ES2191677T3 - Seleccion directa de celulas mediante un producto de secrecion. - Google Patents

Seleccion directa de celulas mediante un producto de secrecion.

Info

Publication number
ES2191677T3
ES2191677T3 ES94900375T ES94900375T ES2191677T3 ES 2191677 T3 ES2191677 T3 ES 2191677T3 ES 94900375 T ES94900375 T ES 94900375T ES 94900375 T ES94900375 T ES 94900375T ES 2191677 T3 ES2191677 T3 ES 2191677T3
Authority
ES
Spain
Prior art keywords
cells
product
direct selection
secretion product
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94900375T
Other languages
English (en)
Inventor
Stefan Miltenyi
Andreas Radbruch
Rudi Manz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of ES2191677T3 publication Critical patent/ES2191677T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Massaging Devices (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

UNAS CELULAS PUEDEN SER CLASIFICADAS CON PRODUCTOS QUE SECRETAN Y LIBERAN DE UNA MANERA EFICAZ POR ACOPLAMIENTO DE LAS CELULAS EN SU SUPERFICIE A UN LIGANDO DE UNION ESPECIFICO PARA EL PRODUCTO Y PERMITIENDO AL PRODUCTO QUE SEA CAPTURADO POR EL LIGANDO DE UNION ESPECIFICO A MEDIDA QUE ES SECRETADO Y LIBERADO. LAS CELULAS CLASIFICADAS CON EL PRODUCTO PUEDEN SER ACOPLADAS A CONTINUACION A CLASES APROPIADAS, SI SE DESEA, Y SEPARADAS DE ACUERDO CON LA PRESENCIA, AUSENCIA, O CANTIDAD DE PRODUCTO.
ES94900375T 1992-10-21 1993-10-21 Seleccion directa de celulas mediante un producto de secrecion. Expired - Lifetime ES2191677T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US96593492A 1992-10-21 1992-10-21

Publications (1)

Publication Number Publication Date
ES2191677T3 true ES2191677T3 (es) 2003-09-16

Family

ID=25510696

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94900375T Expired - Lifetime ES2191677T3 (es) 1992-10-21 1993-10-21 Seleccion directa de celulas mediante un producto de secrecion.

Country Status (10)

Country Link
US (1) US20060141540A1 (es)
EP (2) EP0667896B1 (es)
JP (1) JP3731891B2 (es)
KR (1) KR100306635B1 (es)
AT (1) ATE237808T1 (es)
AU (1) AU679949B2 (es)
CA (1) CA2146974C (es)
DE (1) DE69332884T2 (es)
ES (1) ES2191677T3 (es)
WO (1) WO1994009117A1 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2163620A1 (en) * 1993-05-28 1994-12-08 Michael V. Doyle Method for selection of biologically active peptide sequences
US7119248B1 (en) 1994-04-12 2006-10-10 Miltenyi Biotec Gmbh Antibodies against epitopes with homology to self antigens, methods of preparation and applications thereof
JP4601166B2 (ja) * 1998-05-11 2010-12-22 ミルテニィ バイオテック ゲーエムベーハー 抗原特異的ｔ細胞の直接的選択方法
AU3347900A (en) * 1999-01-23 2000-08-07 Minerva Biotechnologies Corporation Interaction of colloid-immobilized species with species on non-colloidal structures
ES2260063T3 (es) * 1999-09-03 2006-11-01 Miltenyi Biotec Gmbh Proceso de modificacion de celulas seleccionadas en una columna de separacion magnetica de celulas.
WO2002057423A2 (en) * 2001-01-16 2002-07-25 Regeneron Pharmaceuticals, Inc. Isolating cells expressing secreted proteins
US20090137416A1 (en) 2001-01-16 2009-05-28 Regeneron Pharmaceuticals, Inc. Isolating Cells Expressing Secreted Proteins
US20030022249A1 (en) * 2001-05-17 2003-01-30 Juergen Schmitz Antigen-binding fragments that recognize a subset of dendritic cells and methods of use thereof
US7993864B2 (en) 2002-12-03 2011-08-09 Ucb Pharma S.A. Assay for identifying antibody producing cells
US20060263353A1 (en) 2003-08-20 2006-11-23 Lawson Alastair D G Methods for obtaining antibodies
EP1658498A1 (en) * 2003-08-20 2006-05-24 Celltech R & D Limited Methods for obtaining antibodies
GB0412973D0 (en) * 2004-06-10 2004-07-14 Celltech R&D Ltd Identification of antibody producing cells
MX2007000644A (es) 2004-07-20 2007-03-28 Symphogen As Anticuerpo policlonal recombinante anti-rhesus d y metodos de fabricacion.
WO2007085266A1 (en) * 2006-01-30 2007-08-02 Dako Denmark A/S High-speed quantification of antigen specific t-cells in whole blood by flow cytometry
GB0605965D0 (en) * 2006-03-24 2006-05-03 Univ East Anglia Fluorescence based detection of substances
US8709980B2 (en) * 2007-03-26 2014-04-29 Celexion, Llc Cell surface display, screening and production of proteins of interest
EP2155782A2 (en) 2007-03-26 2010-02-24 Dako Denmark A/S Mhc peptide complexes and uses thereof in infectious diseases
EP2167537A2 (en) 2007-07-03 2010-03-31 Dako Denmark A/S Compiled methods for analysing and sorting samples
US10611818B2 (en) 2007-09-27 2020-04-07 Agilent Technologies, Inc. MHC multimers in tuberculosis diagnostics, vaccine and therapeutics
DK2254592T3 (da) 2008-02-28 2019-09-09 Dako Denmark As MHC-multimerer til Borrelia-diagnostik og sygdom
US8067339B2 (en) 2008-07-09 2011-11-29 Merck Sharp & Dohme Corp. Surface display of whole antibodies in eukaryotes
WO2010009735A2 (en) * 2008-07-23 2010-01-28 Dako Denmark A/S Combinatorial analysis and repair
GB0817244D0 (en) * 2008-09-20 2008-10-29 Univ Cardiff Use of a protein kinase inhibitor to detect immune cells, such as T cells
WO2010037402A1 (en) 2008-10-02 2010-04-08 Dako Denmark A/S Molecular vaccines for infectious disease
US11992518B2 (en) 2008-10-02 2024-05-28 Agilent Technologies, Inc. Molecular vaccines for infectious disease
EP2700713B1 (en) 2012-08-21 2016-07-13 Miltenyi Biotec GmbH Screening and enrichment system for protein expression in eukaryotic cells using a tricistronic expression cassette
TW202423993A (zh) 2012-11-14 2024-06-16 美商再生元醫藥公司 重組細胞表面捕捉蛋白質
US10526394B2 (en) 2014-04-20 2020-01-07 New / Era / Mabs Gmbh Biomolecule-releasing cell and selection thereof by means of a surface protein
JP6740906B2 (ja) * 2015-02-12 2020-08-19 コニカミノルタ株式会社 抗体結合蛍光体集積ナノ粒子、抗体結合蛍光体集積ナノ粒子の製造方法および免疫染色キット
WO2016180948A1 (en) 2015-05-12 2016-11-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for labeling, detection and isolation of foxp3+ regulatory t cells, isolated population of foxp3+ regulatory t cells thus obtained and uses thereof
WO2017056844A1 (ja) * 2015-09-28 2017-04-06 コニカミノルタ株式会社 前立腺癌の病理組織診断結果（グリーソンスコア）の推定方法
WO2020127222A2 (en) 2018-12-17 2020-06-25 Immudex Aps Panel comprising borrelia mhc multimers
WO2022256839A1 (en) * 2021-06-03 2022-12-08 Georgia Tech Research Corporation Isolation and analysis of single cells secreting molecules using heterofunctional particles

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281061A (en) * 1979-07-27 1981-07-28 Syva Company Double antibody for enhanced sensitivity in immunoassay
US4557979A (en) * 1984-02-17 1985-12-10 Monsanto Company Process for deposition of resin dispersions on metal substrates
IL73883A (en) * 1984-12-20 1990-12-23 Yeda Res & Dev Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha
US4676980A (en) * 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US4935233A (en) * 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US5238811A (en) * 1988-04-26 1993-08-24 Nippon Telegraph And Telephone Corporation Laser magnetic immunoassay method and apparatus therefor and superparamagnetic material-labeled body and method for the manufacture of same
US5256532A (en) * 1988-05-02 1993-10-26 Zynaxis Technologies, Inc. Methods, reagents and test kits for determination of subpopulations of biological entities
US6020145A (en) * 1989-06-30 2000-02-01 Bristol-Myers Squibb Company Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96
JP4601166B2 (ja) * 1998-05-11 2010-12-22 ミルテニィ バイオテック ゲーエムベーハー 抗原特異的ｔ細胞の直接的選択方法

Also Published As

Publication number Publication date
EP0667896B1 (en) 2003-04-16
EP1324040A3 (en) 2007-06-20
WO1994009117A1 (en) 1994-04-28
AU679949B2 (en) 1997-07-17
EP0667896A4 (en) 1996-09-04
JP3731891B2 (ja) 2006-01-05
JPH08504574A (ja) 1996-05-21
KR100306635B1 (ko) 2001-11-30
DE69332884D1 (de) 2003-05-22
EP0667896A1 (en) 1995-08-23
ATE237808T1 (de) 2003-05-15
AU5538594A (en) 1994-05-09
KR950704475A (ko) 1995-11-20
CA2146974A1 (en) 1994-04-28
DE69332884T2 (de) 2003-11-20
EP1324040A2 (en) 2003-07-02
US20060141540A1 (en) 2006-06-29
CA2146974C (en) 2010-02-02

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