ATE233741T1 - Antivirale 2,4-pyrimidindion-derivate und verfahren zu ihrer herstellung - Google Patents

Antivirale 2,4-pyrimidindion-derivate und verfahren zu ihrer herstellung

Info

Publication number
ATE233741T1
ATE233741T1 AT97920976T AT97920976T ATE233741T1 AT E233741 T1 ATE233741 T1 AT E233741T1 AT 97920976 T AT97920976 T AT 97920976T AT 97920976 T AT97920976 T AT 97920976T AT E233741 T1 ATE233741 T1 AT E233741T1
Authority
AT
Austria
Prior art keywords
pct
hydrogen
alkyl group
derivatives
date nov
Prior art date
Application number
AT97920976T
Other languages
English (en)
Inventor
Jong Chan Son
Ill Young Lee
Hyun Sook Kim
Jin Chel Kim
Eui Hwan Cho
Sun Gan Chung
Joung Young Kim
Soon Hwan Lee
Ho Seok Kwon
Jae Weung Lee
Original Assignee
Korea Res Inst Chem Tech
Samjin Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea Res Inst Chem Tech, Samjin Pharm Co Ltd filed Critical Korea Res Inst Chem Tech
Application granted granted Critical
Publication of ATE233741T1 publication Critical patent/ATE233741T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT97920976T 1996-05-16 1997-05-15 Antivirale 2,4-pyrimidindion-derivate und verfahren zu ihrer herstellung ATE233741T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR19960016413 1996-05-16
KR1019970013560A KR100219922B1 (ko) 1996-05-16 1997-04-14 신규한 항바이러스성 6-아릴옥시 및 6-아릴카르보닐 2,4-피리미딘디온 유도체 및 그의 제조 방법
PCT/KR1997/000084 WO1997043266A1 (en) 1996-05-16 1997-05-15 Antiviral 2,4-pyrimidinedione derivatives and process for the preparation thereof

Publications (1)

Publication Number Publication Date
ATE233741T1 true ATE233741T1 (de) 2003-03-15

Family

ID=26631836

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97920976T ATE233741T1 (de) 1996-05-16 1997-05-15 Antivirale 2,4-pyrimidindion-derivate und verfahren zu ihrer herstellung

Country Status (8)

Country Link
US (1) US6136815A (de)
EP (1) EP0912526B1 (de)
JP (1) JP3078333B2 (de)
KR (1) KR100219922B1 (de)
AT (1) ATE233741T1 (de)
AU (1) AU2713897A (de)
DE (1) DE69719511T2 (de)
WO (1) WO1997043266A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100390096B1 (ko) * 1998-03-10 2003-08-19 한국화학연구원 알파-치환된아릴메틸렌기로씨-6위치가치환된신규한항바이러스성2,4-피리미딘디온유도체및이의제조방법
SK287269B6 (sk) * 1998-11-10 2010-05-07 Janssen Pharmaceutica N. V. Derivát pyrimidínu, jeho použitie, spôsob jeho prípravy a farmaceutická kompozícia, kombinácia a produkt s jeho obsahom
US6713486B1 (en) * 1999-03-04 2004-03-30 Korea Research Institute Of Chemical Technology Antiviral 2,4-pyrimidinedione derivatives and process for the preparation thereof
KR100311949B1 (ko) * 1999-03-10 2001-11-02 최승주 1-[(사이클로펜트-3-엔-1-일)메틸]-5-에틸-6-(3,5-다이메틸벤조일)-2,4-피리미딘다이온의제조방법
KR20000065885A (ko) * 1999-04-10 2000-11-15 최승주 항바이러스성 피리미딘다이온 유도체 및 그 제조방법
AU2002248910A1 (en) 2000-11-17 2002-05-27 Idenix (Cayman) Limited Methods for inhibiting the transmission of HIV using topically applied substituted 6-benzyl-4-oxopyrmidines
BRPI0714880A2 (pt) * 2006-07-24 2013-05-21 Gilead Sciences Inc inibidores da transcriptase reversa do hiv
EA200971115A1 (ru) * 2007-06-29 2010-04-30 Корея Рисерч Инститьют Оф Кемикал Текнолоджи Новые ингибиторы обратной транскриптазы вич
KR20100041798A (ko) * 2007-06-29 2010-04-22 한국화학연구원 신규 ｈｉｖ 역전사효소 억제제
KR20100092960A (ko) * 2007-12-21 2010-08-23 한국화학연구원 Ｈｉｖ 역전사 효소 억제제의 제조 방법
CN104119283B (zh) * 2013-04-24 2016-06-22 北京大学 Hiv逆转录酶/整合酶双靶点抑制剂6-苯甲酰基取代尿嘧啶类化合物的制备及应用
WO2016141220A1 (en) * 2015-03-03 2016-09-09 Regents Of The University Of Minnesota 3-hydroxypyrimidine-2,4-dione-5-carboxamides as potent inhibitors of hiv

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112835A (en) * 1988-03-31 1992-05-12 Mitsubishi Kasei Corporation 6-substituted acyclopyrimidine nucleoside derivatives and antiviral agents containing the same as active ingredient thereof
FR2652547B1 (fr) * 1989-09-29 1995-06-02 Valeo Timonerie de transmission de forces pour vehicules automobiles.
KR0155168B1 (ko) * 1989-09-29 1998-11-16 미우라 아끼라 6-치환된 아시클로피리미딘 뉴클레오시드 유도체 및 이를 활성성분으로 함유하는 항비루스제
CA2131797C (en) * 1992-03-12 2010-05-18 Laramie Mary Gaster Condensed indole derivatives as 5ht4-receptor antagonists
KR0151811B1 (ko) * 1993-12-21 1998-10-15 강박광 신규한 항바이러스성 2,4-피리미딘디온 유도체 및 그의 제조방법

Also Published As

Publication number Publication date
DE69719511D1 (de) 2003-04-10
KR100219922B1 (ko) 1999-09-01
DE69719511T2 (de) 2003-10-02
US6136815A (en) 2000-10-24
EP0912526A1 (de) 1999-05-06
EP0912526B1 (de) 2003-03-05
JPH11513996A (ja) 1999-11-30
KR970074773A (ko) 1997-12-10
AU2713897A (en) 1997-12-05
WO1997043266A1 (en) 1997-11-20
JP3078333B2 (ja) 2000-08-21

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