ATE236975T1 - Haarnadelförmiges ribozym - Google Patents
Haarnadelförmiges ribozymInfo
- Publication number
- ATE236975T1 ATE236975T1 AT93914943T AT93914943T ATE236975T1 AT E236975 T1 ATE236975 T1 AT E236975T1 AT 93914943 T AT93914943 T AT 93914943T AT 93914943 T AT93914943 T AT 93914943T AT E236975 T1 ATE236975 T1 AT E236975T1
- Authority
- AT
- Austria
- Prior art keywords
- polyribonucleotide
- ribozyme
- hairpin
- shaped
- forth
- Prior art date
Links
- 108091092562 ribozyme Proteins 0.000 title abstract 3
- 102000053642 Catalytic RNA Human genes 0.000 title abstract 2
- 108090000994 Catalytic RNA Proteins 0.000 title abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 3
- 102000040430 polynucleotide Human genes 0.000 abstract 3
- 229940124321 AIDS medicine Drugs 0.000 abstract 1
- 230000003327 cancerostatic effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/122—Hairpin
Landscapes
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17570692 | 1992-07-02 | ||
| JP23691692 | 1992-09-04 | ||
| PCT/JP1993/000907 WO1994001549A1 (fr) | 1992-07-02 | 1993-07-02 | Ribozyme bouclee en epingle a cheveux |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE236975T1 true ATE236975T1 (de) | 2003-04-15 |
Family
ID=26496887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93914943T ATE236975T1 (de) | 1992-07-02 | 1993-07-02 | Haarnadelförmiges ribozym |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5631115A (de) |
| EP (1) | EP0653488B1 (de) |
| AT (1) | ATE236975T1 (de) |
| AU (1) | AU672018B2 (de) |
| CA (1) | CA2139411A1 (de) |
| DE (1) | DE69332856D1 (de) |
| NO (1) | NO311258B1 (de) |
| WO (1) | WO1994001549A1 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19532651A1 (de) * | 1995-09-05 | 1997-03-06 | Aloysius Dr Dickgreber | Mittel zur therapeutischen Anwendung bei HIV-Infektionen |
| US5888767A (en) | 1996-11-27 | 1999-03-30 | The Johns Hopkins University School Of Medicine | Method of using a conditionally replicating viral vector to express a gene |
| US5885806A (en) * | 1995-11-28 | 1999-03-23 | The Johns Hopkins University School Of Medicine | Methods to prepare conditionally replicating viral vectors |
| US6274369B1 (en) * | 1996-02-02 | 2001-08-14 | Invitrogen Corporation | Method capable of increasing competency of bacterial cell transformation |
| US8568766B2 (en) | 2000-08-24 | 2013-10-29 | Gattadahalli M. Anantharamaiah | Peptides and peptide mimetics to treat pathologies associated with eye disease |
| EP1326892A2 (de) | 2000-10-12 | 2003-07-16 | University of Rochester | Zusammensetzungen die die proliferation von krebszellen hemmen |
| WO2003065997A2 (en) | 2002-02-06 | 2003-08-14 | Vicor Technologies, Inc. | Anti-infarction molecules |
| AU2003253580A1 (en) * | 2002-02-26 | 2003-11-17 | University Of Minnesota | Variants of nedd4l associated with hypertension and viral budding |
| US20040005546A1 (en) * | 2002-02-28 | 2004-01-08 | Oncolytics Biotech Inc. | Use of ribozymes in the detection of adventitious agents |
| CA2374388C (en) | 2002-02-28 | 2005-07-12 | Matthew C. Coffey | The use of ribozymes in the detection of adventitious agents |
| EP1575992A4 (de) | 2002-08-05 | 2007-02-21 | Univ Rochester | Chimäre proteine aus proteintransduzierender domäne/deaminase, verwandte verbindungen und deren verwendungen |
| US9233120B2 (en) | 2002-11-15 | 2016-01-12 | Jyant Technologies | Anti-CCL25 and anti-CCR9 antibodies for the prevention and treatment of cancer and cancer cell migration |
| US8512701B2 (en) | 2002-11-15 | 2013-08-20 | Morehouse School Of Medicine | Anti-CXCL13 and anti-CXCR5 antibodies for the prevention and treatment of cancer and cancer cell migration |
| US8658377B2 (en) | 2002-11-15 | 2014-02-25 | Morehouse School Of Medicine | Detecting cancer with anti-CCL25 and anti-CCR9 antibodies |
| AU2003298921A1 (en) * | 2002-12-04 | 2004-06-23 | Algos Therapeutics, Inc. | Methods and materials for modulating trpm2 |
| JP5562521B2 (ja) | 2005-02-02 | 2014-07-30 | ザ ユーエービー リサーチ ファンデーション | アポトーシス誘導デスレセプターアゴニストに対する抵抗性を低減することに関する薬剤及び方法 |
| JP5225069B2 (ja) | 2005-03-23 | 2013-07-03 | ゲンマブ エー／エス | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
| US7476733B2 (en) | 2005-03-25 | 2009-01-13 | The United States Of America As Represented By The Department Of Health And Human Services | Development of a real-time PCR assay for detection of pneumococcal DNA and diagnosis of pneumococccal disease |
| FR2887259B1 (fr) * | 2005-06-21 | 2007-09-14 | Agronomique Inst Nat Rech | CONSTRUCTION D'ADNc D'ALPHAVIRUS DE SALMONIDES |
| WO2007044607A2 (en) * | 2005-10-06 | 2007-04-19 | Emthrax, Llc | Methods and compositions relating to anthrax spore glycoproteins as vaccines |
| EP1934348B1 (de) * | 2005-10-11 | 2018-05-02 | Ben-Gurion University Of The Negev Research And Development Authority | Zusammensetzung zum silencing der expression von vdac1 und verwendungen davon |
| EP2392645A1 (de) | 2005-10-14 | 2011-12-07 | MUSC Foundation For Research Development | Targeting von PAX2 zur Induktion der DEFB1-vermittelten Tumorimmunität und Krebstherapie |
| US8080534B2 (en) | 2005-10-14 | 2011-12-20 | Phigenix, Inc | Targeting PAX2 for the treatment of breast cancer |
| EP2560001B1 (de) | 2006-09-21 | 2016-04-13 | University of Rochester | Zusammensetzungen und Verfahren für eine Proteinverlagerungstherapie für myotone Dystrophie |
| ATE508191T1 (de) | 2006-11-01 | 2011-05-15 | Medical Res And Infrastructure Fund Of The Tel Aviv Sourasky Medical Ct | Adipozytenspezifische konstrukte und verfahren zur hemmung der expression von blutplättchen-typ- 12-lipoxygenase |
| US8999317B2 (en) | 2006-11-01 | 2015-04-07 | University Of Rochester | Methods and compositions related to the structure and function of APOBEC3G |
| BRPI0720038A2 (pt) | 2006-12-11 | 2013-12-24 | Univ Utah Res Found | Métodos para inibir a permeabilidade vascular em tecido, para triar ou avaliar um agente que inibe a permeabilidade vascular, para tratar ou prevenir a síndrome da angústia respiratória, a retinopatia de prematuridade, a retinopatia diabética e a degeneração macular úmida em um indivíduo, para tratar indivíduos com sugestões repulsivas ou miméticos e para promover a angiogênese em um tecido, polipeptídeo isolado, ácido nucleico isolado, e, vetor |
| EP2195331B1 (de) | 2007-08-28 | 2013-11-20 | Uab Research Foundation | Synthetische, apolipoprotein e nachahmende polypeptide und anwendungsverfahren |
| WO2009032702A2 (en) | 2007-08-28 | 2009-03-12 | Uab Research Foundation | Synthetic apolipoprotein e mimicking polypeptides and methods of use |
| WO2010070380A2 (en) | 2007-12-03 | 2010-06-24 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health Of Human Services, National Institutes Of Health | Doc1 compositions and methods for treating cancer |
| US20090233993A1 (en) * | 2008-03-06 | 2009-09-17 | Burnham Institute For Medical Research | Compositions and methods for inhibiting gsk3 activity and uses thereof |
| US20110262395A1 (en) | 2008-05-08 | 2011-10-27 | University Of Utah Research Foundation | Sensory receptors for chronic fatigue and pain and uses thereof |
| US20120070443A1 (en) | 2008-12-02 | 2012-03-22 | University Of Utah Research Foundation | Pde1 as a target therapeutic in heart disease |
| WO2011031974A1 (en) | 2009-09-10 | 2011-03-17 | Southern Research Institute | Acridine analogs in the treatment of gliomas |
| US20110207789A1 (en) | 2010-02-19 | 2011-08-25 | Ye Fang | Methods related to casein kinase ii (ck2) inhibitors and the use of purinosome-disrupting ck2 inhibitors for anti-cancer therapy agents |
| US20160051629A1 (en) | 2013-04-15 | 2016-02-25 | Yeda Research And Development Co. Ltd. | Inhibition of rip kinases for treating lysosomal storage diseases |
| WO2016018665A1 (en) | 2014-07-31 | 2016-02-04 | Uab Research Foundation | Apoe mimetic peptides and higher potency to clear plasma cholesterol |
| US10723794B2 (en) | 2015-03-18 | 2020-07-28 | University Of South Carolina | Anti-CcL8 antibodies and uses thereof |
| CN110087665A (zh) | 2016-08-03 | 2019-08-02 | H·李·莫菲特癌症中心与研究所公司 | Tlr9靶向治疗 |
| US12016314B2 (en) | 2017-09-08 | 2024-06-25 | Ohio State Innovation Foundation | MicroRNA inhibitor therapy in systemic lupus erythematosus |
| IL267614A (en) | 2019-06-24 | 2019-09-26 | Lotem Michal | Nucleic acids to modulate SLAMF6 isoforms |
| US12492245B2 (en) | 2021-09-21 | 2025-12-09 | University Of South Carolina | Anti-CCL8 antibodies and treatment of lung injury by CCL8 inhibition |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MC2115A1 (fr) * | 1987-12-15 | 1991-07-05 | Gene Shears Pty Ltd | Ribozynes |
| CA1340323C (en) * | 1988-09-20 | 1999-01-19 | Arnold E. Hampel | Rna catalyst for cleaving specific rna sequences |
-
1993
- 1993-07-02 AU AU45130/93A patent/AU672018B2/en not_active Ceased
- 1993-07-02 WO PCT/JP1993/000907 patent/WO1994001549A1/ja not_active Ceased
- 1993-07-02 CA CA002139411A patent/CA2139411A1/en not_active Abandoned
- 1993-07-02 DE DE69332856T patent/DE69332856D1/de not_active Expired - Lifetime
- 1993-07-02 AT AT93914943T patent/ATE236975T1/de not_active IP Right Cessation
- 1993-07-02 US US08/367,175 patent/US5631115A/en not_active Expired - Fee Related
- 1993-07-02 EP EP93914943A patent/EP0653488B1/de not_active Expired - Lifetime
-
1994
- 1994-12-30 NO NO19945103A patent/NO311258B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO945103D0 (no) | 1994-12-30 |
| EP0653488B1 (de) | 2003-04-09 |
| EP0653488A1 (de) | 1995-05-17 |
| NO311258B1 (no) | 2001-11-05 |
| CA2139411A1 (en) | 1994-01-20 |
| DE69332856D1 (de) | 2003-05-15 |
| US5631115A (en) | 1997-05-20 |
| AU4513093A (en) | 1994-01-31 |
| AU672018B2 (en) | 1996-09-19 |
| EP0653488A4 (de) | 1997-01-15 |
| WO1994001549A1 (fr) | 1994-01-20 |
| NO945103L (no) | 1995-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |