ATE235495T1 - 8-arylalkyl- und 8-arylheteroalkyl-5, 11-dihydro- 6h-dipyrido-(3,2-b:2', 3'-e)(1,4)diazepine und ihre verwendung zur vorbeugung oder behandlung von hiv-infektion - Google Patents

8-arylalkyl- und 8-arylheteroalkyl-5, 11-dihydro- 6h-dipyrido-(3,2-b:2', 3'-e)(1,4)diazepine und ihre verwendung zur vorbeugung oder behandlung von hiv-infektion

Info

Publication number
ATE235495T1
ATE235495T1 AT96115901T AT96115901T ATE235495T1 AT E235495 T1 ATE235495 T1 AT E235495T1 AT 96115901 T AT96115901 T AT 96115901T AT 96115901 T AT96115901 T AT 96115901T AT E235495 T1 ATE235495 T1 AT E235495T1
Authority
AT
Austria
Prior art keywords
arylalkyl
dihydro
infection
dipyrido
arylheteroalkyl
Prior art date
Application number
AT96115901T
Other languages
English (en)
Inventor
Charles L Cywin
Maryann Hoermann
Janice M Klunder
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of ATE235495T1 publication Critical patent/ATE235495T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT96115901T 1995-10-06 1996-10-04 8-arylalkyl- und 8-arylheteroalkyl-5, 11-dihydro- 6h-dipyrido-(3,2-b:2', 3'-e)(1,4)diazepine und ihre verwendung zur vorbeugung oder behandlung von hiv-infektion ATE235495T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US480695P 1995-10-06 1995-10-06
US869595P 1995-12-15 1995-12-15

Publications (1)

Publication Number Publication Date
ATE235495T1 true ATE235495T1 (de) 2003-04-15

Family

ID=26673503

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96115901T ATE235495T1 (de) 1995-10-06 1996-10-04 8-arylalkyl- und 8-arylheteroalkyl-5, 11-dihydro- 6h-dipyrido-(3,2-b:2', 3'-e)(1,4)diazepine und ihre verwendung zur vorbeugung oder behandlung von hiv-infektion

Country Status (8)

Country Link
US (1) US5705499A (de)
EP (1) EP0767172B1 (de)
JP (1) JPH09188680A (de)
AT (1) ATE235495T1 (de)
DE (1) DE69626915T2 (de)
DK (1) DK0767172T3 (de)
ES (1) ES2191075T3 (de)
PT (1) PT767172E (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747488A (en) * 1996-01-30 1998-05-05 Boehringer Ingelheim Pharmaceuticals, Inc. 2-aryl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-E! 1, 4!diazepines and their use in the treatment of HIV infection
GB9715584D0 (en) * 1997-07-23 1997-10-01 Eisai Co Ltd Compounds
UA71971C2 (en) 1999-06-04 2005-01-17 Agoron Pharmaceuticals Inc Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases
US6455554B1 (en) 1999-06-07 2002-09-24 Targacept, Inc. Oxopyridinyl pharmaceutical compositions and methods for use
US7141581B2 (en) * 1999-07-02 2006-11-28 Agouron Pharmaceuticals, Inc. Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
TWI262914B (en) * 1999-07-02 2006-10-01 Agouron Pharma Compounds and pharmaceutical compositions for inhibiting protein kinases
HN2001000008A (es) * 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
BR0110302A (pt) 2000-04-18 2003-01-14 Agouron Pharma Compostos de pirazol para inibição de proteìnas cinase, sal e pró-droga farmaceuticamente aceitável, metabólito farmaceuticamente ativo ou sal farmaceuticamente aceitável de metabólito, composição farmacêutica, método de tratamento de condição doentia em mamìferos mediada pela atividade de proteìna cinase, método de modulação ou inibição da atividade de um receptor de proteìna cinase
TWI270547B (en) * 2000-06-16 2007-01-11 Boehringer Ingelheim Ca Ltd Non-nucleoside reverse transcriptase inhibitors
SI1294720T1 (sl) * 2000-06-16 2006-08-31 Boehringer Ingelheim Ca Ltd Nenukleozidni inhibitorji reverzne transkriptaze
US6716836B2 (en) 2001-03-22 2004-04-06 Boehringer Ingelheim (Canada) Ltd. Non-nucleoside reverse transcriptase inhibitors
US6673791B2 (en) * 2001-07-30 2004-01-06 Boehringer Ingelheim (Canada) Ltd. Non-nucleoside reverse transcriptase inhibitors
US6706706B2 (en) 2002-03-27 2004-03-16 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors
US6806265B2 (en) * 2002-05-16 2004-10-19 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors
DE60306539T2 (de) * 2002-09-19 2007-07-19 Boehringer Ingelheim (Canada) Ltd., Laval Nicht-nukleosidische inhibitoren der reverse transkriptase
WO2004026875A1 (en) * 2002-09-19 2004-04-01 Boehringer Ingelheim (Canada) Ltd. Non-nucleoside reverse transcriptase inhibitors
US7384937B2 (en) 2002-11-06 2008-06-10 Bristol-Myers Squibb Co. Fused heterocyclic compounds and use thereof
EP1610782A1 (de) * 2003-03-27 2006-01-04 Boehringer Ingelheim International GmbH Antivirale kombination eines dipyridodiazepinons und einer weiteren antiretroviralen verbindung
EP1737852A2 (de) * 2004-04-13 2007-01-03 Icagen, Inc. Polycyclische pyridine als kaliumionenkanalmodulatoren
EP1781300A1 (de) 2004-07-16 2007-05-09 ProteoSys AG Muscarinische antagonisten mit parp und sir modulierender aktivität als mittel gegen entzündliche erkrankungen
EP2387405A2 (de) 2009-01-13 2011-11-23 ProteoSys AG Pirenzepin als mittel für die krebstherapie
CA2968464A1 (en) 2014-11-25 2016-06-02 Bayer Pharma Aktiengesellschaft Substituted pyridobenzodiazepinone-derivatives and use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5366972A (en) * 1989-04-20 1994-11-22 Boehringer Ingelheim Pharmaceuticals, Inc. 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
CA2183571A1 (en) * 1994-02-18 1995-08-24 Karl D. Hargrave 2-heteroaryl-5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepines and their use in the prevention or treatment of hiv infection

Also Published As

Publication number Publication date
DE69626915D1 (de) 2003-04-30
EP0767172A1 (de) 1997-04-09
EP0767172B1 (de) 2003-03-26
US5705499A (en) 1998-01-06
DE69626915T2 (de) 2003-11-13
PT767172E (pt) 2003-08-29
JPH09188680A (ja) 1997-07-22
ES2191075T3 (es) 2003-09-01
DK0767172T3 (da) 2003-07-21

Similar Documents

Publication Publication Date Title
DE69626915D1 (de) 8-Arylalkyl- und 8-Arylheteroalkyl-5, 11-dihydro-6H-dipyrido-(3,2-b:2', 3'-e)(1,4)diazepine und ihre Verwendung zur Vorbeugung oder Behandlung von HIV-Infektion
DE69033003D1 (de) 5,11-Dihydro-6H-dipyrido(3,2-b:2'3'-e)(1,4)diazepine und ihre Verwendung zur Verhinderung oder Behandlung von HIV-Infektionen
ATE178055T1 (de) Hiv-proteaseinhibitoren und ihre verwendung zur behandlung von aids
EP1001782A4 (de) 5,6-HETEROARYL-DIPYRIDO (2-3-b:3',2'-f) AZEPINE UND DEREN VERWENDUNG ZUR PROPHYLAXE UND BEHANDLUNG VON HIV-INFEKTIONEN
DE60031396D1 (de) Zubereitung zur behandlung von einer neurologischen erkrankung
ATE81978T1 (de) Verwendung von 3'-azido-3'-deoxythymidin zur behandlung oder vorbeugung von menschlichen retrovirus-infektionen.
BR9306040A (pt) Tratamento e profilaxia de doenças provocadas por parasitos ou bactérias
ATE251903T1 (de) Verwendung von phosphororganischen verbindungen zur therapeutischen und prophylaktischen behandlung von infektionen
DE69312853D1 (de) Behandlung von Gummiartikeln
ATE103918T1 (de) 5,11-dihydro-6h-dipyrido(3,2-b:2',3'e>(1,4>diazepin-6-one und -thione und ihre verwendung bei der aids-vorbeugung oder behandlung.
DK0604183T3 (da) HIV-protease-inhibitorer anvendelige i behandlingen af AIDS
DE69405711D1 (de) Behandlung von rueckstandsoel
DE69914951D1 (de) Substituierte tricyclische Verbindungen und deren Verwendung zur Behandlung von sPLA2-bedingten Erkrankungen
ATE166353T1 (de) 2-heteroaryl-5,11-dihydro-6h-dipyrido(3,2-b:2', '-e> (1,4>diazepine und ihre verwendung zur vorbeugung und behandlung von hiv-infektion
ATE217191T1 (de) Verwendung von phanquinon zur behandlung von alzheimer's krankheit
DE69701458D1 (de) Verwendung von buckminsterfulleren zur behandlung neurotoxischer verletzungen
DE69213777D1 (de) Pyridobenzodiazepine, Dipyrido-[3,2-b:2',3'-3] [1,4]-diazepine und deren Verwendung in der Vorbeugung und Behandlung von AIDS
DK99993D0 (da) Treatment and prophylaxis of diseases caused by parasites or bacteria
FI944687L (fi) Koostumus likinäköisyyden ennaltaehkäisemiseksi ja hoitamiseksi
FI911533A7 (fi) Bentsoksatsiini-johdannaisia, menetelmä niiden valmistamiseksi ja niiden käyttö sairauksien hoitamiseen tai ennalta ehkäisemiseksi
DE69015411D1 (de) 5,11-Dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one und -thione und deren Verwendung bei der Vorbeugung und und Behandlung von AIDS.
DE69919578D1 (de) VERWENDUNG von NIEDERMOLEKULAREM HEPARIN zur Behandlung und/oder Prophylaxe motoneuronaler Krankheiten
ATE225181T1 (de) Verwendung von heparinen niedrigeren molekulargewichtes zur behandlung von hirnödemen
NO965591D0 (no) Kombinasjonsbehandling av HIV-infeksjon
DK120892D0 (da) Treatment and prophylaxis of diseases caused by parasites, fungi or bacteria

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0767172

Country of ref document: EP

REN Ceased due to non-payment of the annual fee