ATE237808T1 - Direkte auswahl von zellen durch ein aussheidungsprodukt - Google Patents

Direkte auswahl von zellen durch ein aussheidungsprodukt

Info

Publication number
ATE237808T1
ATE237808T1 AT94900375T AT94900375T ATE237808T1 AT E237808 T1 ATE237808 T1 AT E237808T1 AT 94900375 T AT94900375 T AT 94900375T AT 94900375 T AT94900375 T AT 94900375T AT E237808 T1 ATE237808 T1 AT E237808T1
Authority
AT
Austria
Prior art keywords
cells
product
direct selection
secretion product
labelled
Prior art date
Application number
AT94900375T
Other languages
English (en)
Inventor
Stefan Miltenyi
Andreas Radbruch
Rudi Manz
Original Assignee
Stefan Miltenyi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stefan Miltenyi filed Critical Stefan Miltenyi
Application granted granted Critical
Publication of ATE237808T1 publication Critical patent/ATE237808T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Massaging Devices (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT94900375T 1992-10-21 1993-10-21 Direkte auswahl von zellen durch ein aussheidungsprodukt ATE237808T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96593492A 1992-10-21 1992-10-21
PCT/US1993/010126 WO1994009117A1 (en) 1992-10-21 1993-10-21 Direct selection of cells by secretion product

Publications (1)

Publication Number Publication Date
ATE237808T1 true ATE237808T1 (de) 2003-05-15

Family

ID=25510696

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94900375T ATE237808T1 (de) 1992-10-21 1993-10-21 Direkte auswahl von zellen durch ein aussheidungsprodukt

Country Status (10)

Country Link
US (1) US20060141540A1 (de)
EP (2) EP0667896B1 (de)
JP (1) JP3731891B2 (de)
KR (1) KR100306635B1 (de)
AT (1) ATE237808T1 (de)
AU (1) AU679949B2 (de)
CA (1) CA2146974C (de)
DE (1) DE69332884T2 (de)
ES (1) ES2191677T3 (de)
WO (1) WO1994009117A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08510325A (ja) * 1993-05-28 1996-10-29 カイロン コーポレイション 生物学的に活性なペプチド配列の選択方法
US7119248B1 (en) 1994-04-12 2006-10-10 Miltenyi Biotec Gmbh Antibodies against epitopes with homology to self antigens, methods of preparation and applications thereof
AU765085B2 (en) * 1998-05-11 2003-09-11 Miltenyi Biotec Gmbh Method of direct selection of antigen-specific T cells
JP2002535656A (ja) * 1999-01-23 2002-10-22 ミナーヴァ・バイオテクノロジーズ・コーポレーション コロイド固定化種と非コロイド構造上の種との相互作用
US6468432B1 (en) * 1999-09-03 2002-10-22 Miltenyi Biotec Gmbh Methods of modification of selected cells in a magnetic cell separation column
US20090137416A1 (en) 2001-01-16 2009-05-28 Regeneron Pharmaceuticals, Inc. Isolating Cells Expressing Secreted Proteins
WO2002057423A2 (en) * 2001-01-16 2002-07-25 Regeneron Pharmaceuticals, Inc. Isolating cells expressing secreted proteins
EP1395826A4 (de) * 2001-05-17 2005-11-09 Miltenyi Biotec Gmbh Antigenbindende fragmente für eine untergruppe dendritischer zellen und verwendung davon
JP4603894B2 (ja) 2002-12-03 2010-12-22 ユセベ ファルマ ソシエテ アノニム 抗体産生細胞を同定するためのアッセイ
EP1658498A1 (de) 2003-08-20 2006-05-24 Celltech R & D Limited Verfahren zur gewinnung von antikörpern
ATE554390T1 (de) 2003-08-20 2012-05-15 Ucb Pharma Sa Verfahren zur gewinnung von antikörpern
GB0412973D0 (en) * 2004-06-10 2004-07-14 Celltech R&D Ltd Identification of antibody producing cells
KR20070038556A (ko) 2004-07-20 2007-04-10 심포젠 에이/에스 항-ｒｈｅｓｕｓ ｄ 재조합 폴리클로날 항체 및 이의 제조방법
EP1982176A1 (de) * 2006-01-30 2008-10-22 Dako Denmark A/S Quantifizierung antigenspezifischer t-zellen in vollblut mit hoher geschwindigkeit mittels durchflusszytometrie
GB0605965D0 (en) * 2006-03-24 2006-05-03 Univ East Anglia Fluorescence based detection of substances
EP2137308B1 (de) 2007-03-26 2016-08-03 Agenus Inc. Zelloberflächenpräsentation, screening und produktion von interessierenden proteinen
WO2008116468A2 (en) 2007-03-26 2008-10-02 Dako Denmark A/S Mhc peptide complexes and uses thereof in infectious diseases
WO2009003493A2 (en) 2007-07-03 2009-01-08 Dako Denmark A/S Mhc multimers, methods for their generation, labeling and use
EP2197908A2 (de) 2007-09-27 2010-06-23 Dako Denmark A/S Mhc-multimere in tuberkulose-diagnostika, -impfstoff und therapeutika
DK2254592T3 (da) 2008-02-28 2019-09-09 Dako Denmark As MHC-multimerer til Borrelia-diagnostik og sygdom
US8067339B2 (en) 2008-07-09 2011-11-29 Merck Sharp & Dohme Corp. Surface display of whole antibodies in eukaryotes
US10722562B2 (en) * 2008-07-23 2020-07-28 Immudex Aps Combinatorial analysis and repair
GB0817244D0 (en) * 2008-09-20 2008-10-29 Univ Cardiff Use of a protein kinase inhibitor to detect immune cells, such as T cells
US10369204B2 (en) 2008-10-02 2019-08-06 Dako Denmark A/S Molecular vaccines for infectious disease
US11992518B2 (en) 2008-10-02 2024-05-28 Agilent Technologies, Inc. Molecular vaccines for infectious disease
EP2700713B1 (de) 2012-08-21 2016-07-13 Miltenyi Biotec GmbH Untersuchungs- und Anreicherungssystem für die Proteinexpression in eukaryotischen Zellen unter Verwendung einer trizistronischen Expressionskassette
TWI675044B (zh) 2012-11-14 2019-10-21 美商再生元醫藥公司 重組細胞表面捕捉蛋白質
US10526394B2 (en) 2014-04-20 2020-01-07 New / Era / Mabs Gmbh Biomolecule-releasing cell and selection thereof by means of a surface protein
WO2016129444A1 (ja) * 2015-02-12 2016-08-18 コニカミノルタ株式会社 抗体結合蛍光体集積ナノ粒子、抗体結合蛍光体集積ナノ粒子の製造方法および免疫染色キット
US10591465B2 (en) 2015-05-12 2020-03-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for labeling, detection and isolation of Foxp3+ regulatory T cells, isolated population of Foxp3+ regulatory T cells thus obtained and uses thereof
JP6729595B2 (ja) * 2015-09-28 2020-07-22 コニカミノルタ株式会社 前立腺癌の病理組織診断結果（グリーソンスコア）の推定方法
EP3898666A2 (de) 2018-12-17 2021-10-27 Immudex ApS Panel mit borrelia-mhc-multimeren
WO2022256839A1 (en) * 2021-06-03 2022-12-08 Georgia Tech Research Corporation Isolation and analysis of single cells secreting molecules using heterofunctional particles

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281061A (en) * 1979-07-27 1981-07-28 Syva Company Double antibody for enhanced sensitivity in immunoassay
US4557979A (en) * 1984-02-17 1985-12-10 Monsanto Company Process for deposition of resin dispersions on metal substrates
IL73883A (en) * 1984-12-20 1990-12-23 Yeda Res & Dev Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha
US4676980A (en) * 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US4935233A (en) * 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US5238811A (en) * 1988-04-26 1993-08-24 Nippon Telegraph And Telephone Corporation Laser magnetic immunoassay method and apparatus therefor and superparamagnetic material-labeled body and method for the manufacture of same
US5256532A (en) * 1988-05-02 1993-10-26 Zynaxis Technologies, Inc. Methods, reagents and test kits for determination of subpopulations of biological entities
US6020145A (en) * 1989-06-30 2000-02-01 Bristol-Myers Squibb Company Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96
AU765085B2 (en) * 1998-05-11 2003-09-11 Miltenyi Biotec Gmbh Method of direct selection of antigen-specific T cells

Also Published As

Publication number Publication date
EP0667896B1 (de) 2003-04-16
EP0667896A4 (de) 1996-09-04
CA2146974A1 (en) 1994-04-28
US20060141540A1 (en) 2006-06-29
ES2191677T3 (es) 2003-09-16
EP1324040A2 (de) 2003-07-02
DE69332884T2 (de) 2003-11-20
EP1324040A3 (de) 2007-06-20
JPH08504574A (ja) 1996-05-21
AU679949B2 (en) 1997-07-17
KR950704475A (ko) 1995-11-20
KR100306635B1 (ko) 2001-11-30
EP0667896A1 (de) 1995-08-23
JP3731891B2 (ja) 2006-01-05
CA2146974C (en) 2010-02-02
DE69332884D1 (de) 2003-05-22
AU5538594A (en) 1994-05-09
WO1994009117A1 (en) 1994-04-28

Similar Documents

Publication Publication Date Title
ATE237808T1 (de) Direkte auswahl von zellen durch ein aussheidungsprodukt
FI834039A0 (fi) Straolningshaerdbara bindemedelkompositioner
AU562063B2 (en) Block copolymer adhesive composition
AU8542382A (en) Amphoteric alkoxylated carboxylic acid complexes and detergent compositions
EP1591462A3 (de) Temperaturbeeinflusste Polymerverbindung und Verfahren zu seiner Herstellung
FI961238L (fi) Erityssekvenssi heterologisen proteiinin tuottamiseksi hiivassa
CA2195333A1 (en) Method of reclaiming waste plastic material and a compound including waste plastic material
FI831559L (fi) Termoplastiska blandningar baserade pao inte-polaera organiska polymerisat och zeoliter i syraform,som har stark vidhaeftningsfoermaoga vid metaller och sammansatta foeremaol som kan erhaollas fraon
AU570733B2 (en) Coupling agents, coupled products and uses in immunoassay
GB2023607B (en) Specific binding assay method with a prosthetic group as alabel component
AU9094982A (en) Photogenic labels to alleviate quenching in immuno assays
SE8501180L (sv) Centrifugalkoppling
CA2033326A1 (en) Process for binding dust in fertilizer granules
EP0366476A3 (de) Harzmischung vum Verkleben von Polyarylensulfiden und Polyvinylidenfluoriden, Verklebungsverfahren und Verbundstoffe
AT365230B (de) Formpresse fuer pastenartige materialien, wie seifen u. dgl.
AU4835979A (en) Emulsion-polymerized polydimethylsiloxanes in durable press resins
GB2012923B (en) Shear pin coupling
JPS6189005A (ja) 故紙緩衝材の成形方法
SE8306472D0 (sv) Method of bonding a ceramic member with a thermoplastic resin member, and a composite member produce by the method
GB8430784D0 (en) Continuous blank form
GB2074703B (en) Shear pin coupling
AU1062588A (en) Immunoassay utilizing microparticle neutralization
EP0638414A3 (de) Nichtgewebtes Material verwendet als Substrat in thermoplastischen Verbundmaterialien für Dachplatten.
TH37160A (th) กรรมวิธีสำหรับการยึดติดวัสดุ ลิกนอเซลลูโลสิค
IE812355L (en) Prostaglandins

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties