ATE231879T1 - Verfahren zur herstellung von clarithromycinkristallen der form ii - Google Patents

Verfahren zur herstellung von clarithromycinkristallen der form ii

Info

Publication number: ATE231879T1
Authority: AT; Austria
Prior art keywords: crystals; clarithromycin; water; producing clarithromycin; producing
Prior art date: 1998-09-09

Application number

AT99941861T

Other languages

English (en)

Inventor

Tae Suk Lee

Bundang-Gu Sunae-Dong

Ju Cheol Lee

Kyoung Ik Lee

Gwan Sun Lee

Wan Joo Kim

Original Assignee

Hanmi Pharm Ind Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-09-09

Filing date

1999-09-08

Publication date

2003-02-15

1999-09-08 Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd

2003-02-15 Application granted granted Critical

2003-02-15 Publication of ATE231879T1 publication Critical patent/ATE231879T1/de

Links

239000013078 crystal Substances 0.000 title abstract 4
AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 title abstract 3
229960002626 clarithromycin Drugs 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
238000001914 filtration Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT99941861T 1998-09-09 1999-09-08 Verfahren zur herstellung von clarithromycinkristallen der form ii ATE231879T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
KR10-1998-0037181A KR100377159B1 (ko)	1998-09-09	1998-09-09	잔류 용매가 없는 클라리스로마이신의 결정형 2의 제조 방법
PCT/KR1999/000530 WO2000014099A1 (en)	1998-09-09	1999-09-08	Method of preparing form ii crystals of clarithromycin

Publications (1)

Publication Number	Publication Date
ATE231879T1 true ATE231879T1 (de)	2003-02-15

Family

ID=19550077

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99941861T ATE231879T1 (de)	1998-09-09	1999-09-08	Verfahren zur herstellung von clarithromycinkristallen der form ii

Country Status (8)

Country	Link
US (1)	US6506886B1 (de)
EP (1)	EP1112280B1 (de)
JP (1)	JP3779155B2 (de)
KR (1)	KR100377159B1 (de)
AT (1)	ATE231879T1 (de)
DE (1)	DE69905176T2 (de)
ES (1)	ES2192072T3 (de)
WO (1)	WO2000014099A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2245398C (en)	1998-08-21	2002-01-29	Apotex Inc.	Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
KR100377159B1 (ko) *	1998-09-09	2003-08-19	한미약품공업 주식회사	잔류 용매가 없는 클라리스로마이신의 결정형 2의 제조 방법
WO2001044262A1 (en)	1999-12-16	2001-06-21	Teva Pharmaceutical Industries Ltd.	Processes for preparing clarithromycin polymorphs and novel polymorph iv
AU2261901A (en) *	2000-01-11	2001-07-24	Teva Pharma	Processes for preparing clarithromycin polymorphs
US6544555B2 (en) *	2000-02-24	2003-04-08	Advancis Pharmaceutical Corp.	Antibiotic product, use and formulation thereof
US6565882B2 (en) *	2000-02-24	2003-05-20	Advancis Pharmaceutical Corp	Antibiotic composition with inhibitor
KR20030047873A (ko) *	2000-02-29	2003-06-18	테바 파마슈티컬 인더스트리즈 리미티드	클라리트로마이신 및 클라리트로마이신 중간체의 제조방법, 실질적으로는 옥심이 제거된 클라리트로마이신 및이를 포함하는 약학적 조성물
US20020068078A1 (en) *	2000-10-13	2002-06-06	Rudnic Edward M.	Antifungal product, use and formulation thereof
US6541014B2 (en) *	2000-10-13	2003-04-01	Advancis Pharmaceutical Corp.	Antiviral product, use and formulation thereof
US20020197314A1 (en) *	2001-02-23	2002-12-26	Rudnic Edward M.	Anti-fungal composition
KR100408848B1 (ko) *	2001-03-12	2003-12-06	주식회사 씨트리	클래리스로마이신의 정제방법
SI1390377T1 (sl) *	2001-05-22	2006-06-30	Pfizer Prod Inc	Nova kristalna oblika azitromicina
US6861413B2 (en)	2001-05-22	2005-03-01	Pfizer Inc.	Stable non-dihydrate azithromycin oral suspensions
ES2258142T3 (es) *	2001-05-22	2006-08-16	Pfizer Products Inc.	Nueva forma cristalina.
AU2004258953B2 (en) *	2003-07-21	2011-02-10	Shionogi, Inc.	Antibiotic product, use and formulation thereof
AU2004258949B2 (en) *	2003-07-21	2011-02-10	Shionogi, Inc.	Antibiotic product, use and formulation thereof
JP2006528185A (ja) *	2003-07-21	2006-12-14	アドバンシスファーマスーティカルコーポレイション	抗生物質製剤、その使用法及び作成方法
CA2535177A1 (en) *	2003-08-11	2005-02-24	Advancis Pharmaceutical Corporation	Robust pellet
US8062672B2 (en) *	2003-08-12	2011-11-22	Shionogi Inc.	Antibiotic product, use and formulation thereof
AU2004270170B2 (en) *	2003-08-29	2011-01-27	Shionogi, Inc.	Antibiotic product, use and formulation thereof
CA2538064C (en) *	2003-09-15	2013-12-17	Advancis Pharmaceutical Corporation	Antibiotic product, use and formulation thereof
AU2004308419B2 (en) *	2003-12-24	2011-06-02	Victory Pharma, Inc.	Enhanced absorption of modified release dosage forms
CA2572292A1 (en) *	2004-07-02	2006-02-09	Advancis Pharmaceutical Corporation	Tablet for pulsed delivery
JP2009500356A (ja) *	2005-07-07	2009-01-08	エランファーマインターナショナルリミテッド	ナノ粒子クラリスロマイシン製剤
US8357394B2 (en)	2005-12-08	2013-01-22	Shionogi Inc.	Compositions and methods for improved efficacy of penicillin-type antibiotics
US8299052B2 (en)	2006-05-05	2012-10-30	Shionogi Inc.	Pharmaceutical compositions and methods for improved bacterial eradication
CN103087130B (zh) *	2013-02-06	2015-12-23	浙江国邦药业有限公司	一种克拉霉素晶型转换方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5187140A (en) *	1989-10-18	1993-02-16	Union Carbide Chemicals & Plastics Technology Corporation	Alkylene oxide catalysts containing high silver content
DE69730138T2 (de) *	1996-07-29	2005-03-03	Abbott Laboratories, Abbott Park	Herstellung von kristallinen form ii von clarithromycin
US5844105A (en) *	1996-07-29	1998-12-01	Abbott Laboratories	Preparation of crystal form II of clarithromycin
US5858986A (en) *	1996-07-29	1999-01-12	Abbott Laboratories	Crystal form I of clarithromycin
US5945405A (en) *	1997-01-17	1999-08-31	Abbott Laboratories	Crystal form O of clarithromycin
KR100377159B1 (ko) *	1998-09-09	2003-08-19	한미약품공업 주식회사	잔류 용매가 없는 클라리스로마이신의 결정형 2의 제조 방법

1998
- 1998-09-09 KR KR10-1998-0037181A patent/KR100377159B1/ko not_active Expired - Fee Related
1999
- 1999-09-08 US US09/786,636 patent/US6506886B1/en not_active Expired - Fee Related
- 1999-09-08 EP EP99941861A patent/EP1112280B1/de not_active Expired - Lifetime
- 1999-09-08 AT AT99941861T patent/ATE231879T1/de not_active IP Right Cessation
- 1999-09-08 WO PCT/KR1999/000530 patent/WO2000014099A1/en not_active Ceased
- 1999-09-08 DE DE69905176T patent/DE69905176T2/de not_active Expired - Fee Related
- 1999-09-08 ES ES99941861T patent/ES2192072T3/es not_active Expired - Lifetime
- 1999-09-08 JP JP2000568857A patent/JP3779155B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2002524465A (ja)	2002-08-06
EP1112280A1 (de)	2001-07-04
JP3779155B2 (ja)	2006-05-24
US6506886B1 (en)	2003-01-14
KR20000019206A (ko)	2000-04-06
DE69905176T2 (de)	2003-10-09
EP1112280B1 (de)	2003-01-29
DE69905176D1 (de)	2003-03-06
KR100377159B1 (ko)	2003-08-19
WO2000014099A1 (en)	2000-03-16
ES2192072T3 (es)	2003-09-16

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Legal Events

Date	Code	Title	Description
2003-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties