ATE232239T1 - Stereoselektiver, mikrobieller reduktionsprozess - Google Patents

Stereoselektiver, mikrobieller reduktionsprozess

Info

Publication number: ATE232239T1
Authority: AT; Austria
Prior art keywords: formula; compound; stereoselective; hydroxy; iii
Prior art date: 1995-09-27

Application number

AT96935829T

Other languages

English (en)

Inventor

Michael J Homann

Edward Previte

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-27

Filing date

1996-09-26

Publication date

2003-02-15

1996-01-04 Priority claimed from US08/583,166 external-priority patent/US5618707A/en

1996-09-26 Application filed by Schering Corp filed Critical Schering Corp

2003-02-15 Application granted granted Critical

2003-02-15 Publication of ATE232239T1 publication Critical patent/ATE232239T1/de

Links

230000000813 microbial effect Effects 0.000 title 1
238000011946 reduction process Methods 0.000 title 1
230000000707 stereoselective effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 5
150000002440 hydroxy compounds Chemical class 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
238000011916 stereoselective reduction Methods 0.000 abstract 2
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 2
241000235350 Schizosaccharomyces octosporus Species 0.000 abstract 1
241000235029 Zygosaccharomyces bailii Species 0.000 abstract 1
239000003529 anticholesteremic agent Substances 0.000 abstract 1
229940127226 anticholesterol agent Drugs 0.000 abstract 1
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT96935829T 1995-09-27 1996-09-26 Stereoselektiver, mikrobieller reduktionsprozess ATE232239T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US434895P	1995-09-27	1995-09-27
US08/583,166 US5618707A (en)	1996-01-04	1996-01-04	Stereoselective microbial reduction of 5-fluorophenyl-5-oxo-pentanoic acid and a phenyloxazolidinone condensation product thereof
PCT/US1996/014836 WO1997012053A1 (en)	1995-09-27	1996-09-26	Stereoselective microbial reduction process

Publications (1)

Publication Number	Publication Date
ATE232239T1 true ATE232239T1 (de)	2003-02-15

Family

ID=26672887

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96935829T ATE232239T1 (de)	1995-09-27	1996-09-26	Stereoselektiver, mikrobieller reduktionsprozess

Country Status (10)

Country	Link
EP (1)	EP0862645B1 (de)
JP (1)	JP3023179B2 (de)
AT (1)	ATE232239T1 (de)
AU (1)	AU7361796A (de)
CA (1)	CA2231808C (de)
DE (1)	DE69626128T2 (de)
DK (1)	DK0862645T3 (de)
ES (1)	ES2191771T3 (de)
MX (1)	MX9802377A (de)
WO (1)	WO1997012053A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU1302999A (en) *	1997-11-04	1999-05-24	Eli Lilly And Company	Ketoreductase gene and protein from yeast
JP2003000290A (ja) *	2001-06-25	2003-01-07	Kanegafuchi Chem Ind Co Ltd	光学活性（ｒ）−２−クロロ−１−（３′−クロロフェニル）エタノールの製造法
JP2006006133A (ja) *	2004-06-23	2006-01-12	Daicel Chem Ind Ltd	光学活性なヒドロキシカルボン酸誘導体の製造方法
HU0501164D0 (en)	2005-12-20	2006-02-28	Richter Gedeon Vegyeszet	New industrial process for the production of ezetimibe

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0357787B1 (de) *	1988-02-12	1996-05-08	Daicel Chemical Industries, Ltd.	Verfahren zur herstellung von optisch aktiven 2-hydroxysäureabkömmlingen
CA2004081C (en) *	1988-12-01	1998-06-23	Arnoldus L. G. M. Boog	Process for producing gamma-lactones
JPH0779706B2 (ja) *	1990-03-22	1995-08-30	田辺製薬株式会社	２―クロロ―３―ヒドロキシ―３―フエニルプロピオン酸エステル類の製法
ES2107548T3 (es) *	1991-07-23	1997-12-01	Schering Corp	Compuestos de beta-lactama sustituidos utiles como agentes hipocolesterolemicos y procedimientos para su preparacion.
US5631365A (en) *	1993-09-21	1997-05-20	Schering Corporation	Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents

1996
- 1996-09-26 AT AT96935829T patent/ATE232239T1/de active
- 1996-09-26 EP EP96935829A patent/EP0862645B1/de not_active Expired - Lifetime
- 1996-09-26 CA CA002231808A patent/CA2231808C/en not_active Expired - Fee Related
- 1996-09-26 DK DK96935829T patent/DK0862645T3/da active
- 1996-09-26 MX MX9802377A patent/MX9802377A/es not_active IP Right Cessation
- 1996-09-26 AU AU73617/96A patent/AU7361796A/en not_active Abandoned
- 1996-09-26 WO PCT/US1996/014836 patent/WO1997012053A1/en not_active Ceased
- 1996-09-26 ES ES96935829T patent/ES2191771T3/es not_active Expired - Lifetime
- 1996-09-26 DE DE69626128T patent/DE69626128T2/de not_active Expired - Lifetime
- 1996-09-26 JP JP9513488A patent/JP3023179B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2231808C (en)	2007-05-22
MX9802377A (es)	1998-08-30
DE69626128T2 (de)	2003-11-27
DK0862645T3 (da)	2003-04-07
JP3023179B2 (ja)	2000-03-21
WO1997012053A1 (en)	1997-04-03
ES2191771T3 (es)	2003-09-16
EP0862645B1 (de)	2003-02-05
CA2231808A1 (en)	1997-04-03
EP0862645A1 (de)	1998-09-09
AU7361796A (en)	1997-04-17
JPH10512454A (ja)	1998-12-02
DE69626128D1 (de)	2003-03-13

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2003-09-15

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