ATE231553T1 - Adrenomedullin - Google Patents

Adrenomedullin

Info

Publication number: ATE231553T1
Authority: AT; Austria
Prior art keywords: proam; proadrenomedullin; peptide; adrenomedullin; peptides
Prior art date: 1993-04-26

Application number

AT94302948T

Other languages

English (en)

Inventor

Kazuo Kitamura

Kenji Kangawa

Hisayuki Matsuo

Tanenao Eto

Original Assignee

Shionogi & Co

Kenji Kangawa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-26

Filing date

1994-04-25

Publication date

2003-02-15

1994-04-25 Application filed by Shionogi & Co, Kenji Kangawa filed Critical Shionogi & Co

2003-02-15 Application granted granted Critical

2003-02-15 Publication of ATE231553T1 publication Critical patent/ATE231553T1/de

Links

102000004379 Adrenomedullin Human genes 0.000 title abstract 7
101800004616 Adrenomedullin Proteins 0.000 title abstract 7
ULCUCJFASIJEOE-NPECTJMMSA-N adrenomedullin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC(=O)N[C@@H]1C(N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CSSC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)[C@@H](C)O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 ULCUCJFASIJEOE-NPECTJMMSA-N 0.000 title abstract 3
108090000765 processed proteins & peptides Proteins 0.000 abstract 4
230000002401 inhibitory effect Effects 0.000 abstract 2
102000034567 proadrenomedullin Human genes 0.000 abstract 2
108010012004 proadrenomedullin Proteins 0.000 abstract 2
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
150000001413 amino acids Chemical group 0.000 abstract 1
150000003943 catecholamines Chemical class 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1
230000001077 hypotensive effect Effects 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/003—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by transforming the C-terminal amino acid to amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/13—Labelling of peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Analytical Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Fats And Perfumes (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Saccharide Compounds (AREA)

AT94302948T 1993-04-26 1994-04-25 Adrenomedullin ATE231553T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP9985693		1993-04-26
JP18310793		1993-07-23
JP29873693		1993-11-29
JP6079035A JP2774769B2 (ja)	1993-04-26	1994-04-18	アドレノメデュリン

Publications (1)

Publication Number	Publication Date
ATE231553T1 true ATE231553T1 (de)	2003-02-15

Family

ID=27466245

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94302948T ATE231553T1 (de)	1993-04-26	1994-04-25	Adrenomedullin

Country Status (9)

Country	Link
US (4)	US5639855A (de)
EP (1)	EP0622458B1 (de)
JP (1)	JP2774769B2 (de)
KR (1)	KR100312443B1 (de)
AT (1)	ATE231553T1 (de)
CA (1)	CA2122112C (de)
DE (1)	DE69432033T2 (de)
DK (1)	DK0622458T3 (de)
ES (1)	ES2191674T3 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN114044824A (zh) *	2011-11-16	2022-02-15	艾德里诺医药公司	用于治疗的抗肾上腺髓质素(ADM)抗体或抗ADM抗体片段或抗ADM非Ig骨架

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69602756T2 (de)	1995-08-18	2000-02-10	The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Rockville	Funktionelle rolle von adrenomedullin(am) und dem gen-verwandten produkt(pamp) in der menschlichen pathologie und physiologie
US6440421B1 (en)	1996-04-18	2002-08-27	Auchkland Uniservices Limited	Treatment of bone disorders with adrenomedullin or adrenomedullin agonists
US5888963A (en) *	1996-04-18	1999-03-30	Auckland Uniservices Limited	Treatment of bone disorders with adrenomedullin
DE69836689D1 (de)	1997-09-26	2007-02-01	Auckland Uniservices Ltd	Verwendung von Amylin, Adrenomedullin und deren Analoga zur Behandlung von Knorpeldefekten
WO2000078339A1 (fr) *	1999-06-23	2000-12-28	Shionogi & Co., Ltd.	Inhibiteurs de contractions uterines
EP1205186B1 (de) *	1999-06-23	2006-04-05	Shionogi & Co., Ltd.	Adrenomedullin zur behandlung von störungen des harnlassens
FR2821080B1 (fr) *	2001-02-20	2003-12-19	Sanofi Synthelabo	Anticorps specifique de l'adrenomedulline humaine, composition pharmaceutique le contenant, ses applications therapeutiques
EP1489093A4 (de) *	2002-03-19	2005-07-20	Oncorex Inc	Peptide, medizinische zusammensetzungen, die die peptide enthalten, und medizinische zusammensetzungen zur behandlung von krebs
EP1575417A4 (de) *	2002-09-30	2007-07-04	Bayer Pharmaceuticals Corp	Verfahren zur vorhersage und prognose von krebs und berwachung der krebstherapie
CA2501282C (en) *	2002-10-04	2012-12-04	The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Vasoregulating compounds and methods of their use
JP5068428B2 (ja) *	2002-11-07	2012-11-07	アメリカ合衆国	血管新生および抗血管新生療法のための標的
US6727277B1 (en)	2002-11-12	2004-04-27	Kansas State University Research Foundation	Compounds affecting cholesterol absorption
DE10316583A1 (de)	2003-04-10	2004-10-28	B.R.A.H.M.S Aktiengesellschaft	Bestimmung eines midregionalen Proadrenomedullin-Teilpeptids in biologischen Flüssigkeiten zu diagnostischen Zwecken, sowie Immunoassays für die Durchführung einer solchen Bestimmung
CA2539467C (en) *	2003-09-08	2012-11-13	Frank Cuttitta	Non-peptide agonists and antagonists of adrenomedullin and gastric releasing peptide
US20060099608A1 (en) *	2004-03-29	2006-05-11	Medstar Research Institute	Methods of diagnosing cardiovascular disease
US8703693B2 (en) *	2004-03-31	2014-04-22	The Feinstein Institute For Medical Research	Adrenomedullin and adrenomedullin binding protein for ischemia/reperfusion treatment
JP4914344B2 (ja)	2004-03-31	2012-04-11	ザ・フェインスタイン・インスティチュート・フォー・メディカル・リサーチ	虚血／再灌流障害治療用のアドレノメデュリン及びアドレノメデュリン結合タンパク質
WO2006063133A2 (en) *	2004-12-06	2006-06-15	The Johns Hopkins University	Biomarker for inflammatory bowel disease
DE102005003687A1 (de)	2005-01-26	2006-07-27	Sphingo Tec Gmbh	Immunoassay zur Bestimmung der Freisetzung von Neurotensin in die Zirkulation
EP1878436B1 (de) *	2005-03-07	2014-07-23	National Cerebral and Cardiovascular Center	Verfahren zur regeneration oder reparatur von geschädigtem gewebe mit adrenomedulin
JP4505640B2 (ja) *	2005-04-12	2010-07-21	国立大学法人宮崎大学	心筋障害の予防又は治療剤
EP1878789A4 (de) *	2005-04-14	2008-08-27	Japan As Represented By Genera	Aus fett stammende vorläuferzelle und verwendung davon
DE102005036094A1 (de) *	2005-08-01	2007-02-08	B.R.A.H.M.S Ag	In vitro Verfahren zur Diagnose von neurodegenerativen Erkrankungen
US8906857B2 (en) *	2005-12-01	2014-12-09	B.R.A.H.M.S. Gmbh	Methods for the diagnosis and treatment of critically ill patients with endothelin, endothelin agonists and adrenomedullin antagonists
US9829494B2 (en)	2005-12-01	2017-11-28	Adrenomed Ag	Methods of treatment using ADM antibodies
DE102006060112A1 (de)	2006-12-20	2008-06-26	Brahms Aktiengesellschaft	Diagnose und Risikostratifizierung mittels dem neuen Marker CT-proADM
CN101945659A (zh)	2008-02-19	2011-01-12	国立大学法人旭川医科大学	肾上腺髓质素产生增强剂
JP5954736B2 (ja)	2011-01-12	2016-07-20	国立大学法人宮崎大学	難治性炎症性腸疾患の予防又は治療方法
ES2387240B2 (es) *	2011-01-31	2013-04-26	Fundación Rioja Salud	Péptido capaz de aumentar la velocidad de desplazamiento de una kinesina o su homóloga funcional sobre microtúbulos.
PT2780371T (pt) *	2011-11-16	2019-01-30	Adrenomed Ag	Anticorpo anti-adrenomedulina (adm) ou fragmento de anticorpo anti-adm ou uma estrutura não ig anti-adm para a regulação do equilíbrio de fluidos num doente com uma doença aguda ou crónica
ES2494190T3 (es)	2011-11-16	2014-09-15	Adrenomed Ag	Anticuerpo anti-adrenomedulina (ADM) o fragmento de anticuerpo anti-ADM o andamiaje proteico sin Ig anti-ADM para reducir el riesgo de mortalidad en un paciente que padece una enfermedad crónica o aguda o un estado agudo
HRP20170427T1 (hr) *	2011-11-16	2017-06-16	Sphingotec Gmbh	Testovi na adrenomedulin i postupci određivanja zrelog adrenomedulina
LT3553084T (lt)	2011-11-16	2023-03-10	Adrenomed Ag	Anti-adrenomedulino (adm) antikūnas arba anti-adm antikūno fragmentas, arba anti-adm ne-ig karkasas, skirtas organų funkcijos sutrikimo arba organų nepakankamumo profilaktikai arba sumažinimui paciento, sergančio lėtine arba ūmine liga arba esančio ūminės būklės, organizme
EP2780370B1 (de) *	2011-11-16	2019-09-25	AdrenoMed AG	Anti-adrenomedullin (adm)-antikörper oder anti-adm-antikörperfragment oder anti-adm-non-ig-gerüst zur verwendung in der therapie einer akuten erkrankung bei einem patienten zur stabilisierung des kreislaufs
US11067586B2 (en)	2011-11-16	2021-07-20	Sphingotec Gmbh	Adrenomedullin assays and methods for determining mature adrenomedullin
SG11201507774YA (en) *	2013-03-20	2015-10-29	Sphingotec Gmbh	Adrenomedullin to guide therapy of blood pressure decline
CN106164088B (zh)	2014-03-20	2021-11-23	国立大学法人宫崎大学	长效肾上腺髓质素衍生物
CU20170038A7 (es) *	2014-09-26	2017-10-05	Bayer Pharma AG	Derivados de adrenomedulina estabililzados especialmente útiles en el tratamiento y/o prevención de trastornos cardiovasculares, edematosos y/o inflamatorios
NZ740534A (en)	2015-09-18	2019-07-26	Univ Miyazaki	Long-acting adrenomedullin derivative
RU2019103403A (ru)	2016-07-08	2020-08-10	Сфинготек Гмбх	Адреномедуллин для оценки застоя у индивидуума с острой сердечной недостаточностью
JP7727371B2 (ja)	2016-12-16	2025-08-21	アドレノメトアクチェンゲゼルシャフト	うっ血の処置と治療を必要とする患者でその処置と治療に使用するための抗アドレノメデュリン（ＡＤＭ）抗体、または抗ＡＤＭ抗体フラグメント、または抗ＡＤＭ非Ｉｇ足場
EP3339324A1 (de)	2016-12-22	2018-06-27	sphingotec GmbH	Anti-adrenomedullin (adm)-antikörper oder anti-adm antikörperfragment oder anti-adm-nicht-ig-gerüst zur verwendung in einer intervention und therapie von verstopfung bei einem darauf angewiesenen patienten
JP7001285B2 (ja) *	2017-03-29	2022-01-19	国立大学法人宮崎大学	長時間作用型アドレノメデュリン誘導体
EP3438668A1 (de)	2017-08-04	2019-02-06	B.R.A.H.M.S GmbH	Diagnose und risikostratifizierung von pilzinfektionen
WO2019077082A1 (en)	2017-10-18	2019-04-25	Adrenomed Ag	SURVEILLANCE OF THERAPY UNDER TREATMENT WITH ANTI-ADRENOMEDULIN BINDER (ADM)
EP3502706A1 (de)	2017-12-20	2019-06-26	B.R.A.H.M.S GmbH	Workflow für risikobewertung und patientenmanagement unter verwendung von procalcitonin und midregional-proadrenomedullin
CN119770645A (zh)	2018-02-08	2025-04-08	斯弗因高泰克有限公司	用于诊断和/或预测痴呆症的肾上腺髓质素和抗肾上腺髓质素结合物在治疗或预防痴呆症中的应用
WO2020201078A1 (en)	2019-03-29	2020-10-08	B.R.A.H.M.S Gmbh	Prescription of remote patient management based on biomarkers
EP3715851A1 (de)	2019-03-29	2020-09-30	B.R.A.H.M.S GmbH	Verschreibung von fernpatientenmanagement auf der basis von biomarkern
EP3871689A1 (de)	2020-02-26	2021-09-01	sphingotec GmbH	Anti-adm-antikörper, die an den freien n-terminus binden, für einen beschleunigten übergang von adm-gly zu bio-adm bei patienten mit einem adm-gly/bio-adm-verhältnis über einem schwellenwert und kombination mit vitamin c
US20230193348A1 (en)	2020-02-27	2023-06-22	4TEEN4 Pharmaceuticals GmbH	Dpp3 for therapy guidance, monitoring and stratification of nt-adm antibodies in patients with shock
CN115244080A (zh)	2020-02-27	2022-10-25	艾德里诺医药公司	用于治疗或预防休克的抗肾上腺髓质素(ADM)抗体或抗ADM抗体片段或抗ADM非Ig支架
AU2021238591A1 (en)	2020-03-16	2022-11-17	Adrenomed Ag	Pro-Adrenomedullin or fragment thereof in patients infected with Corona virus and treatments with binder against adrenomedullin
CN116034159A (zh)	2020-04-02	2023-04-28	国立大学法人宫崎大学	新型肾上腺髓质素类似物及其制备方法和医药用途
EP4023218A1 (de)	2020-12-02	2022-07-06	S-Form Pharma	Kombinationstherapie für patienten mit akuter und/oder anhaltender dyspnoe
WO2022234111A1 (en)	2021-05-07	2022-11-10	Sphingotec Gmbh	Mature adrenomedullin for therapy stratification of corticosteroids in critically ill patients
AU2023315168A1 (en)	2022-07-29	2025-02-13	4TEEN4 Pharmaceuticals GmbH	Prediction of an increase of dpp3 in a patient with septic shock
AU2023313376A1 (en)	2022-07-29	2025-03-06	Adrenomed Ag	Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for use in therapy or prevention of shock
WO2026046982A1 (en)	2024-08-26	2026-03-05	Pam Theragnostics Gmbh	A method for the prediction of a risk or severity of side effects in a cancer patient that is to be treated or has been treated with immune effector cell therapy (iect)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4708934A (en) *	1984-09-27	1987-11-24	Unigene Laboratories, Inc.	α-amidation enzyme
JPH04282399A (ja) *	1991-03-08	1992-10-07	Fujisawa Pharmaceut Co Ltd	放射性ヨウ素標識インシュリン様成長因子ｉ
RO117259B1 (ro) *	1993-08-09	2001-12-28	Biomeasure Inc.	Derivaţi peptidici, terapeutici

1994
- 1994-04-18 JP JP6079035A patent/JP2774769B2/ja not_active Expired - Lifetime
- 1994-04-25 EP EP94302948A patent/EP0622458B1/de not_active Expired - Lifetime
- 1994-04-25 CA CA002122112A patent/CA2122112C/en not_active Expired - Lifetime
- 1994-04-25 AT AT94302948T patent/ATE231553T1/de active
- 1994-04-25 DK DK94302948T patent/DK0622458T3/da active
- 1994-04-25 DE DE69432033T patent/DE69432033T2/de not_active Expired - Lifetime
- 1994-04-25 ES ES94302948T patent/ES2191674T3/es not_active Expired - Lifetime
- 1994-04-26 KR KR1019940008834A patent/KR100312443B1/ko not_active Expired - Fee Related
- 1994-04-26 US US08/233,389 patent/US5639855A/en not_active Expired - Lifetime
1995
- 1995-06-07 US US08/486,596 patent/US5837823A/en not_active Expired - Lifetime
1997
- 1997-02-18 US US08/801,863 patent/US5830703A/en not_active Expired - Lifetime
1998
- 1998-01-07 US US09/004,713 patent/US5910416A/en not_active Expired - Lifetime

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN114044824A (zh) *	2011-11-16	2022-02-15	艾德里诺医药公司	用于治疗的抗肾上腺髓质素(ADM)抗体或抗ADM抗体片段或抗ADM非Ig骨架

Also Published As

Publication number	Publication date
EP0622458B1 (de)	2003-01-22
KR100312443B1 (ko)	2002-02-28
US5639855A (en)	1997-06-17
DE69432033D1 (de)	2003-02-27
CA2122112C (en)	1999-02-16
US5837823A (en)	1998-11-17
US5830703A (en)	1998-11-03
US5910416A (en)	1999-06-08
JPH07196693A (ja)	1995-08-01
ES2191674T3 (es)	2003-09-16
JP2774769B2 (ja)	1998-07-09
DK0622458T3 (da)	2003-05-19
EP0622458A2 (de)	1994-11-02
CA2122112A1 (en)	1994-10-27
EP0622458A3 (en)	1996-06-12
AU6064894A (en)	1994-10-27
DE69432033T2 (de)	2003-09-25
AU678212B2 (en)	1997-05-22

Legal Events

Date

Code

Title

Description

2003-07-15

UEP

Publication of translation of european patent specification

Ref document number: 0622458

Country of ref document: EP

Publication	Publication Date	Title
DE69432033D1 (de)	2003-02-27	Adrenomedullin
BR9500732A (pt)	1995-10-24	Peptídio imunologicamente ativo,fragmento de DNA isolado,kit de teste e aplicação
DK150992A (da)	1992-12-17	Fremgangsmaade til fremstilling af et polypeptidfragment af faktor viii:c, dna-sekvens og ekstrachromosomalt element indeholdende en saadan dna-sekvens, som koder herfor
ATE105867T1 (de)	1994-06-15	Immunaffinitäts-reinigungssystem.
DK532284A (da)	1984-11-08	Fremgangsmaade til bestemmelse af antigenaktive aminosyresekvenser
IE841734L (en)	1985-01-07	Modified protease inhibitors
ATE73494T1 (de)	1992-03-15	Antigene proteine und diese enthaltende impfstoffe zur verhuetung von kokzidiose.
ES2129487T3 (es)	1999-06-16	Peptidos sinteticos, anticuerpos dirigidos contra ellos y su utilizacion.
IL85020A0 (en)	1988-06-30	Pancreatic secretory trypsin inhibitor and variants thereof,process expression vector and recombinant host therefor and pharmaceutical compositions containing it
WO2002008767A3 (en)	2003-08-28	Methods and kits for sequencing polypeptides
DK1336109T3 (da)	2007-10-15	Kit og fremgangsmåde til at påvise proteinet EMS-1
DK611386A (da)	1987-02-18	Recombinant humant fsh, fremgangsmaade til fremstilling deraf og vektorer og celler til anvendelse ved fremgangsmaaden
DE69331501D1 (de)	2002-03-14	Unterdrückung der Proliferation von T-Zellen mittels Peptidfragmenten des basischen Proteins aus Myelin
KR900700500A (ko)	1990-08-13	재조합 유전자 기술에 의한 에라스타제 억제 폴리펩티드 제조방법 및 에라스타제 억제 폴리펩티드
MX167236B (es)	1993-03-11	Peptidos sinteticos de timosina -1 y metodo para su obtencion
GB9816514D0 (en)	1998-09-30	Novel method
EP0152612A3 (en)	1986-04-16	Determination of fibrin with fibrin-specific antibodies
DE69607034D1 (de)	2000-04-13	Pcna bindende substanz
CY1111763T1 (el)	2015-10-07	ΑΝΤΙΣΩΜΑΤΑ ΕΝΑΝΤΙΟΝ ΤΗΣ ΠΡΩΤΕΪΝΗΣ p51
Akashi et al.	1988	A determination of the positions of disulphide bonds in Paim I, α‐amylase inhibitor from Streptomyces corchorushii, using fast atom bombardment mass spectrometry
AUPP627498A0 (en)	1998-10-22	Novel peptides - i
DK450187D0 (da)	1987-08-28	Fremgangsmaade til fremstilling af proteiner
ES2158235T3 (es)	2001-09-01	Peptidos antigenicos con substituciones de glicina.
ES2051152B1 (es)	1994-12-16	Procedimiento de sistesis de peptidos con capacidad de detectar anticuerpos anti-virus de la hepatitis c (vhc) en suero de individuos afectados.
AR033043A1 (es)	2003-12-03	Proteina del tipo reg

ATE231553T1 - Adrenomedullin - Google Patents

Info

Links

Classifications

Landscapes

Applications Claiming Priority (4)

Publications (1)

Family

ID=27466245

Family Applications (1)

Country Status (9)

Cited By (1)

Families Citing this family (59)

Family Cites Families (3)

Cited By (1)

Also Published As

Similar Documents

Legal Events