BG93298A - Имуностимулиращи 6-арил-5,6-дихидроимидазо(2,1-в)тиазолови производни - Google Patents

Имуностимулиращи 6-арил-5,6-дихидроимидазо(2,1-в)тиазолови производни

Info

Publication number
BG93298A
BG93298A BG093298A BG9329890A BG93298A BG 93298 A BG93298 A BG 93298A BG 093298 A BG093298 A BG 093298A BG 9329890 A BG9329890 A BG 9329890A BG 93298 A BG93298 A BG 93298A
Authority
BG
Bulgaria
Prior art keywords
immunostimutant
dihydroimidazo
aryl
thiazole derivatives
disorders
Prior art date
Application number
BG093298A
Other languages
English (en)
Other versions
BG60587B1 (bg
Inventor
Alfons Raeymaekers
Leopold Frans Roevens
Willy Joannes Carolus Laerhoven
Jean Pierre Frans Wauwe
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BG93298A publication Critical patent/BG93298A/bg
Publication of BG60587B1 publication Critical patent/BG60587B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Съединенията намират приложение за лечение на хора и топлокръвни животни, страдащи от нарушения и/или заболявания, свързани с увреждане или потискане на имунната система. Те се включват като активен компонент във фармацевтични състави. 11 претенции
BG93298A 1989-11-24 1990-11-22 Имуностимулиращи 6-арил-5,6-дихидроимидазо(2,1-в)тиазолови производни BG60587B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44084289A 1989-11-24 1989-11-24

Publications (2)

Publication Number Publication Date
BG93298A true BG93298A (bg) 1993-12-24
BG60587B1 BG60587B1 (bg) 1995-09-29

Family

ID=23750399

Family Applications (1)

Application Number Title Priority Date Filing Date
BG93298A BG60587B1 (bg) 1989-11-24 1990-11-22 Имуностимулиращи 6-арил-5,6-дихидроимидазо(2,1-в)тиазолови производни

Country Status (25)

Country Link
EP (1) EP0430334B1 (bg)
JP (1) JPH03170487A (bg)
KR (1) KR910009714A (bg)
CN (1) CN1032754C (bg)
AT (1) ATE127795T1 (bg)
AU (1) AU630766B2 (bg)
BG (1) BG60587B1 (bg)
CA (1) CA2028756A1 (bg)
CZ (1) CZ281422B6 (bg)
DE (1) DE69022370T2 (bg)
FI (1) FI93459C (bg)
HU (1) HU206361B (bg)
IE (1) IE67656B1 (bg)
IL (1) IL96435A (bg)
MY (1) MY131024A (bg)
NO (1) NO300065B1 (bg)
NZ (1) NZ236026A (bg)
PL (1) PL165413B1 (bg)
PT (1) PT95978B (bg)
RO (1) RO108869B1 (bg)
RU (1) RU2051153C1 (bg)
YU (1) YU47955B (bg)
ZA (1) ZA909445B (bg)
ZM (1) ZM5390A1 (bg)
ZW (1) ZW17890A1 (bg)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0524055A1 (fr) * 1991-07-19 1993-01-20 Synthelabo Dérivés d'imidazo[2,1-b]benzothiazole-3-acétamide, leur préparation et leur application en thérapeutique
US6165253A (en) * 1994-05-23 2000-12-26 New Jersey Institute Of Technology Apparatus for removal of volatile organic compounds from gaseous mixtures
RU2129870C1 (ru) * 1998-04-07 1999-05-10 Ливицкий Василий Иванович Способ получения антимикробного и противоопухолевого лечебного средства
ATE380548T1 (de) 1999-01-29 2007-12-15 Univ Illinois Verwendung von p53 inhibitoren zur behandlung von nebenerscheinungen bei der krebstherapie
EP1797880A3 (en) * 1999-01-29 2010-04-28 Board Of Trustees Of The University Of Illinois P53 inhibitors and their use for the treatment of cancer, hyperthermia, hypoxia, a burn, trauma to the central nervous system, a seizure, acute inflammation, tissue ageing, preservation of organs for transplant and preparation of a host for bone marrow transplant
AU2005288522B2 (en) 2004-09-28 2012-06-28 Quark Pharmaceuticals, Inc. Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases
RU2282438C1 (ru) * 2005-03-24 2006-08-27 Александра Петровна Безрукова Средство, обладающее противоопухолевой активностью
US7825099B2 (en) 2006-01-20 2010-11-02 Quark Pharmaceuticals, Inc. Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes
US7910566B2 (en) 2006-03-09 2011-03-22 Quark Pharmaceuticals Inc. Prevention and treatment of acute renal failure and other kidney diseases by inhibition of p53 by siRNA
HRP20140522T1 (hr) 2007-06-27 2014-08-15 Quark Pharmaceuticals, Inc. Pripravci i metode za inhibiranje izražaja proapoptotiäśkih gena
CN104557979A (zh) * 2013-10-23 2015-04-29 丹阳恒安化学科技研究所有限公司 盐酸左旋咪唑的制备方法
RU2763739C1 (ru) * 2021-06-28 2021-12-30 Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) (Z)-9-ароил-8-гидрокси-6-(2-гидроксифенил)-2-(((Z)-2-оксоиндолин-3-илиден)гидразоно)-1-тиа-3,6-диазаспиро[4.4]нон-8-ен-4,7-дионы, обладающие противомикробной активностью
JP7814782B2 (ja) * 2021-11-29 2026-02-17 オーシャン ユニバーシティ オブ チャイナ イミダゾチアゾール誘導体およびその製造方法と使用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU409983B2 (en) * 1965-07-19 1970-12-31 Imperial Chemical Industries Of Australia New Zealand Limited Process for the manufacture of thia zolidines and thiazolidines produced thereby
GB1444743A (en) * 1973-09-20 1976-08-04 Pfizer Ltd 7-substituted imidazo-1,1-b-thiazolium and 9-substituted thiazolo-3,2-a-benzimidazolium derivatives having hypogly caemic and/or growth promotant properties
US4340738A (en) * 1979-06-21 1982-07-20 Janssen Pharmaceutica, N.V. 2,3-Dihydro-imidazo[2,1-b]benzothiazoles

Also Published As

Publication number Publication date
HUT59414A (en) 1992-05-28
FI93459B (fi) 1994-12-30
HU206361B (en) 1992-10-28
RU2051153C1 (ru) 1995-12-27
ATE127795T1 (de) 1995-09-15
BG60587B1 (bg) 1995-09-29
PL287907A1 (en) 1992-04-21
DE69022370D1 (de) 1995-10-19
CN1052117A (zh) 1991-06-12
ZM5390A1 (en) 1992-06-30
HU907633D0 (en) 1991-06-28
IE904241A1 (en) 1991-06-05
CZ281422B6 (cs) 1996-09-11
YU47955B (sh) 1996-07-24
EP0430334A1 (en) 1991-06-05
ZA909445B (en) 1992-07-29
AU630766B2 (en) 1992-11-05
NO300065B1 (no) 1997-04-01
IL96435A0 (en) 1991-08-16
PT95978B (pt) 1998-01-30
EP0430334B1 (en) 1995-09-13
CZ580390A3 (en) 1996-06-12
RO108869B1 (ro) 1994-09-30
FI905788L (fi) 1991-05-25
JPH03170487A (ja) 1991-07-24
CA2028756A1 (en) 1991-05-25
AU6680990A (en) 1991-05-30
PL165413B1 (pl) 1994-12-30
NO905086D0 (no) 1990-11-23
YU220890A (sh) 1992-12-21
KR910009714A (ko) 1991-06-28
FI905788A0 (fi) 1990-11-23
FI93459C (fi) 1995-04-10
DE69022370T2 (de) 1996-03-14
PT95978A (pt) 1991-09-13
NO905086L (no) 1991-05-27
IL96435A (en) 1995-03-15
MY131024A (en) 2007-07-31
CN1032754C (zh) 1996-09-11
NZ236026A (en) 1992-03-26
ZW17890A1 (en) 1992-07-08
IE67656B1 (en) 1996-04-17

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