ATE238061T1 - Verwendung von zytokinen und mitogenen für inhibierung von pathologischen immunantworten - Google Patents

Verwendung von zytokinen und mitogenen für inhibierung von pathologischen immunantworten

Info

Publication number: ATE238061T1
Authority: AT; Austria
Prior art keywords: mitogens; cytokines; inhibition; immune responses; pathological immune
Prior art date: 1997-11-05

Application number

AT98957605T

Other languages

English (en)

Inventor

David Horwitz

Original Assignee

Univ Southern California

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-11-05

Filing date

1998-11-05

Publication date

2003-05-15

1998-11-05 Application filed by Univ Southern California filed Critical Univ Southern California

2003-05-15 Application granted granted Critical

2003-05-15 Publication of ATE238061T1 publication Critical patent/ATE238061T1/de

Links

102000004127 Cytokines Human genes 0.000 title 1
108090000695 Cytokines Proteins 0.000 title 1
230000005764 inhibitory process Effects 0.000 title 1
239000003226 mitogen Substances 0.000 title 1
230000001575 pathological effect Effects 0.000 title 1
230000002401 inhibitory effect Effects 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
208000023275 Autoimmune disease Diseases 0.000 abstract 1
108010002350 Interleukin-2 Proteins 0.000 abstract 1
102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 1
108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 1
239000012190 activator Substances 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
230000016784 immunoglobulin production Effects 0.000 abstract 1
210000005087 mononuclear cell Anatomy 0.000 abstract 1
210000003819 peripheral blood mononuclear cell Anatomy 0.000 abstract 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/22—Immunosuppressive or immunotolerising
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/416—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Animal Behavior & Ethology (AREA)
Biotechnology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Epidemiology (AREA)
Microbiology (AREA)
Hematology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Cell Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Plant Substances (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT98957605T 1997-11-05 1998-11-05 Verwendung von zytokinen und mitogenen für inhibierung von pathologischen immunantworten ATE238061T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US6450797P	1997-11-05	1997-11-05
PCT/US1998/023584 WO1999025366A1 (en)	1997-11-05	1998-11-05	Use of cytokines and mitogens to inhibit pathological immune responses

Publications (1)

Publication Number	Publication Date
ATE238061T1 true ATE238061T1 (de)	2003-05-15

Family

ID=22056456

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98957605T ATE238061T1 (de)	1997-11-05	1998-11-05	Verwendung von zytokinen und mitogenen für inhibierung von pathologischen immunantworten

Country Status (11)

Country	Link
US (1)	US6228359B1 (de)
EP (1)	EP1028738B1 (de)
JP (1)	JP4309047B2 (de)
AT (1)	ATE238061T1 (de)
AU (1)	AU747767B2 (de)
CA (1)	CA2309115C (de)
DE (1)	DE69813868T2 (de)
DK (1)	DK1028738T3 (de)
ES (1)	ES2198774T3 (de)
PT (1)	PT1028738E (de)
WO (1)	WO1999025366A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6358506B1 (en) *	1997-11-05	2002-03-19	University Of Southern California	Use of cytokines and mitogens to inhibit pathological immune responses
US20030157057A1 (en) *	1999-05-05	2003-08-21	Horwitz David A.	Methods for the induction of professional and cytokine-producing regulatory T cells
US6803036B1 (en)	1998-03-03	2004-10-12	University Of Southern California	Use of cytokines, cells and mitogens to inhibit graft versus host disease
US6447765B1 (en)	1998-03-03	2002-09-10	University Of Southern California	Use of cytokines and mitogens to inhibit graft versus host disease
ATE404662T1 (de) *	1999-05-05	2008-08-15	Univ Southern California	Verwendung von zytokinen und mitogenen zur inhibierung von pathologischen immunantworten
WO2001016296A2 (en) *	1999-09-01	2001-03-08	University Of Southern California	Use of cytokines, cells, and mitogens to inhibit graft versus host disease
JP5008810B2 (ja) *	2000-04-11	2012-08-22	ユニバーシティオブサザンカリフォルニア	抑制性Ｔ細胞を誘導するためにＴＧＦ−βを用いる移植拒絶反応を防止する方法
AU2007202534B2 (en) *	2000-04-11	2011-06-09	University Of Southern California	A method to prevent graft rejection using TGF-beta to induce T suppressor cells
JP2005514054A (ja) *	2001-12-21	2005-05-19	ユニバーシティ・オブ・サザン・カリフォルニア	プロフェッショナルおよびサイトカイン産生制御ｔ細胞の誘導のための方法
US20050202010A1 (en) *	2003-08-29	2005-09-15	Giroir Brett P.	Method of treatment and bioassay involving macrophage migration inhibitory factor (MIF) as cardiac-derived myocardial depressant factor
CN102971416B (zh)	2010-04-22	2018-03-30	南加州大学	用于扩增和稳定天然调节性t细胞的方法和组合物
EP2763692A2 (de)	2011-10-06	2014-08-13	European Molecular Biology Laboratory	Verwendung von igf-1 in der modulation der treg-zellaktivität sowie behandlung und vorbeugung von autoimmunen erkrankungen oder störungen
US9958456B2 (en)	2011-10-07	2018-05-01	Baxalta Incorporated	OxMIF as a diagnostic marker
US20150110738A1 (en)	2012-05-04	2015-04-23	University Of Southern California	Methods and compositions for generating and using allogeneic suppressor cells
GB201421716D0 (en) *	2014-12-05	2015-01-21	King S College London	Cell expansion procedure

1998
- 1998-11-05 DK DK98957605T patent/DK1028738T3/da active
- 1998-11-05 AT AT98957605T patent/ATE238061T1/de active
- 1998-11-05 ES ES98957605T patent/ES2198774T3/es not_active Expired - Lifetime
- 1998-11-05 US US09/186,771 patent/US6228359B1/en not_active Expired - Lifetime
- 1998-11-05 PT PT98957605T patent/PT1028738E/pt unknown
- 1998-11-05 CA CA2309115A patent/CA2309115C/en not_active Expired - Fee Related
- 1998-11-05 JP JP2000520799A patent/JP4309047B2/ja not_active Expired - Fee Related
- 1998-11-05 EP EP98957605A patent/EP1028738B1/de not_active Expired - Lifetime
- 1998-11-05 AU AU13827/99A patent/AU747767B2/en not_active Ceased
- 1998-11-05 WO PCT/US1998/023584 patent/WO1999025366A1/en not_active Ceased
- 1998-11-05 DE DE69813868T patent/DE69813868T2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP4309047B2 (ja)	2009-08-05
AU1382799A (en)	1999-06-07
DE69813868T2 (de)	2004-03-04
DE69813868D1 (de)	2003-05-28
DK1028738T3 (da)	2003-08-11
CA2309115C (en)	2010-10-19
EP1028738A1 (de)	2000-08-23
EP1028738B1 (de)	2003-04-23
WO1999025366A1 (en)	1999-05-27
JP2001523443A (ja)	2001-11-27
ES2198774T3 (es)	2004-02-01
US6228359B1 (en)	2001-05-08
PT1028738E (pt)	2003-08-29
CA2309115A1 (en)	1999-05-27
AU747767B2 (en)	2002-05-23

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Publication	Publication Date	Title
ATE238061T1 (de)	2003-05-15	Verwendung von zytokinen und mitogenen für inhibierung von pathologischen immunantworten
ES2099158T3 (es)	1997-05-16	Tratamiento del rechazo de trasplantes o de enfermedades autoinmunitarias y complejo de la formula general x-pro-y-boropro asociada al mismo.
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