ATE229978T1 - Helicobacter proteine und impstoffe - Google Patents

Helicobacter proteine und impstoffe

Info

Publication number
ATE229978T1
ATE229978T1 AT95922708T AT95922708T ATE229978T1 AT E229978 T1 ATE229978 T1 AT E229978T1 AT 95922708 T AT95922708 T AT 95922708T AT 95922708 T AT95922708 T AT 95922708T AT E229978 T1 ATE229978 T1 AT E229978T1
Authority
AT
Austria
Prior art keywords
helicobacter
proteins
vaccines
kda
vaccine
Prior art date
Application number
AT95922708T
Other languages
English (en)
Inventor
Dermot Kelleher
Henry Windle
William Byrne
Ross Mcmanus
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IE940538A external-priority patent/IE940538A1/en
Application filed by Chiron Corp filed Critical Chiron Corp
Application granted granted Critical
Publication of ATE229978T1 publication Critical patent/ATE229978T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/105—Delta proteobacteriales, e.g. Lawsonia; Epsilon proteobacteriales, e.g. campylobacter, helicobacter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • C07K16/121—Helicobacter (G); Campylobacter (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56922—Campylobacter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A61K2039/55527—Interleukins
    • A61K2039/55538—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/205—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Campylobacter (G)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
AT95922708T 1994-07-01 1995-07-03 Helicobacter proteine und impstoffe ATE229978T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IE940538A IE940538A1 (en) 1994-07-01 1994-07-01 Vaccine
IE950249 1995-04-06
PCT/IE1995/000036 WO1996001272A1 (en) 1994-07-01 1995-07-03 Helicobacter proteins and vaccines

Publications (1)

Publication Number Publication Date
ATE229978T1 true ATE229978T1 (de) 2003-01-15

Family

ID=26319740

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95922708T ATE229978T1 (de) 1994-07-01 1995-07-03 Helicobacter proteine und impstoffe

Country Status (9)

Country Link
US (2) US20010010821A1 (de)
EP (2) EP0769018B1 (de)
JP (3) JPH10502365A (de)
AT (1) ATE229978T1 (de)
AU (2) AU696941B2 (de)
CA (2) CA2194237A1 (de)
DE (1) DE69529219T2 (de)
GB (2) GB2303855B (de)
WO (2) WO1996001272A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7141244B1 (en) * 1992-03-02 2006-11-28 Chiron Srl Helicobacter pylori proteins useful for vaccines and diagnostics
JPH10502365A (ja) * 1994-07-01 1998-03-03 リカン・リミテッド ヘリコバクタータンパク質およびワクチン
WO1996033220A1 (en) * 1995-04-21 1996-10-24 Csl Limited Protective helicobacter antigens
AU693679B2 (en) * 1995-04-21 1998-07-02 Csl Limited Protective helicobacter antigens
WO1997002283A1 (en) * 1995-07-05 1997-01-23 Jacqueline Ilene Keenan Helicobacter antigens
EP0909323B1 (de) * 1996-01-04 2007-02-28 Novartis Vaccines and Diagnostics, Inc. Bakterioferritin aus helicobacter pylori
AU724743B2 (en) 1996-05-31 2000-09-28 Genetics Institute, Llc IL-12 as an adjuvant for Bordetella Pertussis vaccines
DE69724515T2 (de) * 1996-06-07 2004-04-01 Oxoid Ltd., Basingstoke Vorrichtung und Testsatz zum Test von Serum und dergleichen
EP0811845B1 (de) * 1996-06-07 2003-09-03 Oxoid Limited Vorrichtung und Testsatz zum Test von Serum und dergleichen
IT1289578B1 (it) * 1996-12-06 1998-10-15 Sanitaria Scaligera Spa Immunopurificazione di un antigene dall'apparente peso molecolare di 16 +- 2 kda dell' helicobacter pylori e metodi per la sua
WO1998032768A1 (en) * 1997-01-24 1998-07-30 Cortecs (Uk) Limited H. pylori antigens
US6599509B2 (en) * 1997-09-02 2003-07-29 Massachusetts Institute Of Technology Compositions and methods comprising helicobacter antigens for treatment and prevention of inflammatory bowel disease
CN1200730C (zh) * 1998-02-12 2005-05-11 惠氏控股有限公司 用白细胞介素-12配制的肺炎球菌和脑膜炎球菌疫苗
GB9807721D0 (en) * 1998-04-08 1998-06-10 Chiron Spa Antigen
US6841155B1 (en) 1998-04-30 2005-01-11 Chiron S.R.L. Immunization against and treatment for infection by H. pylori
EP1278768B1 (de) * 2000-04-27 2006-11-15 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Methode zur identifizierung von helicobacter antigenen
US20020107368A1 (en) * 2000-12-07 2002-08-08 Jing-Hui Tian Helicobacter proteins, gene sequences and uses thereof
GB0115176D0 (en) 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
GB0220194D0 (en) 2002-08-30 2002-10-09 Chiron Spa Improved vesicles
CA2506318C (en) 2002-11-15 2011-07-12 Chiron Srl Unexpected surface proteins in neisseria meningitidis
GB0227346D0 (en) 2002-11-22 2002-12-31 Chiron Spa 741
GB0308198D0 (en) 2003-04-09 2003-05-14 Chiron Srl ADP-ribosylating bacterial toxin
WO2005019265A1 (en) 2003-08-13 2005-03-03 Chiron Corporation Improved method of purifying tfpi and tfpi analogs
GB0700562D0 (en) 2007-01-11 2007-02-21 Novartis Vaccines & Diagnostic Modified Saccharides
NZ591768A (en) 2008-09-18 2012-11-30 Novartis Ag Vaccine adjuvant combinations
JP6166533B2 (ja) * 2009-07-31 2017-07-19 ナショナル リサーチ カウンシル オブ カナダ ピロリ菌リポ多糖類の外殻エピトープ
AU2010288239B2 (en) 2009-08-27 2014-01-16 Novartis Ag Adjuvant comprising aluminium, oligonucleotide and polycation
US9950062B2 (en) 2009-09-02 2018-04-24 Glaxosmithkline Biologicals Sa Compounds and compositions as TLR activity modulators
JP2013538217A (ja) 2010-09-01 2013-10-10 ノバルティス アーゲー 不溶性金属塩への免疫増強物質の吸着
ES2630029T3 (es) 2010-12-14 2017-08-17 Glaxosmithkline Biologicals Sa Análisis de citometría de flujo de materiales adsorbidos en sales metálicas
CN103533954B (zh) 2011-03-02 2015-09-09 诺华股份有限公司 含较低剂量的抗原和/或佐剂的联合疫苗
WO2013131983A1 (en) 2012-03-07 2013-09-12 Novartis Ag Adjuvanted formulations of streptococcus pneumoniae antigens
RU2014140336A (ru) 2012-03-07 2016-04-27 Новартис Аг Иммунологически полезные соли аргинина
CA2866406A1 (en) 2012-03-08 2013-09-12 Novartis Ag Adjuvanted formulations of booster vaccines
DK2870072T3 (en) 2012-07-05 2017-12-04 P C O A Devices Ltd medicine dispensers
EP2879974B1 (de) 2012-07-30 2017-08-23 P.C.O.A. Devices Ltd. Behälter zur aufnahme und ausgabe fester medizinischer pillen
USD776435S1 (en) 2013-12-19 2017-01-17 Colgate-Palmolive Company Head portion of a toothbrush
USD769626S1 (en) 2013-12-19 2016-10-25 Colgate-Palmolive Company Refill head for electric toothbrush
USD766581S1 (en) 2013-12-19 2016-09-20 Colgate-Palmolive Company Electric toothbrush handle
IL233295B (en) 2014-06-22 2019-11-28 Ilan Paz A control pill dispensing system
IL238387B (en) 2015-04-20 2019-01-31 Paz Ilan Drug dispenser release mechanism
EP3362030B1 (de) 2015-10-15 2023-09-06 Dosentrx Ltd. Auf bilderkennung basierende darreichungsformspender
WO2017077529A1 (en) 2015-11-02 2017-05-11 P.C.O.A. Lockable advanceable oral dosage form dispenser containers
USD794333S1 (en) 2015-11-25 2017-08-15 Colgate-Palmolive Company Electric toothbrush brush head
USD790860S1 (en) 2015-11-25 2017-07-04 Colgate-Palmolive Company Electric toothbrush brush head

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US653064A (en) * 1900-04-16 1900-07-03 Daniel Carroll Device for straightening chain-links.
DE875881C (de) * 1951-06-17 1953-05-07 Concordia Elek Zitaets Ag Gasanzeigegeraet, insbesondere Schlagwetteranzeiger, mit Temperaturausgleich
JPS59211922A (ja) * 1983-05-17 1984-11-30 三菱電機株式会社 ガス封入電気機器用ガス監視装置
US4751181A (en) * 1984-12-31 1988-06-14 Duke University Methods and compositions useful in the diagnosis and treatment of autoimmune diseases
US4997823A (en) * 1986-02-18 1991-03-05 Syntex (U.S.A.) Inc. Anti-infective injectable formulations
US5554372A (en) * 1986-09-22 1996-09-10 Emory University Methods and vaccines comprising surface-active copolymers
US4879213A (en) * 1986-12-05 1989-11-07 Scripps Clinic And Research Foundation Synthetic polypeptides and antibodies related to Epstein-Barr virus early antigen-diffuse
US4882271A (en) * 1988-03-10 1989-11-21 Baylor College Of Medicine Process for preparation of high molecular weight cell-associated protein of campylobacter pylori and use for serological detection of campylobacter pylori infection
AU3054789A (en) * 1988-03-23 1989-10-16 Julie Claire Dent Detection of campylobacter pylori urease antibodies and reagent therefor
GB2223756A (en) * 1988-09-29 1990-04-18 Health Lab Service Board Protein purification process
US5231860A (en) * 1989-09-22 1993-08-03 Kabushiki Kaisha Komatsu Seisakusho Work feeder controller
GB8928625D0 (en) * 1989-12-19 1990-02-21 3I Res Expl Ltd H.pylori dna probes
US5292658A (en) * 1989-12-29 1994-03-08 University Of Georgia Research Foundation, Inc. Boyd Graduate Studies Research Center Cloning and expressions of Renilla luciferase
JPH04364160A (ja) * 1990-08-03 1992-12-16 Terumo Corp チオウレア誘導体およびこれを含有する抗菌剤および抗潰瘍剤
US5153312A (en) * 1990-09-28 1992-10-06 American Cyanamid Company Oligosaccharide conjugate vaccines
DE4139840B4 (de) * 1990-12-04 2005-06-02 Quidel Corp., San Diego Antigen-Zubereitung zum Nachweis von H. pylori
US5567594A (en) * 1991-04-26 1996-10-22 Enteron, L.P. Methods and compositions for the detection and treatment of diseases associated with antigens of microorganisms
US5262156A (en) * 1991-08-12 1993-11-16 Hycor Biomedical, Inc. Antigenic compositions and their use for the detection of Helicobacter pylori
DK0529493T3 (da) * 1991-08-27 1998-08-24 Hoffmann La Roche Fremgangsmåder og reagenser til hepatitis C-detektion
JPH0559038A (ja) * 1991-09-06 1993-03-09 Terumo Corp チオウレア誘導体及びこれを含有する医薬製剤
US5866375A (en) * 1991-10-31 1999-02-02 Chiron S.P.A. Method for the culture of microorganisms of the genera helicobacter, campylobacter and arcobacter employing culture media comprising cyclodextrins
IT1251751B (it) * 1991-10-31 1995-05-23 Sclavo Ricerca S R L Metodo per la coltura di microrganismi dei generi helicobacter, campylobacter e arcobacter, utilizzando terreni di coltura contenenti ciclodestrine o metil-cellulosa o loro miscele
US5354854A (en) * 1991-11-07 1994-10-11 The Curators Of The University Of Missouri Expression system for use in plants to suppress foreign expression and method
US5721349A (en) * 1992-02-26 1998-02-24 Vanderbilt University Vacuolating toxin-deficient H. pylori
CA2117490C (en) * 1992-02-26 2009-01-06 Timothy L. Cover Purified vacuolating toxin from helicobacter pylori and methods to use same
IT1262895B (it) * 1992-03-02 1996-07-22 Proteina estratta da ceppi citotossici di helicobacter pylori, gene che la esprime, uso della proteina come vaccino o diagnostico.
US7141244B1 (en) * 1992-03-02 2006-11-28 Chiron Srl Helicobacter pylori proteins useful for vaccines and diagnostics
AU3630093A (en) * 1992-03-02 1993-10-05 Biocine S.P.A. Helicobacter pylori proteins useful for vaccines and diagnostics
MX9301706A (es) * 1992-04-13 1994-05-31 Oravax Inc Composicion de vacuna para el tratamiento de la infeccion por helicobacter.
US5733740A (en) * 1992-10-13 1998-03-31 Vanderbilt University Taga gene and methods for detecting predisposition to peptic ulceration and gastric carcinoma
US5403924A (en) * 1992-10-13 1995-04-04 Vanderbilt University Taga gene and methods for detecting predisposition to peptic ulceration
US5972336A (en) * 1992-11-03 1999-10-26 Oravax Merieux Co. Urease-based vaccine against helicobacter infection
EP0716613B1 (de) * 1993-07-27 2003-07-09 Csl Limited Behandlung eines durch helicobakter verursachten gastroduodenalen krankheit
JPH09505588A (ja) * 1993-11-23 1997-06-03 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 多くの細胞外生成物及びそれらの製造法並びに使用
US5434253A (en) * 1994-03-21 1995-07-18 Vanderbilt University DNA encoding Helicobacter pylori recombinase
US5571515A (en) * 1994-04-18 1996-11-05 The Wistar Institute Of Anatomy & Biology Compositions and methods for use of IL-12 as an adjuvant
AUPM612494A0 (en) * 1994-06-08 1994-06-30 Csl Limited Treatment or prevention of helicobacter infection
JPH10502365A (ja) * 1994-07-01 1998-03-03 リカン・リミテッド ヘリコバクタータンパク質およびワクチン
US6019982A (en) * 1994-08-26 2000-02-01 The Administrators Of The Tulane Educational Fund Mutant enterotoxin effective as a non-toxic oral adjuvant
WO1996009757A1 (en) * 1994-09-28 1996-04-04 Biocine Spa Mouse model for helicobacter pylori infection
US5679564A (en) * 1994-10-05 1997-10-21 Antex Biologics, Inc. Methods for producing enhanced antigenic campylobacter bacteria and vaccines
US5527678A (en) * 1994-10-21 1996-06-18 Vanderbilt University CagB and CagC genes of helicobacter pylori and related compositions
US5861518A (en) * 1994-11-21 1999-01-19 Dekker; Koenraad A. Phthalide compounds and their production process
GB9501560D0 (en) * 1995-01-26 1995-03-15 Nycomed Imaging As Contrast agents
DE19511276C2 (de) * 1995-03-27 1999-02-18 Immuno Ag Adjuvans auf der Basis kolloidaler Eisenverbindungen
US5854221A (en) * 1996-12-12 1998-12-29 The Children's Medical Center Corporation Endothelial cell proliferation inhibitor and method of use
EP0909323B1 (de) * 1996-01-04 2007-02-28 Novartis Vaccines and Diagnostics, Inc. Bakterioferritin aus helicobacter pylori
US5900410A (en) * 1996-08-27 1999-05-04 Hartmann; John F. Monotherapy of peptic ulcers and gastritis
US20040052799A1 (en) * 1996-11-15 2004-03-18 Astra Aktiebolag Nucleic acid and amino acid sequences relating to Helicobacter pylori for diagnostics and therapeutics
US6902903B1 (en) * 1996-12-19 2005-06-07 Chiron Corporation Helicobacter pylori diagnostics
ATE291617T1 (de) * 1997-01-24 2005-04-15 Avi Biopharm Inc Verfahren und konjugat zur behandlung von helicobacter pylori-infektionen
SE9700661D0 (sv) * 1997-02-25 1997-02-25 Astra Ab New compounds
DE19709897A1 (de) * 1997-03-11 1998-09-17 Hoechst Ag Wismutsalze von Antibiotika der Moenomycin-Gruppe, Verfahren zu ihrer Herstellung, ihre Verwendung und solche Salze enthaltende Arzneimittel
US20020115078A1 (en) * 1997-04-01 2002-08-22 Harold Kleanthous Identification of polynucleotides encoding novel helicobacter polypeptides in the helicobacter genome
JP3933244B2 (ja) * 1997-04-04 2007-06-20 株式会社資生堂 アルキレンジアミン誘導体及び抗潰瘍剤、抗菌剤
JP4113602B2 (ja) * 1997-04-04 2008-07-09 株式会社資生堂 ピロリジン誘導体及び抗潰瘍剤、抗菌剤
JP4090087B2 (ja) * 1997-04-04 2008-05-28 株式会社資生堂 ベンズアミド誘導体及び抗潰瘍剤、抗菌剤
CA2289542A1 (en) * 1997-05-28 1998-12-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Fused dihydropyrans
US6914131B1 (en) * 1998-10-09 2005-07-05 Chiron S.R.L. Neisserial antigens
ATE480625T1 (de) * 1997-11-21 2010-09-15 Merck Serono Biodevelopment Äusseres membranpolypeptid von chlamydia pneumoniae sowie fragmente davon und deren verwendung, insbesondere zur diagnose, prävention und behandlung einer infektion
GB9807721D0 (en) * 1998-04-08 1998-06-10 Chiron Spa Antigen
US6841155B1 (en) * 1998-04-30 2005-01-11 Chiron S.R.L. Immunization against and treatment for infection by H. pylori
US6248329B1 (en) * 1998-06-01 2001-06-19 Ramaswamy Chandrashekar Parasitic helminth cuticlin nucleic acid molecules and uses thereof
BR9914374A (pt) * 1998-10-09 2002-09-17 Chiron Corp Sequências genÈmicas de neisseria e métodos para seu uso
US6552047B2 (en) * 1998-11-17 2003-04-22 Nitromed, Inc. H2 receptor antagonist compounds in combination with nitric oxide donors, compositions and methods of use
US20020065296A1 (en) * 1999-01-13 2002-05-30 Bayer Corporation Heteroaryl ureas containing nitrogen hetero-atoms as p38 kinase inhibitors
EP2298311B1 (de) * 1999-01-13 2012-05-09 Bayer HealthCare LLC Omega-carboxyarylsubstituierte-Diphenyl-Harnstoffe als p38-Kinasehemmer
US6346283B1 (en) * 1999-03-26 2002-02-12 Ancile Pharmaceuticals Use of valeriana for the treatment of restless leg syndrome and related disorders
GB9928196D0 (en) * 1999-11-29 2000-01-26 Chiron Spa Combinations of B, C and other antigens
JP2003523958A (ja) * 1999-12-23 2003-08-12 ニトロメド インコーポレーテッド ニトロソ化およびニトロシル化されたシクロオキシゲナーゼ−2の阻害剤、組成物ならびに使用法
US7851212B2 (en) * 2000-05-10 2010-12-14 Sanofi Pasteur Limited Immunogenic polypeptides encoded by MAGE minigenes and uses thereof
ATE440861T1 (de) * 2000-07-03 2009-09-15 Novartis Vaccines & Diagnostic Immunisierung gegen chlamydia pneumoniae
US20030232324A1 (en) * 2001-05-31 2003-12-18 Chiron Corporation Chimeric alphavirus replicon particles
US20040029129A1 (en) * 2001-10-25 2004-02-12 Liangsu Wang Identification of essential genes in microorganisms
US20090100536A1 (en) * 2001-12-04 2009-04-16 Monsanto Company Transgenic plants with enhanced agronomic traits
US20090158452A1 (en) * 2001-12-04 2009-06-18 Johnson Richard G Transgenic plants with enhanced agronomic traits
US20040126811A1 (en) * 2002-02-21 2004-07-01 Thomas Boren Helicobacter pylori sialic acid binding adhesin, saba and saba-gene

Also Published As

Publication number Publication date
GB9626484D0 (en) 1997-02-05
WO1996001272A1 (en) 1996-01-18
GB2303854B (en) 1998-10-21
GB2303855B (en) 1998-10-28
US20070104731A1 (en) 2007-05-10
AU2751395A (en) 1996-01-25
JP2006348036A (ja) 2006-12-28
GB9626483D0 (en) 1997-02-05
WO1996001273A1 (en) 1996-01-18
AU2751495A (en) 1996-01-25
GB2303855A (en) 1997-03-05
CA2194236A1 (en) 1996-01-18
GB2303854A (en) 1997-03-05
DE69529219D1 (en) 2003-01-30
EP0769019A1 (de) 1997-04-23
EP0769018B1 (de) 2002-12-18
AU695769B2 (en) 1998-08-20
CA2194236C (en) 2009-02-24
AU696941B2 (en) 1998-09-24
DE69529219T2 (de) 2003-11-06
EP0769018A1 (de) 1997-04-23
CA2194237A1 (en) 1996-01-18
JPH10502365A (ja) 1998-03-03
JPH10502366A (ja) 1998-03-03
US20010010821A1 (en) 2001-08-02

Similar Documents

Publication Publication Date Title
DE69529219D1 (en) Helicobacter proteine und impstoffe
DE69939706D1 (de) Verbesserte adjuvant zusammensetzungen auf basis von saponin und damit zusammenhängende methoden
NO894614D0 (no) Hudtest og testkit for aids.
ITTO950367A0 (it) Proteine di prrsv ricombinanti, corredi diagnostici e vaccini contenenti tali proteine di prrsv ricombinanti.
ATE127345T1 (de) Stressproteine und verwendungen dafür.
WO2000039299A3 (en) Streptococcus antigens
IT1262895B (it) Proteina estratta da ceppi citotossici di helicobacter pylori, gene che la esprime, uso della proteina come vaccino o diagnostico.
FI960977L (fi) Bakteeriperäiset eksportoidut proteiinit ja niihin perustuvat asellulaariset rokotteet
EP1757697A3 (de) Gruppe B-Streptococcus Antigene
DK0957935T3 (da) Chlamydia-vacciner og immunogene præparater indeholdende et ydre membran-antigen samt fremgangsmåde til fremstilling deraf
DE69533673D1 (de) Behandlung und prävention von helicobacter-infektionen
NO912825L (no) Fremgangsmaate for fremstilling av kokonjugatvaksiner omfattende im munogent protein, hiv-beslektede peptider og anioniske grupper.
ATE355375T1 (de) Bakterioferritin aus helicobacter pylori
EP0716613A4 (de) BEHANDLUNG EINES DURCH -i(HELICOBAKTER PYLORI) VERURSACHTEN GASTRODUODENALEN KRANKHEIT
DK0792165T3 (da) Immunogene præparater
DE122005000015I1 (de) Azellul{rer Impfstoff.
DE68915046D1 (de) Haemophilus influenzae Typ B Polysaccharid-Aussermembranprotein-Konjugat als Impfstoff.
EA200100395A1 (ru) Фармацевтическая композиция, содержащая фрагменты днк, кодирующей антигенный белок, обладающая противоопухолевым действием
GB9810084D0 (en) Proteins
MX9700215A (es) Proteinas y vacunas de helicobacter.
DK0732339T3 (da) Peptider fra HIV-gag-proteinet, fremstilling og anvendelse deraf
IT1270184B (it) Uso di proteine da schock termico per il trattamento di malattie virali di interesse veterinario
EP1950302A3 (de) Streptokokken-Antigene

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0769018

Country of ref document: EP

EEIH Change in the person of patent owner