ATE210134T1 - Heterocyclisch substituierte imidazolidine, verfahren und zwischenprodukte zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zubereitungen - Google Patents

Heterocyclisch substituierte imidazolidine, verfahren und zwischenprodukte zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zubereitungen

Info

Publication number: ATE210134T1
Authority: AT; Austria
Prior art keywords: opt; substd; products; production; pharmaceutical preparations
Prior art date: 1994-09-29

Application number

AT95402174T

Other languages

English (en)

Inventor

Andre Claussner

Francois Goubet

Jean-Georges Teutsch

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-29

Filing date

1995-09-28

Publication date

2001-12-15

1995-09-28 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

2001-12-15 Application granted granted Critical

2001-12-15 Publication of ATE210134T1 publication Critical patent/ATE210134T1/de

Links

150000002461 imidazolidines Chemical class 0.000 title abstract 2
239000013067 intermediate product Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
229940126601 medicinal product Drugs 0.000 title 1
238000000034 method Methods 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000000896 monocarboxylic acid group Chemical group 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT95402174T 1994-09-29 1995-09-28 Heterocyclisch substituierte imidazolidine, verfahren und zwischenprodukte zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zubereitungen ATE210134T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9411649A FR2725206B1 (fr)	1994-09-29	1994-09-29	Nouvelles imidazolidines substituees par un heterocycle, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant

Publications (1)

Publication Number	Publication Date
ATE210134T1 true ATE210134T1 (de)	2001-12-15

Family

ID=9467411

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95402174T ATE210134T1 (de)	1994-09-29	1995-09-28	Heterocyclisch substituierte imidazolidine, verfahren und zwischenprodukte zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zubereitungen

Country Status (19)

Country	Link
US (3)	US5646172A (de)
EP (1)	EP0704448B1 (de)
JP (1)	JPH0899977A (de)
CN (1)	CN1055471C (de)
AT (1)	ATE210134T1 (de)
AU (1)	AU707569B2 (de)
BR (1)	BR9504205A (de)
CA (1)	CA2159425A1 (de)
DE (1)	DE69524344T2 (de)
DK (1)	DK0704448T3 (de)
ES (1)	ES2169112T3 (de)
FI (1)	FI111259B (de)
FR (1)	FR2725206B1 (de)
HU (1)	HU222564B1 (de)
IL (1)	IL114939A (de)
PT (1)	PT704448E (de)
RU (1)	RU2170231C2 (de)
UA (1)	UA48937C2 (de)
ZA (1)	ZA957568B (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2741342B1 (fr) *	1995-11-22	1998-02-06	Roussel Uclaf	Nouvelles phenylimidazolidines fluorees ou hydroxylees, procede, intermediaires de preparation, application comme medicaments, nouvelle utilisation et compositions pharmaceutiques
FR2742749B1 (fr) *	1995-12-22	1998-02-06	Roussel Uclaf	Nouvelles phenylimidazolidines comportant notamment un radical nitrooxy ou carbonyloxy, procede et intermediaires de preparation, application comme medicaments, nouvelles utilisations et compositions pharmaceutiques
DE19632126A1 (de) *	1996-08-09	1998-02-12	Bayer Ag	Phenylsubstituierte cyclische Ketoenole
US20020142993A1 (en) *	2000-10-12	2002-10-03	Dr. Reddy's Laboratories Ltd.	Pharmaceutically acceptable salts of bicyclic compounds
DK1385515T3 (da) *	2001-04-18	2008-10-27	Euro Celtique Sa	Spiropyrazole forbindelser
RU2243227C1 (ru) *	2003-07-25	2004-12-27	Институт проблем химической физики РАН	(dl)-1-гидрокси-3,7,7,9,9-пентаметил-1,4,8-триазаспиро [4,5] декан-2-он и способ его получения
EP1786816A4 (de) *	2003-09-10	2009-11-04	Virochem Pharma Inc	Spirohydantoinverbindungen und -verfahren zur modulation von chemokin-rezeptoraktivität
EP1709193B1 (de) *	2003-12-19	2011-03-16	The Regents of The University of California	Verfahren und materialien zur beurteilung von prostatakrebstherapien
WO2005099693A2 (en) *	2004-02-24	2005-10-27	The Regents Of The University Of California	Methods and materials for assessing prostate cancer therapies and compounds
US7709517B2 (en)	2005-05-13	2010-05-04	The Regents Of The University Of California	Diarylhydantoin compounds
CA2608436C (en)	2005-05-13	2015-03-24	The Regents Of The University Of California	Diarylhydantoin compounds and their use in the treatment of hyperproliferative disorders
US8211904B2 (en) *	2005-07-18	2012-07-03	Merck, Sharp & Dohme Corp.	Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease
ES2689292T3 (es)	2006-03-27	2018-11-13	The Regents Of The University Of California	Modulador del receptor de andrógenos para el tratamiento del cáncer de próstata y enfermedades asociadas con el receptor de andrógenos
NZ572374A (en)	2006-03-29	2011-12-22	Univ California	Diarylthiohydantoin compounds
US8168667B2 (en)	2006-05-31	2012-05-01	Galapagos Nv	Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such
GB0610765D0 (en) *	2006-05-31	2006-07-12	Proskelia Sas	Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such
AU2007293416A1 (en) *	2006-09-07	2008-03-13	Merck & Co., Inc.	Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease
EP2220050A2 (de)	2007-10-26	2010-08-25	The Regents Of The University Of California	Diarylhydantoinverbindungen als androgenrezeptormodulatoren
CA2773038A1 (en)	2009-09-04	2011-03-10	P. Jeffrey Conn	Mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
KR101456994B1 (ko)	2009-09-10	2014-11-04	통유지	안드로겐 수용체 길항제 및 그의 용도
SG10201907588XA (en)	2010-02-16	2019-09-27	Aragon Pharmaceuticals Inc	Androgen Receptor Modulators And Uses Thereof
RU2434851C1 (ru) *	2010-07-22	2011-11-27	Александр Васильевич Иващенко	Циклические n, n'-диарилтиомочевины или n, n'-диарилмочевины - антагонисты андрогенных рецепторов, противораковое средство, способ получения и применения
CN103608333B (zh) *	2011-03-10	2016-01-06	苏州开拓药业有限公司	雄激素受体拮抗剂及其用途
CN115737643A (zh)	2012-09-26	2023-03-07	阿拉贡药品公司	用于治疗非转移性去势抵抗性前列腺癌的抗雄激素
DK2945628T3 (da)	2013-01-15	2020-05-04	Aragon Pharmaceuticals Inc	Androgen receptormodulator i kombination med abirateronacetat og prednison til behandling af prostatacancer
EP3327144B1 (de)	2013-02-25	2020-03-25	Novartis AG	Neuartige androgenrezeptormutation
TWI726969B (zh)	2016-01-11	2021-05-11	比利時商健生藥品公司	用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
EP3500310A1 (de)	2016-08-20	2019-06-26	FTF Pharma Private Limited	Pharmazeutische zusammensetzung mit einem androgenrezeptorinhibitor
MX2020003845A (es)	2017-10-16	2020-11-06	Aragon Pharmaceuticals Inc	Antiandrógenos para el tratamiento de cáncer de próstata no metastásico resistente a la castración.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS421179Y1 (de) *	1964-03-13	1967-01-24
JPS4623738Y1 (de) *	1968-05-29	1971-08-16
DE2126532A1 (de) *	1971-05-28	1972-12-07	Merck Patent Gmbh, 6100 Darmstadt	Neue Derivate der 6-Aminopenicillansäure und Verfahren zu ihrer Herstellung
FR2329276A1 (fr) *	1975-10-29	1977-05-27	Roussel Uclaf	Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant
US4200642A (en) *	1978-08-21	1980-04-29	Pfizer Inc.	Spiro-oxazolidindiones
US4320135A (en) *	1980-05-19	1982-03-16	Sandoz, Inc.	Inhibiting growth hormone secretion with 5,5-substituted hydantoin derivatives
DE3382406D1 (de) *	1982-04-08	1991-10-17	Shell Int Research	Neue hydantoine, ihre herstellung und verwendung.
US5221675A (en) *	1989-12-15	1993-06-22	Abbott Laboratories	Aza-spirocyclic compounds that enhance cholinergic neurotransmission
US5534520A (en) *	1990-04-10	1996-07-09	Fisher; Abraham	Spiro compounds containing five-membered rings
FR2694290B1 (fr) *	1992-07-08	1994-09-02	Roussel Uclaf	Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.

1994
- 1994-09-29 FR FR9411649A patent/FR2725206B1/fr not_active Expired - Fee Related
1995
- 1995-08-15 IL IL11493995A patent/IL114939A/xx not_active IP Right Cessation
- 1995-09-07 US US08/524,508 patent/US5646172A/en not_active Expired - Fee Related
- 1995-09-08 ZA ZA957568A patent/ZA957568B/xx unknown
- 1995-09-27 UA UA95094318A patent/UA48937C2/uk unknown
- 1995-09-27 JP JP7272076A patent/JPH0899977A/ja active Pending
- 1995-09-28 ES ES95402174T patent/ES2169112T3/es not_active Expired - Lifetime
- 1995-09-28 CA CA002159425A patent/CA2159425A1/fr not_active Abandoned
- 1995-09-28 BR BR9504205A patent/BR9504205A/pt active Search and Examination
- 1995-09-28 AT AT95402174T patent/ATE210134T1/de not_active IP Right Cessation
- 1995-09-28 RU RU95116592/04A patent/RU2170231C2/ru not_active IP Right Cessation
- 1995-09-28 HU HU9502841A patent/HU222564B1/hu not_active IP Right Cessation
- 1995-09-28 FI FI954612A patent/FI111259B/fi active
- 1995-09-28 DK DK95402174T patent/DK0704448T3/da active
- 1995-09-28 DE DE69524344T patent/DE69524344T2/de not_active Expired - Fee Related
- 1995-09-28 EP EP95402174A patent/EP0704448B1/de not_active Expired - Lifetime
- 1995-09-28 AU AU32921/95A patent/AU707569B2/en not_active Ceased
- 1995-09-28 CN CN95117799A patent/CN1055471C/zh not_active Expired - Fee Related
- 1995-09-28 PT PT95402174T patent/PT704448E/pt unknown
1996
- 1996-08-12 US US08/695,690 patent/US5705654A/en not_active Expired - Fee Related
1997
- 1997-09-23 US US08/935,708 patent/US5958936A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69524344T2 (de)	2002-08-22
FI954612A0 (fi)	1995-09-28
CN1127753A (zh)	1996-07-31
DK0704448T3 (da)	2002-03-25
ZA957568B (en)	1996-09-09
CN1055471C (zh)	2000-08-16
JPH0899977A (ja)	1996-04-16
FI111259B (fi)	2003-06-30
US5705654A (en)	1998-01-06
AU3292195A (en)	1996-04-18
FR2725206A1 (fr)	1996-04-05
HU222564B1 (hu)	2003-08-28
DE69524344D1 (de)	2002-01-17
BR9504205A (pt)	1996-08-06
FI954612L (fi)	1996-03-30
ES2169112T3 (es)	2002-07-01
EP0704448A1 (de)	1996-04-03
FR2725206B1 (fr)	1996-12-06
IL114939A0 (en)	1995-12-08
AU707569B2 (en)	1999-07-15
RU2170231C2 (ru)	2001-07-10
US5646172A (en)	1997-07-08
US5958936A (en)	1999-09-28
IL114939A (en)	2005-11-20
UA48937C2 (uk)	2002-09-16
HU9502841D0 (en)	1995-11-28
CA2159425A1 (fr)	1996-03-30
EP0704448B1 (de)	2001-12-05
PT704448E (pt)	2002-05-31
HUT72748A (en)	1996-05-28

Legal Events

Date	Code	Title	Description
2002-05-15	UEP	Publication of translation of european patent specification
2007-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69524344D1 (de)	2002-01-17	Heterocyclisch substituierte Imidazolidine, Verfahren und Zwischenprodukte zu ihrer Herstellung, ihre Verwendung als Arzneimittel und diese enthaltende pharmazeutische Zubereitungen
ATE128975T1 (de)	1995-10-15	Harnstoffderivate, verfahren zu ihrer herstellung und diese enthaltende medikamente.
DE3778800D1 (de)	1992-06-11	Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel.
DE69327438D1 (de)	2000-02-03	Therapeutische Mittel für die Parkinsonsche Krankheit
ATE141277T1 (de)	1996-08-15	Neue phosphonobernsteinsäurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE50011034D1 (de)	2005-09-29	N-substituierte 4-aminopteridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3677452D1 (de)	1991-03-14	Chinazolinderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
IT1224416B (it)	1990-10-04	Chelanti macrociclici e loro chelati
DE58901510D1 (de)	1992-07-02	6-phenyldihydro-3(2h)-pyridazinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
ATE122042T1 (de)	1995-05-15	Pyrazoloisoquinoline-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
DE3777852D1 (de)	1992-05-07	Dekahydrochinolinderivate, verfahren zu ihrer herstellung, zwischenprodukte zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende zubereitungen.
ATE127807T1 (de)	1995-09-15	N-heteroaryl-purin-6-amine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
EP0369263A3 (de)	1990-12-27	Präparate zur topischen Behandlung von Hautkrankheiten
DE3888340D1 (de)	1994-04-14	Verwendung von 1,4-disubstituierten-Piperidinyl-Verbindungen zur Herstellung eines Arzneimittels zur Behandlung von Schlaflosigkeit.
DE3882438D1 (de)	1993-08-26	Alkansulfonanilid-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung.
HUP9801442A2 (hu)	1998-09-28	Fenil-ecetsav-származékok, eljárás és intermedierek előállításukhoz, valamint inszekticidként, akaricidként, nematocidként és fungicidként való alkalmazásuk
ATE157656T1 (de)	1997-09-15	Neue phthalazine, die in 1-stellung eine ether- gruppierung enthalten und verfahren zu deren herstellung
DK0637583T3 (da)	1997-05-12	1-Aryloxy-3-alkylamino-2-propanol-nitratestere, anvendelse heraf og tilsvarende farmaceutisk præparat
DE69130266D1 (de)	1998-11-05	Optisch wirksame Alkylendioxybenzolderivate und ihre Verwendung als Arzneimittel
DE68906122D1 (de)	1993-05-27	Verbindungen zur behandlung von harninkontinenz.
ATE238660T1 (de)	2003-05-15	Triazolyloxybenzyl-alkoxyacrylsäureester, verfahren zu ihrer herstellung und ihre verwendung
ATE123493T1 (de)	1995-06-15	3-(1h-indazol-3-yl)-4-pyridiname, verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung als arzneimittel.
ATE123776T1 (de)	1995-06-15	Aminoalkylchromone, verfahren zu ihrer herstellung und diese enthaltende zusammensetzungen.
IE800900L (en)	1980-11-04	Pyrrolidinyl-benzoic acid derivatives.
ATE122340T1 (de)	1995-05-15	Verfahren zur herstellung von (-)2-(2-(2- aminoethoxy)ethoxy)methyl)-4-(2,3-dichlorphenyl - 3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4 dihydropyridin, und zwischenprodukt zu dessen herstellung.