ATE278676T1 - Imdazol-derivate, deren herstellung und deren verwendung als s-adenosylmethionin decarboxylase (=samdc) inhibitoren - Google Patents

Imdazol-derivate, deren herstellung und deren verwendung als s-adenosylmethionin decarboxylase (=samdc) inhibitoren

Info

Publication number
ATE278676T1
ATE278676T1 AT96900957T AT96900957T ATE278676T1 AT E278676 T1 ATE278676 T1 AT E278676T1 AT 96900957 T AT96900957 T AT 96900957T AT 96900957 T AT96900957 T AT 96900957T AT E278676 T1 ATE278676 T1 AT E278676T1
Authority
AT
Austria
Prior art keywords
hydrogen
pct
samdc
inhibitors
production
Prior art date
Application number
AT96900957T
Other languages
English (en)
Inventor
Joerg Frei
Jaroslav Stanek
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE278676T1 publication Critical patent/ATE278676T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/46—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms attached to said nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT96900957T 1995-01-26 1996-01-15 Imdazol-derivate, deren herstellung und deren verwendung als s-adenosylmethionin decarboxylase (=samdc) inhibitoren ATE278676T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH21595 1995-01-26
PCT/EP1996/000143 WO1996022979A1 (en) 1995-01-26 1996-01-15 Imidazole derivatives, their preparation and their use as s-adenosylmethionine decarboxylase (=samdc) inhibitors

Publications (1)

Publication Number Publication Date
ATE278676T1 true ATE278676T1 (de) 2004-10-15

Family

ID=4181898

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96900957T ATE278676T1 (de) 1995-01-26 1996-01-15 Imdazol-derivate, deren herstellung und deren verwendung als s-adenosylmethionin decarboxylase (=samdc) inhibitoren

Country Status (9)

Country Link
US (1) US5840911A (de)
EP (1) EP0808309B1 (de)
JP (1) JP3989543B2 (de)
AT (1) ATE278676T1 (de)
AU (1) AU4486796A (de)
CA (1) CA2210533C (de)
DE (1) DE69633557T2 (de)
ES (1) ES2229260T3 (de)
WO (1) WO1996022979A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4437399A (en) * 1998-06-12 1999-12-30 Waters Investments Limited Novel ion exchange porous resins for solid phase extraction and chromatography
US20030224970A1 (en) * 2002-05-17 2003-12-04 Sanjoy Mahanty Methods for the identification of inhibitors of S-adenosylmethionine decarboxylase as antibiotics
US7264819B2 (en) * 2003-06-23 2007-09-04 Anticancer, Inc. Lyase treatment for P. carinii
CN106389403B (zh) * 2016-04-22 2019-02-19 三峡大学 小分子共价抑制剂在制备抑制s-腺苷甲硫氨酸脱羧酶的药物上的应用及筛选方法
CN106389415B (zh) * 2016-04-22 2019-02-19 三峡大学 小分子共价抑制剂在制备抑制s-腺苷甲硫氨酸脱羧酶的药物上的应用及其筛选方法
CN106389399B (zh) * 2016-04-22 2019-02-19 三峡大学 一种小分子共价抑制剂在制备抑制s-腺苷甲硫氨酸脱羧酶的药物上的应用及其筛选方法
ES3022196A1 (es) * 2023-11-27 2025-05-28 Univ Madrid Complutense Derivados de 2-indolinona y usos de los mismos

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659720A (en) * 1982-12-20 1987-04-21 Merck & Co., Inc. 5-amino or substituted amino imidazoles useful to treat coccidiosis
CA1332572C (en) * 1988-01-29 1994-10-18 Anthony Cerami Method and agents for preventing staining of teeth
US4971986A (en) * 1988-03-25 1990-11-20 Ciba-Geigy Corporation Arylhydrazones useful as SAMDC inhibitors
AU645799B2 (en) * 1990-05-07 1994-01-27 Novartis Ag Hydrazones
RU2081108C1 (ru) * 1991-10-16 1997-06-10 Циба-Гейги АГ Аддитивные соли кислот с основанием и фармацевтическая композиция, обладающая противоопухолевой активностью

Also Published As

Publication number Publication date
CA2210533A1 (en) 1996-08-01
JPH10512578A (ja) 1998-12-02
JP3989543B2 (ja) 2007-10-10
US5840911A (en) 1998-11-24
EP0808309B1 (de) 2004-10-06
DE69633557T2 (de) 2005-10-13
DE69633557D1 (de) 2004-11-11
EP0808309A1 (de) 1997-11-26
ES2229260T3 (es) 2005-04-16
CA2210533C (en) 2007-12-04
AU4486796A (en) 1996-08-14
WO1996022979A1 (en) 1996-08-01

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