ATE237808T1 - Direkte auswahl von zellen durch ein aussheidungsprodukt - Google Patents

Direkte auswahl von zellen durch ein aussheidungsprodukt

Info

Publication number
ATE237808T1
ATE237808T1 AT94900375T AT94900375T ATE237808T1 AT E237808 T1 ATE237808 T1 AT E237808T1 AT 94900375 T AT94900375 T AT 94900375T AT 94900375 T AT94900375 T AT 94900375T AT E237808 T1 ATE237808 T1 AT E237808T1
Authority
AT
Austria
Prior art keywords
cells
product
direct selection
secretion product
labelled
Prior art date
Application number
AT94900375T
Other languages
English (en)
Inventor
Stefan Miltenyi
Andreas Radbruch
Rudi Manz
Original Assignee
Stefan Miltenyi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stefan Miltenyi filed Critical Stefan Miltenyi
Application granted granted Critical
Publication of ATE237808T1 publication Critical patent/ATE237808T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Massaging Devices (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT94900375T 1992-10-21 1993-10-21 Direkte auswahl von zellen durch ein aussheidungsprodukt ATE237808T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96593492A 1992-10-21 1992-10-21
PCT/US1993/010126 WO1994009117A1 (en) 1992-10-21 1993-10-21 Direct selection of cells by secretion product

Publications (1)

Publication Number Publication Date
ATE237808T1 true ATE237808T1 (de) 2003-05-15

Family

ID=25510696

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94900375T ATE237808T1 (de) 1992-10-21 1993-10-21 Direkte auswahl von zellen durch ein aussheidungsprodukt

Country Status (10)

Country Link
US (1) US20060141540A1 (de)
EP (2) EP0667896B1 (de)
JP (1) JP3731891B2 (de)
KR (1) KR100306635B1 (de)
AT (1) ATE237808T1 (de)
AU (1) AU679949B2 (de)
CA (1) CA2146974C (de)
DE (1) DE69332884T2 (de)
ES (1) ES2191677T3 (de)
WO (1) WO1994009117A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU684510B2 (en) * 1993-05-28 1997-12-18 Chiron Corporation Method for selection of biologically active peptide sequences
US7119248B1 (en) 1994-04-12 2006-10-10 Miltenyi Biotec Gmbh Antibodies against epitopes with homology to self antigens, methods of preparation and applications thereof
AU765085B2 (en) * 1998-05-11 2003-09-11 Miltenyi Biotec Gmbh Method of direct selection of antigen-specific T cells
AU3347900A (en) * 1999-01-23 2000-08-07 Minerva Biotechnologies Corporation Interaction of colloid-immobilized species with species on non-colloidal structures
CA2383791C (en) * 1999-09-03 2012-11-06 Miltenyi Biotec Gmbh Methods of modification of selected cells in a magnetic cell separation column
US20090137416A1 (en) 2001-01-16 2009-05-28 Regeneron Pharmaceuticals, Inc. Isolating Cells Expressing Secreted Proteins
US6919183B2 (en) * 2001-01-16 2005-07-19 Regeneron Pharmaceuticals, Inc. Isolating cells expressing secreted proteins
WO2002093172A1 (en) * 2001-05-17 2002-11-21 Miltenyi Biotec Gmbh Antigen binding fragments for dendritic cell subset and use thereof
ES2374068T3 (es) 2002-12-03 2012-02-13 Ucb Pharma, S.A. Ensayo para identificar células productoras de anticuerpos.
US7771969B2 (en) 2003-08-20 2010-08-10 Celltech R&D Limited Methods for obtaining antibodies
ES2385829T3 (es) 2003-08-20 2012-08-01 Ucb Pharma, S.A. Métodos para obtener anticuerpos
GB0412973D0 (en) * 2004-06-10 2004-07-14 Celltech R&D Ltd Identification of antibody producing cells
EA014182B1 (ru) 2004-07-20 2010-10-29 Симфоген А/С КОМПОЗИЦИЯ ПОЛИКЛОНАЛЬНЫХ АНТИ-RhD АНТИТЕЛ, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЕ КОМПОЗИЦИИ
US20090061478A1 (en) * 2006-01-30 2009-03-05 Lene Have Poulsen High-Speed Quantification of Antigen Specific T-Cells in Whole Blood by Flow Cytometry
GB0605965D0 (en) * 2006-03-24 2006-05-03 Univ East Anglia Fluorescence based detection of substances
EP2617827A1 (de) 2007-03-26 2013-07-24 Celexion, LLC Zelloberflächenanzeige, Abtastung und Herstellung von Proteinen von Interesse
WO2008116468A2 (en) 2007-03-26 2008-10-02 Dako Denmark A/S Mhc peptide complexes and uses thereof in infectious diseases
EP3620465B1 (de) 2007-07-03 2025-02-19 Dako Denmark A/S Verbesserte verfahren zur herstellung, markierung und verwendung von mhc-multimeren
US10611818B2 (en) 2007-09-27 2020-04-07 Agilent Technologies, Inc. MHC multimers in tuberculosis diagnostics, vaccine and therapeutics
DK2254592T3 (da) 2008-02-28 2019-09-09 Dako Denmark As MHC-multimerer til Borrelia-diagnostik og sygdom
US8067339B2 (en) 2008-07-09 2011-11-29 Merck Sharp & Dohme Corp. Surface display of whole antibodies in eukaryotes
WO2010009735A2 (en) * 2008-07-23 2010-01-28 Dako Denmark A/S Combinatorial analysis and repair
GB0817244D0 (en) * 2008-09-20 2008-10-29 Univ Cardiff Use of a protein kinase inhibitor to detect immune cells, such as T cells
US11992518B2 (en) 2008-10-02 2024-05-28 Agilent Technologies, Inc. Molecular vaccines for infectious disease
WO2010037402A1 (en) 2008-10-02 2010-04-08 Dako Denmark A/S Molecular vaccines for infectious disease
EP2700713B1 (de) 2012-08-21 2016-07-13 Miltenyi Biotec GmbH Untersuchungs- und Anreicherungssystem für die Proteinexpression in eukaryotischen Zellen unter Verwendung einer trizistronischen Expressionskassette
TW202423993A (zh) 2012-11-14 2024-06-16 美商再生元醫藥公司 重組細胞表面捕捉蛋白質
DE112014006603A5 (de) 2014-04-20 2017-01-19 new/era/mabs GmbH Biomoleküle freisetzende Zelle und deren Selektion mittels eines Oberflächenproteins sowie für dieses codierende Nukleinsäure, deren Expressionsvektor und dessen Empfängerzelle
WO2016129444A1 (ja) * 2015-02-12 2016-08-18 コニカミノルタ株式会社 抗体結合蛍光体集積ナノ粒子、抗体結合蛍光体集積ナノ粒子の製造方法および免疫染色キット
EP3295171A1 (de) 2015-05-12 2018-03-21 INSERM - Institut National de la Santé et de la Recherche Médicale Verfahren und kits zur markierung, zum nachweis und zur isolierung von foxp3+-regulierenden t-zellen, isolierten populationen von foxp3+-regulierenden t-zellen und verwendungen davon
EP3358352B1 (de) 2015-09-28 2019-11-20 Konica Minolta, Inc. Verfahren zur kalkulation eines pathologischen gewebediagnoseergebnisses (gleason)-score) von prostatakrebs
WO2020127222A2 (en) 2018-12-17 2020-06-25 Immudex Aps Panel comprising borrelia mhc multimers
US20240248093A1 (en) * 2021-06-03 2024-07-25 Georgia Tech Research Corporation Isolation and analysis of single cells secreting molecules using heterofunctional particles

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281061A (en) * 1979-07-27 1981-07-28 Syva Company Double antibody for enhanced sensitivity in immunoassay
US4557979A (en) * 1984-02-17 1985-12-10 Monsanto Company Process for deposition of resin dispersions on metal substrates
IL73883A (en) * 1984-12-20 1990-12-23 Yeda Res & Dev Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha
US4676980A (en) * 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US4935233A (en) * 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US5238811A (en) * 1988-04-26 1993-08-24 Nippon Telegraph And Telephone Corporation Laser magnetic immunoassay method and apparatus therefor and superparamagnetic material-labeled body and method for the manufacture of same
US5256532A (en) * 1988-05-02 1993-10-26 Zynaxis Technologies, Inc. Methods, reagents and test kits for determination of subpopulations of biological entities
US6020145A (en) * 1989-06-30 2000-02-01 Bristol-Myers Squibb Company Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96
AU765085B2 (en) * 1998-05-11 2003-09-11 Miltenyi Biotec Gmbh Method of direct selection of antigen-specific T cells

Also Published As

Publication number Publication date
CA2146974A1 (en) 1994-04-28
EP0667896A1 (de) 1995-08-23
KR950704475A (ko) 1995-11-20
EP1324040A3 (de) 2007-06-20
CA2146974C (en) 2010-02-02
AU679949B2 (en) 1997-07-17
WO1994009117A1 (en) 1994-04-28
EP1324040A2 (de) 2003-07-02
EP0667896B1 (de) 2003-04-16
ES2191677T3 (es) 2003-09-16
EP0667896A4 (de) 1996-09-04
JP3731891B2 (ja) 2006-01-05
AU5538594A (en) 1994-05-09
JPH08504574A (ja) 1996-05-21
US20060141540A1 (en) 2006-06-29
DE69332884D1 (de) 2003-05-22
DE69332884T2 (de) 2003-11-20
KR100306635B1 (ko) 2001-11-30

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Legal Events

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