ATE246688T1 - Verfahren zur herstellung von opiaten - Google Patents
Verfahren zur herstellung von opiatenInfo
- Publication number
- ATE246688T1 ATE246688T1 AT99301361T AT99301361T ATE246688T1 AT E246688 T1 ATE246688 T1 AT E246688T1 AT 99301361 T AT99301361 T AT 99301361T AT 99301361 T AT99301361 T AT 99301361T AT E246688 T1 ATE246688 T1 AT E246688T1
- Authority
- AT
- Austria
- Prior art keywords
- lower alkyl
- phenyl
- opiates
- producing
- substituted
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940127240 opiate Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 230000003647 oxidation Effects 0.000 abstract 2
- 238000007254 oxidation reaction Methods 0.000 abstract 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- XYYVYLMBEZUESM-CMKMFDCUSA-N codeinone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=CC(=O)[C@@H]1OC1=C2C3=CC=C1OC XYYVYLMBEZUESM-CMKMFDCUSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9805516.3A GB9805516D0 (en) | 1998-03-17 | 1998-03-17 | Preparation of opiates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE246688T1 true ATE246688T1 (de) | 2003-08-15 |
Family
ID=10828597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99301361T ATE246688T1 (de) | 1998-03-17 | 1999-02-24 | Verfahren zur herstellung von opiaten |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6235906B1 (de) |
| EP (1) | EP0943617B1 (de) |
| JP (1) | JPH11292866A (de) |
| AT (1) | ATE246688T1 (de) |
| DE (1) | DE69910101T2 (de) |
| ES (1) | ES2205711T3 (de) |
| GB (1) | GB9805516D0 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ968300A0 (en) * | 2000-08-25 | 2000-09-21 | Glaxo Wellcome Australia Ltd | Chemical methods |
| AU2001281599B2 (en) * | 2000-08-25 | 2007-07-12 | Glaxo Wellcome Australia Ltd | Chemical methods |
| JP2005522460A (ja) * | 2002-02-28 | 2005-07-28 | マリンクロッド・インコーポレイテッド | 逆相分取用クロマトグラフィーを用いる少なくとも１種の麻薬性アルカロイドの分離および精製のための方法およびシステム |
| US7399858B2 (en) * | 2002-11-11 | 2008-07-15 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof |
| US7323565B2 (en) * | 2002-11-11 | 2008-01-29 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone and hydromorphone |
| US7321038B2 (en) * | 2002-11-11 | 2008-01-22 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone and hydromorphone |
| US6864370B1 (en) | 2003-06-05 | 2005-03-08 | Zhaiwei Lin | Process for manufacturing oxycodone |
| TWI483944B (zh) | 2004-03-30 | 2015-05-11 | Euro Celtique Sa | 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝 |
| US6946556B1 (en) * | 2004-05-21 | 2005-09-20 | Acura Pharmaceuticals, Inc. | Preparation of opioid analgesics by a one-pot process |
| US8115373B2 (en) * | 2005-07-06 | 2012-02-14 | Rochester Institute Of Technology | Self-regenerating particulate trap systems for emissions and methods thereof |
| TR2021022252A2 (tr) * | 2021-12-31 | 2022-01-21 | Toprak Mahsulleri Ofisi Genel Mueduerluegue | Kodei̇n kamphosulfonat üreti̇mi̇ne dai̇r yeni̇ bi̇r yöntem |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE408870C (de) * | 1923-09-11 | 1925-01-24 | Merck Chem Fab E | Verfahren zur Darstellung von Kodeienon |
| US2654756A (en) * | 1949-10-20 | 1953-10-06 | Mallinckrodt Chemical Works | Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone |
| US4277604A (en) * | 1980-01-25 | 1981-07-07 | The United States Of America As Represented By The Department Of Health And Human Services | Facile synthesis of codeine precursors from thebaine |
-
1998
- 1998-03-17 GB GBGB9805516.3A patent/GB9805516D0/en not_active Ceased
-
1999
- 1999-02-24 DE DE69910101T patent/DE69910101T2/de not_active Expired - Fee Related
- 1999-02-24 EP EP99301361A patent/EP0943617B1/de not_active Expired - Lifetime
- 1999-02-24 ES ES99301361T patent/ES2205711T3/es not_active Expired - Lifetime
- 1999-02-24 AT AT99301361T patent/ATE246688T1/de not_active IP Right Cessation
- 1999-03-11 JP JP11064713A patent/JPH11292866A/ja active Pending
- 1999-03-17 US US09/271,349 patent/US6235906B1/en not_active Expired - Fee Related
-
2001
- 2001-04-17 US US09/835,525 patent/US20010018519A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JPH11292866A (ja) | 1999-10-26 |
| ES2205711T3 (es) | 2004-05-01 |
| DE69910101T2 (de) | 2004-05-13 |
| EP0943617A1 (de) | 1999-09-22 |
| DE69910101D1 (de) | 2003-09-11 |
| EP0943617B1 (de) | 2003-08-06 |
| US6235906B1 (en) | 2001-05-22 |
| GB9805516D0 (en) | 1998-05-13 |
| US20010018519A1 (en) | 2001-08-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |