ATE236885T1 - Hydrazono-benzazulen-derivate, pharmazeutische zusammensetzungen und zwischenprodukte - Google Patents

Hydrazono-benzazulen-derivate, pharmazeutische zusammensetzungen und zwischenprodukte

Info

Publication number
ATE236885T1
ATE236885T1 AT98945363T AT98945363T ATE236885T1 AT E236885 T1 ATE236885 T1 AT E236885T1 AT 98945363 T AT98945363 T AT 98945363T AT 98945363 T AT98945363 T AT 98945363T AT E236885 T1 ATE236885 T1 AT E236885T1
Authority
AT
Austria
Prior art keywords
benzazulene
hydrazono
derivatives
pharmaceutical compositions
intermediate products
Prior art date
Application number
AT98945363T
Other languages
English (en)
Inventor
Denis Carniato
Thomas R Gadek
Francois Goubet
Jean-Francois Gourvest
Jochen Knolle
Robert Mcdowell
Karl-Heinz Scheunemann
Original Assignee
Aventis Pharma Sa
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa, Genentech Inc filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE236885T1 publication Critical patent/ATE236885T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02—Monothiocarbamic acids; Derivatives thereof
    • C07C333/04—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/52—Nitrogen atoms not forming part of a nitro radical with hetero atoms directly attached to said nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT98945363T 1997-09-24 1998-09-23 Hydrazono-benzazulen-derivate, pharmazeutische zusammensetzungen und zwischenprodukte ATE236885T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9711859A FR2768734B1 (fr) 1997-09-24 1997-09-24 Nouveaux composes tricycliques, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
PCT/FR1998/002039 WO1999015507A1 (fr) 1997-09-24 1998-09-23 Derives d'hydrazono-benzazulene, compositions pharmaceutiques et intermediaires

Publications (1)

Publication Number Publication Date
ATE236885T1 true ATE236885T1 (de) 2003-04-15

Family

ID=9511409

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98945363T ATE236885T1 (de) 1997-09-24 1998-09-23 Hydrazono-benzazulen-derivate, pharmazeutische zusammensetzungen und zwischenprodukte

Country Status (11)

Country Link
US (1) US6277845B1 (de)
EP (1) EP1017681B1 (de)
JP (1) JP4493839B2 (de)
AT (1) ATE236885T1 (de)
AU (1) AU9270598A (de)
DE (1) DE69813263T2 (de)
DK (1) DK1017681T3 (de)
ES (1) ES2192789T3 (de)
FR (1) FR2768734B1 (de)
PT (1) PT1017681E (de)
WO (1) WO1999015507A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2768736B1 (fr) * 1997-09-24 2000-05-26 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
US6514964B1 (en) 1999-09-27 2003-02-04 Amgen Inc. Fused cycloheptane and fused azacycloheptane compounds and their methods of use
EP1381384B1 (de) 2001-04-24 2011-05-25 Merck Patent GmbH KOMBINATIONSTHERAPIE MIT ANTIANGIOGENEN MITTELN UND TNFalpha
EP1973569B1 (de) 2006-01-18 2013-05-22 Merck Patent GmbH Spezifische therapie mit integrin-liganden zur krebsbehandlung
JP2010516645A (ja) 2007-01-18 2010-05-20 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 癌を治療するためのインテグリンリガンドを用いる特異的療法および薬剤
WO2010068371A2 (en) * 2008-12-11 2010-06-17 University Of Georgia Research Foundation, Inc. Preparation of alkenes by mild thermolysis of sulfoxides
US20120130146A1 (en) 2009-05-25 2012-05-24 Merck Patent Gmbh Continuous administration of cilengitide in cancer treatments
ES2864079T3 (es) 2014-05-30 2021-10-13 Pfizer Derivados de carbonitrilo como moduladores selectivos del receptor de andrógenos
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0777657A1 (de) * 1994-08-22 1997-06-11 Smithkline Beecham Corporation Bicyclische verbindungen
FR2731217B1 (fr) * 1995-03-03 1997-06-13 Roussel Uclaf Nouveaux derives tricycliques, leur preparation, leur application a la preparation de la colchicine et de la thiocolchicine optiquement actives ou racemiques et d'analogues ou derives et intermediaires
JP4091983B2 (ja) * 1996-03-20 2008-05-28 アベンティス ファルマ ソシエテ アノニム 新規な三環式化合物、それらの製造方法及びこの方法の中間体、それらの薬剤としての使用並びにそれらを含有する製薬組成物
DE19629817A1 (de) * 1996-07-24 1998-01-29 Hoechst Ag Neue Imino-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten

Also Published As

Publication number Publication date
JP4493839B2 (ja) 2010-06-30
FR2768734B1 (fr) 2000-01-28
AU9270598A (en) 1999-04-12
PT1017681E (pt) 2004-06-30
DK1017681T3 (da) 2003-07-14
DE69813263T2 (de) 2004-01-29
ES2192789T3 (es) 2003-10-16
JP2001517657A (ja) 2001-10-09
US6277845B1 (en) 2001-08-21
FR2768734A1 (fr) 1999-03-26
DE69813263D1 (de) 2003-05-15
EP1017681A1 (de) 2000-07-12
WO1999015507A1 (fr) 1999-04-01
EP1017681B1 (de) 2003-04-09

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Legal Events

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