ATE259815T1 - Neue antagonistische verbindungen - Google Patents

Neue antagonistische verbindungen

Info

Publication number
ATE259815T1
ATE259815T1 AT95920328T AT95920328T ATE259815T1 AT E259815 T1 ATE259815 T1 AT E259815T1 AT 95920328 T AT95920328 T AT 95920328T AT 95920328 T AT95920328 T AT 95920328T AT E259815 T1 ATE259815 T1 AT E259815T1
Authority
AT
Austria
Prior art keywords
pct
antagonistic compounds
sec
date
new antagonistic
Prior art date
Application number
AT95920328T
Other languages
English (en)
Inventor
Helmut Schmidhammer
Original Assignee
Schmidhammer Helmut Prof Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schmidhammer Helmut Prof Dr filed Critical Schmidhammer Helmut Prof Dr
Application granted granted Critical
Publication of ATE259815T1 publication Critical patent/ATE259815T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT95920328T 1994-05-18 1995-05-09 Neue antagonistische verbindungen ATE259815T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9401728A SE9401728D0 (sv) 1994-05-18 1994-05-18 New compounds II
PCT/SE1995/000503 WO1995031463A1 (en) 1994-05-18 1995-05-09 New antagonist compounds

Publications (1)

Publication Number Publication Date
ATE259815T1 true ATE259815T1 (de) 2004-03-15

Family

ID=20394059

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95920328T ATE259815T1 (de) 1994-05-18 1995-05-09 Neue antagonistische verbindungen

Country Status (11)

Country Link
US (1) US6136817A (de)
EP (1) EP0759922B1 (de)
JP (1) JP4117801B2 (de)
AT (1) ATE259815T1 (de)
AU (1) AU690996B2 (de)
DE (1) DE69532580T2 (de)
ES (1) ES2214501T3 (de)
IL (1) IL113631A0 (de)
SE (1) SE9401728D0 (de)
WO (1) WO1995031463A1 (de)
ZA (1) ZA953701B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU712012B2 (en) * 1995-09-26 1999-10-28 Toray Industries, Inc. Indole derivatives and medical application thereof
US5994327A (en) * 1995-11-17 1999-11-30 Astra Ab Process for the preparation of morphinans
JP2001504829A (ja) * 1996-11-19 2001-04-10 アストラ・アクチエボラーグ モルフィナン類の新規な製造方法
ES2217533T3 (es) * 1997-01-16 2004-11-01 Toray Industries, Inc. Derivados de indolomorfinano y medicamentos/preventivos para transtornos cerebrales.
DE19939044A1 (de) * 1999-08-18 2001-03-15 Gruenenthal Gmbh Verwendung von Morphinanderivaten als Arzneimittel
WO2003070175A2 (en) * 2002-02-15 2003-08-28 Howard Brooks-Korn Use of opioid compound to treat a neurologic or neurogenic disorder
DE10229842A1 (de) * 2002-07-03 2004-02-05 Helmut Prof. Dr. Schmidhammer Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung
US7285665B2 (en) 2002-11-08 2007-10-23 Mallinckrodt Inc. Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
EP1595541A1 (de) * 2004-05-12 2005-11-16 Alcasynn Pharmaceuticals Gmbh Verwendung von Opioid-Rezeptor Antagonisten zur Vorbeugung und/oder Behandlung von Krankheiten die im zusammenhang mit den Angrifftspunkt Calcineurin stehen
EP1768662A2 (de) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Immunstimulatoren kleiner moleküle und assays für deren nachweis
CA2590182A1 (en) * 2004-12-14 2006-06-22 Shionogi & Co., Ltd. Indolomorphinan derivatives having carboxy at the 6'-position
US8114133B2 (en) * 2006-04-18 2012-02-14 Joseph Nicholas Logan Spinal rod system
EP2099764B1 (de) * 2006-09-20 2011-07-27 Mallinckrodt Inc. Herstellung substituierter morphinan-6-one und salzen und zwischenprodukten davon
US9040726B2 (en) * 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
JP5875748B2 (ja) * 2007-03-06 2016-03-02 マリンクロッド エルエルシー 第４級ｎ−アルキルモルフィナンアルカロイド塩の調製のための方法
CA2702680A1 (en) * 2007-10-18 2009-04-23 Aiko Biotechnology Combination analgesic employing opioid and neutral antagonist
US8748448B2 (en) 2007-10-18 2014-06-10 Aiko Biotechnology Combination analgesic employing opioid agonist and neutral antagonist
US8067596B2 (en) 2007-12-17 2011-11-29 Mallinckrodt Llc Processes for the production of (+)- “Nal” morphinan compounds
WO2009132313A2 (en) * 2008-04-25 2009-10-29 Progenics Pharmaceuticals, Inc. Morphinan derivatives of organic and inorganic acids
EP2896614B1 (de) * 2008-05-27 2017-07-12 Mallinckrodt LLC Verfahren und Verbindungen zur Herstellung von Normorphinanen
WO2010028004A2 (en) 2008-09-03 2010-03-11 Mallinckrodt Inc. Substituted berbines and processes for their synthesis
EP2340832A1 (de) 2009-12-23 2011-07-06 Universität Innsbruck Morphinan-6-one-Verbindungen zur Behandlung oder Prävention von neurodegenerativen Erkrankungen
EP2966074B1 (de) * 2013-03-08 2018-07-25 The Kitasato Institute Morphinanderivat
WO2015082932A1 (en) 2013-12-05 2015-06-11 The University Of Bath Novel opioid compounds and their uses
US10799496B2 (en) 2018-07-13 2020-10-13 Alkermes Pharma Ireland Limited Naphthylenyl compounds for long-acting injectable compositions and related methods
US10807995B2 (en) 2018-07-13 2020-10-20 Alkermes Pharma Ireland Limited Thienothiophene compounds for long-acting injectable compositions and related methods
US10975099B2 (en) 2018-11-05 2021-04-13 Alkermes Pharma Ireland Limited Thiophene compounds for long-acting injectable compositions and related methods

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816586A (en) * 1987-07-29 1989-03-28 Regents Of The University Of Minnesota Delta opioid receptor antagonists
JP2906654B2 (ja) * 1989-11-28 1999-06-21 東レ株式会社 免疫抑制剤及びその製造方法
JPH04342529A (ja) * 1991-05-21 1992-11-30 Toray Ind Inc 抗アレルギー剤
US5223507A (en) * 1992-01-21 1993-06-29 G. D. Searle & Co. Method of using opioid compounds as delta opioid selective agonist analgesics
US5225417A (en) * 1992-01-21 1993-07-06 G. D. Searle & Co. Opioid agonist compounds
FI942499A7 (fi) * 1992-09-29 1994-07-27 Toray Industries Indolijohdannainen, menetelmä sen valmistamiseksi ja sen lääkekäyttö

Also Published As

Publication number Publication date
SE9401728D0 (sv) 1994-05-18
ZA953701B (en) 1995-11-20
US6136817A (en) 2000-10-24
WO1995031463A1 (en) 1995-11-23
EP0759922A1 (de) 1997-03-05
DE69532580T2 (de) 2004-07-29
DE69532580D1 (de) 2004-03-25
EP0759922B1 (de) 2004-02-18
JPH10500131A (ja) 1998-01-06
ES2214501T3 (es) 2004-09-16
AU2581795A (en) 1995-12-05
JP4117801B2 (ja) 2008-07-16
AU690996B2 (en) 1998-05-07
IL113631A0 (en) 1995-08-31

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