ATE234624T1 - Zusammensetzungen zur verstärkung der pharmakologischen aktivität von immunosuppressiva - Google Patents

Zusammensetzungen zur verstärkung der pharmakologischen aktivität von immunosuppressiva

Info

Publication number: ATE234624T1
Authority: AT; Austria
Prior art keywords: compositions; immunosuppressants; rapamycin; site; enhancing
Prior art date: 1997-05-19

Application number

AT98921528T

Other languages

English (en)

Inventor

Vladimir Petrovich Zavialov

Raisa Nikolaevna Vasilenko

Dmitry Aleksandrovich Dolgikh

Mikhail Petrovich Kirpichnikov

Elena Vitalievna Navolotskaya

Timo Kalevi Korpela

Original Assignee

Vladimir Petrovich Zavialov

Raisa Nikolaevna Vasilenko

Dmitry Aleksandrovich Dolgikh

Mikhail Petrovich Kirpichnikov

Elena Vitalievna Navolotskaya

Timo Kalevi Korpela

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-19

Filing date

1998-05-18

Publication date

2003-04-15

1998-05-18 Application filed by Vladimir Petrovich Zavialov, Raisa Nikolaevna Vasilenko, Dmitry Aleksandrovich Dolgikh, Mikhail Petrovich Kirpichnikov, Elena Vitalievna Navolotskaya, Timo Kalevi Korpela filed Critical Vladimir Petrovich Zavialov

2003-04-15 Application granted granted Critical

2003-04-15 Publication of ATE234624T1 publication Critical patent/ATE234624T1/de

Links

239000000203 mixture Substances 0.000 title abstract 3
229960003444 immunosuppressant agent Drugs 0.000 title abstract 2
239000003018 immunosuppressive agent Substances 0.000 title abstract 2
230000002708 enhancing effect Effects 0.000 title 1
230000000144 pharmacologic effect Effects 0.000 title 1
108010036941 Cyclosporins Proteins 0.000 abstract 2
229930182912 cyclosporin Natural products 0.000 abstract 2
ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 abstract 2
229960002930 sirolimus Drugs 0.000 abstract 2
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 abstract 2
QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 abstract 2
102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 1
108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
230000003321 amplification Effects 0.000 abstract 1
230000002244 anti-lymphoproliferative effect Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
238000003199 nucleic acid amplification method Methods 0.000 abstract 1
210000000056 organ Anatomy 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
238000002054 transplantation Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Transplantation (AREA)
Zoology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AT98921528T 1997-05-19 1998-05-18 Zusammensetzungen zur verstärkung der pharmakologischen aktivität von immunosuppressiva ATE234624T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FI972121A FI104363B (fi)	1997-05-19	1997-05-19	Immunosuppressanttien ja interferonien farmakologisten keskinäisten vaikutusten parantaminen lisäaineilla
PCT/FI1998/000418 WO1998052594A1 (en)	1997-05-19	1998-05-18	Compositions for enhancing immunosuppressants' pharmaceutical activities

Publications (1)

Publication Number	Publication Date
ATE234624T1 true ATE234624T1 (de)	2003-04-15

Family

ID=8548873

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98921528T ATE234624T1 (de)	1997-05-19	1998-05-18	Zusammensetzungen zur verstärkung der pharmakologischen aktivität von immunosuppressiva

Country Status (7)

Country	Link
EP (1)	EP0981359B1 (de)
JP (1)	JP2001526675A (de)
AT (1)	ATE234624T1 (de)
AU (1)	AU7435298A (de)
DE (1)	DE69812347T9 (de)
FI (1)	FI104363B (de)
WO (1)	WO1998052594A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI20021774L (fi) *	2002-10-07	2004-04-08	Dmitry Aleksandrovich Dolgikh	Peptidit ja yhdistelmäproteiinit, jotka jäljittelevät interferonien antiviraalia ja kasvua estävää toimintaa
WO2004073614A2 (en) *	2003-02-14	2004-09-02	Combinatorx, Incorporated	Combination therapy for the treatment of immunoinflammatory disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990009806A2 (en) *	1989-03-02	1990-09-07	University Of Florida	Composition for the inhibition of tumors and for the non-cytotoxic inhibition of replication of viruses
TW391983B (en) *	1992-10-30	2000-06-01	Univ Florida	Human interferon TAU, processes thereof and pharmaceutical uses thereof
FR2706772A1 (en) *	1993-06-22	1994-12-30	Vacsyn Sa	Prevention and treatment of septic syndrome with an immunosuppressant, in particular cyclosporin.

1997
- 1997-05-19 FI FI972121A patent/FI104363B/fi not_active IP Right Cessation
1998
- 1998-05-18 JP JP55000998A patent/JP2001526675A/ja not_active Ceased
- 1998-05-18 WO PCT/FI1998/000418 patent/WO1998052594A1/en not_active Ceased
- 1998-05-18 AU AU74352/98A patent/AU7435298A/en not_active Abandoned
- 1998-05-18 DE DE69812347T patent/DE69812347T9/de not_active Expired - Fee Related
- 1998-05-18 AT AT98921528T patent/ATE234624T1/de not_active IP Right Cessation
- 1998-05-18 EP EP98921528A patent/EP0981359B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FI972121A0 (fi)	1997-05-19
FI972121L (fi)	1998-11-20
WO1998052594A1 (en)	1998-11-26
DE69812347T9 (de)	2004-09-23
DE69812347T2 (de)	2004-02-19
EP0981359A1 (de)	2000-03-01
JP2001526675A (ja)	2001-12-18
AU7435298A (en)	1998-12-11
DE69812347D1 (de)	2003-04-24
EP0981359B1 (de)	2003-03-19
FI104363B (fi)	2000-01-14

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Legal Events

Date

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Title

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2004-01-15

UEP

Publication of translation of european patent specification

Ref document number: 0981359

Country of ref document: EP

2006-02-15

REN

Ceased due to non-payment of the annual fee