ATE369840T1 - Orale zusammensetzungen von itraconazol und verfahren zu herstellung derselbigen - Google Patents

Orale zusammensetzungen von itraconazol und verfahren zu herstellung derselbigen

Info

Publication number: ATE369840T1
Authority: AT; Austria
Prior art keywords: itraconazole; acid; working solution; particles; coated particles
Prior art date: 2001-02-06

Application number

AT02700887T

Other languages

English (en)

Inventor

Ranga Namburi

John Kerr

Original Assignee

Stiefel Laboratories

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-06

Filing date

2002-02-01

Publication date

2007-09-15

2002-02-01 Application filed by Stiefel Laboratories filed Critical Stiefel Laboratories

2007-09-15 Application granted granted Critical

2007-09-15 Publication of ATE369840T1 publication Critical patent/ATE369840T1/de

Links

229960004130 itraconazole Drugs 0.000 title abstract 8
238000000034 method Methods 0.000 title abstract 3
VHVPQPYKVGDNFY-ZPGVKDDISA-N itraconazole Chemical compound O=C1N(C(C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-ZPGVKDDISA-N 0.000 title 1
239000000203 mixture Substances 0.000 title 1
VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 abstract 7
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 6
239000002245 particle Substances 0.000 abstract 5
239000002253 acid Substances 0.000 abstract 3
239000012224 working solution Substances 0.000 abstract 3
239000006186 oral dosage form Substances 0.000 abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
239000011162 core material Substances 0.000 abstract 1
238000001035 drying Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
229920003169 water-soluble polymer Polymers 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics

Landscapes

Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

AT02700887T 2001-02-06 2002-02-01 Orale zusammensetzungen von itraconazol und verfahren zu herstellung derselbigen ATE369840T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US26665301P	2001-02-06	2001-02-06
US09/933,032 US6663897B2 (en)	2001-02-06	2001-08-20	Oral itraconazole formulations and methods of making the same

Publications (1)

Publication Number	Publication Date
ATE369840T1 true ATE369840T1 (de)	2007-09-15

Family

ID=26951964

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02700887T ATE369840T1 (de)	2001-02-06	2002-02-01	Orale zusammensetzungen von itraconazol und verfahren zu herstellung derselbigen

Country Status (9)

Country	Link
US (1)	US6663897B2 (de)
EP (1)	EP1357899B1 (de)
JP (1)	JP2004521897A (de)
AT (1)	ATE369840T1 (de)
AU (1)	AU2002233822A1 (de)
CA (1)	CA2437372A1 (de)
DE (1)	DE60221795T2 (de)
MX (1)	MXPA03006980A (de)
WO (1)	WO2002062318A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0015239D0 (en) *	2000-06-21	2000-08-16	Biochemie Gmbh	Organic compounds
US8071133B2 (en)	2001-08-20	2011-12-06	Stiefel Laboratories, Inc.	Oral dosage forms of water insoluble drugs and methods of making the same
US20040115266A1 (en) *	2002-02-01	2004-06-17	Namburi Ranga Raju	Oral itraconazole formulations and methods of making the same
US7927613B2 (en)	2002-02-15	2011-04-19	University Of South Florida	Pharmaceutical co-crystal compositions
US7446107B2 (en)	2002-02-15	2008-11-04	Transform Pharmaceuticals, Inc.	Crystalline forms of conazoles and methods of making and using the same
US7790905B2 (en)	2002-02-15	2010-09-07	Mcneil-Ppc, Inc.	Pharmaceutical propylene glycol solvate compositions
IL163846A0 (en)	2002-03-01	2005-12-18	Univ South Florida	Multiple-component solid phases containing at least one active pharmaceutical ingredient
GB0205253D0 (en) *	2002-03-06	2002-04-17	Univ Gent	Immediate release pharmaceutical granule compositions and a continuous process for making them
EP1511490A4 (de)	2002-05-31	2009-03-11	Transform Pharmaceuticals Inc	Neue kristalline conazol-formen und verwandte prozesse, pharmazeutische zusammensetzungen und verfahren
CN100360117C (zh)	2002-06-21	2008-01-09	转化医药公司	具有提高的溶出度的药物组合物
WO2004012714A1 (en) *	2002-08-05	2004-02-12	Dsm Ip Assets B.V.	Oral dosage forms of water insoluble drugs and methods of making the same
US8183290B2 (en)	2002-12-30	2012-05-22	Mcneil-Ppc, Inc.	Pharmaceutically acceptable propylene glycol solvate of naproxen
US20050074494A1 (en) *	2003-10-06	2005-04-07	Xiu-Xiu Cheng	Itraconazole immediate release formulation
US20050118265A1 (en) *	2003-11-28	2005-06-02	Anandi Krishnan	Antifungal oral dosage forms and the methods for preparation
GB0612695D0 (en) *	2006-06-27	2006-08-09	Univ Gent	Process for preparing a solid dosage form

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4791111A (en)	1985-12-23	1988-12-13	Janssen Pharmaceutica, N.V.	[[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties
PH30929A (en) *	1992-09-03	1997-12-23	Janssen Pharmaceutica Nv	Beads having a core coated with an antifungal and a polymer.
IT1263831B (it)	1993-01-29	1996-09-04	Paolo Chiesi	Complessi di inclusione multicomponente ad elevata solubilita' costituiti da un farmaco di tipo basico, un acido ed una ciclodestrina
CA2258683C (en) *	1996-06-28	2007-07-31	Schering Corporation	Oral composition comprising a triazole antifungal compound
FR2758461A1 (fr)	1997-01-17	1998-07-24	Pharma Pass	Composition pharmaceutique presentant une biodisponibilite elevee et son procede de preparation
WO1998042318A1 (en) *	1997-03-26	1998-10-01	Janssen Pharmaceutica N.V.	Pellets having a core coated with an antifungal and a polymer
JP2002520351A (ja) *	1998-07-17	2002-07-09	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	抗菌・カビ剤及びポリマーを被覆したコアを有するペレット
IL143197A0 (en)	1998-11-20	2002-04-21	Rtp Pharma Inc	Dispersible phospholipid stabilized microparticles
CN1156461C (zh)	1999-03-24	2004-07-07	R·P·希拉技术股份有限公司	改良的水溶性药物制剂
US6383471B1 (en) *	1999-04-06	2002-05-07	Lipocine, Inc.	Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
KR100331529B1 (ko)	1999-06-16	2002-04-06	민경윤	난용성 항진균제의 경구투여용 조성물 및 그의 제조 방법

2001
- 2001-08-20 US US09/933,032 patent/US6663897B2/en not_active Expired - Lifetime
2002
- 2002-02-01 MX MXPA03006980A patent/MXPA03006980A/es active IP Right Grant
- 2002-02-01 WO PCT/NL2002/000080 patent/WO2002062318A2/en not_active Ceased
- 2002-02-01 AT AT02700887T patent/ATE369840T1/de not_active IP Right Cessation
- 2002-02-01 DE DE60221795T patent/DE60221795T2/de not_active Expired - Fee Related
- 2002-02-01 JP JP2002562325A patent/JP2004521897A/ja active Pending
- 2002-02-01 AU AU2002233822A patent/AU2002233822A1/en not_active Abandoned
- 2002-02-01 CA CA002437372A patent/CA2437372A1/en not_active Abandoned
- 2002-02-01 EP EP02700887A patent/EP1357899B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO2002062318A3 (en)	2002-11-21
JP2004521897A (ja)	2004-07-22
DE60221795T2 (de)	2007-12-27
EP1357899A2 (de)	2003-11-05
AU2002233822A1 (en)	2002-08-19
EP1357899B1 (de)	2007-08-15
US6663897B2 (en)	2003-12-16
US20020150620A1 (en)	2002-10-17
WO2002062318A2 (en)	2002-08-15
DE60221795D1 (de)	2007-09-27
CA2437372A1 (en)	2002-08-15
MXPA03006980A (es)	2004-10-15

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Legal Events

Date	Code	Title	Description
2008-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties