ATE234353T1 - Biologische faktoren und neuronale stammzellen - Google Patents

Biologische faktoren und neuronale stammzellen

Info

Publication number
ATE234353T1
ATE234353T1 AT93923994T AT93923994T ATE234353T1 AT E234353 T1 ATE234353 T1 AT E234353T1 AT 93923994 T AT93923994 T AT 93923994T AT 93923994 T AT93923994 T AT 93923994T AT E234353 T1 ATE234353 T1 AT E234353T1
Authority
AT
Austria
Prior art keywords
stem cells
biological factors
neuronal stem
oligodendrocytes
astrocytes
Prior art date
Application number
AT93923994T
Other languages
English (en)
Inventor
Samuel Weiss
Brent A Reynolds
Joseph P Hammang
E Edward Baetge
Original Assignee
Neurospheres Holdings Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25513066&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE234353(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Neurospheres Holdings Ltd filed Critical Neurospheres Holdings Ltd
Application granted granted Critical
Publication of ATE234353T1 publication Critical patent/ATE234353T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01011—Phosphopyruvate hydratase (4.2.1.11), i.e. enolase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/46—Amines, e.g. putrescine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/148—Transforming growth factor alpha [TGF-a]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C12N2501/392—Sexual steroids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT93923994T 1992-10-28 1993-10-27 Biologische faktoren und neuronale stammzellen ATE234353T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96762292A 1992-10-28 1992-10-28
PCT/CA1993/000456 WO1994010292A1 (en) 1992-10-28 1993-10-27 Biological factors and neural stem cells

Publications (1)

Publication Number Publication Date
ATE234353T1 true ATE234353T1 (de) 2003-03-15

Family

ID=25513066

Family Applications (2)

Application Number Title Priority Date Filing Date
AT93923994T ATE234353T1 (de) 1992-10-28 1993-10-27 Biologische faktoren und neuronale stammzellen
AT02018736T ATE483795T1 (de) 1992-10-28 1993-10-27 Biologische faktoren und neuronale stammzellen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT02018736T ATE483795T1 (de) 1992-10-28 1993-10-27 Biologische faktoren und neuronale stammzellen

Country Status (14)

Country Link
EP (2) EP0669973B9 (de)
JP (2) JPH08502652A (de)
KR (1) KR950704476A (de)
AT (2) ATE234353T1 (de)
AU (2) AU5367694A (de)
CA (1) CA2148138C (de)
DE (2) DE69334344D1 (de)
DK (1) DK0669973T4 (de)
ES (1) ES2194016T5 (de)
FI (1) FI952022L (de)
NO (1) NO324412B1 (de)
PT (1) PT669973E (de)
RU (1) RU95115822A (de)
WO (1) WO1994010292A1 (de)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981165A (en) * 1991-07-08 1999-11-09 Neurospheres Holdings Ltd. In vitro induction of dopaminergic cells
US5849553A (en) * 1992-07-27 1998-12-15 California Institute Of Technology Mammalian multipotent neural stem cells
US5928947A (en) * 1992-07-27 1999-07-27 California Institute Of Technology Mammalian multipotent neural stem cells
US6872699B2 (en) 1992-11-13 2005-03-29 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften, E.V. Truncated Flk-1 receptor protein, methods of use and a recombinant vector containing a nucleotide encoding the truncated Flk-1 protein
US6001654A (en) * 1994-01-28 1999-12-14 California Institute Of Technology Methods for differentiating neural stem cells to neurons or smooth muscle cells using TGT-β super family growth factors
WO1996004368A1 (en) * 1994-07-29 1996-02-15 Dalhousie University Propagation and inducible differentiation of human fetal central nervous system progenitor cells
DE69523771T2 (de) * 1994-09-23 2002-08-01 Neurospheres Holding Ltd., Calgary In vitro-modelle für cns-funktion und-dysfunktion
FI971956L (fi) * 1994-11-14 1997-07-04 Neurospheres Holdings Ltd Hermosolujen lisääntymisen säännöstely
CA2218817A1 (en) * 1995-05-24 1996-11-28 Cellfactors Plc Cell differentiation agents
FR2746109B1 (fr) 1996-03-12 1998-04-17 Rhone Poulenc Rorer Sa Milieu pour la conservation de materiel biologique
US5753506A (en) * 1996-05-23 1998-05-19 Cns Stem Cell Technology, Inc. Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
US7544511B2 (en) 1996-09-25 2009-06-09 Neuralstem Biopharmaceuticals Ltd. Stable neural stem cell line methods
US6787355B1 (en) 1996-08-26 2004-09-07 Mcgill University Multipotent neural stem cells from peripheral tissues and uses thereof
US6969608B1 (en) 1996-08-26 2005-11-29 Mcgill University Pharmaceuticals containing multipotential precursor cells from tissues containing sensory receptors
US6713247B1 (en) 1996-09-03 2004-03-30 Signal Pharmaceuticials, Inc. Human CNS cell lines and methods of use therefor
CA2216439A1 (en) * 1996-09-25 1998-03-25 Derek Van Der Kooy Pharmaceuticals containing retinal stem cells
AU755657B2 (en) * 1997-07-04 2002-12-19 University Of Utah Research Foundation Lineage-restricted neuronal precursors
US20020123143A1 (en) 1997-08-22 2002-09-05 Jean Toma Multipotent stem cells from peripheral tissues and uses thereof
US5968829A (en) * 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
US6165783A (en) 1997-10-24 2000-12-26 Neuro Spheres Holdings Ltd. Erythropoietin-mediated neurogenesis
JP3291698B2 (ja) * 1998-07-24 2002-06-10 スティーブン・カーティン 可変眼鏡用レンズ
US6787356B1 (en) 1998-07-24 2004-09-07 The United States Of America As Represented By The Department Of Health And Human Services Cell expansion system for use in neural transplantation
WO2000006700A1 (en) * 1998-07-29 2000-02-10 Layton Bioscience, Inc. Production and use of dopaminergic cells to treat dopaminergic deficiencies
SE9804064D0 (sv) * 1998-11-25 1998-11-25 A & Science Invest Ab Medicinal product and method for treatment of conditions affecting neural stem cells or progenitor cells
US6291516B1 (en) 1999-01-13 2001-09-18 Curis, Inc. Regulators of the hedgehog pathway, compositions and uses related thereto
AU7263300A (en) * 1999-09-16 2001-04-17 Neurotrophic Bioscience, Inc. Opaminergic neuronal survival-promoting factors and uses thereof
WO2001029206A1 (en) 1999-10-15 2001-04-26 Advanced Cell Technology, Inc. Methods of producing differentiated progenitor cells and lineage-defective embryonic stem cells
US7544509B2 (en) 2000-01-24 2009-06-09 Mcgill University Method for preparing stem cell preparations
AU3499801A (en) 2000-02-11 2001-08-20 Schepens Eye Res Inst Isolation and transplantation of retinal stem cells
US6683108B1 (en) 2000-03-30 2004-01-27 Curis, Inc. Agonists of hedgehog signaling pathways and uses related thereto
US7115653B2 (en) 2000-03-30 2006-10-03 Curis, Inc. Small organic molecule regulators of cell proliferation
US8852937B2 (en) 2000-03-30 2014-10-07 Curis, Inc. Small organic molecule regulators of cell proliferation
US6613798B1 (en) 2000-03-30 2003-09-02 Curis, Inc. Small organic molecule regulators of cell proliferation
AU2001283504A1 (en) * 2000-07-27 2002-02-13 The Mclean Hospital Corporation Cell implantation therapy for neurological diseases or disorders
US6908732B2 (en) 2000-10-13 2005-06-21 President & Fellows Of Harvard College Compounds and methods for regulating cell differentiation
AU2002325712C1 (en) 2001-08-30 2008-07-31 Stem Cell Therapeutics Inc. Differentiation of neural stem cells and therapeutic use theeof
JP4906231B2 (ja) 2001-09-14 2012-03-28 ステム セル セラピューティクス インコーポレイテッド プロラクチン誘導性の神経幹細胞数の増加ならびにその治療用途
CA2461290C (en) 2001-09-24 2014-11-25 Sangamo Biosciences, Inc. Modulation of stem cells using zinc finger proteins
US20050019910A1 (en) * 2001-12-13 2005-01-27 Mutsumi Takagi Human cell culture medium and culture method
EP1471970A4 (de) 2002-01-14 2006-08-02 Univ Illinois Neue multipotente säugetier-stammzellen und zusammensetzungen, verfahren zur herstellung und verfahren zu ihrer verabreichung
AU2003211063A1 (en) * 2002-02-15 2003-09-09 Cornell Research Foundation, Inc. Myelination of congenitally dysmyelinated forebrains using oligodendrocyte progenitor cells
DE60322869D1 (de) 2002-04-22 2008-09-25 Univ Johns Hopkins Modulatoren von hedgehog signalpfaden, zusammensetzungen und verwandte verwendungen
AU2003250697B2 (en) 2002-07-30 2008-05-01 Stem Cell Therapeutics Inc. Oligodendrocyte production from multipotent neural stem cells
WO2004011497A1 (en) * 2002-07-31 2004-02-05 Stem Cell Therapeutics Inc. Method of enhancing neural stem cell proliferation, differentiation, and survival using pituitary adenylate cyclase activating polypeptide (pacap)
US8293488B2 (en) 2002-12-09 2012-10-23 Neuralstem, Inc. Method for screening neurogenic agents
AU2003293409A1 (en) 2002-12-09 2004-06-30 Karl K. Johe Method for discovering neurogenic agents
WO2004053084A2 (en) 2002-12-09 2004-06-24 The Mclean Hospital Corporation Dopaminergic neurons differentiated from embryonic cells for treating neurodegenerative diseases
US7459152B2 (en) 2003-04-23 2008-12-02 Rush University Medical Center Erythropoietin administration to improve graft survival
CN1867678B (zh) 2003-09-12 2012-10-03 干细胞技术公司 神经集落形成分析
WO2005056755A2 (en) * 2003-12-02 2005-06-23 Catholic Healthcare West Compositions and methods for propagation of neural progenitor cells
US20070269412A1 (en) 2003-12-02 2007-11-22 Celavie Biosciences, Llc Pluripotent cells
WO2005077404A1 (en) 2004-02-13 2005-08-25 Stem Cell Therapeutics Corp. Use of luteinizing hormone (lh) and chorionic gonadotropin (hcg) for proliferation of neural stem cells and neurogenesis
CN101084303A (zh) 2004-11-17 2007-12-05 神经干公司 用于治疗神经变性症状的人类神经细胞的移植
US7534765B2 (en) 2005-09-27 2009-05-19 Stem Cell Therapeutics Corp. Pregnancy-induced oligodendrocyte precursor cell proliferation regulated by prolactin
KR20080103108A (ko) 2006-03-17 2008-11-26 스템 셀 테라퓨틱스 코포레이션 신경 장애 치료를 위한 ｌｈ 또는 ｈｃｇ 및 ｅｐｏ의 투여방법
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
JP2008220205A (ja) * 2007-03-09 2008-09-25 Sumitomo Bakelite Co Ltd 神経幹細胞凝集塊形成用容器、その製造方法、及び神経幹細胞凝集塊の作成方法。
US8945919B2 (en) * 2007-08-15 2015-02-03 San Bio, Inc. Methods and composition for treating neural degeneration
KR20110011658A (ko) 2008-05-08 2011-02-08 유니버시티 오브 로체스터 최적화된 세포 제제에 의한 수초 질환의 치료
US20100158878A1 (en) 2008-12-23 2010-06-24 Alexandra Capela Target populations of oligodendrocyte precursor cells and methods of making and using same
EP2380972B1 (de) 2010-04-19 2012-09-19 Technische Universität Dresden Verfahren und Zusammensetzungen zur Ausdehnung von somatischen Stammzellen und Vorläuferzellen
CN103237553A (zh) 2010-07-28 2013-08-07 神经干细胞公司 治疗和/或逆转神经退行性疾病和/或病症的方法
JP5867797B2 (ja) * 2011-05-27 2016-02-24 国立大学法人京都大学 ドーパミン産生神経の分化誘導用の細胞培養基材
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
CN108588025A (zh) 2012-02-17 2018-09-28 斯格本斯眼科研究所 人视网膜祖细胞的表型谱
EP2954046B1 (de) 2013-02-06 2025-10-15 University Of Rochester Aus induzierten pluripotenten zellen gewonnene oligodendrozyten-vorläuferzellen zur behandlung von myelinerkrankungen
MX382488B (es) 2014-10-20 2025-03-13 Neuralstem Inc Celulas madre neurales estables que comprenden un polinucleótido exógeno que codifica un factor de crecimiento y métodos de uso de las mismas.
US9724432B2 (en) 2015-04-30 2017-08-08 University Of Rochester Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder
WO2017075271A1 (en) * 2015-10-29 2017-05-04 The Regents Of The University Of Claifornia Astrocyte differentiation protocol
JP7457505B2 (ja) 2017-05-10 2024-03-28 ユニバーシティー オブ ロチェスター 神経精神障害を処置する方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ226750A (en) * 1987-10-29 1990-09-26 Amrad Corp Ltd Immortalisation of neural precursor cells by introducing a retrovirus vector containing a myc-oncogene
WO1991002003A1 (en) * 1989-08-04 1991-02-21 Board Of Regents, The University Of Texas System Methods and compositions; purified preparation of neural progenitor regulatory factor
ES2198404T5 (es) * 1991-07-08 2008-05-01 Neurospheres Holdings Ltd. Celulas progenitoras neurales que responden a factor de crecimiento y que se pueden hacer proliferar in vitro.

Also Published As

Publication number Publication date
EP0669973B2 (de) 2007-04-18
ES2194016T3 (es) 2003-11-16
NO951617L (no) 1995-04-27
WO1994010292A1 (en) 1994-05-11
DE69334344D1 (de) 2010-11-18
PT669973E (pt) 2003-06-30
AU4924197A (en) 1998-03-12
DK0669973T3 (da) 2003-07-14
EP0669973B1 (de) 2003-03-12
NO951617D0 (no) 1995-04-27
EP0669973A1 (de) 1995-09-06
EP0669973B9 (de) 2007-10-10
FI952022A7 (fi) 1995-04-27
EP1298202B1 (de) 2010-10-06
ATE483795T1 (de) 2010-10-15
CA2148138A1 (en) 1994-05-11
CA2148138C (en) 2002-01-08
ES2194016T5 (es) 2007-11-16
JP2007014352A (ja) 2007-01-25
KR950704476A (ko) 1995-11-20
DE69332759T2 (de) 2003-10-16
JPH08502652A (ja) 1996-03-26
DE69332759T3 (de) 2008-01-24
AU5367694A (en) 1994-05-24
FI952022A0 (fi) 1995-04-27
AU703729B2 (en) 1999-04-01
DK0669973T4 (da) 2007-08-27
DE69332759D1 (de) 2003-04-17
EP1298202A2 (de) 2003-04-02
FI952022L (fi) 1995-04-27
RU95115822A (ru) 1997-03-20
NO324412B1 (no) 2007-10-08
EP1298202A3 (de) 2003-12-03

Similar Documents

Publication Publication Date Title
DE69334344D1 (de) Biologische Faktoren und neuronale Stammzellen
PT664832E (pt) Remielinizacao usando celulas estaminais neurais
DE69433661D1 (de) Genetische modifikation von neuralen stammzellen
DE59813404D1 (de) Neurale vorläuferzellen, verfahren zu ihrer herstellung und ihre verwendung zur therapie von neuralen defekten
DK0594669T4 (da) Neurale progenitorceller, som reagerer på vækstfaktorer og kan formeres in vitro
FI971168A0 (fi) Keskushermoston toiminnan ja häiriön in vitro -mallit
EP0270615A4 (de) TRANSFORMATION UND EXPRESSION EINES FREMDEN GENS IN -i(BRASSICA) SPEZIES.
GR3032105T3 (en) Callus cell induction and the preparation of taxanes.
ATE103325T1 (de) Verfahren zur steigerung von enzym-aktivitaeten und der syntheseleistung von mikroorganismen und hoeheren pflanzen.
Chintamani et al. Zinc induced changes in growth of the cyanobacterium Synechococcus(6031): Characteristics of adaptation to elevated zinc concentration.
IT1220516B (it) Impianto perfezionato per la coltura in strato laminare sottile dei microrganismi fotosintetici
Osipov et al. Fluorescence Determination of the Concentration of Bacteria in Liquid Media(In Russian)
GR3005343T3 (de)
Baryshnikova et al. Effect of the purple membranes on glucose transport and respiration in Rhodococcus minimus B 293.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0669973

Country of ref document: EP

UEP Publication of translation of european patent specification

Ref document number: 0669973

Country of ref document: EP