ATE237586T1 - Verfahren zur herstellung von 16-dehydro vitamin d verbindungen - Google Patents

Verfahren zur herstellung von 16-dehydro vitamin d verbindungen

Info

Publication number: ATE237586T1
Authority: AT; Austria
Prior art keywords: compounds; alkyl; hydrogen; group; cycloalkyl
Prior art date: 1997-05-02

Application number

AT98201381T

Other languages

English (en)

Inventor

D Velde J P V

S J Halkes

J Zorgdrager

Los Angeles Rey M Del

A Mourino

Y Fall

K M Halkes

A Fernandez-Gacio

Original Assignee

Duphar Int Res

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-02

Filing date

1998-04-28

Publication date

2003-05-15

1998-04-28 Application filed by Duphar Int Res filed Critical Duphar Int Res

2003-05-15 Application granted granted Critical

2003-05-15 Publication of ATE237586T1 publication Critical patent/ATE237586T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
229940088594 vitamin Drugs 0.000 title 1
229930003231 vitamin Natural products 0.000 title 1
235000013343 vitamin Nutrition 0.000 title 1
239000011782 vitamin Substances 0.000 title 1
150000003722 vitamin derivatives Chemical class 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
229930003316 Vitamin D Natural products 0.000 abstract 1
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
235000019166 vitamin D Nutrition 0.000 abstract 1
239000011710 vitamin D Substances 0.000 abstract 1
-1 vitamin D compounds Chemical class 0.000 abstract 1
229940046008 vitamin d Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT98201381T 1997-05-02 1998-04-28 Verfahren zur herstellung von 16-dehydro vitamin d verbindungen ATE237586T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP97201334		1997-05-02

Publications (1)

Publication Number	Publication Date
ATE237586T1 true ATE237586T1 (de)	2003-05-15

Family

ID=8228295

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98201381T ATE237586T1 (de)	1997-05-02	1998-04-28	Verfahren zur herstellung von 16-dehydro vitamin d verbindungen

Country Status (8)

Country	Link
US (1)	US6080878A (de)
EP (1)	EP0884308B1 (de)
JP (1)	JPH10316652A (de)
AT (1)	ATE237586T1 (de)
DE (1)	DE69813380T2 (de)
DK (1)	DK0884308T3 (de)
ES (1)	ES2196476T3 (de)
IL (1)	IL124284A (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8404667B2 (en) *	2006-12-29	2013-03-26	Wisconsin Alumni Research Foundation	Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog
WO2005074389A2 (ja) *	2004-02-03	2005-08-18	Chugai Pharmaceutical Co Ltd	ビタミンｄ化合物及びそれらの合成中間体の合成方法
SG2014006324A (en) *	2009-01-27	2014-03-28	Berg Llc	Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
US20120184514A1 (en) *	2009-07-01	2012-07-19	Vitamin Derivatives Inc.	Vitamin d compounds and methods for preparing same
CN102655869B (zh)	2009-08-14	2016-08-10	博格有限责任公司	用于治疗脱发的维生素d3及其类似物
ES2396524B2 (es) *	2012-12-11	2013-08-01	Universidade De Santiago De Compostela	Intermedios versátiles y funcionalizados en la síntesis de vitamina D y nuevos derivados de vitamina D
HK1222819A1 (zh)	2013-05-29	2017-07-14	博格有限责任公司	使用维生素d预防或减轻化疗诱发的脱发

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA8923B (en) *	1988-01-20	1989-09-27	Hoffmann La Roche	16-dehydro-vitamin d3-derivatives
DK0398217T3 (da) *	1989-05-18	1994-02-14	Hoffmann La Roche	Dehydrocholecalciferolderivater
TW267161B (de) *	1992-11-20	1996-01-01	Hoffmann La Roche
US5401733A (en) *	1993-10-01	1995-03-28	Hoffmann-La Roche Inc.	Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol
EP0654476B1 (de) *	1993-11-24	2001-01-24	TARGOR GmbH	Metallocene, Verfahren zu ihrer Herstellung und ihrer Verwendung als Katalysatoren
US5428029A (en) *	1993-11-24	1995-06-27	Hoffmann-La Roche Inc.	Vitamin D3 fluorinated analogs
US5384314B1 (en) *	1994-03-11	1997-08-05	Hoffmann La Roche	1alpha-fluoro-25-hydroxy-16-ene-23-yne-cholecalciferol
ATE178596T1 (de) *	1994-12-14	1999-04-15	Duphar Int Res	Vitamin-d-derivate und verfahren zur herstellung dieser verbindungen

1998
- 1998-04-28 DK DK98201381T patent/DK0884308T3/da active
- 1998-04-28 JP JP10132611A patent/JPH10316652A/ja active Pending
- 1998-04-28 ES ES98201381T patent/ES2196476T3/es not_active Expired - Lifetime
- 1998-04-28 DE DE69813380T patent/DE69813380T2/de not_active Expired - Fee Related
- 1998-04-28 EP EP98201381A patent/EP0884308B1/de not_active Expired - Lifetime
- 1998-04-28 AT AT98201381T patent/ATE237586T1/de not_active IP Right Cessation
- 1998-04-29 US US09/067,903 patent/US6080878A/en not_active Expired - Fee Related
- 1998-04-29 IL IL12428498A patent/IL124284A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK0884308T3 (da)	2003-07-21
EP0884308A3 (de)	1999-05-19
EP0884308B1 (de)	2003-04-16
DE69813380T2 (de)	2003-12-04
JPH10316652A (ja)	1998-12-02
EP0884308A2 (de)	1998-12-16
DE69813380D1 (de)	2003-05-22
IL124284A (en)	2004-09-27
US6080878A (en)	2000-06-27
ES2196476T3 (es)	2003-12-16

Legal Events

Date

Code

Title

Description

2003-10-15

UEP

Publication of translation of european patent specification

Ref document number: 0884308

Country of ref document: EP

2008-01-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE174589T1 (de)	1999-01-15	Verfahren zur herstellung von piperidinderivaten
DE69024757D1 (de)	1996-02-22	Methode zur Herstellung von Taxol unter Verwendung von Oxazinon
ATE346062T1 (de)	2006-12-15	Verfahren zur herstellung von optisch-aktiven sulfoxid-derivaten
ATE237586T1 (de)	2003-05-15	Verfahren zur herstellung von 16-dehydro vitamin d verbindungen
ATE207055T1 (de)	2001-11-15	Verfahren zur herstellung von 4-aryl-3- hydroxymethyl-piperidinen
ATE260238T1 (de)	2004-03-15	Verfahren zur herstellung von arylethern
DE69915713D1 (de)	2004-04-22	Verfahren zur herstellung von citalopram
DE3767351D1 (de)	1991-02-21	Sialosylceramide und verfahren zu deren herstellung.
ATE304004T1 (de)	2005-09-15	Verfahren zur herstellung von 2-alkyl-3- aminothiophen derivate und 3-aminothiophen derivate
ATE372332T1 (de)	2007-09-15	Verfahren zur herstellung von zwischenverbindungen in der herstellung von discodermolid und discodermolid-analoga
DE69516156D1 (de)	2000-05-11	Verfahren zur herstellung von alkoxyimino acetamid-derivaten
FR2702220B1 (fr)	1995-05-12	Dédoublement enzymatique de dérivés de 4-alkyl-2-pipéridine-carboxylate et utilisation des composés obtenus, comme intermédiaires de synthèse.
ATE222902T1 (de)	2002-09-15	Verfahren zur herstellung von hetero-bizyklischem alkohol-enantiomer
ATE311375T1 (de)	2005-12-15	Verfahren zur herstellung antiosteoporicagenz
DK0963998T3 (da)	2004-08-16	Azasteroidforbindelse til behandling eller prævention af prostatacancer
DE69900528D1 (de)	2002-01-17	Herstellung von Di-tert-peroxiden
ATE293095T1 (de)	2005-04-15	Verfahren zur herstellung von cyclopropancarboxylaten
ATE250569T1 (de)	2003-10-15	Verfahren zur herstellung von 1- aminomethylcyclohexanessigsäure
DE69101790D1 (de)	1994-06-01	Verfahren zur Herstellung von Vitamin A Aldehyd.
DE60000890D1 (de)	2003-01-16	Verfahren zur Herstellung von 1,1,1-Trifluoro-2-aminoalkane
ATE244228T1 (de)	2003-07-15	Verfahren zur herstellung von chloroacetylaminothiazoleaceticsäure derivate
DE3772703D1 (de)	1991-10-10	Verfahren zur herstellung von penemen.
ATE59375T1 (de)	1991-01-15	Verfahren zur herstellung von polyenaldehyden.
ATE272618T1 (de)	2004-08-15	Verfahren zur herstellung von s-alkylcysteinen
ATE206109T1 (de)	2001-10-15	Verfahren zur herstellung von carbamoylmethylharnstoff-derivaten