ATE230739T1 - Indanol-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen - Google Patents

Indanol-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen

Info

Publication number: ATE230739T1
Authority: AT; Austria
Prior art keywords: alkyl; alkoxy; atoms; production; indanol derivatives
Prior art date: 1997-10-03

Application number

AT98402415T

Other languages

English (en)

Inventor

Jean-Louis Peglion

Bertrand Goument

Mark Millan

Adrian Newman-Tancredi

Anne Dekeyne

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-03

Filing date

1998-10-01

Publication date

2003-01-15

1998-10-01 Application filed by Servier Lab filed Critical Servier Lab

2003-01-15 Application granted granted Critical

2003-01-15 Publication of ATE230739T1 publication Critical patent/ATE230739T1/de

Links

YIAPLDFPUUJILH-UHFFFAOYSA-N indan-1-ol Chemical class C1=CC=C2C(O)CCC2=C1 YIAPLDFPUUJILH-UHFFFAOYSA-N 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 7
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000004432 carbon atom Chemical group C* 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000005842 heteroatom Chemical group 0.000 abstract 2
CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
KAQJERBONUSJEE-UHFFFAOYSA-N 1-piperidin-1-yl-2,3-dihydroinden-1-ol Chemical class C1CC2=CC=CC=C2C1(O)N1CCCCC1 KAQJERBONUSJEE-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003302 alkenyloxy group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000005133 alkynyloxy group Chemical group 0.000 abstract 1
125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004193 piperazinyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

AT98402415T 1997-10-03 1998-10-01 Indanol-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen ATE230739T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9712336A FR2769312B1 (fr)	1997-10-03	1997-10-03	Nouveaux composes de l'indanol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
ATE230739T1 true ATE230739T1 (de)	2003-01-15

Family

ID=9511782

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98402415T ATE230739T1 (de)	1997-10-03	1998-10-01	Indanol-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen

Country Status (18)

Country	Link
US (2)	US5958927A (de)
EP (1)	EP0906912B1 (de)
JP (1)	JP3884177B2 (de)
CN (1)	CN1122666C (de)
AT (1)	ATE230739T1 (de)
AU (1)	AU736710B2 (de)
BR (1)	BR9804485A (de)
CA (1)	CA2249756C (de)
DE (1)	DE69810560T2 (de)
DK (1)	DK0906912T3 (de)
ES (1)	ES2190574T3 (de)
FR (1)	FR2769312B1 (de)
HU (1)	HUP9802194A1 (de)
NO (1)	NO316693B1 (de)
NZ (1)	NZ332142A (de)
PL (1)	PL191091B1 (de)
PT (1)	PT906912E (de)
ZA (1)	ZA989011B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2769312B1 (fr) *	1997-10-03	1999-12-03	Adir	Nouveaux composes de l'indanol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP2002519323A (ja) *	1998-06-30	2002-07-02	イーライ・リリー・アンド・カンパニー	セロトニン関連系に効果を及ぼすピペリジン誘導体
US6197798B1 (en)	1998-07-21	2001-03-06	Novartis Ag	Amino-benzocycloalkane derivatives
US6878707B2 (en) *	2000-01-18	2005-04-12	Novartis Ag	Carboxamides useful as inhibitors of microsomal triglyceride transfer protein and of apolipoprotein b secretion
US20020077278A1 (en) *	2000-06-05	2002-06-20	Yong V. Wee	Use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders
US7504395B2 (en) *	2001-07-20	2009-03-17	Psychogenics, Inc.	Treatment for attention-deficit hyperactivity disorder
DE10142661B4 (de) *	2001-08-31	2004-06-09	Aventis Pharma Deutschland Gmbh	Mehrfach substituierte Indan-1-ol-Systeme und ihre Verwendung als Arzneimittel
DE10142667B4 (de) *	2001-08-31	2004-06-09	Aventis Pharma Deutschland Gmbh	C2-substituierte Indan-1-ole und ihre Derivate und ihre Verwendung als Arzneimittel
DE10142662B4 (de) *	2001-08-31	2004-07-08	Aventis Pharma Deutschland Gmbh	Derivate von C2-substituierten Indan-1-ol-Systemen und ihre Verwendung als Arzneimittel
FR2883876B1 (fr) *	2005-03-30	2007-05-04	Servier Lab	Derives d'indanyl-piperazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0190472B1 (de) *	1984-12-21	1989-07-12	Duphar International Research B.V	Arzneimittel mit antipsychotischer Wirkung
JPH01503777A (ja) *	1985-10-04	1989-12-21	マツジヨ‐ニ‐ウインスロツプ・ソチエタ・ペル・アチオニ	縮合脂環式アミノアルコール類
FR2670491B1 (fr) *	1990-12-14	1993-02-05	Adir	Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant.
FR2692264B1 (fr) *	1992-06-12	1994-08-05	Adir	Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
FR2734819B1 (fr) *	1995-05-31	1997-07-04	Adir	Nouveaux composes de la piperazine, de la piperidine et de la 1,2,5,6-tetrahydropyridine, leur procede de preparation et les compositions pharmaceutiques les contenant
FR2769312B1 (fr) *	1997-10-03	1999-12-03	Adir	Nouveaux composes de l'indanol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

1997
- 1997-10-03 FR FR9712336A patent/FR2769312B1/fr not_active Expired - Fee Related
1998
- 1998-09-30 CN CN98120594A patent/CN1122666C/zh not_active Expired - Fee Related
- 1998-10-01 CA CA002249756A patent/CA2249756C/fr not_active Expired - Fee Related
- 1998-10-01 DK DK98402415T patent/DK0906912T3/da active
- 1998-10-01 AT AT98402415T patent/ATE230739T1/de not_active IP Right Cessation
- 1998-10-01 EP EP98402415A patent/EP0906912B1/de not_active Expired - Lifetime
- 1998-10-01 DE DE69810560T patent/DE69810560T2/de not_active Expired - Fee Related
- 1998-10-01 PT PT98402415T patent/PT906912E/pt unknown
- 1998-10-01 ES ES98402415T patent/ES2190574T3/es not_active Expired - Lifetime
- 1998-10-02 JP JP28063998A patent/JP3884177B2/ja not_active Expired - Fee Related
- 1998-10-02 HU HU9802194A patent/HUP9802194A1/hu unknown
- 1998-10-02 US US09/165,844 patent/US5958927A/en not_active Expired - Fee Related
- 1998-10-02 NZ NZ332142A patent/NZ332142A/xx unknown
- 1998-10-02 AU AU87875/98A patent/AU736710B2/en not_active Ceased
- 1998-10-02 NO NO19984620A patent/NO316693B1/no unknown
- 1998-10-02 ZA ZA989011A patent/ZA989011B/xx unknown
- 1998-10-02 PL PL328989A patent/PL191091B1/pl not_active IP Right Cessation
- 1998-10-05 BR BR9804485-0A patent/BR9804485A/pt not_active Application Discontinuation
1999
- 1999-03-22 US US09/273,889 patent/US6060487A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PT906912E (pt)	2003-04-30
CA2249756A1 (fr)	1999-04-03
DE69810560D1 (de)	2003-02-13
HK1019736A1 (en)	2000-02-25
PL328989A1 (en)	1999-04-12
US5958927A (en)	1999-09-28
HU9802194D0 (en)	1998-11-30
AU8787598A (en)	1999-04-22
DK0906912T3 (da)	2003-04-22
US6060487A (en)	2000-05-09
AU736710B2 (en)	2001-08-02
NO984620D0 (no)	1998-10-02
FR2769312A1 (fr)	1999-04-09
CN1218051A (zh)	1999-06-02
NZ332142A (en)	2000-05-26
CA2249756C (fr)	2003-12-02
FR2769312B1 (fr)	1999-12-03
PL191091B1 (pl)	2006-03-31
EP0906912A1 (de)	1999-04-07
ES2190574T3 (es)	2003-08-01
EP0906912B1 (de)	2003-01-08
CN1122666C (zh)	2003-10-01
DE69810560T2 (de)	2003-11-27
HUP9802194A1 (hu)	1999-12-28
NO316693B1 (no)	2004-03-26
BR9804485A (pt)	2000-04-11
ZA989011B (en)	1999-04-12
NO984620L (no)	1999-04-06
JPH11158179A (ja)	1999-06-15
JP3884177B2 (ja)	2007-02-21

Legal Events

Date

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Title

Description

2003-07-15

UEP

Publication of translation of european patent specification

Ref document number: 0906912

Country of ref document: EP

2009-07-15

REN

Ceased due to non-payment of the annual fee

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