ATE232727T1 - Kombinationen von hiv-protease inhibitoren - Google Patents

Kombinationen von hiv-protease inhibitoren

Info

Publication number: ATE232727T1
Authority: AT; Austria
Prior art keywords: hiv protease; hiv; protease inhibitors; combinations; treatment
Prior art date: 1994-08-11

Application number

AT95930118T

Other languages

English (en)

Inventor

Paul J Deutsch

Emilio A Emini

Joseph P Vacca

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-11

Filing date

1995-08-07

Publication date

2003-03-15

1995-08-07 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2003-03-15 Application granted granted Critical

2003-03-15 Publication of ATE232727T1 publication Critical patent/ATE232727T1/de

Links

239000004030 hiv protease inhibitor Substances 0.000 title abstract 3
208000030507 AIDS Diseases 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
208000015181 infectious disease Diseases 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
108010010369 HIV Protease Proteins 0.000 abstract 1
229940122440 HIV protease inhibitor Drugs 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
239000002955 immunomodulating agent Substances 0.000 abstract 1
229940121354 immunomodulator Drugs 0.000 abstract 1
239000004615 ingredient Substances 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
229940042443 other antivirals in atc Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229960005486 vaccine Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Virology (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT95930118T 1994-08-11 1995-08-07 Kombinationen von hiv-protease inhibitoren ATE232727T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US28947494A	1994-08-11	1994-08-11
US33936994A	1994-11-14	1994-11-14
US49246195A	1995-07-20	1995-07-20
PCT/US1995/009956 WO1996004913A1 (en)	1994-08-11	1995-08-07	Hiv protease inhibitor combination

Publications (1)

Publication Number	Publication Date
ATE232727T1 true ATE232727T1 (de)	2003-03-15

Family

ID=27403895

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95930118T ATE232727T1 (de)	1994-08-11	1995-08-07	Kombinationen von hiv-protease inhibitoren

Country Status (19)

Country	Link
EP (1)	EP0774969B8 (de)
JP (1)	JPH10504036A (de)
KR (1)	KR970704441A (de)
CN (1)	CN1101190C (de)
AT (1)	ATE232727T1 (de)
AU (1)	AU698664B2 (de)
CA (1)	CA2197207C (de)
CY (1)	CY2360B1 (de)
CZ (1)	CZ292577B6 (de)
DE (1)	DE69529678T2 (de)
DK (1)	DK0774969T3 (de)
ES (1)	ES2190456T3 (de)
HU (1)	HUT76540A (de)
IL (1)	IL114808A (de)
MX (1)	MX9701121A (de)
NO (1)	NO314168B1 (de)
PL (1)	PL181578B1 (de)
SK (1)	SK18197A3 (de)
WO (1)	WO1996004913A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA49803C2 (uk) *	1994-06-03	2002-10-15	Дж.Д. Сьорль Енд Ко	Спосіб лікування ретровірусних інфекцій
US6037157A (en) *	1995-06-29	2000-03-14	Abbott Laboratories	Method for improving pharmacokinetics
US20020068749A1 (en) *	1996-11-08	2002-06-06	Hideharu Sato	Aids remedy

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US517041A (en) *		1894-03-27		Fruit-picker
CA1340588C (en) *	1988-06-13	1999-06-08	Balraj Krishan Handa	Amino acid derivatives
ATE155779T1 (de) *	1990-11-19	1997-08-15	Monsanto Co	Retrovirale protease-inhibitoren
AU662309B2 (en) *	1990-11-19	1995-08-31	Monsanto Company	Retroviral protease inhibitors
IE20010533A1 (en) *	1990-11-20	2003-03-05	Abbott Lab	Intermediates for preparing retroviral protease inhibiting compounds
SG52731A1 (en) *	1991-11-08	1998-09-28	Merck & Co Inc	Hiv protease inhibitors useful for the treatment of aids
DK0727419T3 (da) *	1992-12-29	2002-06-10	Abbott Lab	Mellemprodukter til fremstilling af forbindelser, som inhiberer retroviral protease

1995
- 1995-08-02 IL IL11480895A patent/IL114808A/xx not_active IP Right Cessation
- 1995-08-07 EP EP95930118A patent/EP0774969B8/de not_active Expired - Lifetime
- 1995-08-07 WO PCT/US1995/009956 patent/WO1996004913A1/en not_active Ceased
- 1995-08-07 JP JP8507422A patent/JPH10504036A/ja active Pending
- 1995-08-07 SK SK181-97A patent/SK18197A3/sk unknown
- 1995-08-07 DK DK95930118T patent/DK0774969T3/da active
- 1995-08-07 MX MX9701121A patent/MX9701121A/es unknown
- 1995-08-07 CN CN95195548A patent/CN1101190C/zh not_active Expired - Fee Related
- 1995-08-07 CZ CZ1997389A patent/CZ292577B6/cs not_active IP Right Cessation
- 1995-08-07 HU HU9700402A patent/HUT76540A/hu unknown
- 1995-08-07 ES ES95930118T patent/ES2190456T3/es not_active Expired - Lifetime
- 1995-08-07 PL PL95318506A patent/PL181578B1/pl not_active IP Right Cessation
- 1995-08-07 CA CA002197207A patent/CA2197207C/en not_active Expired - Fee Related
- 1995-08-07 DE DE69529678T patent/DE69529678T2/de not_active Expired - Fee Related
- 1995-08-07 AT AT95930118T patent/ATE232727T1/de not_active IP Right Cessation
- 1995-08-07 AU AU33611/95A patent/AU698664B2/en not_active Ceased
- 1995-08-07 KR KR1019970700855A patent/KR970704441A/ko not_active Ceased
1997
- 1997-02-11 NO NO19970632A patent/NO314168B1/no unknown
2003
- 2003-05-07 CY CY0300040A patent/CY2360B1/xx unknown

Also Published As

Publication number	Publication date
JPH10504036A (ja)	1998-04-14
ES2190456T3 (es)	2003-08-01
IL114808A (en)	1999-10-28
WO1996004913A1 (en)	1996-02-22
NO970632L (no)	1997-04-10
SK18197A3 (en)	1997-09-10
DE69529678T2 (de)	2003-09-25
IL114808A0 (en)	1995-12-08
EP0774969B8 (de)	2003-07-02
DE69529678D1 (de)	2003-03-27
KR970704441A (ko)	1997-09-06
CY2360B1 (en)	2004-06-04
CN1101190C (zh)	2003-02-12
NO314168B1 (no)	2003-02-10
CA2197207C (en)	2006-10-17
EP0774969B1 (de)	2003-02-19
MX9701121A (es)	1997-05-31
PL318506A1 (en)	1997-06-23
CZ292577B6 (cs)	2003-10-15
CA2197207A1 (en)	1996-02-22
CN1160350A (zh)	1997-09-24
CZ38997A3 (en)	1997-11-12
HUT76540A (en)	1997-09-29
PL181578B1 (pl)	2001-08-31
EP0774969A1 (de)	1997-05-28
AU3361195A (en)	1996-03-07
NO970632D0 (no)	1997-02-11
AU698664B2 (en)	1998-11-05
DK0774969T3 (da)	2003-03-31

Legal Events

Date

Code

Title

Description

2003-11-15

UEP

Publication of translation of european patent specification

Ref document number: 0774969

Country of ref document: EP

2009-05-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69228106D1 (de)	1999-02-18	HIV-Protease-Inhibitoren
DE60036961D1 (de)	2007-12-13	Gamma-hydroxy-2-(fluoralkylaminocarbonyl)-1-piperazinpentanamide als hiv-proteasehemmer
ATE252081T1 (de)	2003-11-15	Neue hiv-protease-inhibitoren
MY109834A (en)	1997-08-30	Benzoxazinones as inhibitors of hiv reverse transcriptase
EA200300449A1 (ru)	2003-10-30	Аза- и полиаза-нафталинилкарбоксамиды, полезные в качестве ингибиторов вич-интегразы
LU91428I2 (fr)	2008-06-09	ISENTRESS- raltégravir
DZ1766A1 (fr)	2002-02-17	Inhibiteurs de vih protéase utiles pour le traitement du sida.
DE69430385D1 (de)	2002-05-16	Hiv-proteaseinhibitoren
ATE404563T1 (de)	2008-08-15	8-hydroxy-1- oxotetrahydropyrrolopyrazinverbindungen, die sich als inhibitoren von hiv-integrase eignen
EA199700150A1 (ru)	1997-12-30	КОМБИНИРОВАННОЕ ЛЕЧЕНИЕ ПО ПОВОДУ ВИЧ ИНФЕКЦИИ С ИСПОЛЬЗОВАНИЕМ ИНГИБИТОРА ПРОТЕАЗЫ ВИЧ ИНДИНАВИРА И ИНГИБИТОРА ОБРАТНОЙ ТРАНСКРИПТАЗЫ 3TC, НЕОБЯЗАТЕЛЬНО СОВМЕСТНО С AZT, ddI ИЛИ ddC
WO1996000068A3 (en)	1996-02-22	Combination therapy for hiv infection
DE69529678D1 (de)	2003-03-27	Kombinationen von hiv-protease inhibitoren
FI970565A0 (fi)	1997-02-10	HIV-proteaasia inhiboiva yhdistelmä
ECSP982741A (es)	1999-04-21	Terapia combinada para el tratamiento del sida