ATE235912T1 - Bradikininanaloge als selektive thrombininhibitoren - Google Patents

Bradikininanaloge als selektive thrombininhibitoren

Info

Publication number: ATE235912T1
Authority: AT; Austria
Prior art keywords: induced; pct; thrombin; bradykinin; adp
Prior art date: 1995-06-09

Application number

AT96923268T

Other languages

German (de)

English (en)

Inventor

Alvin H Schmaier

Ahmed A K Hasan

Original Assignee

Univ Michigan

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-09

Filing date

1996-06-07

Publication date

2003-04-15

1996-06-07 Application filed by Univ Michigan filed Critical Univ Michigan

2003-04-15 Application granted granted Critical

2003-04-15 Publication of ATE235912T1 publication Critical patent/ATE235912T1/de

Links

229940122388 Thrombin inhibitor Drugs 0.000 title 1
239000003868 thrombin inhibitor Substances 0.000 title 1
QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical group NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 abstract 5
108090000190 Thrombin Proteins 0.000 abstract 4
108090000765 processed proteins & peptides Proteins 0.000 abstract 3
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
102400000967 Bradykinin Human genes 0.000 abstract 1
101800004538 Bradykinin Proteins 0.000 abstract 1
QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 abstract 1
238000007792 addition Methods 0.000 abstract 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
230000020411 cell activation Effects 0.000 abstract 1
230000037430 deletion Effects 0.000 abstract 1
238000012217 deletion Methods 0.000 abstract 1
230000010118 platelet activation Effects 0.000 abstract 1
230000002797 proteolythic effect Effects 0.000 abstract 1
230000027425 release of sequestered calcium ion into cytosol Effects 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1
229960004072 thrombin Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/18—Kallidins; Bradykinins; Related peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Genetics & Genomics (AREA)
Animal Behavior & Ethology (AREA)
Biophysics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Zoology (AREA)
Diabetes (AREA)
Hematology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AT96923268T 1995-06-09 1996-06-07 Bradikininanaloge als selektive thrombininhibitoren ATE235912T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US9695P	1995-06-09	1995-06-09
PCT/US1996/009940 WO1996041640A1 (fr)	1995-06-09	1996-06-07	Analogues de la bradykinine utilises comme inhibiteurs selectifs de la thrombine

Publications (1)

Publication Number	Publication Date
ATE235912T1 true ATE235912T1 (de)	2003-04-15

Family

ID=21689904

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96923268T ATE235912T1 (de)	1995-06-09	1996-06-07	Bradikininanaloge als selektive thrombininhibitoren

Country Status (8)

Country	Link
US (1)	US6143719A (fr)
EP (1)	EP0871464B1 (fr)
JP (1)	JP4067117B2 (fr)
AT (1)	ATE235912T1 (fr)
AU (1)	AU703256B2 (fr)
CA (1)	CA2221865C (fr)
DE (1)	DE69627191T2 (fr)
WO (1)	WO1996041640A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6346510B1 (en)	1995-10-23	2002-02-12	The Children's Medical Center Corporation	Therapeutic antiangiogenic endostatin compositions
US20020076782A1 (en) *	1996-07-05	2002-06-20	John P.N. Rosazza	Purified nitric oxide synthase
US6982249B1 (en)	1997-04-23	2006-01-03	The Regents Of The University Of Michigan	Bradykinin analogs as selective inhibitors of cell activation
CA2288027A1 (fr) *	1997-04-23	1998-10-29	The Regents Of The University Of Michigan	Analogues de bradykinine inhibiteurs selectifs de l'activation cellulaire
AU761624B2 (en) *	1997-04-23	2003-06-05	Regents Of The University Of Michigan, The	Bradykinin analogs as selective inhibitors of cell activation
AU1521500A (en)	1998-11-10	2000-05-29	W. Robert Colman	Inhibition of angiogenesis by peptide analogs of high molecular weight kininogendomain
US6767889B1 (en)	1998-11-10	2004-07-27	Temple University Of The Commonwealth System Of Higher Education	Inhibition of angiogenesis by high molecular weight kininogen and peptide analogs thereof
NZ512837A (en) *	1998-12-16	2003-08-29	Univ Temple	Inhibition of angiogenesis by high molecular weight kininogen domain 3 peptide analogs
US6869931B1 (en) *	1998-12-16	2005-03-22	Temple University - Of The Commonwealth System Of Higher Education	Inhibition of angiogenesis by high molecular weight kininogen domain 3 peptide analogs
US6544750B1 (en) *	1999-08-17	2003-04-08	Thromgen, Inc.	Peptide analogs as selective inhibitors of thrombin activation of protease activated receptor 1
US6994852B1 (en)	1999-11-12	2006-02-07	Temple University-Of The Commonwealth System Of Higher Education	Inhibition of angiogenesis by antibodies against high molecular weight kininogen domain 5
US7074765B2 (en) *	2003-05-01	2006-07-11	The Regents Of The University Of Michigan	Synthetic peptide analogs of Arg-Pro-Pro-Gly-Phe as selective inhibitors of thrombin and thrombin activation of protease activated receptors 1 and 4
JP2008510726A (ja) *	2004-08-20	2008-04-10	エントレメッドインコーポレイテッド	プロテイナーゼ活性化受容体アンタゴニストを含む組成物および方法
PT1737889E (pt)	2004-10-19	2010-12-13	Lonza Ag	Método para síntese de péptidos em fase sólida
US7879792B2 (en) *	2005-06-02	2011-02-01	The Regents Of The University Of Michigan	Synthetic peptide inhibitors of thrombin and thrombin activation of protease activated receptors 1 and 4
EP2645932B1 (fr)	2010-12-02	2016-03-02	Becton, Dickinson and Company	Dispositifs de prélèvement sanguin contenant un agent de stabilisation du sang
WO2018225830A1 (fr) *	2017-06-08	2018-12-13	国立大学法人宮崎大学	Procédé de détection du cancer du poumon

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8305985D0 (en) *	1983-03-04	1983-04-07	Szelke M	Enzyme inhibition
US4693993A (en) *	1985-06-13	1987-09-15	Stewart John M	Bradykinin antagonist peptides
US4870017A (en) *	1985-09-20	1989-09-26	Cetus Corporation	Bacterial methionine N-terminal peptidase
US5231080A (en) *	1985-10-15	1993-07-27	Hoechst Aktiengesellschaft	Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
US4923963A (en) *	1987-09-02	1990-05-08	Nova Technology Limited Partnership	Bradykinin antagonist peptides
US5084274A (en) *	1987-11-17	1992-01-28	Scripps Clinic And Research Foundation	Inhibition of arterial thrombotic occlusion or thromboembolism
US5202421A (en) *	1988-12-27	1993-04-13	Mochida Pharmaceutical Co., Ltd.	Anticoagulant substance obtained from urine and process for the preparation thereof
JPH06508116A (ja) *	1991-04-01	1994-09-14	コルテク，インコーポレイテッド	ブラジキニンアンタゴニスト
US5416191A (en) *	1991-04-01	1995-05-16	Cortech, Inc.	Bradykinin antagonists
CA2106762C (fr) *	1991-04-19	2000-10-10	Donald J. Kyle	Peptides antagonistes de la bradykinine
WO1993003748A1 (fr) *	1991-08-13	1993-03-04	Temple University - Of The Commonwealth System Of Higher Education	Modulation de la tension arterielle et inhibition de l'activation plaquettaire a l'aide d'un fragment de kininogene
FR2686343B1 (fr) *	1992-01-17	1994-03-11	Adir Cie	Nouveaux derives pseudopeptidiques a activite antagoniste de la bradykinine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
WO1993018141A1 (fr) *	1992-03-02	1993-09-16	Biogen, Inc.	Antagonistes de recepteur de thrombine
IL107400A0 (en) *	1992-11-10	1994-01-25	Cortech Inc	Bradykinin antagonists

1996
- 1996-06-07 CA CA002221865A patent/CA2221865C/fr not_active Expired - Fee Related
- 1996-06-07 DE DE69627191T patent/DE69627191T2/de not_active Expired - Fee Related
- 1996-06-07 AT AT96923268T patent/ATE235912T1/de not_active IP Right Cessation
- 1996-06-07 EP EP96923268A patent/EP0871464B1/fr not_active Expired - Lifetime
- 1996-06-07 JP JP50324397A patent/JP4067117B2/ja not_active Expired - Fee Related
- 1996-06-07 US US08/676,242 patent/US6143719A/en not_active Expired - Fee Related
- 1996-06-07 WO PCT/US1996/009940 patent/WO1996041640A1/fr not_active Ceased
- 1996-06-07 AU AU63828/96A patent/AU703256B2/en not_active Ceased

Also Published As

Publication number	Publication date
WO1996041640A1 (fr)	1996-12-27
HK1016090A1 (en)	1999-10-29
AU703256B2 (en)	1999-03-25
JP4067117B2 (ja)	2008-03-26
EP0871464A1 (fr)	1998-10-21
CA2221865C (fr)	2007-12-11
JP2001511762A (ja)	2001-08-14
CA2221865A1 (fr)	1996-12-27
DE69627191D1 (de)	2003-05-08
US6143719A (en)	2000-11-07
EP0871464B1 (fr)	2003-04-02
DE69627191T2 (de)	2004-01-08
EP0871464A4 (fr)	2001-05-16
AU6382896A (en)	1997-01-09

Legal Events

Date	Code	Title	Description
2003-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE235912T1 (de)	2003-04-15	Bradikininanaloge als selektive thrombininhibitoren
Tsujinaka et al.	1988	Synthesis of a new cell penetrating calpain inhibitor (calpeptin)
US5849690A (en)	1998-12-15	Anti-aggregatory peptides
DK173509B1 (da)	2001-01-15	Polypeptider med blodkoaguleringshæmmende virkning, deres fremstilling eller udvinding samt midler med indhold deraf
Ishiura et al.	1979	Studies of a Calcium-Activated Neutral Protease from Chicken Skeletal Muscle II. Substrate Specificity
BR9708911A (pt)	1999-08-03	Composto fragmento de peptídeo processo par tratar uma doença em um paciente em necessidade de terapia antioangiogênese composição polinucleotídeo único ou de duplo-filamento isolado vetor e processo para produzir um fragmento de peptídeo de kringle 5 ou proteína de fusão de kringle 5 solúvel
CO4600683A1 (es)	1998-05-08	Bikunina humana
KR910007542A (ko)	1991-05-30	폴리펩타이드의 서방형 조성물
RU94036776A (ru)	1996-09-27	Домен ингибитора протеазы, днк, вектор, клетка, способ получения ингибитора протеазы, фармацевтическая композиция, применение домена ингибитора протеазы
Al-Obeidi et al.	1998	Factor Xa inhibitors by classical and combinatorial chemistry
MX9200882A (es)	1992-09-01	Preparacion de factor ix.
Zavalova et al.	2002	Fibrinogen–fibrin system regulators from bloodsuckers
MY104909A (en)	1994-06-30	Peptide compounds.
Furlan et al.	1983	Inhibition of fibrin polymerization by fragment D is affected by calcium, Gly-Pro-Arg and Gly-His-Arg
ES2003112A6 (es)	1988-10-16	Un procedimiento para la preparacion de un decapeptido.
DE69630583D1 (de)	2003-12-11	Peptide, bronchodilator und den blutstrom verbesserndes mittel
ATE42308T1 (de)	1989-05-15	Pharmakologisch aktive peptide.
Stubbs et al.	1994	Crystal structures of thrombin and thrombin complexes as a framework for antithrombotic drug design
EP0238473A3 (fr)	1989-06-07	Inhibiteurs de sérine protéases
US5260060A (en)	1993-11-09	Fibrinolytic enzymes
ATE82984T1 (de)	1992-12-15	Hemmende peptide.
TW340849B (en)	1998-09-21	Novel cyclopeptides and pharmaceutical compositions as integrin inhibitors comprizing the same
Barelli et al.	1988	Further characterization of a neurotensin-degrading neutral metalloendopeptidase from rat brain
AU685470B2 (en)	1998-01-22	Trifunctional antithrombin and antiplatelet peptides
WO1989001490A3 (fr)	1989-04-06	Molecules biologiquement actives