ATE235470T1 - Gastrin- und cck-antagonisten - Google Patents

Gastrin- und cck-antagonisten

Info

Publication number: ATE235470T1
Authority: AT; Austria
Prior art keywords: pct; gastrin; cck antagonists; date dec; sec
Prior art date: 1994-05-27

Application number

AT95919561T

Other languages

English (en)

Inventor

Sarkis Barret Kalindjian

Nigel Paul Shankley

Robert Antony David Hull

Atul Kotecha

Sonia Patricia Roberts

Elaine Anne Harper

Original Assignee

Black James Foundation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-27

Filing date

1995-05-25

Publication date

2003-04-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27267041&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE235470(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1994-05-27 Priority claimed from GB9410688A external-priority patent/GB9410688D0/en

1994-08-09 Priority claimed from PCT/GB1994/001741 external-priority patent/WO1995004720A2/en

1995-02-09 Priority claimed from GB9502503A external-priority patent/GB2290539A/en

1995-05-25 Application filed by Black James Foundation filed Critical Black James Foundation

2003-04-15 Application granted granted Critical

2003-04-15 Publication of ATE235470T1 publication Critical patent/ATE235470T1/de

Links

102100021022 Gastrin Human genes 0.000 title abstract 2
108010052343 Gastrins Proteins 0.000 title abstract 2
239000005557 antagonist Substances 0.000 title abstract 2
AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
230000003389 potentiating effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/48—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system of the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

AT95919561T 1994-05-27 1995-05-25 Gastrin- und cck-antagonisten ATE235470T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB9410688A GB9410688D0 (en)	1993-08-10	1994-05-27	Gastrin and CCK receptor ligands
PCT/GB1994/001741 WO1995004720A2 (en)	1993-08-10	1994-08-09	Gastrin and cck receptor ligands
GB9502503A GB2290539A (en)	1994-05-27	1995-02-09	Indole and benzimidazole gastrin and CCK antagonists
PCT/GB1995/001194 WO1995032949A1 (en)	1994-05-27	1995-05-25	Gastrin and cck antagonists

Publications (1)

Publication Number	Publication Date
ATE235470T1 true ATE235470T1 (de)	2003-04-15

Family

ID=27267041

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95919561T ATE235470T1 (de)	1994-05-27	1995-05-25	Gastrin- und cck-antagonisten

Country Status (7)

Country	Link
US (1)	US5912260A (de)
EP (1)	EP0763026B1 (de)
JP (1)	JPH10504525A (de)
AT (1)	ATE235470T1 (de)
AU (1)	AU2534295A (de)
DE (1)	DE69530081T2 (de)
WO (1)	WO1995032949A1 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT810223E (pt) *	1996-05-28	2001-12-28	Pfizer	Oxindoles substituidos por adamantilo como agentes farmaceuticos
SE9904505D0 (sv)	1999-12-09	1999-12-09	Astra Pharma Prod	Novel compounds
TWI258462B (en)	1999-12-17	2006-07-21	Astrazeneca Ab	Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same
EP2335700A1 (de)	2001-07-25	2011-06-22	Boehringer Ingelheim (Canada) Ltd.	Hepatitis C Virus Polymerase Inhibitoren mit heterobicylischer Struktur
US7098231B2 (en) *	2003-01-22	2006-08-29	Boehringer Ingelheim International Gmbh	Viral polymerase inhibitors
US7223785B2 (en) *	2003-01-22	2007-05-29	Boehringer Ingelheim International Gmbh	Viral polymerase inhibitors
UY28758A1 (es) *	2004-02-20	2005-09-30	Boehringer Ingelheim Int	Inhibidores de polimerasa viral
US8138342B2 (en) *	2004-10-12	2012-03-20	High Point Pharmacueticals, LLC	11β-hydroxysteroid dehydrogenase type 1 active spiro compounds
JP5015154B2 (ja) *	2005-08-12	2012-08-29	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	ウイルスポリメラーゼインヒビター
JP2009513611A (ja) *	2005-11-01	2009-04-02	ハイポイントファーマシューティカルズ，リミティドライアビリティカンパニー	置換アミドの医薬用途
KR20080076916A (ko) *	2005-11-01	2008-08-20	트랜스테크 파르마, 인크.	치환된 아미드의 약학적 사용
EP2007722A1 (de) *	2006-03-21	2008-12-31	High Point Pharmaceuticals, LLC	Adamantanderivate zur behandlung des metabolischen syndroms
KR20090014347A (ko)	2006-04-07	2009-02-10	하이 포인트 파마슈티칼스, 엘엘씨	11β-히드록시스테로이드 탈수소효소 타입 1 활성 화합물
JP2009539937A (ja) *	2006-06-16	2009-11-19	ハイポイントファーマシューティカルズ，リミティドライアビリティカンパニー	置換型ピペリジンカルボキサミドの医薬的使用
US8048908B2 (en) *	2006-07-13	2011-11-01	High Point Pharmaceuticals, Llc	11β-hydroxysteroid dehydrogenase type 1 active compounds
EP1878721A1 (de) *	2006-07-13	2008-01-16	Novo Nordisk A/S	4-Piperidylbenzamide als Inhibitoren der 11-beta-hydroxysteroiddehydrogenase Typ 1
CA2675669C (en) *	2007-02-23	2015-05-26	High Point Pharmaceuticals, Llc	Novel compounds
EP2125704A1 (de) *	2007-02-23	2009-12-02	High Point Pharmaceuticals, LLC	N-adamantylbenzamide als inhibitoren von 11-beta-hydroxysteroiddehydrogenase
US8334305B2 (en) *	2007-02-23	2012-12-18	High Point Pharmaceuticals, Llc	N-adamantyl benzamides as inhibitors of 11-β-hydroxysteroid dehydrogenase
WO2008101885A1 (en) *	2007-02-23	2008-08-28	High Point Pharmaceuticals, Llc	N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
CN101652359A (zh) *	2007-03-09	2010-02-17	高点制药有限责任公司	作为羟类固醇脱氢酶抑制剂的吲哚-和苯并咪唑酰胺类
CA2681934A1 (en) *	2007-03-28	2008-10-02	High Point Pharmaceuticals, Llc	11beta-hsd1 active compounds
WO2008127924A1 (en) *	2007-04-11	2008-10-23	High Point Pharmaceuticals, Llc.	Novel compounds
US8383683B2 (en) *	2007-04-24	2013-02-26	High Point Pharmaceuticals, Llc	Pharmaceutical use of substituted amides
MX2011005037A (es) *	2008-11-21	2011-06-16	High Point Pharmaceuticals Llc	Compuestos de adamantilo benzamida.
KR101939710B1 (ko)	2011-12-21	2019-01-17	노비라 테라퓨틱스, 인코포레이티드	B형 간염의 항바이러스성 제제
UY34993A (es)	2012-08-28	2014-02-28	Janssen R & D Ireland	Sulfamoilarilamidas y su uso como medicamentos para el tratamiento de la hepatitis b
WO2014131847A1 (en)	2013-02-28	2014-09-04	Janssen R&D Ireland	Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b
JP6419155B2 (ja)	2013-04-03	2018-11-07	ヤンセン・サイエンシズ・アイルランド・ユーシー	Ｎ−フェニル−カルボキサミド誘導体およびｂ型肝炎を治療するための医薬品としてのその使用
JO3583B1 (ar)	2013-05-17	2020-07-05	Janssen Sciences Ireland Uc	مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي
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1995
- 1995-05-25 WO PCT/GB1995/001194 patent/WO1995032949A1/en not_active Ceased
- 1995-05-25 DE DE69530081T patent/DE69530081T2/de not_active Expired - Fee Related
- 1995-05-25 AU AU25342/95A patent/AU2534295A/en not_active Abandoned
- 1995-05-25 US US08/737,725 patent/US5912260A/en not_active Expired - Fee Related
- 1995-05-25 EP EP95919561A patent/EP0763026B1/de not_active Expired - Lifetime
- 1995-05-25 JP JP8500483A patent/JPH10504525A/ja not_active Ceased
- 1995-05-25 AT AT95919561T patent/ATE235470T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69530081T2 (de)	2003-12-24
AU2534295A (en)	1995-12-21
DE69530081D1 (de)	2003-04-30
WO1995032949A1 (en)	1995-12-07
EP0763026A1 (de)	1997-03-19
EP0763026B1 (de)	2003-03-26
JPH10504525A (ja)	1998-05-06
US5912260A (en)	1999-06-15

Legal Events

Date	Code	Title	Description
2003-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69530081D1 (de)	2003-04-30	Gastrin- und cck-antagonisten
MY132671A (en)	2007-10-31	Substituted 6,6-hetero-bicyclic derivatives
GR3033827T3 (en)	2000-10-31	New compounds and their compositions having anti-inflammatory and anti-thrombotic activities
WO1996032003A3 (en)	1997-01-03	Tetrahydroimidazopyridoindolediones and their use as medicaments
ATE269312T1 (de)	2004-07-15	N-(amidinophenyl)-n'-(subst.)-3h-2,4- benzodiazepin-3-on derivative als faktor xa inhibitoren
NZ325449A (en)	2000-01-28	Naphthyl-substituted benzimidazole derivatives as anticoagulants
TR199902593T2 (xx)	2000-03-21	�kame edilmi� fenil t�revleri, bunlar�n haz�rlanmas� ve kullan�m�.
ES2193154T3 (es)	2003-11-01	Procedimiento para la preparacion de 9-desoxotaxanos.
ATE259815T1 (de)	2004-03-15	Neue antagonistische verbindungen
DK0699207T3 (da)	1997-12-08	Mellemprodukt til azithromycin
AU1070895A (en)	1995-06-06	Indole-derived arylpiperazines as ligands for 5HT1-like receptors 5HT1B and 5HT1D
TR199801268T2 (xx)	1998-10-21	Ta�ikinin antagonistleri olarak 3-Azetidinilalkilpiperidinler veya pirolidinler.
NZ300942A (en)	1998-12-23	1-aryl-2-acylamino-ethane derivatives as neurokinin 1 antagonists
IS4367A (is)	1996-09-30	CCK eða gastrín temprandi 5-heterósýklísk-1,5-bensódíazepín
PA8465101A1 (es)	2000-09-29	Compuestos de triazina
NO306554B1 (no)	1999-11-22	Syklopentadienylmagnesium-broforbindelser, fremgangsmåte for deres fremstilling, og deres anvendelse for fremstilling av metallocenene
YU48915B (sh)	2002-11-15	Sulfonilkarbamid i postupak za njegovo dobijanje
MX9708557A (es)	1997-12-31	Nuevo uso farmacologico de los antagonistas del receptor aii.
ATE189894T1 (de)	2000-03-15	Naphthamidderivate von 3-beta-amino azabicyclooctan oder nonan als antipsychotische arzneimittel
MX9205385A (es)	1993-03-01	Perhidro-1-h-pirido(1,2-a)piracinas 2-sustituidas neurolepticas.
DK0625982T3 (da)	2002-09-30	4-Oxo- og 4H-imidazo(5,1-c)(1,4)benzoxaziner anvendelige som benzodiazepinreceptor-bindemidler
SE9404438D0 (sv)	1994-12-21	New process
SE9301831D0 (sv)	1993-05-28	Pharmaceutical compositions
NO964921L (no)	1996-11-20	Mellomprodukt for fremstilling av farmasöytisk aktiv forbindelse
MX9703610A (es)	1998-06-30	Nuevas (5,6)-heteroaril condensado-pirimidin-4-onas 2,3 disustituidas.