ATE234298T1 - Zyklische etherverbindungen als natriumkanal- modulatoren - Google Patents
Zyklische etherverbindungen als natriumkanal- modulatorenInfo
- Publication number
- ATE234298T1 ATE234298T1 AT97937828T AT97937828T ATE234298T1 AT E234298 T1 ATE234298 T1 AT E234298T1 AT 97937828 T AT97937828 T AT 97937828T AT 97937828 T AT97937828 T AT 97937828T AT E234298 T1 ATE234298 T1 AT E234298T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- sodium channel
- lower alkyl
- cyclic ether
- ether compounds
- Prior art date
Links
- 108010052164 Sodium Channels Proteins 0.000 title abstract 2
- 102000018674 Sodium Channels Human genes 0.000 title abstract 2
- -1 CYCLIC ETHER COMPOUNDS Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000001054 5 membered carbocyclic group Chemical group 0.000 abstract 1
- 125000004008 6 membered carbocyclic group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 101100073357 Streptomyces halstedii sch2 gene Proteins 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000006355 carbonyl methylene group Chemical group [H]C([H])([*:2])C([*:1])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Transmitters (AREA)
- Optical Modulation, Optical Deflection, Nonlinear Optics, Optical Demodulation, Optical Logic Elements (AREA)
- Plural Heterocyclic Compounds (AREA)
- Liquid Crystal Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22884596 | 1996-08-29 | ||
| JP8649697 | 1997-04-04 | ||
| PCT/JP1997/003007 WO1998008842A1 (en) | 1996-08-29 | 1997-08-28 | Cyclic ether compounds as sodium channel modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE234298T1 true ATE234298T1 (de) | 2003-03-15 |
Family
ID=26427602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97937828T ATE234298T1 (de) | 1996-08-29 | 1997-08-28 | Zyklische etherverbindungen als natriumkanal- modulatoren |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6172085B1 (de) |
| EP (1) | EP0923575B1 (de) |
| CN (1) | CN1076022C (de) |
| AT (1) | ATE234298T1 (de) |
| AU (1) | AU4031697A (de) |
| CA (1) | CA2264231A1 (de) |
| DE (1) | DE69719766T2 (de) |
| HU (1) | HUP9903557A2 (de) |
| NO (1) | NO990583L (de) |
| WO (1) | WO1998008842A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6479536B1 (en) | 1998-12-04 | 2002-11-12 | Takeda Chemical Industries, Ltd. | Benzofuran derivatives, process for the preparation of the same and uses thereof |
| DK1169060T3 (da) | 1999-04-09 | 2006-01-16 | Euro Celtique Sa | Natriumkanalblokkerpræparater og anvendelse deraf |
| US20030060487A1 (en) * | 2000-04-12 | 2003-03-27 | Bamdad R. Shoshana | Treatment of neurodegenerative disease |
| US6825201B2 (en) * | 2001-04-25 | 2004-11-30 | Bristol-Myers Squibb Company | Indole, azaindole and related heterocyclic amidopiperazine derivatives |
| DK1423168T3 (da) | 2001-09-03 | 2006-05-15 | Newron Pharm Spa | Farmaceutisk præparat omfattende gabapentin eller en analog deraf og et alfa-aminoamid og dets analgetiske anvendelse |
| WO2003037274A2 (en) | 2001-11-01 | 2003-05-08 | Icagen, Inc. | Pyrazole-amides and-sulfonamides |
| SI1458386T1 (sl) * | 2001-12-27 | 2007-08-31 | Ortho Mcneil Pharm Inc | Aroil pirol heteroeril in metanoli, uporabni za zdravljenje motnje centralnega živčnega sistema |
| US20030236277A1 (en) * | 2002-02-14 | 2003-12-25 | Kadow John F. | Indole, azaindole and related heterocyclic pyrrolidine derivatives |
| CA2474751A1 (en) | 2002-02-25 | 2003-09-04 | Vanderbilt University | Expression system for human brain-specific voltage-gated sodium channel, type 1 |
| US7037913B2 (en) | 2002-05-01 | 2006-05-02 | Bristol-Myers Squibb Company | Bicyclo 4.4.0 antiviral derivatives |
| PL1637527T3 (pl) * | 2003-06-26 | 2013-09-30 | Takeda Pharmaceuticals Co | Modulator receptora kanabinoidowego |
| WO2006022311A1 (ja) * | 2004-08-27 | 2006-03-02 | Takeda Pharmaceutical Company Limited | アゾ化合物とその製造方法 |
| US20060100209A1 (en) * | 2004-11-09 | 2006-05-11 | Chong-Hui Gu | Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
| US20060100432A1 (en) * | 2004-11-09 | 2006-05-11 | Matiskella John D | Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
| DE102004061593A1 (de) * | 2004-12-21 | 2006-06-22 | Abbott Gmbh & Co. Kg | Substituierte N-heterocyclische Verbindungen und ihre therapeutische Verwendung |
| US7598380B2 (en) * | 2005-08-03 | 2009-10-06 | Bristol-Myers Squibb Company | Method of preparation of azaindole derivatives |
| CA2620179C (en) | 2005-08-16 | 2013-10-29 | Icagen, Inc. | Inhibitors of voltage-gated sodium channels |
| AU2006311954A1 (en) | 2005-11-02 | 2007-05-18 | Icagen, Inc. | Inhibitors of ion channels |
| US7851476B2 (en) * | 2005-12-14 | 2010-12-14 | Bristol-Myers Squibb Company | Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine |
| US7807671B2 (en) * | 2006-04-25 | 2010-10-05 | Bristol-Myers Squibb Company | Diketo-piperazine and piperidine derivatives as antiviral agents |
| EP1995241B1 (de) * | 2007-03-23 | 2010-03-17 | ICAgen, Inc. | Ionenkanal-Hemmer |
| US8124610B2 (en) * | 2007-07-13 | 2012-02-28 | Icagen Inc. | Sodium channel inhibitors |
| CN103554002B (zh) * | 2013-10-08 | 2016-04-27 | 常州大学 | 1-苯基吲哚及其制备方法 |
| US10752588B2 (en) | 2014-12-19 | 2020-08-25 | The Broad Institute, Inc. | Dopamine D2 receptor ligands |
| WO2016100940A1 (en) | 2014-12-19 | 2016-06-23 | The Broad Institute, Inc. | Dopamine d2 receptor ligands |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW199152B (de) * | 1990-11-01 | 1993-02-01 | Takeda Pharm Industry Co Ltd | |
| JP3198395B2 (ja) * | 1992-05-28 | 2001-08-13 | 武田薬品工業株式会社 | アミノクマラン誘導体 |
| TW334433B (en) | 1992-12-09 | 1998-06-21 | Takeda Pharm Industry Co Ltd | Crystalline salt of (S)-(+)-5-amino-2,4,6,7-tetramethyl-2-(4-phenylpiperidinomethyl)-2,3-dihydrobenzo(b)furan dihydrochloride their production and use |
-
1997
- 1997-08-28 AT AT97937828T patent/ATE234298T1/de not_active IP Right Cessation
- 1997-08-28 WO PCT/JP1997/003007 patent/WO1998008842A1/en not_active Ceased
- 1997-08-28 CN CN97195849A patent/CN1076022C/zh not_active Expired - Fee Related
- 1997-08-28 DE DE69719766T patent/DE69719766T2/de not_active Expired - Lifetime
- 1997-08-28 HU HU9903557A patent/HUP9903557A2/hu unknown
- 1997-08-28 US US09/242,067 patent/US6172085B1/en not_active Expired - Fee Related
- 1997-08-28 AU AU40316/97A patent/AU4031697A/en not_active Abandoned
- 1997-08-28 EP EP97937828A patent/EP0923575B1/de not_active Expired - Lifetime
- 1997-08-28 CA CA002264231A patent/CA2264231A1/en not_active Abandoned
-
1999
- 1999-02-08 NO NO990583A patent/NO990583L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69719766D1 (de) | 2003-04-17 |
| CN1223652A (zh) | 1999-07-21 |
| CN1076022C (zh) | 2001-12-12 |
| DE69719766T2 (de) | 2004-01-15 |
| HUP9903557A2 (en) | 2002-08-28 |
| EP0923575A1 (de) | 1999-06-23 |
| NO990583D0 (no) | 1999-02-08 |
| WO1998008842A1 (en) | 1998-03-05 |
| AU4031697A (en) | 1998-03-19 |
| NO990583L (no) | 1999-02-08 |
| EP0923575B1 (de) | 2003-03-12 |
| CA2264231A1 (en) | 1998-03-05 |
| US6172085B1 (en) | 2001-01-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |