ATE246688T1 - Verfahren zur herstellung von opiaten - Google Patents
Verfahren zur herstellung von opiatenInfo
- Publication number
- ATE246688T1 ATE246688T1 AT99301361T AT99301361T ATE246688T1 AT E246688 T1 ATE246688 T1 AT E246688T1 AT 99301361 T AT99301361 T AT 99301361T AT 99301361 T AT99301361 T AT 99301361T AT E246688 T1 ATE246688 T1 AT E246688T1
- Authority
- AT
- Austria
- Prior art keywords
- lower alkyl
- phenyl
- opiates
- producing
- substituted
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940127240 opiate Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 230000003647 oxidation Effects 0.000 abstract 2
- 238000007254 oxidation reaction Methods 0.000 abstract 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- XYYVYLMBEZUESM-CMKMFDCUSA-N codeinone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=CC(=O)[C@@H]1OC1=C2C3=CC=C1OC XYYVYLMBEZUESM-CMKMFDCUSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9805516.3A GB9805516D0 (en) | 1998-03-17 | 1998-03-17 | Preparation of opiates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE246688T1 true ATE246688T1 (de) | 2003-08-15 |
Family
ID=10828597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99301361T ATE246688T1 (de) | 1998-03-17 | 1999-02-24 | Verfahren zur herstellung von opiaten |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6235906B1 (de) |
| EP (1) | EP0943617B1 (de) |
| JP (1) | JPH11292866A (de) |
| AT (1) | ATE246688T1 (de) |
| DE (1) | DE69910101T2 (de) |
| ES (1) | ES2205711T3 (de) |
| GB (1) | GB9805516D0 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ968300A0 (en) * | 2000-08-25 | 2000-09-21 | Glaxo Wellcome Australia Ltd | Chemical methods |
| AU2001281599B2 (en) * | 2000-08-25 | 2007-07-12 | Glaxo Wellcome Australia Ltd | Chemical methods |
| ATE407136T1 (de) * | 2002-02-28 | 2008-09-15 | Mallinckrodt Inc | Verfahren und system zur trennung und aufreinigung wenigstens eines narkotischen alkaloids unter anwendung von präparativer umkehrphasenchromatographie |
| US7321038B2 (en) * | 2002-11-11 | 2008-01-22 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone and hydromorphone |
| US7399858B2 (en) * | 2002-11-11 | 2008-07-15 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof |
| US7323565B2 (en) * | 2002-11-11 | 2008-01-29 | Mallinckrodt Inc. | Method for the catalytic production of hydrocodone and hydromorphone |
| US6864370B1 (en) | 2003-06-05 | 2005-03-08 | Zhaiwei Lin | Process for manufacturing oxycodone |
| TWI365880B (en) | 2004-03-30 | 2012-06-11 | Euro Celtique Sa | Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp |
| US6946556B1 (en) * | 2004-05-21 | 2005-09-20 | Acura Pharmaceuticals, Inc. | Preparation of opioid analgesics by a one-pot process |
| US8115373B2 (en) | 2005-07-06 | 2012-02-14 | Rochester Institute Of Technology | Self-regenerating particulate trap systems for emissions and methods thereof |
| TR2021022252A2 (tr) * | 2021-12-31 | 2022-01-21 | Toprak Mahsulleri Ofisi Genel Mueduerluegue | Kodei̇n kamphosulfonat üreti̇mi̇ne dai̇r yeni̇ bi̇r yöntem |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE408870C (de) * | 1923-09-11 | 1925-01-24 | Merck Chem Fab E | Verfahren zur Darstellung von Kodeienon |
| US2654756A (en) * | 1949-10-20 | 1953-10-06 | Mallinckrodt Chemical Works | Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone |
| US4277604A (en) * | 1980-01-25 | 1981-07-07 | The United States Of America As Represented By The Department Of Health And Human Services | Facile synthesis of codeine precursors from thebaine |
-
1998
- 1998-03-17 GB GBGB9805516.3A patent/GB9805516D0/en not_active Ceased
-
1999
- 1999-02-24 EP EP99301361A patent/EP0943617B1/de not_active Expired - Lifetime
- 1999-02-24 ES ES99301361T patent/ES2205711T3/es not_active Expired - Lifetime
- 1999-02-24 AT AT99301361T patent/ATE246688T1/de not_active IP Right Cessation
- 1999-02-24 DE DE69910101T patent/DE69910101T2/de not_active Expired - Fee Related
- 1999-03-11 JP JP11064713A patent/JPH11292866A/ja active Pending
- 1999-03-17 US US09/271,349 patent/US6235906B1/en not_active Expired - Fee Related
-
2001
- 2001-04-17 US US09/835,525 patent/US20010018519A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE69910101T2 (de) | 2004-05-13 |
| DE69910101D1 (de) | 2003-09-11 |
| EP0943617A1 (de) | 1999-09-22 |
| GB9805516D0 (en) | 1998-05-13 |
| ES2205711T3 (es) | 2004-05-01 |
| JPH11292866A (ja) | 1999-10-26 |
| EP0943617B1 (de) | 2003-08-06 |
| US6235906B1 (en) | 2001-05-22 |
| US20010018519A1 (en) | 2001-08-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |