ATE235240T1 - Wässriges verfahren zur herstellung fester paroxetin-dispersionen - Google Patents
Wässriges verfahren zur herstellung fester paroxetin-dispersionenInfo
- Publication number
- ATE235240T1 ATE235240T1 AT99920358T AT99920358T ATE235240T1 AT E235240 T1 ATE235240 T1 AT E235240T1 AT 99920358 T AT99920358 T AT 99920358T AT 99920358 T AT99920358 T AT 99920358T AT E235240 T1 ATE235240 T1 AT E235240T1
- Authority
- AT
- Austria
- Prior art keywords
- paroxetine
- dispersions
- amorphous
- producing solid
- aqueous process
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/074,355 US6168805B1 (en) | 1998-05-07 | 1998-05-07 | Aqueous process for manufacturing paroxetine solid dispersions |
| PCT/US1999/009835 WO1999056751A1 (en) | 1998-05-07 | 1999-05-05 | Aqueous process for manufacturing paroxetine solid dispersions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE235240T1 true ATE235240T1 (de) | 2003-04-15 |
Family
ID=22119113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99920358T ATE235240T1 (de) | 1998-05-07 | 1999-05-05 | Wässriges verfahren zur herstellung fester paroxetin-dispersionen |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6168805B1 (de) |
| EP (1) | EP1075263B1 (de) |
| JP (1) | JP2002513760A (de) |
| KR (1) | KR20010043418A (de) |
| CN (1) | CN1115149C (de) |
| AT (1) | ATE235240T1 (de) |
| AU (1) | AU3787699A (de) |
| CA (1) | CA2331288C (de) |
| DE (1) | DE69906269T2 (de) |
| ES (1) | ES2196803T3 (de) |
| HK (1) | HK1038699B (de) |
| MX (1) | MXPA00010928A (de) |
| WO (1) | WO1999056751A1 (de) |
| ZA (1) | ZA993081B (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6548084B2 (en) * | 1995-07-20 | 2003-04-15 | Smithkline Beecham Plc | Controlled release compositions |
| US6699882B2 (en) | 1998-03-24 | 2004-03-02 | Smithkline Beecham P.L.C. | Paroxetine compositions |
| US6503927B1 (en) * | 1999-10-28 | 2003-01-07 | Pentech Pharmaceuticals, Inc. | Amorphous paroxetine composition |
| DE10000792A1 (de) * | 2000-01-11 | 2001-07-19 | Bernhard C Lippold | Formulierungen von Wirkstoffen in Form einer festen Dispersion |
| GB0003232D0 (en) * | 2000-02-11 | 2000-04-05 | Smithkline Beecham Plc | Novel composition |
| US6660298B1 (en) * | 2000-07-27 | 2003-12-09 | Pentech Pharmaceuticals, Inc. | Paroxetine tablets and capsules |
| US6720003B2 (en) * | 2001-02-16 | 2004-04-13 | Andrx Corporation | Serotonin reuptake inhibitor formulations |
| US20030032809A1 (en) * | 2001-04-25 | 2003-02-13 | Subhash P. Upadhyaya | Optimized procedures for the manufacture of paroxetine salts |
| JP2004534056A (ja) * | 2001-06-08 | 2004-11-11 | エンドー ファーマシューティカルズ， インコーポレイティド | アクリルポリマーを使用する制御放出投薬形態、およびそれを作製するためのプロセス |
| US20040225128A1 (en) * | 2001-08-02 | 2004-11-11 | Callewaert George Leo | Paroxetine isethionate salt, process of preparation and use in the treatment of depression |
| GB0119467D0 (en) * | 2001-08-09 | 2001-10-03 | Smithkline Beecham Plc | Novel compound |
| AU2002359857B8 (en) * | 2001-12-28 | 2009-01-08 | Teva Pharmaceutical Industries Ltd. | A stable pharmaceutical formulation of paroxetine hydrochloride anhydrous and a process for preparation thereof |
| WO2005107716A1 (en) * | 2004-03-25 | 2005-11-17 | Cadila Healthcare Limited | Controlled release paroxetine-containing tablets based on a core and a coating |
| US20050266082A1 (en) * | 2004-05-26 | 2005-12-01 | Patel Satishkumar A | Preparation of stable paroxetine HC1 ER tablets using a melt granulation process |
| DE102005026755A1 (de) * | 2005-06-09 | 2006-12-14 | Basf Ag | Herstellung von festen Lösungen schwerlöslicher Wirkstoffe durch Kurzzeitüberhitzung und schnelle Trocknung |
| JP5153629B2 (ja) * | 2005-08-02 | 2013-02-27 | ルピン・リミテッド | 選択的セロトニン再取り込み阻害剤の新規の制御放出組成物 |
| US20070112031A1 (en) * | 2005-11-14 | 2007-05-17 | Gant Thomas G | Substituted phenylpiperidines with serotoninergic activity and enhanced therapeutic properties |
| US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| US20080033050A1 (en) | 2006-08-04 | 2008-02-07 | Richards Patricia Allison Tewe | Method of treating thermoregulatory disfunction with paroxetine |
| CN101573030B (zh) * | 2006-12-01 | 2015-01-28 | 巴斯夫欧洲公司 | 通过短期过热和快速干燥制备农药固溶体的方法 |
| PL2217207T3 (pl) * | 2007-11-09 | 2019-05-31 | Intervet Int Bv | Preparat o szybkim uwalnianiu w postaci stałej, jego przygotowanie i zastosowanie |
| DK3354276T3 (da) | 2007-11-13 | 2020-03-30 | Meritage Pharma Inc | Sammensætninger til behandlingen af gastrointestinal inflammation |
| US9138430B2 (en) * | 2007-12-27 | 2015-09-22 | Mylan Specialty L.P. | Formulation and method for the release of paroxetine in the large intestine |
| DE102008047910A1 (de) | 2008-09-19 | 2010-03-25 | Molkerei Meggle Wasserburg Gmbh & Co. Kg | Tablettierhilfsstoff auf Laktose- und Cellulosebasis |
| EP2440210A4 (de) | 2009-06-12 | 2014-01-29 | Meritage Pharma Inc | Verfahren zur behandlung von magen-darm-erkrankungen |
| CN107802603B (zh) * | 2017-12-14 | 2021-08-20 | 乐普制药科技有限公司 | 一种纳普醚醇分散体及其制备方法 |
| CN110037995B (zh) * | 2019-04-17 | 2021-07-06 | 石家庄龙泽制药股份有限公司 | 一种稳定的盐酸帕罗西汀片剂及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9325644D0 (en) | 1993-12-15 | 1994-02-16 | Smithkline Beecham Plc | Novel formulation |
| US5597826A (en) | 1994-09-14 | 1997-01-28 | Pfizer Inc. | Compositions containing sertraline and a 5-HT1D receptor agonist or antagonist |
| CA2206592A1 (en) | 1996-05-30 | 1997-11-30 | Shu-Zhong Wang | Method of producing amorphous paroxetine hydrochloride |
| NZ336587A (en) | 1997-01-15 | 2001-01-26 | Smithkline Beecham P | Spray dried paroxetine compositions using organic solvent selected from pyridine, acetic acid, acetonitrile, acetone, ethanol, propan-1-ol or tetrahydrofuran |
| US5955475A (en) | 1997-06-30 | 1999-09-21 | Endo Pharmaceuticals Inc. | Process for manufacturing paroxetine solid dispersions |
-
1998
- 1998-05-07 US US09/074,355 patent/US6168805B1/en not_active Expired - Fee Related
-
1999
- 1999-05-04 ZA ZA9903081A patent/ZA993081B/xx unknown
- 1999-05-05 DE DE69906269T patent/DE69906269T2/de not_active Expired - Fee Related
- 1999-05-05 WO PCT/US1999/009835 patent/WO1999056751A1/en not_active Ceased
- 1999-05-05 AT AT99920358T patent/ATE235240T1/de not_active IP Right Cessation
- 1999-05-05 CN CN99807123A patent/CN1115149C/zh not_active Expired - Fee Related
- 1999-05-05 EP EP99920358A patent/EP1075263B1/de not_active Expired - Lifetime
- 1999-05-05 HK HK02100281.6A patent/HK1038699B/zh not_active IP Right Cessation
- 1999-05-05 CA CA002331288A patent/CA2331288C/en not_active Expired - Fee Related
- 1999-05-05 AU AU37876/99A patent/AU3787699A/en not_active Abandoned
- 1999-05-05 ES ES99920358T patent/ES2196803T3/es not_active Expired - Lifetime
- 1999-05-05 MX MXPA00010928A patent/MXPA00010928A/es unknown
- 1999-05-05 KR KR1020007012453A patent/KR20010043418A/ko not_active Withdrawn
- 1999-05-05 JP JP2000546776A patent/JP2002513760A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1075263A1 (de) | 2001-02-14 |
| CN1115149C (zh) | 2003-07-23 |
| EP1075263B1 (de) | 2003-03-26 |
| CA2331288C (en) | 2007-01-23 |
| HK1038699A1 (en) | 2002-03-28 |
| DE69906269T2 (de) | 2004-01-29 |
| AU3787699A (en) | 1999-11-23 |
| CN1304308A (zh) | 2001-07-18 |
| DE69906269D1 (de) | 2003-04-30 |
| CA2331288A1 (en) | 1999-11-11 |
| ZA993081B (en) | 1999-11-05 |
| KR20010043418A (ko) | 2001-05-25 |
| MXPA00010928A (es) | 2005-06-06 |
| ES2196803T3 (es) | 2003-12-16 |
| JP2002513760A (ja) | 2002-05-14 |
| WO1999056751A1 (en) | 1999-11-11 |
| HK1038699B (zh) | 2003-12-12 |
| US6168805B1 (en) | 2001-01-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |