 (en)	1994-08-08	1995-07-18	Distamycin a analogues as antitumour or antiviral agents

Publications (1)

Publication Number	Publication Date
ATE229524T1 true ATE229524T1 (de)	2002-12-15

Family

ID=10759569

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95926927T ATE229524T1 (de)	1994-08-08	1995-07-18	Distamycin a analoga als antitumor- oder antivirale wirkstoffe

Country Status (19)

Country	Link
US (1)	US5753629A (de)
EP (1)	EP0722446B1 (de)
JP (1)	JPH09504039A (de)
KR (1)	KR960704884A (de)
CN (1)	CN1131946A (de)
AT (1)	ATE229524T1 (de)
AU (1)	AU689623B2 (de)
CA (1)	CA2172629A1 (de)
DE (1)	DE69529143T2 (de)
ES (1)	ES2188666T3 (de)
FI (1)	FI961506A7 (de)
GB (1)	GB9416005D0 (de)
HU (1)	HUT76267A (de)
IL (1)	IL114794A0 (de)
NO (1)	NO961377L (de)
NZ (1)	NZ290404A (de)
PL (1)	PL313821A1 (de)
WO (1)	WO1996005196A1 (de)
ZA (1)	ZA956590B (de)

Families Citing this family (40)

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JP2002515897A (ja)	1996-02-26	2002-05-28	カリフォルニア・インスティチュート・オブ・テクノロジー	特異的ポリアミドｄｎａ−結合リガンドの設計、合成、および使用
EP0968186A1 (de) *	1996-02-26	2000-01-05	California Institute Of Technology	Polyamide zum binden an den kleinen graben von doppelsträngiger dna
US6555692B1 (en)	1996-02-26	2003-04-29	California Institute Of Technology	Preparation and use of bifunctional molecules having DNA sequence binding specificity
CN1260006A (zh) *	1996-02-26	2000-07-12	加利福尼亚州技术学院	双链dna和杂环低聚物之间复合物的形成
WO1998045284A1 (en)	1996-02-26	1998-10-15	California Institute Of Technology	Stereochemical control of the dna binding affinity, sequence specificity, and orientation-preference of chiral hairpin polyamides in the minor groove
US6506906B1 (en)	1996-02-26	2003-01-14	California Institute Of Technology	Preparation and use of bifunctional molecules having DNA sequence binding specificity
US6635417B1 (en)	1996-07-31	2003-10-21	California Institute Of Technology	Complex formation between DSDNA and oligomer of cyclic heterocycles
US6143901A (en) *	1996-07-31	2000-11-07	Genesoft, Inc.	Complex formation between dsDNA and pyrrole imidazole polyamides
US6090947A (en) *	1996-02-26	2000-07-18	California Institute Of Technology	Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
GB9610079D0 (en) *	1996-05-14	1996-07-17	Pharmacia Spa	Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents
US5998140A (en) *	1996-07-31	1999-12-07	The Scripps Research Institute	Complex formation between dsDNA and oligomer of cyclic heterocycles
GB9623522D0 (en) *	1996-11-11	1997-01-08	Pharmacia & Upjohn Spa	Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents
GB9806692D0 (en)	1998-03-27	1998-05-27	Pharmacia & Upjohn Spa	Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents
GB9806689D0 (en)	1998-03-27	1998-05-27	Pharmacia & Upjohn Spa	Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
US6384005B1 (en) *	1998-04-27	2002-05-07	Procter & Gamble Company	Garment conditioning composition
GB9812211D0 (en)	1998-06-05	1998-08-05	Pharmacia & Upjohn Spa	Cinnamoyl distamycin analogous derivatives,process for their preparation,and their use as antitumor agents
GB9928703D0 (en) *	1999-12-03	2000-02-02	Pharmacia & Upjohn Spa	Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
CA2403537A1 (en) *	2000-03-16	2001-10-11	Genesoft, Inc.	Charged compounds comprising a nucleic acid binding moiety and uses therefor
US7078536B2 (en) *	2001-03-14	2006-07-18	Genesoft Pharmaceuticals, Inc.	Charged compounds comprising a nucleic acid binding moiety and uses therefor
GB0011059D0 (en) *	2000-05-08	2000-06-28	Pharmacia & Upjohn Spa	Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015446D0 (en)	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0015447D0 (en)	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0016447D0 (en)	2000-07-04	2000-08-23	Pharmacia & Upjohn Spa	Process for preparing distamycin derivatives
GB0029004D0 (en)	2000-11-28	2001-01-10	Pharmacia & Upjohn Spa	Process for preparing distamycin derivatives
WO2002088119A1 (en) *	2001-04-26	2002-11-07	Genesoft Pharmaceuticals, Inc	Halogen-substituted thienyl compounds
EP1470119A4 (de) *	2001-06-13	2005-10-19	Genesoft Pharmaceuticals Inc	Benzothiophenverbindungen mit antiinfektiver wirkung
US20030236198A1 (en) *	2001-06-13	2003-12-25	Genesoft, Inc.	Antipathogenic benzamide compounds
ITTO20010633A1 (it)	2001-07-02	2003-01-02	Univ Ferrara	Nuovo impiego di poliammidi eterocicliche e benzoeterocicliche strutturalmente correlate all'antibiotico naturale distamicina a.
US6969592B2 (en)	2001-09-26	2005-11-29	Pharmacia Italia S.P.A.	Method for predicting the sensitivity to chemotherapy
GB0130868D0 (en) *	2001-12-24	2002-02-06	Univ Strathclyde	New compounds
ATE425753T1 (de)	2002-08-02	2009-04-15	Genesoft Pharmaceuticals Inc	Biaryl-verbindungen mit antiinfektiver wirkung
EP1562931A2 (de) *	2002-10-25	2005-08-17	Genesoft Pharmaceuticals, Inc.	Biarylverbindungen mitantiinfektionswirkung
JP2006509027A (ja) *	2002-12-10	2006-03-16	オーシェントファーマシューティカルズコーポレーション	（ピロールカルボキサミド）−（ベンズアミド）−（イミダゾールカルボキサミド）モチーフを有する抗菌化合物
JP2006525361A (ja) *	2003-05-02	2006-11-09	エランファーマシューティカルズ，インコーポレイテッド	ブラジキニンｂ１受容体アンタゴニストとしての選択された置換ピラゾール誘導体および関連化合物
EP1633349A1 (de) *	2003-05-02	2006-03-15	Elan Pharmaceuticals, Inc.	4-bromo-5- (2-chlorobenzoylamino)-1h-pyrazol-3-carbonsäure (1-(aminocarbonyl) eth-1-yl) amid-derivate und verwandte verbindungen als bradykinin-b1-rezeptorantagonisten zur behandlung von entzündlichen erkrankungen
JP2006526015A (ja) *	2003-05-02	2006-11-16	エランファーマシューティカルズ，インコーポレイテッド	炎症疾患治療のためのブラジキニンｂ１受容体アンタゴニストとしての４−ブロモ−５−（２−クロロ−ベンゾイルアミノ）−１ｈ−ピラゾール−３−カルボン酸アミド誘導体および関連化合物
GB0619325D0 (en) *	2006-09-30	2006-11-08	Univ Strathclyde	New compounds
CN104845967B (zh)	2015-04-15	2020-12-11	苏州新海生物科技股份有限公司	寡聚核苷酸片段及使用其的选择性扩增目标核酸序列变异体的方法及应用
WO2018047148A1 (en)	2016-09-12	2018-03-15	Novartis Ag	Compounds for the inhibition of mirna
EP3381897A1 (de)	2017-03-27	2018-10-03	Leadiant Biosciences SA	Derivate des dinatrium 2,2'-{carbonylbis[imino-3,1-phenylencarbonylimino(1-methyl-1h-pyrrol-4,2-diyl)carbonylimino]}dinaphthalen-1,5-disulfonat salzes und verwandte verbindungen als heparanase inhibitoren zur behandlung von krebs

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE468642B (sv) *	1985-07-16	1993-02-22	Erba Farmitalia	Poly-4-aminopyrrol-2-karboxamidoderivat och foerfarande foer deras framstaellning och en farmaceutisk komposition
GB8612218D0 (en) *	1986-05-20	1986-06-25	Erba Farmitalia	Site specific alkylating agents
GB8906709D0 (en) *	1989-03-23	1989-05-10	Creighton Andrew M	Acryloyl substituted pyrrole derivatives
IT1271456B (it) *	1993-03-01	1997-05-28	Menarini Farma Ind	Composti pirrol-amidinici, e loro sali farmaceuticamente accettabili, processi di preparazione e composizioni farmaceutiche che li contengono
IT1263089B (it) *	1993-04-26	1996-07-24	Menarini Farma Ind	Composti pirrol-amidinici, processi di preparazione e composizioni farmaceutiche che li contengono.

1994
- 1994-08-08 GB GB9416005A patent/GB9416005D0/en active Pending
1995
- 1995-07-18 AU AU31136/95A patent/AU689623B2/en not_active Ceased
- 1995-07-18 PL PL95313821A patent/PL313821A1/xx unknown
- 1995-07-18 EP EP95926927A patent/EP0722446B1/de not_active Expired - Lifetime
- 1995-07-18 KR KR1019960701819A patent/KR960704884A/ko not_active Withdrawn
- 1995-07-18 CA CA002172629A patent/CA2172629A1/en not_active Abandoned
- 1995-07-18 AT AT95926927T patent/ATE229524T1/de not_active IP Right Cessation
- 1995-07-18 ES ES95926927T patent/ES2188666T3/es not_active Expired - Lifetime
- 1995-07-18 HU HU9601218A patent/HUT76267A/hu unknown
- 1995-07-18 NZ NZ290404A patent/NZ290404A/en unknown
- 1995-07-18 JP JP8506945A patent/JPH09504039A/ja active Pending
- 1995-07-18 US US08/612,836 patent/US5753629A/en not_active Expired - Fee Related
- 1995-07-18 CN CN95190742A patent/CN1131946A/zh active Pending
- 1995-07-18 DE DE69529143T patent/DE69529143T2/de not_active Expired - Fee Related
- 1995-07-18 WO PCT/EP1995/002814 patent/WO1996005196A1/en not_active Ceased
- 1995-08-01 IL IL11479495A patent/IL114794A0/xx unknown
- 1995-08-07 ZA ZA956590A patent/ZA956590B/xx unknown
1996
- 1996-04-03 NO NO961377A patent/NO961377L/no unknown
- 1996-04-03 FI FI961506A patent/FI961506A7/fi unknown

Also Published As

Publication number	Publication date
EP0722446B1 (de)	2002-12-11
WO1996005196A1 (en)	1996-02-22
ES2188666T3 (es)	2003-07-01
ZA956590B (en)	1996-03-18
GB9416005D0 (en)	1994-09-28
NO961377D0 (no)	1996-04-03
JPH09504039A (ja)	1997-04-22
CA2172629A1 (en)	1996-02-22
KR960704884A (ko)	1996-10-09
AU3113695A (en)	1996-03-07
NZ290404A (en)	1997-04-24
FI961506A7 (fi)	1996-06-05
US5753629A (en)	1998-05-19
HU9601218D0 (en)	1996-07-29
EP0722446A1 (de)	1996-07-24
PL313821A1 (en)	1996-07-22
DE69529143D1 (en)	2003-01-23
CN1131946A (zh)	1996-09-25
MX9601250A (es)	1998-12-31
DE69529143T2 (de)	2003-09-11
AU689623B2 (en)	1998-04-02
FI961506A0 (fi)	1996-04-03
IL114794A0 (en)	1995-12-08
NO961377L (no)	1996-05-30
HUT76267A (en)	1997-07-28

Legal Events

Date	Code	Title	Description
2003-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE229524T1 (de)	2002-12-15	Distamycin a analoga als antitumor- oder antivirale wirkstoffe
NO963439L (no)	1996-08-16	Sammensetninger inneholdende mikronisert vebivolol
FI970246A0 (fi)	1997-01-21	Dihydrobentsofuraanit
ATE200669T1 (de)	2001-05-15	4-hydroxy-benzopyran-2-one und 4-hydroxy- zykloalkyl(b) - pyran--2-one verwendbarfuer die behandlung von retroviralen infectionen
DE69425273D1 (de)	2000-08-17	N-substituierte azabicycloalkanderivate als neuroleptika usw.
ATE191334T1 (de)	2000-04-15	Hydrophilierte zahnabdruckmassen
WO1997030677A3 (en)	1997-11-20	Pentafluorobenzenesulfonamides and analogs
PL310171A1 (en)	1995-11-27	Novel imidazopyridines
DE69526353D1 (de)	2002-05-16	Immunologische aktivität der rhamnolipide
ATE206402T1 (de)	2001-10-15	3-acylaminobenzazepine
BR9509970A (pt)	1997-11-25	Composto
ES2103440T3 (es)	1997-09-16	Nuevas amidas y sulfonamidas naftalenicas, procedimiento de preparacion y composiciones farmaceuticas que las contienen.
ATE200482T1 (de)	2001-04-15	N-substituierte azabicycloheptan-derivate als neuroleptika usw.
ZA9429B (en)	1994-08-11	Pyrrolidine derivatives their preparation and medicaments containing them
SE9402241L (sv)	1995-12-24	Inhibitor
TR199800958A2 (xx)	1998-12-21	Herbisidal 3,5-Difloropridinleri.
NO960271D0 (no)	1996-01-23	Tiokarbamoylforbindelser anvendt som mikrobiocider