ATE232396T1 - Oxydiertes thymosin beta 4 - Google Patents

Oxydiertes thymosin beta 4

Info

Publication number: ATE232396T1
Authority: AT; Austria
Prior art keywords: oxidated; beta; thymosine beta; present; thymosine
Prior art date: 1998-03-28

Application number

AT99913428T

Other languages

English (en)

Inventor

Robert Duncan Stevenson

Anthony John Lawrence

John Young

Darryl John Cecil Pappin

Original Assignee

Univ Glasgow

Imp Cancer Res Technology Icrt

Robert Duncan Stevenson

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-28

Filing date

1999-03-29

Publication date

2003-02-15

1999-03-29 Application filed by Univ Glasgow, Imp Cancer Res Technology Icrt, Robert Duncan Stevenson filed Critical Univ Glasgow

2003-02-15 Application granted granted Critical

2003-02-15 Publication of ATE232396T1 publication Critical patent/ATE232396T1/de

Links

UGPMCIBIHRSCBV-XNBOLLIBSA-N Thymosin beta 4 Chemical compound N([C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(O)=O)C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(C)=O UGPMCIBIHRSCBV-XNBOLLIBSA-N 0.000 abstract 2
102100035000 Thymosin beta-4 Human genes 0.000 abstract 2
108010079996 thymosin beta(4) Proteins 0.000 abstract 2
206010040070 Septic Shock Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000028709 inflammatory response Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 1
230000036303 septic shock Effects 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57581—Thymosin; Related peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Zoology (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Immunology (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Hematology (AREA)

AT99913428T 1998-03-28 1999-03-29 Oxydiertes thymosin beta 4 ATE232396T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9806632.7A GB9806632D0 (en)	1998-03-28	1998-03-28	Peptide factor
PCT/GB1999/000833 WO1999049883A2 (en)	1998-03-28	1999-03-29	Oxidized thymosin beta 4

Publications (1)

Publication Number	Publication Date
ATE232396T1 true ATE232396T1 (de)	2003-02-15

Family

ID=10829414

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99913428T ATE232396T1 (de)	1998-03-28	1999-03-29	Oxydiertes thymosin beta 4

Country Status (15)

Country	Link
US (3)	US6602519B1 (de)
EP (1)	EP1094833B1 (de)
JP (1)	JP2002509893A (de)
KR (1)	KR20010074461A (de)
CN (2)	CN1644586A (de)
AT (1)	ATE232396T1 (de)
AU (1)	AU766493B2 (de)
CA (1)	CA2325984A1 (de)
DE (1)	DE69905368T2 (de)
ES (1)	ES2192839T3 (de)
GB (1)	GB9806632D0 (de)
IL (1)	IL138665A0 (de)
NZ (1)	NZ507642A (de)
WO (1)	WO1999049883A2 (de)
ZA (1)	ZA200005196B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9806632D0 (en) *	1998-03-28	1998-05-27	Stevenson Robert	Peptide factor
US20070015698A1 (en) *	1998-07-30	2007-01-18	United States Of America As Represented By The Secretary Of Health	Treatment of skin, and wound repair, with thymosin beta 4
AU766826B2 (en) *	1998-07-30	2003-10-23	Government of The United States of America, as represented by The Secretary Department of Health & Human Services, The National Institutes of Health, The	Thymosin beta4 promotes wound repair
US20070191275A1 (en) *	1998-07-30	2007-08-16	Regenerx Biopharmaceuticals, Inc.	Method of treating, preventing, inhibiting or reducing damage to cardiac tissue with thymosin beta 4 fragments
US20060100156A1 (en) *	2004-10-01	2006-05-11	Regenerx Biopharmaceuticals, Inc.	Cell nucleus-entering compositions
US20040067227A1 (en) *	2001-11-02	2004-04-08	Goldstein Allan L.	Inhibition or reversal of skin aging by actin-sequestering peptides
EP1994941A3 (de) *	2000-10-20	2012-07-25	Hamburger Stiftung zur Förderung von Wissenschaft und Kultur	Arzneimittel, enthaltend mindestens ein oxidiertes Protein
PT1335743E (pt)	2000-11-02	2010-03-29	Regenerx Biopharmaceuticals	Inibição ou reversão do envelhecimento da pele por meio de péptidos sequestrando actina
AU2002255736B2 (en) *	2001-03-15	2006-08-31	Regenerx, Biopharmaceuticals, Inc.	Methods of treating disorders of the eye and surrounding tissue with thymosin beta4 (Tbeta4), analogues, isoforms and other derivatives
WO2003020215A2 (en)	2001-08-29	2003-03-13	Regenerx Biopharmaceuticals, Inc.	Methods of treating mycocardial event related coditions with thymosin beta 4
AU2008201749B2 (en) *	2002-02-06	2010-05-13	Regenerx Biopharmaceuticals, Inc.	Treatment of Infections and Other Disorders
AU2003296875B2 (en) *	2002-02-06	2008-01-24	Regenerx Biopharmaceuticals, Inc.	Treatment of infections and other disorders
AU2003223601A1 (en) *	2002-04-12	2003-10-27	King's College London	ANTI-INFLAMMATORY AND WOUND HEALING EFFECTS OF LYMPHOID THYMOSIN Beta 4
US6821524B2 (en) *	2002-06-03	2004-11-23	Jan Marini Skin Research, Inc.	Cosmetic skin care compositions
US20060263360A1 (en) *	2003-03-31	2006-11-23	Regenerx Biopharmaceuticals, Inc.	Compositions and methods for delivering thymosin beta 4, analogues, isoforms and other derivatives
WO2005027958A1 (en) *	2003-09-19	2005-03-31	Imperial College Innovations Ltd	Thymosin-beta-sulphoxide as an immunosuppressive active agent
EP1706136A4 (de) *	2003-12-22	2009-09-16	Regenerx Biopharmaceuticals	Verfahren zur behandlung oder verhinderung von biologischen oder immunantworten auf einen reaktiven chemischen oder biologischen oder toxischen stoff
WO2005087805A1 (en) *	2004-03-05	2005-09-22	Regenerx Biopharmaceuticals, Inc.	Treating or preventing extracellular matrix build-up
EP1835927A4 (de) *	2005-01-14	2008-06-18	Regenerx Biopharmaceuticals	Modifizierte betathymosinpeptide
JP2008543877A (ja)	2005-06-17	2008-12-04	リジェナークス・バイオファーマスーティカルズ・インコーポレイテッド	Ｌｋｋｔｅｔおよび／またはｌｋｋｔｎｔ組成物および組織の悪化、傷害または損傷を処置または予防するための方法
EP1913013A2 (de) *	2005-07-19	2008-04-23	Grannus Biosciences	Gekürztes oxidiertes thymosin-beta4 und derivate davon
ES2288118B1 (es) *	2006-05-10	2008-11-01	Bcn Peptides, S.A.	Procedimiento para sintetizar timosinas.
CN101297965B (zh) *	2008-06-16	2011-01-05	浙江省中医药研究院	胸腺肽β4在制备防治支气管哮喘药物中的应用
US20100247693A1 (en) *	2009-03-24	2010-09-30	Marini Jan L	Cosmetic formulation to treat rosacea telangiectasia
US8580742B2 (en)	2010-03-05	2013-11-12	N.V. Perricone Llc	Topical glutathione formulations for menopausal skin
US20110160144A1 (en) *	2009-12-28	2011-06-30	Perricone Nicholas V	Topical Acyl Glutathione Formulations
US8609604B2 (en)	2009-12-28	2013-12-17	N.V. Perricone Llc	Methods of improving the appearance of aging skin
JP5847418B2 (ja)	2011-03-30	2016-01-20	富士フイルム株式会社	細胞接着性タンパク質
US9808654B2 (en)	2013-02-11	2017-11-07	Jan Marini Skin Research	Post procedure skin care gel and methods of use thereof
CN110215513B (zh) *	2018-11-15	2022-02-22	北京诺思兰德生物技术股份有限公司	经修饰的胸腺素β4在治疗放射性肠炎方面的用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US388234A (en) *		1888-08-21		Car-brake
US3998798A (en) *	1972-12-22	1976-12-21	The Trustees Of The University Of Pennsylvania	Monellin, a sweet polypeptide derived from fruit of dioscoreophyllum cumminsii
US4297276A (en) *	1979-03-23	1981-10-27	Hoffman-La Roche Inc.	Thymosin beta 3 and beta 4
US4389343A (en)	1981-12-24	1983-06-21	Hoffmann-La Roche Inc.	Immunopotentiating peptides from thymus
US4388234A (en)	1981-12-28	1983-06-14	Hoffmann-La Roche Inc.	Peptide isolation
US4572798A (en) *	1984-12-06	1986-02-25	Cetus Corporation	Method for promoting disulfide bond formation in recombinant proteins
US5593964A (en) *	1993-10-07	1997-01-14	The George Washington University Medical Center	Method of treating septic shock by preventing actin polymerization
US5578570A (en) *	1993-10-07	1996-11-26	The George Washington University Medical Center	Method of treating septic shock using thymosin β4
US5468729A (en) *	1993-10-26	1995-11-21	Alpha 1 Biomedicals	Method for treatment of autoimmune hepatitis
GB9806632D0 (en) *	1998-03-28	1998-05-27	Stevenson Robert	Peptide factor

1998
- 1998-03-28 GB GBGB9806632.7A patent/GB9806632D0/en not_active Ceased
1999
- 1999-03-29 CN CNA2004100879091A patent/CN1644586A/zh active Pending
- 1999-03-29 ES ES99913428T patent/ES2192839T3/es not_active Expired - Lifetime
- 1999-03-29 AU AU31553/99A patent/AU766493B2/en not_active Ceased
- 1999-03-29 US US09/647,117 patent/US6602519B1/en not_active Expired - Fee Related
- 1999-03-29 IL IL13866599A patent/IL138665A0/xx not_active IP Right Cessation
- 1999-03-29 EP EP99913428A patent/EP1094833B1/de not_active Expired - Lifetime
- 1999-03-29 CN CNB998059579A patent/CN1178695C/zh not_active Expired - Fee Related
- 1999-03-29 CA CA002325984A patent/CA2325984A1/en not_active Abandoned
- 1999-03-29 NZ NZ507642A patent/NZ507642A/en unknown
- 1999-03-29 WO PCT/GB1999/000833 patent/WO1999049883A2/en not_active Ceased
- 1999-03-29 JP JP2000540846A patent/JP2002509893A/ja active Pending
- 1999-03-29 KR KR1020007010794A patent/KR20010074461A/ko not_active Withdrawn
- 1999-03-29 DE DE69905368T patent/DE69905368T2/de not_active Expired - Fee Related
- 1999-03-29 AT AT99913428T patent/ATE232396T1/de not_active IP Right Cessation
2000
- 2000-09-27 ZA ZA200005196A patent/ZA200005196B/en unknown
2003
- 2003-01-09 US US10/339,271 patent/US20040213772A1/en not_active Abandoned
2006
- 2006-06-14 US US11/452,738 patent/US20060229234A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE69905368D1 (en)	2003-03-20
US20040213772A1 (en)	2004-10-28
DE69905368T2 (de)	2003-12-18
IL138665A0 (en)	2001-10-31
WO1999049883A3 (en)	2001-02-22
WO1999049883A2 (en)	1999-10-07
EP1094833A2 (de)	2001-05-02
ZA200005196B (en)	2002-01-02
CN1644586A (zh)	2005-07-27
AU766493B2 (en)	2003-10-16
EP1094833B1 (de)	2003-02-12
ES2192839T3 (es)	2003-10-16
CA2325984A1 (en)	1999-10-07
CN1308543A (zh)	2001-08-15
CN1178695C (zh)	2004-12-08
US20060229234A1 (en)	2006-10-12
JP2002509893A (ja)	2002-04-02
AU3155399A (en)	1999-10-18
KR20010074461A (ko)	2001-08-04
GB9806632D0 (en)	1998-05-27
NZ507642A (en)	2003-10-31
US6602519B1 (en)	2003-08-05

Legal Events

Date

Code

Title

Description

2003-09-15

UEP

Publication of translation of european patent specification

Ref document number: 1094833

Country of ref document: EP

2008-12-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE232396T1 (de)	2003-02-15	Oxydiertes thymosin beta 4
TR200002218T2 (tr)	2000-12-21	2-(Pürin-9-il)-Tetrahidrofüran -3,4-Diol türevleri
MY155218A (en)	2015-09-30	Small molecules useful in the treatment of inflammatory disease
NO307968B1 (no)	2000-06-26	Pyrazolo- og pyrrolopyridiner og farmasøytisk blanding derav
NO894296D0 (no)	1989-10-27	Fremgangsmaate for behandling av leddgikt og betennelsessykdommer.
DK209088D0 (da)	1988-04-15	Medicinpraeparater, deres fremstilling og anvendelse
CY1108610T1 (el)	2014-04-09	Πεπτιδια της il-2 και παραγωγα αυτων και χρηση αυτων ως θεραπευτικοι παραγοντες
YU60900A (sh)	2003-07-07	Novi kristalni oblici antivirusnog benzimidazolskog jedinjenja
NZ516349A (en)	2004-03-26	Conjugates of phytosterol or phytostanol with ascorbic acid and use thereof in treating or preventing cardiovascular disease
NO972391D0 (no)	1997-05-26	2-substituerte 1,2,5-tiadiazolidin-3-on 1,1-dioksider og preparater og metoder for anvendelse derav
NO994431L (no)	1999-09-13	Ny formulering
BG101401A (bg)	1997-12-30	Състави за орално приложение с удължено освобождаване на цисаприд
IT1290781B1 (it)	1998-12-10	Agente attivo terapeutico per il trattamento di malattie degenerative neuronali.
BG93298A (bg)	1993-12-24	Имуностимулиращи 6-арил-5,6-дихидроимидазо(2,1-в)тиазолови производни
BG101126A (en)	1997-09-30	The use of muramylpeptide compounds
TR200000455T2 (tr)	2000-09-21	Alzheimer hastalığının tedavisinde fankinonun kullanılması.
TR200200278T2 (tr)	2002-06-21	Kalsilitik bileşimler
MX9403032A (es)	1995-01-31	Quinolil-dihidropiridinas condensadas, procedimiento para su fabricacion ysu uso en medicamentos.
ATE254595T1 (de)	2003-12-15	2-amino-6-methyl-7-acetyl-tetralin und pharmazeutische zusammensetzungen zur vorbeugung und therapeutischen behandlung von entzündlichen und/oder autoimmunkrankheiten
TR199901385T2 (xx)	1999-11-22	Piperidin t�revleri.
PT1150703E (pt)	2006-05-31	Terapia de esclerose multipla com chaperonina 10 e beta-interferao
EA200000909A1 (ru)	2001-06-25	ФОРМА VI 5,6-ДИХЛОР-2-(ИЗОПРОПИЛАМИНО)-1-(b-L-РИБОФУРАНОЗИЛ)-1H-БЕНЗИМИДАЗОЛА
NO20005548L (no)	2000-12-04	Mykobakterieinhibitorer
DE68906245D1 (de)	1993-06-03	Therapeutisches mittel gegen aids.
WO2000063348A3 (fr)	2000-12-28	Composition pharmaceutique comprenant des cellules nkt activees par des pim, et son utilisation en therapie