ATE237581T1 - Verfahren zur herstellung von s-n, n'-bis(2- hydroxy-1-(hydroxymethyl)ethyl)- 5-((2-hydroxy-1- oxopropyl)amino)-2, 4, 6-triiodo-1, 3- benzdicarboxamid - Google Patents
Verfahren zur herstellung von s-n, n'-bis(2- hydroxy-1-(hydroxymethyl)ethyl)- 5-((2-hydroxy-1- oxopropyl)amino)-2, 4, 6-triiodo-1, 3- benzdicarboxamidInfo
- Publication number
- ATE237581T1 ATE237581T1 AT99944338T AT99944338T ATE237581T1 AT E237581 T1 ATE237581 T1 AT E237581T1 AT 99944338 T AT99944338 T AT 99944338T AT 99944338 T AT99944338 T AT 99944338T AT E237581 T1 ATE237581 T1 AT E237581T1
- Authority
- AT
- Austria
- Prior art keywords
- hydroxy
- amino
- triiodo
- oxopropyl
- hydroxymethyl
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- BOGCXPVULYNZEK-UHFFFAOYSA-N 2-aminopropane-1,3-diol Chemical compound OCC(N)CO.OCC(N)CO BOGCXPVULYNZEK-UHFFFAOYSA-N 0.000 abstract 1
- -1 2-hydroxy-1-oxopropyl Chemical group 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical group CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1998MI001996A IT1302200B1 (it) | 1998-09-11 | 1998-09-11 | PROCESSO PER LA PREPARAZIONE DELLA S-N,N'-BIS°2-IDROSSI-1-(IDROSSIMETIL)ETILé-5-°(2-IDROSSI-1- |
| PCT/EP1999/005686 WO2000015602A1 (en) | 1998-09-11 | 1999-08-06 | A process for the preparation of s-n,n'-bis [2-hydroxy-1- (hydroxymethyl) ethyl]-5- [(2-hydroxy-1- oxopropyl) amino]-2,4,6- triiodo-1,3- benzenedicarboxamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE237581T1 true ATE237581T1 (de) | 2003-05-15 |
Family
ID=11380706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99944338T ATE237581T1 (de) | 1998-09-11 | 1999-08-06 | Verfahren zur herstellung von s-n, n'-bis(2- hydroxy-1-(hydroxymethyl)ethyl)- 5-((2-hydroxy-1- oxopropyl)amino)-2, 4, 6-triiodo-1, 3- benzdicarboxamid |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6350908B1 (de) |
| EP (1) | EP1112247B1 (de) |
| JP (1) | JP4536925B2 (de) |
| CN (1) | CN1177810C (de) |
| AT (1) | ATE237581T1 (de) |
| AU (1) | AU755166B2 (de) |
| CA (1) | CA2344496C (de) |
| DE (1) | DE69906999T2 (de) |
| IT (1) | IT1302200B1 (de) |
| NO (1) | NO327811B1 (de) |
| WO (1) | WO2000015602A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012136813A2 (en) | 2011-04-07 | 2012-10-11 | Universitetet I Oslo | Agents for medical radar diagnosis |
| CN103687540B (zh) | 2011-05-17 | 2016-03-16 | 大学健康网络 | 使用记录的呼吸音振幅谱图和音高升降曲线诊断osa/csa |
| JP7012722B2 (ja) * | 2016-12-05 | 2022-01-28 | ブラッコ・イメージング・ソシエタ・ペル・アチオニ | 放射線画像診断剤中間体の機械化学的合成 |
| GB202009917D0 (en) * | 2020-06-29 | 2020-08-12 | Ge Healthcare As | Process for the preparation of iopamidol |
| JP2024514435A (ja) * | 2021-03-22 | 2024-04-02 | ブラッコ・イメージング・ソシエタ・ペル・アチオニ | セリノールの工業的合成 |
| EP4727912A1 (de) | 2023-06-13 | 2026-04-22 | Bracco Imaging SPA | Synthese von nichtionischen röntgenkontrastmitteln durch reaktive extrusion |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH608189A5 (de) * | 1974-12-13 | 1978-12-29 | Savac Ag | |
| IT1248741B (it) * | 1991-02-26 | 1995-01-26 | Bracco Spa | Processo di concentrazione e di purificazione di composti organici |
| IT1256163B (it) | 1992-10-27 | 1995-11-29 | Zambon Spa | Processo per la preparazione di un intermedio della sintesi organica |
| IT1283319B1 (it) | 1996-03-29 | 1998-04-16 | Zambon Spa | Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati |
| IT1288114B1 (it) * | 1996-06-13 | 1998-09-10 | Fructamine Spa | Processo per la purificazione di un intermedio |
-
1998
- 1998-09-11 IT IT1998MI001996A patent/IT1302200B1/it active IP Right Grant
-
1999
- 1999-08-06 US US09/786,884 patent/US6350908B1/en not_active Expired - Lifetime
- 1999-08-06 CA CA002344496A patent/CA2344496C/en not_active Expired - Lifetime
- 1999-08-06 AU AU57312/99A patent/AU755166B2/en not_active Expired
- 1999-08-06 AT AT99944338T patent/ATE237581T1/de not_active IP Right Cessation
- 1999-08-06 DE DE69906999T patent/DE69906999T2/de not_active Expired - Lifetime
- 1999-08-06 EP EP99944338A patent/EP1112247B1/de not_active Expired - Lifetime
- 1999-08-06 JP JP2000570143A patent/JP4536925B2/ja not_active Expired - Lifetime
- 1999-08-06 WO PCT/EP1999/005686 patent/WO2000015602A1/en not_active Ceased
- 1999-08-06 CN CNB998119601A patent/CN1177810C/zh not_active Expired - Lifetime
-
2001
- 2001-03-12 NO NO20011241A patent/NO327811B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO327811B1 (no) | 2009-09-28 |
| WO2000015602A1 (en) | 2000-03-23 |
| JP2002524549A (ja) | 2002-08-06 |
| AU5731299A (en) | 2000-04-03 |
| ITMI981996A0 (it) | 1998-09-11 |
| US6350908B1 (en) | 2002-02-26 |
| ITMI981996A1 (it) | 2000-03-11 |
| CN1177810C (zh) | 2004-12-01 |
| IT1302200B1 (it) | 2000-07-31 |
| EP1112247B1 (de) | 2003-04-16 |
| JP4536925B2 (ja) | 2010-09-01 |
| DE69906999T2 (de) | 2003-11-13 |
| AU755166B2 (en) | 2002-12-05 |
| EP1112247A1 (de) | 2001-07-04 |
| NO20011241D0 (no) | 2001-03-12 |
| DE69906999D1 (de) | 2003-05-22 |
| CN1323290A (zh) | 2001-11-21 |
| NO20011241L (no) | 2001-03-12 |
| CA2344496A1 (en) | 2000-03-23 |
| CA2344496C (en) | 2008-10-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |