ATE229976T1 - Gnrh antagonisten - Google Patents

Gnrh antagonisten

Info

Publication number: ATE229976T1
Authority: AT; Austria
Prior art keywords: 4aph; acetyl; 4cpa; 2nal; xaa3
Prior art date: 1997-04-11

Application number

AT98918206T

Other languages

English (en)

Inventor

Guangcheng Jiang

Graeme Semple

Jean E F Dr Rivier

Original Assignee

Ferring Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-11

Filing date

1998-04-13

Publication date

2003-01-15

1998-04-13 Application filed by Ferring Bv filed Critical Ferring Bv

2003-01-15 Application granted granted Critical

2003-01-15 Publication of ATE229976T1 publication Critical patent/ATE229976T1/de

Links

229940121381 gonadotrophin releasing hormone (gnrh) antagonists Drugs 0.000 title abstract 2
125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 5
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 3
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
ZDXPYRJPNDTMRX-GSVOUGTGSA-N D-glutamine Chemical compound OC(=O)[C@H](N)CCC(N)=O ZDXPYRJPNDTMRX-GSVOUGTGSA-N 0.000 abstract 1
NMJREATYWWNIKX-UHFFFAOYSA-N GnRH Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CC(C)C)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 NMJREATYWWNIKX-UHFFFAOYSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 abstract 1
108010070822 acyline Proteins 0.000 abstract 1
ZWNUQDJANZGVFO-YHSALVGYSA-N acyline Chemical compound C([C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CC=1C=CC(NC(C)=O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(NC(C)=O)C=C1 ZWNUQDJANZGVFO-YHSALVGYSA-N 0.000 abstract 1
230000003042 antagnostic effect Effects 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
230000035558 fertility Effects 0.000 abstract 1
239000002474 gonadorelin antagonist Substances 0.000 abstract 1
238000002347 injection Methods 0.000 abstract 1
239000007924 injection Substances 0.000 abstract 1
238000011866 long-term treatment Methods 0.000 abstract 1
-1 methylcarbamoyl Chemical group 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1
150000003431 steroids Chemical class 0.000 abstract 1
230000001629 suppression Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Endocrinology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Reproductive Health (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Investigating Or Analysing Biological Materials (AREA)

AT98918206T 1997-04-11 1998-04-13 Gnrh antagonisten ATE229976T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/837,041 US5821230A (en)	1997-04-11	1997-04-11	GnRH antagonist decapeptides
PCT/US1998/007519 WO1998046635A1 (en)	1997-04-11	1998-04-13	GnRH ANTAGONISTS

Publications (1)

Publication Number	Publication Date
ATE229976T1 true ATE229976T1 (de)	2003-01-15

Family

ID=25273348

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98918206T ATE229976T1 (de)	1997-04-11	1998-04-13	Gnrh antagonisten

Country Status (10)

Country	Link
US (1)	US5821230A (de)
EP (1)	EP0973801B1 (de)
JP (1)	JP4191259B2 (de)
AT (1)	ATE229976T1 (de)
AU (1)	AU7117498A (de)
DE (1)	DE69810283T2 (de)
DK (1)	DK0973801T3 (de)
ES (1)	ES2187958T3 (de)
PT (1)	PT973801E (de)
WO (1)	WO1998046635A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6828415B2 (en) *	1993-02-19	2004-12-07	Zentaris Gmbh	Oligopeptide lyophilisate, their preparation and use
DE19712718C2 (de) *	1997-03-26	1999-09-23	Asta Medica Ag	Immobilisierte und aktivitätsstabilisierte Komplexe von LHRH-Antagonisten und Verfahren zu deren Herstellung
WO1999026964A1 (en) *	1997-11-20	1999-06-03	Ortho-Mcneil Pharmaceutical, Inc.	LIQUID PHASE PROCESS FOR THE PREPARATION OF GnRH PEPTIDES
US20070148228A1 (en) *	1999-02-22	2007-06-28	Merrion Research I Limited	Solid oral dosage form containing an enhancer
US7658938B2 (en)	1999-02-22	2010-02-09	Merrion Reasearch III Limited	Solid oral dosage form containing an enhancer
US8119159B2 (en) *	1999-02-22	2012-02-21	Merrion Research Iii Limited	Solid oral dosage form containing an enhancer
JP4524823B2 (ja) *	1999-04-14	2010-08-18	住友化学株式会社	タンパク質のアミノ末端のアミノ酸配列決定方法
US7109171B2 (en) *	2000-02-28	2006-09-19	Praecis Pharmaceuticals Inc.	Methods for treating FSH related conditions with GnRH antagonists
GB0117057D0 (en) *	2001-07-12	2001-09-05	Ferring Bv	Pharmaceutical composition
CN105232482A (zh) *	2006-04-07	2016-01-13	默里昂研究Iii有限公司	包含增强剂的固体口服剂型
JOP20090061B1 (ar)	2008-02-11	2021-08-17	Ferring Int Center Sa	طريقة معالجة سرطان البروستاتا بمضادات الهرمونات التناسلية GnRH
AU2009244799B2 (en) *	2008-05-07	2014-11-20	Merrion Research Iii Limited	Compositions of GnRH related compounds and processes of preparation
DK3085381T3 (en)	2008-05-21	2018-05-28	Ferring Bv	ORODISPERSIBLE DESMOPRESSIN TO INCREASE THE INITIAL PERIOD OF SLEEP UNDERSTANDED BY NEW TURRY
US11963995B2 (en)	2008-05-21	2024-04-23	Ferring B.V.	Methods comprising desmopressin
US20100286045A1 (en)	2008-05-21	2010-11-11	Bjarke Mirner Klein	Methods comprising desmopressin
TWI480286B (zh) *	2009-02-25	2015-04-11	Merrion Res Iii Ltd	雙膦酸鹽類組合物及藥物遞送
AU2010243273B2 (en)	2009-05-01	2016-06-16	Ferring B.V.	Composition for the treatment of prostate cancer
TW201043221A (en) *	2009-05-06	2010-12-16	Ferring Int Ct Sa	Kit and method for preparation of a Degarelix solution
US20110039787A1 (en) *	2009-07-06	2011-02-17	Ferring International Center S.A.	Compositions, kits and methods for treating benign prostate hyperplasia
US20110182985A1 (en) *	2010-01-28	2011-07-28	Coughlan David C	Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof
US9089484B2 (en) *	2010-03-26	2015-07-28	Merrion Research Iii Limited	Pharmaceutical compositions of selective factor Xa inhibitors for oral administration
EP2447276A1 (de)	2010-10-27	2012-05-02	Ferring B.V.	Verfahren zur Herstellung von Degarelix und seinen Zwischenprodukten
PT2632934T (pt)	2010-10-27	2017-01-06	Ferring Bv	Processo para o fabrico de degarelix e seus intermediários
AU2012204213A1 (en)	2011-01-07	2013-06-13	Merrion Research Iii Limited	Pharmaceutical compositions of iron for oral administration
JO3755B1 (ar)	2011-01-26	2021-01-31	Ferring Bv	تركيبات تستوستيرون
KR102140982B1 (ko)	2012-06-01	2020-08-05	훼링 비.브이.	데가렐릭스의 제조 방법
US10265384B2 (en)	2015-01-29	2019-04-23	Novo Nordisk A/S	Tablets comprising GLP-1 agonist and enteric coating

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5073624A (en) *	1985-04-09	1991-12-17	Administrators Of The Tulane Educational Fund	Therapeutic decapeptides
US4866160A (en) *	1985-04-09	1989-09-12	The Administrators Of The Tulane Educational Fund	Therapeutic decapeptides
US4800191A (en) *	1987-07-17	1989-01-24	Schally Andrew Victor	LHRH antagonists
US4935491A (en) *	1987-08-24	1990-06-19	Board Of Regents, The University Of Texas System	Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine
US5110904A (en) *	1989-08-07	1992-05-05	Abbott Laboratories	Lhrh analogs
US5171835A (en) *	1988-10-21	1992-12-15	The Administrators Of The Tulane Educational Fund	LHRH antagonists
US5169932A (en) *	1989-10-30	1992-12-08	The Salk Institute For Biological Studies	Gnrh analogs
US5296468A (en) *	1989-10-30	1994-03-22	The Salk Institute For Biological Studies	GnRH analogs
US5064939A (en) *	1990-02-06	1991-11-12	The Salk Institute For Biological Studies	Cyclic gnrh antagonists
IL101074A (en) *	1991-03-14	1997-09-30	Salk Inst For Biological Studi	GnRH ANALOGS AND THEIR PREPARATION
DE593491T1 (de) *	1991-04-25	1994-11-17	Romano S.-Cergue Deghenghi	LHRH-Antagonisten.
US5508383A (en) *	1994-03-09	1996-04-16	Tap Holdings Inc.	Cyclic peptide LHRH antagonists
US5506207A (en) *	1994-03-18	1996-04-09	The Salk Institute For Biological Studies	GNRH antagonists XIII
US5681928A (en) *	1994-12-16	1997-10-28	The Salk Institute For Biological Studies	Betides and methods for screening peptides using same
AU4974596A (en) *	1995-12-15	1997-07-14	Salk Institute For Biological Studies, The	Betide-substituted gnrh antagonists

1997
- 1997-04-11 US US08/837,041 patent/US5821230A/en not_active Expired - Lifetime
1998
- 1998-04-13 EP EP98918206A patent/EP0973801B1/de not_active Expired - Lifetime
- 1998-04-13 JP JP54422598A patent/JP4191259B2/ja not_active Expired - Lifetime
- 1998-04-13 AT AT98918206T patent/ATE229976T1/de active
- 1998-04-13 DK DK98918206T patent/DK0973801T3/da active
- 1998-04-13 PT PT98918206T patent/PT973801E/pt unknown
- 1998-04-13 WO PCT/US1998/007519 patent/WO1998046635A1/en not_active Ceased
- 1998-04-13 AU AU71174/98A patent/AU7117498A/en not_active Abandoned
- 1998-04-13 DE DE69810283T patent/DE69810283T2/de not_active Expired - Lifetime
- 1998-04-13 ES ES98918206T patent/ES2187958T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO1998046635A1 (en)	1998-10-22
JP2001523232A (ja)	2001-11-20
ES2187958T3 (es)	2003-06-16
JP4191259B2 (ja)	2008-12-03
DE69810283T2 (de)	2003-07-24
US5821230A (en)	1998-10-13
DK0973801T3 (da)	2003-04-07
AU7117498A (en)	1998-11-11
EP0973801B1 (de)	2002-12-18
DE69810283D1 (de)	2003-01-30
EP0973801A1 (de)	2000-01-26
PT973801E (pt)	2003-04-30

Legal Events

Date

Code

Title

Description

2003-07-15

UEP

Publication of translation of european patent specification

Ref document number: 0973801

Country of ref document: EP

Publication	Publication Date	Title
ATE229976T1 (de)	2003-01-15	Gnrh antagonisten
US5003011A (en)	1991-03-26	Therapeutic decapeptides
CY1107051T1 (el)	2012-10-24	Αντι-διηθητικα και αντι-αγγειογενετικα θραυσματα ουροκινασης και η χρηση τους
NO982731L (no)	1998-08-13	Antagonister av gonadotropinfrigivende hormon
MXPA02006029A (es)	2004-08-23	Lipopeptidos novedosos como agentes antibacterianos.
NO982729D0 (no)	1998-06-12	Antagonister av det gonadotropinfrigj°rende hormon
MXPA02006030A (es)	2004-08-23	Lipopeptidos como agentes antibacterianos.
MY139203A (en)	2009-08-28	Pharmaceutical composition
KR970701730A (ko)	1997-04-12	GnRH 길항물질(GNRH ANTAGONISTS)
MXPA02006028A (es)	2004-08-23	Lipopeptidos novedosos como agentes antibacterianos.
BR9808523A (pt)	2000-05-23	Peptìdeo antagonista de gnrh, composição farmacêutica para inibir a secreção de gonadotropinas em mamìferos, processos para o diagnóstico in vivo ou in vitro de uma condição onde gnrh está causando crescimento de tumor ou secreção hormonal em excesso e para inibir a secreção de gonadotropinas em mamìferos, e, intermediário para fazer um peptìdeo antagonista de gnrh.
SE9604341D0 (sv)	1996-11-26	Hepta-peptide oxytocin analogue
KR920004418A (ko)	1992-03-27	브래디키닌 길항제
DE69231918D1 (de)	2001-08-09	Peptidantagonisten des bradykinin
US5413990A (en)	1995-05-09	N-terminus modified analogs of LHRH
CA2097192A1 (en)	1992-05-30	Bombesin antagonists
US5502035A (en)	1996-03-26	N-terminus modified analogs of LHRH
HU218288B (en)	2000-07-28	Bombesin-antagonistic polypeptide derivatives and pharmaceutical compositions containing them
CY1107990T1 (el)	2013-09-04	Τριπεπτιδια και παραγωγα τριπεπτιδιων για τη θepαπεια νευροεκφυλιστικων ασθενειων
DK1309613T3 (da)	2008-08-11	Farmaceutisk præparat omfattende et analgetisk peptid
RU2010130763A (ru)	2012-01-27	Способы и фармакологические композиции для заживления ран
KR20000076211A (ko)	2000-12-26	택산과 조합된 돌라스태틴-15 유도체
US5516759A (en)	1996-05-14	LHRH antagonists having lactam groups at the N-terminus
WO1995004541A1 (en)	1995-02-16	N-terminus modified analogs of lhrh
IE51068B1 (en)	1986-09-17	Lrf antagonists