ATE234284T1 - Kondensierte isoindolone als proteinkinase c inhibitoren - Google Patents

Kondensierte isoindolone als proteinkinase c inhibitoren

Info

Publication number: ATE234284T1
Authority: AT; Austria
Prior art keywords: inhibitors; protein kinase; isoindolones; fused; condensed
Prior art date: 1995-12-11

Application number

AT96943735T

Other languages

English (en)

Inventor

Robert L Hudkins

Neil W Johnson

Original Assignee

Cephalon Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-11

Filing date

1996-12-11

Publication date

2003-03-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26678542&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE234284(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1996-12-11 Application filed by Cephalon Inc filed Critical Cephalon Inc

2003-03-15 Application granted granted Critical

2003-03-15 Publication of ATE234284T1 publication Critical patent/ATE234284T1/de

Links

229940123924 Protein kinase C inhibitor Drugs 0.000 title 1
239000003881 protein kinase C inhibitor Substances 0.000 title 1
SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
XTBAPWCYTNCZTO-UHFFFAOYSA-N isoindol-1-one Chemical class C1=CC=C2C(=O)N=CC2=C1 XTBAPWCYTNCZTO-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 1
PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
150000005624 indolones Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT96943735T 1995-12-11 1996-12-11 Kondensierte isoindolone als proteinkinase c inhibitoren ATE234284T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US873395P	1995-12-11	1995-12-11
US08/761,951 US5808060A (en)	1995-12-11	1996-12-09	Fused isoindolones
PCT/US1996/019853 WO1997021677A1 (en)	1995-12-11	1996-12-11	Fused isoindolones as inhibitors of protein kinase c

Publications (1)

Publication Number	Publication Date
ATE234284T1 true ATE234284T1 (de)	2003-03-15

Family

ID=26678542

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96943735T ATE234284T1 (de)	1995-12-11	1996-12-11	Kondensierte isoindolone als proteinkinase c inhibitoren

Country Status (14)

Country	Link
US (1)	US5808060A (de)
EP (1)	EP0871612B1 (de)
KR (1)	KR100534528B1 (de)
CN (1)	CN1139573C (de)
AT (1)	ATE234284T1 (de)
AU (1)	AU701412B2 (de)
BR (1)	BR9611947A (de)
CA (1)	CA2239282C (de)
DE (1)	DE69626680T2 (de)
DK (1)	DK0871612T3 (de)
ES (1)	ES2195033T3 (de)
NZ (1)	NZ325073A (de)
PT (1)	PT871612E (de)
WO (1)	WO1997021677A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6127401A (en) *	1998-06-05	2000-10-03	Cephalon, Inc.	Bridged indenopyrrolocarbazoles
US6841567B1 (en)	1999-02-12	2005-01-11	Cephalon, Inc.	Cyclic substituted fused pyrrolocarbazoles and isoindolones
US6399780B1 (en)	1999-08-20	2002-06-04	Cephalon, Inc.	Isomeric fused pyrrolocarbazoles and isoindolones
US6630500B2 (en) *	2000-08-25	2003-10-07	Cephalon, Inc.	Selected fused pyrrolocarbazoles
US20040098106A1 (en) *	2002-11-14	2004-05-20	Williams Michael S.	Intraluminal prostheses and carbon dioxide-assisted methods of impregnating same with pharmacological agents
US7285287B2 (en) *	2002-11-14	2007-10-23	Synecor, Llc	Carbon dioxide-assisted methods of providing biocompatible intraluminal prostheses
US6932930B2 (en) *	2003-03-10	2005-08-23	Synecor, Llc	Intraluminal prostheses having polymeric material with selectively modified crystallinity and methods of making same
US20070161648A1 (en) *	2005-10-14	2007-07-12	Hughes Terry V	Substituted dihydro-isoindolones useful in treating kinase disorders
US20080021013A1 (en) *	2006-07-21	2008-01-24	Cephalon, Inc.	JAK inhibitors for treatment of myeloproliferative disorders
CN103242404A (zh) *	2012-02-03	2013-08-14	复旦大学	N-鼠李糖基苯并咔唑化合物及其合成方法和在制药中的用途
CN116874500B (zh) *	2023-06-21	2025-08-19	南方科技大学	一种基于苯并酰亚胺的稠环受体材料及其制备方法与应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS62220196A (ja) *	1986-03-20	1987-09-28	Kyowa Hakko Kogyo Co Ltd	新規物質ｕｃｎ―０１
US4816450A (en) *	1986-09-15	1989-03-28	Duke University	Inhibition of protein kinase C by long-chain bases
US4735939A (en) *	1987-02-27	1988-04-05	The Dow Chemical Company	Insecticidal activity of staurosporine
US4923986A (en) *	1987-03-09	1990-05-08	Kyowa Hakko Kogyo Co., Ltd.	Derivatives of physiologically active substance K-252
JPH07113027B2 (ja) *	1987-12-24	1995-12-06	協和醗酵工業株式会社	Ｋ−２５２誘導体
US5438050A (en) *	1988-02-06	1995-08-01	Godecke Aktiengesellschaft	Indolocarbazole derivatives, processes for their preparation and compositions containing them
DE3835842A1 (de) *	1988-10-21	1990-04-26	Goedecke Ag	Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
JP3010675B2 (ja) *	1989-03-23	2000-02-21	萬有製薬株式会社	抗腫瘍性物質ｂｅ―１３７９３ｃ
US5618809A (en) *	1989-12-14	1997-04-08	Schering Corporation	Indolocarbazoles from saccharothrix aerocolonigenes copiosa subsp. nov SCC 1951 ATCC 53856
US5489608A (en) *	1989-12-21	1996-02-06	Goedecke Aktiengesellschaft	Indolocarbazole derivatives and the use thereof
US5591842A (en) *	1991-11-29	1997-01-07	Banyu Pharmaceutical Co., Ltd.	Indolopyrrolocarbazole derivatives
US6271242B1 (en) *	1992-02-10	2001-08-07	Bristol-Myers Squibb Co.	Method for treating cancer using a tyrosine protein kinase inhibitor
US5547976A (en) *	1992-03-20	1996-08-20	Burroughs Wellcome Co.	Further indole derivatives with antiviral activity
DE4217963A1 (de) *	1992-05-30	1993-12-02	Goedecke Ag	Verwendung von Indolocarbazolen zur Behandlung von AIDS
US5461146A (en) *	1992-07-24	1995-10-24	Cephalon, Inc.	Selected protein kinase inhibitors for the treatment of neurological disorders
AU679752B2 (en) *	1993-05-28	1997-07-10	Cephalon, Inc.	Use of indolocarbazole derivatives to treat a pathological condition of the prostate
US5468872A (en) *	1993-09-16	1995-11-21	Cephalon, Inc.	K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders
US5705511A (en) *	1994-10-14	1998-01-06	Cephalon, Inc.	Fused pyrrolocarbazoles
US5475110A (en) *	1994-10-14	1995-12-12	Cephalon, Inc.	Fused Pyrrolocarbazoles
US5591855A (en) *	1994-10-14	1997-01-07	Cephalon, Inc.	Fused pyrrolocarbazoles
US5594009A (en) *	1994-10-14	1997-01-14	Cephalon, Inc.	Fused pyrrolocarbazoles

1996
- 1996-12-09 US US08/761,951 patent/US5808060A/en not_active Expired - Fee Related
- 1996-12-11 DE DE69626680T patent/DE69626680T2/de not_active Expired - Fee Related
- 1996-12-11 CA CA002239282A patent/CA2239282C/en not_active Expired - Fee Related
- 1996-12-11 KR KR1019980704400A patent/KR100534528B1/ko not_active Expired - Fee Related
- 1996-12-11 DK DK96943735T patent/DK0871612T3/da active
- 1996-12-11 ES ES96943735T patent/ES2195033T3/es not_active Expired - Lifetime
- 1996-12-11 EP EP96943735A patent/EP0871612B1/de not_active Expired - Lifetime
- 1996-12-11 AT AT96943735T patent/ATE234284T1/de not_active IP Right Cessation
- 1996-12-11 PT PT96943735T patent/PT871612E/pt unknown
- 1996-12-11 WO PCT/US1996/019853 patent/WO1997021677A1/en not_active Ceased
- 1996-12-11 CN CNB961998067A patent/CN1139573C/zh not_active Expired - Fee Related
- 1996-12-11 BR BR9611947A patent/BR9611947A/pt not_active IP Right Cessation
- 1996-12-11 AU AU12893/97A patent/AU701412B2/en not_active Ceased
- 1996-12-11 NZ NZ325073A patent/NZ325073A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0871612A1 (de)	1998-10-21
EP0871612B1 (de)	2003-03-12
ES2195033T3 (es)	2003-12-01
KR100534528B1 (ko)	2006-05-29
CN1224417A (zh)	1999-07-28
US5808060A (en)	1998-09-15
NZ325073A (en)	1999-04-29
AU701412B2 (en)	1999-01-28
BR9611947A (pt)	1999-04-06
DK0871612T3 (da)	2003-07-14
CN1139573C (zh)	2004-02-25
MX9804706A (es)	1998-10-31
CA2239282A1 (en)	1997-06-19
WO1997021677A1 (en)	1997-06-19
PT871612E (pt)	2003-06-30
DE69626680D1 (de)	2003-04-17
CA2239282C (en)	2009-08-18
HK1016599A1 (en)	1999-11-05
DE69626680T2 (de)	2003-11-06
AU1289397A (en)	1997-07-03
KR19990072091A (ko)	1999-09-27

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