ATE414057T1 - Verfahren zur herstellung von iohexol - Google Patents
Verfahren zur herstellung von iohexolInfo
- Publication number
- ATE414057T1 ATE414057T1 AT04748775T AT04748775T ATE414057T1 AT E414057 T1 ATE414057 T1 AT E414057T1 AT 04748775 T AT04748775 T AT 04748775T AT 04748775 T AT04748775 T AT 04748775T AT E414057 T1 ATE414057 T1 AT E414057T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- iohexol
- producing
- dihydroxypropyl
- producing iohexol
- Prior art date
Links
- NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 title abstract 2
- 229960001025 iohexol Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20033058A NO20033058D0 (no) | 2003-07-03 | 2003-07-03 | Prosess |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE414057T1 true ATE414057T1 (de) | 2008-11-15 |
Family
ID=27800766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04748775T ATE414057T1 (de) | 2003-07-03 | 2004-07-01 | Verfahren zur herstellung von iohexol |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20060178533A1 (de) |
| EP (1) | EP1641743B1 (de) |
| JP (1) | JP4933253B2 (de) |
| KR (1) | KR101083147B1 (de) |
| CN (1) | CN100349858C (de) |
| AT (1) | ATE414057T1 (de) |
| DE (1) | DE602004017729D1 (de) |
| ES (1) | ES2314414T3 (de) |
| NO (1) | NO20033058D0 (de) |
| PT (1) | PT1641743E (de) |
| WO (1) | WO2005003080A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO20053676D0 (no) | 2005-07-29 | 2005-07-29 | Amersham Health As | Crystallisation Process |
| NO20053687D0 (no) * | 2005-07-29 | 2005-07-29 | Amersham Health As | Crystallisation Process. |
| NO342021B1 (no) * | 2005-07-29 | 2018-03-12 | Ge Healthcare As | Kontinuerlig krystalliseringsprosess |
| PT103391B (pt) | 2005-11-24 | 2008-10-30 | Hovione Farmaciencia S A | Processo para fabrico de lohexol |
| CN101195587B (zh) * | 2006-12-19 | 2010-07-21 | 浙江尖峰海洲制药有限公司 | 一种碘克沙醇水解物的制备方法 |
| WO2011041275A1 (en) * | 2009-09-30 | 2011-04-07 | Mallinckrodt Inc. | Alkylation of triiodo-substituted arylamides in an aqueous mixed solvent system |
| EP2504298B1 (de) * | 2009-11-26 | 2016-09-21 | iMAX Diagnostic Imaging Holding Limited | Herstellung und aufreinigung von iodixanol |
| JP2014511344A (ja) * | 2010-12-21 | 2014-05-15 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤を含む組成物の脱塩 |
| US20140065076A1 (en) * | 2012-08-30 | 2014-03-06 | Otsuka Pharmaceutical Co. Ltd. | Container with concentrated substance and method of using the same |
| CN110054569B (zh) * | 2019-05-17 | 2022-05-17 | 浙江海洲制药有限公司 | 一种制备碘海醇的方法 |
| CN110590591B (zh) * | 2019-09-25 | 2022-05-17 | 浙江海洲制药有限公司 | 一种碘克沙醇，碘海醇杂质的制备方法 |
| CN115403481A (zh) * | 2022-04-13 | 2022-11-29 | 江苏宇田医药有限公司 | 一种通过离子交换树脂纯化碘海醇的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9618056D0 (en) * | 1996-08-29 | 1996-10-09 | Nycomed Imaging As | Process |
| US5847212A (en) * | 1997-04-21 | 1998-12-08 | Abbott Laboratories | Process for the preparation of iohexol |
| GB9725010D0 (en) * | 1997-11-26 | 1998-01-28 | Nycomed Imaging As | Process |
| ITMI20010773A1 (it) * | 2001-04-11 | 2002-10-11 | Chemi Spa | Processo per la produzione di ioexolo ad elevata purezza |
-
2003
- 2003-07-03 NO NO20033058A patent/NO20033058D0/no unknown
-
2004
- 2004-07-01 KR KR1020067000051A patent/KR101083147B1/ko not_active Expired - Lifetime
- 2004-07-01 JP JP2006517004A patent/JP4933253B2/ja not_active Expired - Lifetime
- 2004-07-01 CN CNB2004800191766A patent/CN100349858C/zh not_active Expired - Lifetime
- 2004-07-01 ES ES04748775T patent/ES2314414T3/es not_active Expired - Lifetime
- 2004-07-01 DE DE602004017729T patent/DE602004017729D1/de not_active Expired - Lifetime
- 2004-07-01 PT PT04748775T patent/PT1641743E/pt unknown
- 2004-07-01 AT AT04748775T patent/ATE414057T1/de not_active IP Right Cessation
- 2004-07-01 EP EP04748775A patent/EP1641743B1/de not_active Expired - Lifetime
- 2004-07-01 WO PCT/NO2004/000199 patent/WO2005003080A1/en not_active Ceased
- 2004-07-01 US US10/560,497 patent/US20060178533A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20060178533A1 (en) | 2006-08-10 |
| WO2005003080A1 (en) | 2005-01-13 |
| EP1641743B1 (de) | 2008-11-12 |
| CN1816519A (zh) | 2006-08-09 |
| PT1641743E (pt) | 2008-12-30 |
| JP4933253B2 (ja) | 2012-05-16 |
| NO20033058D0 (no) | 2003-07-03 |
| CN100349858C (zh) | 2007-11-21 |
| DE602004017729D1 (de) | 2008-12-24 |
| KR20060041207A (ko) | 2006-05-11 |
| ES2314414T3 (es) | 2009-03-16 |
| JP2007521262A (ja) | 2007-08-02 |
| EP1641743A1 (de) | 2006-04-05 |
| KR101083147B1 (ko) | 2011-11-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |