IT1263089B - Composti pirrol-amidinici, processi di preparazione e composizioni farmaceutiche che li contengono. - Google Patents

Composti pirrol-amidinici, processi di preparazione e composizioni farmaceutiche che li contengono.

Info

Publication number
IT1263089B
IT1263089B ITFI930083A ITFI930083A IT1263089B IT 1263089 B IT1263089 B IT 1263089B IT FI930083 A ITFI930083 A IT FI930083A IT FI930083 A ITFI930083 A IT FI930083A IT 1263089 B IT1263089 B IT 1263089B
Authority
IT
Italy
Prior art keywords
pharmaceutical compositions
pyrol
preparation processes
compositions containing
amidine compounds
Prior art date
Application number
ITFI930083A
Other languages
English (en)
Inventor
Fabio Animati
Federico Arcamone
Paolo Lombardi
Original Assignee
Menarini Farma Ind
Bristol Myers Squibb Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Farma Ind, Bristol Myers Squibb Spa filed Critical Menarini Farma Ind
Publication of ITFI930083A0 publication Critical patent/ITFI930083A0/it
Priority to ITFI930083A priority Critical patent/IT1263089B/it
Priority to EP94915076A priority patent/EP0698011A1/en
Priority to US08/549,737 priority patent/US5670534A/en
Priority to AU66463/94A priority patent/AU6646394A/en
Priority to CA002161552A priority patent/CA2161552A1/en
Priority to PCT/EP1994/001235 priority patent/WO1994025436A1/en
Priority to BR9406509A priority patent/BR9406509A/pt
Priority to CN94192517A priority patent/CN1125437A/zh
Publication of ITFI930083A1 publication Critical patent/ITFI930083A1/it
Priority to OA60725A priority patent/OA10239A/en
Application granted granted Critical
Publication of IT1263089B publication Critical patent/IT1263089B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Sono descritti composti pirrol-amidinici di formula generale (I) (FORMULA I) e loro sali farmaceuticamente accettabili, loro processi di preparazione e composizioni farmaceutiche che li contengono utili come antivirali ed antiparassitari.
ITFI930083A 1993-04-26 1993-04-26 Composti pirrol-amidinici, processi di preparazione e composizioni farmaceutiche che li contengono. IT1263089B (it)

Priority Applications (9)

Application Number Priority Date Filing Date Title
ITFI930083A IT1263089B (it) 1993-04-26 1993-04-26 Composti pirrol-amidinici, processi di preparazione e composizioni farmaceutiche che li contengono.
CA002161552A CA2161552A1 (en) 1993-04-26 1994-04-21 Distamycin a derivatives as anti-malarial agent
US08/549,737 US5670534A (en) 1993-04-26 1994-04-21 Distamycin a derivatives as anti-malarial agents
AU66463/94A AU6646394A (en) 1993-04-26 1994-04-21 Distamycin a derivatives as anti-malarial agents
EP94915076A EP0698011A1 (en) 1993-04-26 1994-04-21 Distamycin a derivatives as anti-malarial agents
PCT/EP1994/001235 WO1994025436A1 (en) 1993-04-26 1994-04-21 Distamycin a derivatives as anti-malarial agents
BR9406509A BR9406509A (pt) 1993-04-26 1994-04-21 Compostos processo sua preparação uso dos mesmos composições farmaceuticas e processo para profilaxia e para tratamento terapeutico de malária e doenças causadas por leishmania toxoplasma gondil pneumocy
CN94192517A CN1125437A (zh) 1993-04-26 1994-04-21 用作抗疟药的偏端霉素a衍生物
OA60725A OA10239A (en) 1993-04-26 1995-10-24 Distamycin a derivatives as anti-malarial agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITFI930083A IT1263089B (it) 1993-04-26 1993-04-26 Composti pirrol-amidinici, processi di preparazione e composizioni farmaceutiche che li contengono.

Publications (3)

Publication Number Publication Date
ITFI930083A0 ITFI930083A0 (it) 1993-04-26
ITFI930083A1 ITFI930083A1 (it) 1994-10-26
IT1263089B true IT1263089B (it) 1996-07-24

Family

ID=11350437

Family Applications (1)

Application Number Title Priority Date Filing Date
ITFI930083A IT1263089B (it) 1993-04-26 1993-04-26 Composti pirrol-amidinici, processi di preparazione e composizioni farmaceutiche che li contengono.

Country Status (9)

Country Link
US (1) US5670534A (it)
EP (1) EP0698011A1 (it)
CN (1) CN1125437A (it)
AU (1) AU6646394A (it)
BR (1) BR9406509A (it)
CA (1) CA2161552A1 (it)
IT (1) IT1263089B (it)
OA (1) OA10239A (it)
WO (1) WO1994025436A1 (it)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9416005D0 (en) * 1994-08-08 1994-09-28 Erba Carlo Spa Peptidic compounds analogous to distamycin a and process for their preparation
US6555692B1 (en) 1996-02-26 2003-04-29 California Institute Of Technology Preparation and use of bifunctional molecules having DNA sequence binding specificity
US6635417B1 (en) 1996-07-31 2003-10-21 California Institute Of Technology Complex formation between DSDNA and oligomer of cyclic heterocycles
US6143901A (en) * 1996-07-31 2000-11-07 Genesoft, Inc. Complex formation between dsDNA and pyrrole imidazole polyamides
US6090947A (en) 1996-02-26 2000-07-18 California Institute Of Technology Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
EP1023288A1 (en) 1996-02-26 2000-08-02 California Institute Of Technology Stereochemical control of the dna binding affinity, sequence specificity, and orientation-preference of chiral hairpin polyamides in the minor groove
US6506906B1 (en) 1996-02-26 2003-01-14 California Institute Of Technology Preparation and use of bifunctional molecules having DNA sequence binding specificity
WO1998037066A1 (en) 1996-02-26 1998-08-27 California Institute Of Technology Improved polyamides for binding in the minor groove of double stranded dna
US5998140A (en) 1996-07-31 1999-12-07 The Scripps Research Institute Complex formation between dsDNA and oligomer of cyclic heterocycles
US7078536B2 (en) * 2001-03-14 2006-07-18 Genesoft Pharmaceuticals, Inc. Charged compounds comprising a nucleic acid binding moiety and uses therefor
CN1427839A (zh) 2000-03-16 2003-07-02 根索福特股份有限公司 含有核酸结合部分的带电荷化合物及其用途
US20030236198A1 (en) * 2001-06-13 2003-12-25 Genesoft, Inc. Antipathogenic benzamide compounds
EP1470119A4 (en) * 2001-06-13 2005-10-19 Genesoft Pharmaceuticals Inc BENZOTHIOPHENE COMPOUNDS WITH ANTI-INFECTIOUS ACTIVITY
ITTO20010633A1 (it) 2001-07-02 2003-01-02 Univ Ferrara Nuovo impiego di poliammidi eterocicliche e benzoeterocicliche strutturalmente correlate all'antibiotico naturale distamicina a.
ATE425753T1 (de) 2002-08-02 2009-04-15 Genesoft Pharmaceuticals Inc Biaryl-verbindungen mit antiinfektiver wirkung
EP1562931A2 (en) * 2002-10-25 2005-08-17 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
AU2003297822A1 (en) * 2002-12-10 2004-06-30 Oscient Pharmaceuticals Corporation Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif
ITMI20031015A1 (it) * 2003-05-20 2004-11-21 Naxospharma S R L Poli-(amminopirrolcarbossammidi) per uso nella profilassi e nel trattamento delle endoparassitosi animali e loro composizioni con ciclodestrine.
ITMI20031111A1 (it) * 2003-06-03 2004-12-04 Naxospharma Srl Processo per la sintesi della distramicina e analoghi poli-4-(1-metilpirrolo)-2-carbossiammidici.
US7094791B2 (en) * 2003-07-31 2006-08-22 Avalon Pharmaceuticals, Inc. Derivatives of 3-hydroxy-pyrrole-2,4-dicarboxylic acid and uses thereof
SG155222A1 (en) * 2004-08-13 2009-09-30 Genentech Inc Thiazole based inhibitors of atp-utilizing enzymes
GB0619325D0 (en) * 2006-09-30 2006-11-08 Univ Strathclyde New compounds
US8494795B2 (en) * 2008-05-05 2013-07-23 Schweitzer Engineering Laboratories Inc Apparatus and method for estimating synchronized phasors at predetermined times referenced to a common time standard in an electrical system
GB201905721D0 (en) 2019-04-24 2019-06-05 Univ Dundee Compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1243389B (it) * 1990-11-22 1994-06-10 Menarini Farma Ind Derivati poliaminopirrolcarbossiamidici, processi di preparazione e composizioni farmaceutiche che li contengono.
IT1262921B (it) * 1992-01-10 1996-07-22 Federico Arcamone Agenti antitumorali analoghi di oligopeptidi pirrol-amidinici retroversi processi di preparazione e prodotti farmaceutici che li contengono
IT1271456B (it) * 1993-03-01 1997-05-28 Menarini Farma Ind Composti pirrol-amidinici, e loro sali farmaceuticamente accettabili, processi di preparazione e composizioni farmaceutiche che li contengono

Also Published As

Publication number Publication date
CN1125437A (zh) 1996-06-26
AU6646394A (en) 1994-11-21
ITFI930083A0 (it) 1993-04-26
CA2161552A1 (en) 1994-11-10
WO1994025436A1 (en) 1994-11-10
BR9406509A (pt) 1996-01-09
ITFI930083A1 (it) 1994-10-26
US5670534A (en) 1997-09-23
EP0698011A1 (en) 1996-02-28
OA10239A (en) 1997-10-07

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970429