ATE230923T1 - Verfahren und zusammensetzungen zur herstellung getrockneter, lagerungsstabiler blutplättchen - Google Patents

Verfahren und zusammensetzungen zur herstellung getrockneter, lagerungsstabiler blutplättchen

Info

Publication number
ATE230923T1
ATE230923T1 AT98904260T AT98904260T ATE230923T1 AT E230923 T1 ATE230923 T1 AT E230923T1 AT 98904260 T AT98904260 T AT 98904260T AT 98904260 T AT98904260 T AT 98904260T AT E230923 T1 ATE230923 T1 AT E230923T1
Authority
AT
Austria
Prior art keywords
compositions
storage
producing dried
stable blood
blood plates
Prior art date
Application number
AT98904260T
Other languages
English (en)
Inventor
Valentine Charlton Menys
Diana Johanna Phipps
Lynda Mary Grandage
Bruce Joseph Roser
Original Assignee
Elan Drug Delivery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Drug Delivery Ltd filed Critical Elan Drug Delivery Ltd
Application granted granted Critical
Publication of ATE230923T1 publication Critical patent/ATE230923T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/125—Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/108331—Preservative, buffer, anticoagulant or diluent

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT98904260T 1997-02-07 1998-02-06 Verfahren und zusammensetzungen zur herstellung getrockneter, lagerungsstabiler blutplättchen ATE230923T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3749397P 1997-02-07 1997-02-07
PCT/GB1998/000375 WO1998034478A1 (en) 1997-02-07 1998-02-06 Methods and compositions for producing dried, storage-stable platelets

Publications (1)

Publication Number Publication Date
ATE230923T1 true ATE230923T1 (de) 2003-02-15

Family

ID=21894636

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98904260T ATE230923T1 (de) 1997-02-07 1998-02-06 Verfahren und zusammensetzungen zur herstellung getrockneter, lagerungsstabiler blutplättchen

Country Status (12)

Country Link
US (1) US6221575B1 (de)
EP (1) EP0967862B1 (de)
JP (1) JP2001511174A (de)
CN (1) CN1246778A (de)
AT (1) ATE230923T1 (de)
AU (1) AU732274B2 (de)
CA (1) CA2279376A1 (de)
DE (1) DE69810755T2 (de)
DK (1) DK0967862T3 (de)
ES (1) ES2190063T3 (de)
WO (1) WO1998034478A1 (de)
ZA (1) ZA981031B (de)

Families Citing this family (40)

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EP1221835B1 (de) 1999-11-12 2003-04-09 Elan Drug Delivery Limited Stabilisierung von blutplättchen
DE19964109A1 (de) 1999-12-29 2001-07-05 Dade Behring Marburg Gmbh Gebrauchsfertiges langzeitstabiles Ristocetin Cofaktor Testreagenz
WO2001058266A1 (en) * 2000-02-10 2001-08-16 The Regents Of The University Of California Therapeutic platelets and methods
DE10010959A1 (de) * 2000-03-06 2001-09-20 Eppendorf Geraetebau Netheler Verfahren zum Übertragen von Material in einem Zellsystem
US6653062B1 (en) * 2000-07-26 2003-11-25 Wisconsin Alumni Research Foundation Preservation and storage medium for biological materials
US7011852B2 (en) * 2001-05-07 2006-03-14 Hemogenesis, Llc Separation of platelets from whole blood for use as a healant
US8101077B2 (en) * 2001-05-07 2012-01-24 Sivaprasad Sukavaneshvar Device for separating platelets from fluid suspensions
AU2003268033A1 (en) * 2002-07-26 2004-02-16 The General Hospital Corporation Systems and methods for cell preservation
WO2005002499A2 (en) * 2002-11-29 2005-01-13 The Regents Of The University Of California A method and therapeutic platelets
EP1758937B1 (de) 2004-05-24 2009-09-02 Genvault Corporation Stabile lagerung von protein und stabile lagerung von nukleinsäure in wiedergewinnbarer form
US20060035383A1 (en) * 2004-08-12 2006-02-16 David Ho Dry platelet preparations for use in diagnostics
US7811558B2 (en) * 2004-08-12 2010-10-12 Cellphire, Inc. Use of stabilized platelets as hemostatic agent
CA2577068C (en) 2004-08-12 2016-05-17 Adlyfe, Inc. Methods for preparing freeze-dried platelets, compositions comprising freeze-dried platelets, and methods of use
WO2008051245A2 (en) * 2005-12-02 2008-05-02 Novartis Ag Nanoparticles for use in immunogenic compositions
US8097403B2 (en) * 2006-12-14 2012-01-17 Cellphire, Inc. Freeze-dried platelets, method of making and method of use as a diagnostic agent
US20090081785A1 (en) * 2007-09-24 2009-03-26 Hememics Biotechnologies, Inc. Desiccated Biologics And Methods Of Preparing The Same
US20090090022A1 (en) * 2007-10-09 2009-04-09 Hememics Biotechnologies, Inc. Desiccation Chamber and Methods for Drying Biological Materials
US20100209957A1 (en) * 2008-06-20 2010-08-19 Genvault Corporation Biosample storage devices and methods of use thereof
EP2334792B1 (de) 2008-09-12 2020-09-09 GenTegra LLC Matrizes und medien zur lagerung und stabilisierung von biomolekülen
US8734854B2 (en) * 2009-07-09 2014-05-27 Orogen Biosciences Inc. Process for removing growth factors from platelets
US20110183311A1 (en) * 2010-01-27 2011-07-28 David Ho Dry platelet preparations for use in diagnostics
WO2011103114A1 (en) * 2010-02-17 2011-08-25 Hememics Biotechnologies, Inc. Preservation solutions for biologics and methods related thereto
JP2013524784A (ja) * 2010-04-08 2013-06-20 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 血小板の保存のためのゼオドレーション法
CN101957364A (zh) * 2010-09-19 2011-01-26 李勇 冻干型血小板抗原谱细胞的制备方法
CN102327288B (zh) * 2011-10-17 2012-11-14 济南环肽医药科技有限公司 一种注射用血小板冻干粉制剂及其制备方法
CN106461327B (zh) 2014-06-09 2019-12-13 泰尔茂比司特公司 冻干法
CN104964909B (zh) * 2015-05-28 2018-04-24 上海市血液中心 一种血小板跨膜电位检测方法
US10448631B2 (en) 2015-09-22 2019-10-22 East Carolina University Cryopreservation using sucralose
JP7110360B2 (ja) 2017-10-09 2022-08-01 テルモ ビーシーティー バイオテクノロジーズ，エルエルシー 凍結乾燥方法
US11767511B2 (en) 2018-11-30 2023-09-26 Cellphire, Inc. Platelets as delivery agents
EP3887404A4 (de) 2018-11-30 2022-11-02 Cellphire, Inc. Mit antikrebsmitteln beladene plättchen
CN113614477B (zh) 2019-03-14 2023-04-28 泰尔茂比司特生物技术有限公司 冷冻干燥装载托盘组件及系统
AU2020267368B2 (en) 2019-05-03 2023-05-04 Cellphire, Inc. Materials and methods for producing blood products
EP4013496A4 (de) 2019-08-16 2023-10-18 Cellphire Inc. Thrombosomen als mittel zur aufhebung der thrombozytenaggregationshemmenden wirkung
AU2020333666A1 (en) * 2019-08-16 2022-03-31 Cellphire, Inc. Thrombosomes as an anticoagulant reversal agent
CA3170201A1 (en) 2020-02-04 2021-08-12 Cellphire, Inc. Methods of treating congenital hemophilia with anti-fibrinolytic loaded platelets
TW202245814A (zh) 2021-02-17 2022-12-01 美商賽菲爾公司 用於治療抗血小板誘導的凝血病之凍乾血小板衍生物組成物
CA3212885A1 (en) * 2021-04-20 2022-10-27 Anand PADMANABHAN Methods for maintaining long-term platelet viability and activatability
WO2024233577A1 (en) 2023-05-11 2024-11-14 Vetstem, Inc. Platelet-rich plasma compositions, preparation, and uses thereof

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US4251995A (en) 1979-04-25 1981-02-24 Hedbergska Stiftelsen Method of freezing human blood platelets in glycerol-glucose using a statically controlled cooling rate device
CH660634A5 (de) 1983-08-30 1987-05-15 Dimitrios Giannitsis Verfahren zur herstellung von natuerlichem immunoadsorbens.
EP0208764A4 (de) * 1985-01-11 1987-10-08 Univ California Konservierungsverfahren für liposome.
ATE68524T1 (de) 1985-07-09 1991-11-15 Quadrant Bioresources Ltd Beschuetzung von proteinen und aehnlichem.
GB8604983D0 (en) * 1986-02-28 1986-04-09 Biocompatibles Ltd Protein preservation
GB8715238D0 (en) 1987-06-29 1987-08-05 Quadrant Bioresources Ltd Food process
GB8801338D0 (en) 1988-01-21 1988-02-17 Quadrant Bioresources Ltd Preservation of viruses
US5958670A (en) * 1988-05-18 1999-09-28 Cobe Laboratories, Inc. Method of freezing cells and cell-like materials
US5045446A (en) * 1988-08-26 1991-09-03 Cryopharm Corporation Lyophilization of cells
US5059518A (en) * 1988-10-20 1991-10-22 Coulter Corporation Stabilized lyophilized mammalian cells and method of making same
US5428008A (en) 1989-04-14 1995-06-27 Prp, Inc. Therapeutic composition of micellar structures capable of promoting hemotasis
US5332578A (en) 1989-04-14 1994-07-26 Prp, Inc. Platelet membrane microparticles
US5242792A (en) * 1991-02-25 1993-09-07 The United States Of America As Represented By The Secretary Of The Navy Method for the preservation of red blood cells by lyophilization using glycerol or inositol with disaccharides
GB9114202D0 (en) 1991-07-01 1991-08-21 Quadrant Holdings Cambridge Blood products
AU672775B2 (en) 1992-01-21 1996-10-17 Cobe Laboratories Inc. Method of freezing cells and cell-like materials
DE69333924T2 (de) * 1992-05-29 2006-08-17 University Of North Carolina At Chapel Hill Im immobilisierten Zustand getrocknete pharmazeutisch verträgliche menschliche Blutplättchen
JPH06154318A (ja) 1992-11-25 1994-06-03 Fukuda Sangyo Kaihatsu Center Kk 点滴用輸液量測定装置
DE69534151T2 (de) 1994-02-22 2006-01-12 Nippon Telegraph And Telephone Corp. Gefriergetrocknete Blutzellen, Stammzellen und Plättchen und Verfahren zu deren Herstellung
JPH0920687A (ja) 1995-07-03 1997-01-21 Nippon Telegr & Teleph Corp <Ntt> 凍結乾燥血液の戻し液
US5827741A (en) * 1996-11-19 1998-10-27 The Regents Of The University Of California Cryopreservation of human adult and fetal pancreatic cells and human platelets

Also Published As

Publication number Publication date
DE69810755T2 (de) 2003-08-07
AU732274B2 (en) 2001-04-12
ZA981031B (en) 1998-08-11
EP0967862B1 (de) 2003-01-15
WO1998034478A1 (en) 1998-08-13
CN1246778A (zh) 2000-03-08
US6221575B1 (en) 2001-04-24
DK0967862T3 (da) 2003-05-12
DE69810755D1 (de) 2003-02-20
AU6220898A (en) 1998-08-26
EP0967862A1 (de) 2000-01-05
ES2190063T3 (es) 2003-07-16
CA2279376A1 (en) 1998-08-13
JP2001511174A (ja) 2001-08-07

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