ATE232211T1 - Verfahren zur herstellung von form ii kristallen des clarithromycins - Google Patents

Verfahren zur herstellung von form ii kristallen des clarithromycins

Info

Publication number: ATE232211T1
Authority: AT; Austria
Prior art keywords: clarithromycin; crystals; organic solvent; water; formate
Prior art date: 1999-10-21

Application number

AT00122798T

Other languages

English (en)

Inventor

Kwee-Hyun Suh

Mi-Ra Seong

Nam-Du Kim

Gwan-Sun Lee

Original Assignee

Hanmi Pharm Ind Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-21

Filing date

2000-10-19

Publication date

2003-02-15

2000-10-19 Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd

2003-02-15 Application granted granted Critical

2003-02-15 Publication of ATE232211T1 publication Critical patent/ATE232211T1/de

Links

AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 title abstract 6
229960002626 clarithromycin Drugs 0.000 title abstract 6
239000013078 crystal Substances 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title 1
BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 abstract 2
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
239000003960 organic solvent Substances 0.000 abstract 2
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
235000019253 formic acid Nutrition 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000003472 neutralizing effect Effects 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT00122798T 1999-10-21 2000-10-19 Verfahren zur herstellung von form ii kristallen des clarithromycins ATE232211T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
KR1019990045703A KR100322313B1 (ko)	1999-10-21	1999-10-21	클라리스로마이신 결정형 2의 제조방법 및 이에 사용되는 클라리스로마이신 포르메이트

Publications (1)

Publication Number	Publication Date
ATE232211T1 true ATE232211T1 (de)	2003-02-15

Family

ID=19616246

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00122798T ATE232211T1 (de)	1999-10-21	2000-10-19	Verfahren zur herstellung von form ii kristallen des clarithromycins

Country Status (7)

Country	Link
US (1)	US6444796B1 (de)
EP (1)	EP1097938B1 (de)
JP (1)	JP2001122890A (de)
KR (1)	KR100322313B1 (de)
AT (1)	ATE232211T1 (de)
DE (1)	DE60001346T2 (de)
ES (1)	ES2192165T3 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6544555B2 (en)	2000-02-24	2003-04-08	Advancis Pharmaceutical Corp.	Antibiotic product, use and formulation thereof
US6565882B2 (en)	2000-02-24	2003-05-20	Advancis Pharmaceutical Corp	Antibiotic composition with inhibitor
WO2001064224A1 (en) *	2000-02-29	2001-09-07	Teva Pharmaceutical Industries Ltd.	Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same
US20020068078A1 (en)	2000-10-13	2002-06-06	Rudnic Edward M.	Antifungal product, use and formulation thereof
US6541014B2 (en)	2000-10-13	2003-04-01	Advancis Pharmaceutical Corp.	Antiviral product, use and formulation thereof
CA2533178C (en)	2003-07-21	2014-03-11	Advancis Pharmaceutical Corporation	Antibiotic product, use and formulation thereof
JP2006528185A (ja)	2003-07-21	2006-12-14	アドバンシスファーマスーティカルコーポレイション	抗生物質製剤、その使用法及び作成方法
JP2006528190A (ja)	2003-07-21	2006-12-14	アドバンシスファーマスーティカルコーポレイション	抗生物質製剤、その使用法及び作成方法
WO2005016311A1 (en)	2003-08-11	2005-02-24	Advancis Pharmaceutical Corporation	Robust pellet
AU2004264356B2 (en)	2003-08-12	2011-01-27	Shionogi, Inc.	Antibiotic product, use and formulation thereof
JP5686494B2 (ja) *	2003-08-29	2015-03-18	シオノギインコーポレイテッド	抗生物質製剤、その使用法及び作成方法
EP1663169A4 (de)	2003-09-15	2010-11-24	Middlebrook Pharmaceuticals In	Antibiotisches produkt, seine verwendung und formulierung
US7384921B2 (en) *	2004-02-20	2008-06-10	Enanta Pharmaceuticals, Inc.	Polymorphic forms of 6-11 bicyclic ketolide derivatives
WO2006014427A1 (en)	2004-07-02	2006-02-09	Advancis Pharmaceutical Corporation	Tablet for pulsed delivery
US20060111560A1 (en) *	2004-11-01	2006-05-25	Glenmark Pharmaceuticals Limited	Process for the preparation of crystalline form II of clarithromycin
WO2007008537A2 (en) *	2005-07-07	2007-01-18	Elan Pharma International, Limited	Nanoparticulate clarithromycin formulations
WO2007036951A2 (en) *	2005-08-31	2007-04-05	Alembic Limited	Process to obtain 6-o-methylerythromycin a (clarithromycin)_form ii
US8357394B2 (en)	2005-12-08	2013-01-22	Shionogi Inc.	Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en)	2006-12-04	2014-07-15	Shionogi Inc.	Modified release amoxicillin products
US8299052B2 (en)	2006-05-05	2012-10-30	Shionogi Inc.	Pharmaceutical compositions and methods for improved bacterial eradication
EP2030613A1 (de)	2007-08-17	2009-03-04	Abbott GmbH & Co. KG	Herstellung von Zusammensetzungen mit hauptsächlich nichtkristallinen eingebetteten Makrolid-Antibiotika
JP7506892B2 (ja) *	2018-08-21	2024-06-27	東和薬品株式会社	化合物の特定形状の結晶及びその製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2751385B2 (ja) *	1988-05-19	1998-05-18	大正製薬株式会社	エリスロマイシンａオキシム及びその塩の製造方法
US5844105A (en) *	1996-07-29	1998-12-01	Abbott Laboratories	Preparation of crystal form II of clarithromycin
PT915899E (pt) *	1996-07-29	2004-11-30	Abbott Lab	Preparacao da forma cristalina ii da eritromicina
US5945405A (en) *	1997-01-17	1999-08-31	Abbott Laboratories	Crystal form O of clarithromycin

1999
- 1999-10-21 KR KR1019990045703A patent/KR100322313B1/ko not_active Expired - Fee Related
2000
- 2000-10-19 DE DE60001346T patent/DE60001346T2/de not_active Expired - Fee Related
- 2000-10-19 AT AT00122798T patent/ATE232211T1/de not_active IP Right Cessation
- 2000-10-19 EP EP00122798A patent/EP1097938B1/de not_active Expired - Lifetime
- 2000-10-19 ES ES00122798T patent/ES2192165T3/es not_active Expired - Lifetime
- 2000-10-20 US US09/693,795 patent/US6444796B1/en not_active Expired - Fee Related
- 2000-10-23 JP JP2000322546A patent/JP2001122890A/ja active Pending

Also Published As

Publication number	Publication date
EP1097938B1 (de)	2003-02-05
DE60001346T2 (de)	2004-04-08
KR100322313B1 (ko)	2002-02-06
JP2001122890A (ja)	2001-05-08
US6444796B1 (en)	2002-09-03
DE60001346D1 (de)	2003-03-13
EP1097938A1 (de)	2001-05-09
KR20010037942A (ko)	2001-05-15
ES2192165T3 (es)	2003-10-01

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Legal Events

Date	Code	Title	Description
2003-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties