ATE238068T1 - Hydrolysierbare hydrogele zur gesteuerten freisetzung - Google Patents

Hydrolysierbare hydrogele zur gesteuerten freisetzung

Info

Publication number
ATE238068T1
ATE238068T1 AT97929571T AT97929571T ATE238068T1 AT E238068 T1 ATE238068 T1 AT E238068T1 AT 97929571 T AT97929571 T AT 97929571T AT 97929571 T AT97929571 T AT 97929571T AT E238068 T1 ATE238068 T1 AT E238068T1
Authority
AT
Austria
Prior art keywords
hydrolyzable
hydrogels
controlled release
hydrogel
physiological conditions
Prior art date
Application number
AT97929571T
Other languages
English (en)
Inventor
Wilhelmus Everhardus Hennink
Dijk-Wolthuis Wendelmoed N Van
Original Assignee
Univ Utrecht
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Utrecht filed Critical Univ Utrecht
Application granted granted Critical
Publication of ATE238068T1 publication Critical patent/ATE238068T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Colloid Chemistry (AREA)
  • Lubricants (AREA)
  • Catalysts (AREA)
  • Soft Magnetic Materials (AREA)
AT97929571T 1996-07-01 1997-07-01 Hydrolysierbare hydrogele zur gesteuerten freisetzung ATE238068T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP96201821 1996-07-01
US3167196P 1996-11-22 1996-11-22
PCT/NL1997/000374 WO1998000170A1 (en) 1996-07-01 1997-07-01 Hydrolysable hydrogels for controlled release

Publications (1)

Publication Number Publication Date
ATE238068T1 true ATE238068T1 (de) 2003-05-15

Family

ID=26142938

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97929571T ATE238068T1 (de) 1996-07-01 1997-07-01 Hydrolysierbare hydrogele zur gesteuerten freisetzung

Country Status (10)

Country Link
US (2) US6497903B1 (de)
EP (1) EP0910412B1 (de)
JP (1) JP4625548B2 (de)
AT (1) ATE238068T1 (de)
AU (1) AU3360197A (de)
DE (1) DE69721265T2 (de)
DK (1) DK0910412T3 (de)
ES (1) ES2198579T3 (de)
PT (1) PT910412E (de)
WO (1) WO1998000170A1 (de)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080131512A1 (en) * 1996-07-01 2008-06-05 Wilhelmus Everhardus Hennink Biodegradable hydrogels
CA2266478C (en) † 1996-09-23 2002-11-12 Focal, Inc. Polymerizable biodegradable polymers including carbonate or dioxanone linkages
ES2287971T3 (es) 1997-08-11 2007-12-16 Pfizer Products Inc. Dispersiones farmaceuticas solidas con biodisponibilidad incrementada.
WO2000048576A1 (en) * 1999-02-19 2000-08-24 Universiteit Utrecht Stereocomplex hydrogels
US7425581B2 (en) * 1999-07-30 2008-09-16 Universiteit Utrecht Temperature sensitive polymers
US7008635B1 (en) 1999-09-10 2006-03-07 Genzyme Corporation Hydrogels for orthopedic repair
DE60040411D1 (de) * 1999-11-19 2008-11-13 Nof Corp Gerter freigabe und verfahren zu ihrer herstellung
US6961765B2 (en) 2000-04-06 2005-11-01 Bbx Technologies, Inc. System and method for real time monitoring and control of networked computers
US6800298B1 (en) 2000-05-11 2004-10-05 Clemson University Biological lubricant composition and method of applying lubricant composition
US6805879B2 (en) 2000-06-23 2004-10-19 Biopharm Solutions Inc. Stable polymer aqueous/aqueous emulsion system and uses thereof
US20040018228A1 (en) * 2000-11-06 2004-01-29 Afmedica, Inc. Compositions and methods for reducing scar tissue formation
US7943067B2 (en) * 2001-08-16 2011-05-17 Polytechnic Institute Of New York University Nanogels and their production using liposomes as reactors
DE60132094T3 (de) 2001-10-26 2012-02-02 Octoplus Polyactive Sciences B.V. Verfahren zur Herstellung von gereinigten Partikeln
US8545830B2 (en) * 2003-03-24 2013-10-01 University Of Tennessee Research Foundation Multi-functional polymeric materials and their uses
ES2396689T3 (es) 2003-12-11 2013-02-25 Isto Technologies Inc. Sistema de cartílago particulado
EP1576952A1 (de) * 2004-03-18 2005-09-21 OctoPlus Technologies B.V. Hydrogel-Mikrosphären mit verbessertem Freisetzungsprofil
EP1595534A1 (de) 2004-05-13 2005-11-16 Universiteit Utrecht Holding B.V. Gelzusammensetzung enthaltend geladenepolymere
US7968085B2 (en) * 2004-07-05 2011-06-28 Ascendis Pharma A/S Hydrogel formulations
US7235592B2 (en) * 2004-10-12 2007-06-26 Zimmer Gmbh PVA hydrogel
ITTO20040918A1 (it) * 2004-12-29 2005-03-29 Luigi Ambrosio Idrogel polimerici superassorbenti biodegradabili e procedimento per la loro preparazione
US8017139B2 (en) 2005-02-23 2011-09-13 Zimmer Technology, Inc. Blend hydrogels and methods of making
US20070031498A1 (en) * 2005-08-02 2007-02-08 Wright Medical Technology, Inc. Gel composition for cellular adhesion inhibition
US7571295B2 (en) * 2005-08-04 2009-08-04 Intel Corporation Memory manager for heterogeneous memory control
EP1916964A4 (de) 2005-08-26 2015-11-04 Zimmer Inc Implantate und verfahren zur behebung, ersetzung und behandlung von gelenkkrankheiten
US8932633B2 (en) 2005-08-29 2015-01-13 Biopharm Solutions Inc. Polysaccharide microparticles containing biological agents: their preparation and applications
EP1764117A1 (de) * 2005-09-20 2007-03-21 Zimmer GmbH Implantat zur Wiederherstellung von Knorpeldefekten und Verfahren zu seiner Herstellung
US8383415B2 (en) * 2005-10-13 2013-02-26 Dso National Laboratories Hydrogel composition to enhance fluorescence
US20070098799A1 (en) * 2005-10-28 2007-05-03 Zimmer, Inc. Mineralized Hydrogels and Methods of Making and Using Hydrogels
US8262730B2 (en) * 2005-12-07 2012-09-11 Zimmer, Inc. Methods of bonding or modifying hydrogels using irradiation
US20070141108A1 (en) * 2005-12-20 2007-06-21 Zimmer, Inc. Fiber-reinforced water-swellable articles
US8017107B2 (en) * 2005-12-22 2011-09-13 Zimmer, Inc. Perfluorocyclobutane crosslinked hydrogels
US8110242B2 (en) * 2006-03-24 2012-02-07 Zimmer, Inc. Methods of preparing hydrogel coatings
EP1891941A1 (de) * 2006-08-11 2008-02-27 OctoPlus Technologies B.V. Wässrige Gele enthaltend Mikrokügelchen
US20080114096A1 (en) * 2006-11-09 2008-05-15 Hydromer, Inc. Lubricious biopolymeric network compositions and methods of making same
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
EP1985284A1 (de) * 2007-04-25 2008-10-29 OctoPlus Sciences B.V. Impfstoffformulierung
WO2008100142A2 (en) * 2007-02-12 2008-08-21 Octoplus Sciences B.V. Vaccine formulation
AU2008240191B2 (en) 2007-04-12 2013-09-19 Zimmer, Inc. Compositions and methods for tissue repair
US7731988B2 (en) 2007-08-03 2010-06-08 Zimmer, Inc. Multi-polymer hydrogels
US20090043398A1 (en) * 2007-08-09 2009-02-12 Zimmer, Inc. Method of producing gradient articles by centrifugation molding or casting
US8062739B2 (en) * 2007-08-31 2011-11-22 Zimmer, Inc. Hydrogels with gradient
EP2205224A1 (de) * 2007-09-26 2010-07-14 DSM IP Assets B.V. Mikroteilchen mit einem vernetzten polymer
US7947784B2 (en) * 2007-11-16 2011-05-24 Zimmer, Inc. Reactive compounding of hydrogels
US8034362B2 (en) 2008-01-04 2011-10-11 Zimmer, Inc. Chemical composition of hydrogels for use as articulating surfaces
US20090202642A1 (en) * 2008-02-08 2009-08-13 Xiao Huang Drug Delivery System Comprising Microparticles and Gelation System
WO2009155583A1 (en) * 2008-06-19 2009-12-23 The Trustees Of The University Of Pennsylvania Biomaterials for tissue replacement
US9193948B2 (en) 2008-11-12 2015-11-24 The Trustees Of The University Of Pennsylvania Biomaterials for tissue replacement
US8685458B2 (en) 2009-03-05 2014-04-01 Bend Research, Inc. Pharmaceutical compositions of dextran polymer derivatives
EP2411137B1 (de) 2009-03-27 2016-09-07 Bend Research, Inc. Sprühtrocknungsverfahren
CN102695501A (zh) 2009-11-09 2012-09-26 聚光灯技术合伙有限责任公司 碎裂水凝胶
CN106913902A (zh) 2009-11-09 2017-07-04 聚光灯技术合伙有限责任公司 多糖基水凝胶
US20120003192A1 (en) * 2010-07-02 2012-01-05 Zimmer Orthobiologics, Inc. Hydrogel-forming composition comprising protein and non-protein segments
WO2012031133A2 (en) 2010-09-03 2012-03-08 Bench Research, Inc. Spray-drying apparatus and methods of using the same
US8815294B2 (en) 2010-09-03 2014-08-26 Bend Research, Inc. Pharmaceutical compositions of dextran polymer derivatives and a carrier material
EP2611529B1 (de) 2010-09-03 2019-01-23 Bend Research, Inc. Sprühtrocknungsverfahren
WO2012040502A1 (en) 2010-09-24 2012-03-29 Bend Research, Inc. High-temperature spray drying process and apparatus
US9060938B2 (en) 2011-05-10 2015-06-23 Bend Research, Inc. Pharmaceutical compositions of active agents and cationic dextran polymer derivatives
WO2014034884A1 (ja) * 2012-08-31 2014-03-06 国立大学法人北陸先端科学技術大学院大学 凍結保存可能な細胞足場材料
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
US20160067190A1 (en) * 2013-04-30 2016-03-10 The Children's Medical Center Corporation Injectable nano-network gels for diabetes treatment
AR106018A1 (es) 2015-08-26 2017-12-06 Achillion Pharmaceuticals Inc Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos
WO2017035408A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Compounds for treatment of immune and inflammatory disorders
US10712240B2 (en) 2016-04-19 2020-07-14 Ariana Schanzer Contaminant monitor system and method
SG11201811491YA (en) 2016-06-27 2019-01-30 Achillion Pharmaceuticals Inc Quinazoline and indole compounds to treat medical disorders
US10220096B2 (en) * 2016-10-13 2019-03-05 The Board Of Trustees Of The Leland Stanford Junior University Injectable and stable hydrogels with dynamic properties modulated by biocompatible catalysts
CN110603252A (zh) 2017-03-01 2019-12-20 艾其林医药公司 用于治疗医学障碍的芳基、杂芳基和杂环药物化合物
EP3581168A1 (de) * 2018-06-15 2019-12-18 Universiteit Utrecht Holding B.V. Zusammensetzung mit verzögerter freisetzung
US20230022157A1 (en) 2018-08-20 2023-01-26 Achillion Pharmaceuticals, Inc. Pharmaceutical compounds for the treatment of complement factor d medical disorders
JP7443375B2 (ja) 2018-09-06 2024-03-05 アキリオン ファーマシューティカルズ， インコーポレーテッド 医学的障害の治療のための大環状化合物
EP3866773B1 (de) 2018-10-16 2024-08-28 Georgia State University Research Foundation, Inc. Kohlenmonoxid-prodrugs zur behandlung von erkrankungen
WO2021127452A1 (en) 2019-12-19 2021-06-24 Georgia State University Research Foundation, Inc. Compounds for the treatment of bacterial infections and potentiation of antibiotics
CN110897997B (zh) * 2019-12-31 2023-02-28 广州贝奥吉因生物科技股份有限公司 一种葡聚糖接枝甲基丙烯酸水凝胶微针及其制备方法
CN115362162A (zh) 2020-02-20 2022-11-18 艾其林医药公司 用于治疗补体因子d介导的障碍的杂芳基化合物
CN116437913A (zh) 2020-09-23 2023-07-14 艾其林医药公司 用于治疗补体介导的病症的药物化合物
CN116832213B (zh) * 2023-07-11 2024-07-30 杭州帕莱拉医疗科技有限公司 一种可注射右旋糖苷/聚左旋乳酸互穿网络微球复合水凝胶填充剂的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2370589A (en) * 1944-02-29 1945-02-27 Pittsburgh Plate Glass Co Unsaturated carbonate esters
US4024073A (en) * 1972-01-08 1977-05-17 Toray Industries, Inc. Hydrogel and production thereof
US5356883A (en) * 1989-08-01 1994-10-18 Research Foundation Of State University Of N.Y. Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
EP0610441A4 (de) 1991-10-29 1996-01-10 Clover Cons Ltd Vernetzbare polysacchariden, polykationen und lipiden verwendbar zum einkapseln und abgabe von arzneimitteln.
AU673160B2 (en) 1992-02-28 1996-10-31 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
DE4209160A1 (de) 1992-03-20 1993-09-30 Bauer Kurt Heinz Prof Dr Vernetzte Polysaccharide, Verfahren zu ihrer Herstellung und ihre Verwendung
DK89592D0 (da) 1992-07-07 1992-07-07 Helle Broendsted Laegemiddelafgivelsesindretning samt fremgangsmaade til fremstilling deraf

Also Published As

Publication number Publication date
US20020131952A1 (en) 2002-09-19
US6497903B1 (en) 2002-12-24
WO1998000170A1 (en) 1998-01-08
JP2000515853A (ja) 2000-11-28
US7060296B2 (en) 2006-06-13
DE69721265T2 (de) 2004-05-06
DK0910412T3 (da) 2003-08-11
EP0910412A1 (de) 1999-04-28
DE69721265D1 (de) 2003-05-28
PT910412E (pt) 2003-09-30
EP0910412B1 (de) 2003-04-23
ES2198579T3 (es) 2004-02-01
AU3360197A (en) 1998-01-21
JP4625548B2 (ja) 2011-02-02

Similar Documents

Publication Publication Date Title
DE69721265D1 (de) Hydrolysierbare hydrogele zur gesteuerten freisetzung
DE602004028455D1 (de) Vernetzte polysaccharidzusammensetzung
MX193604B (es) Hidrogeles hidrofilicos altamente hinchables
BRPI0409725B8 (pt) composição polimérica superabsorvente
WO1999029353A3 (en) Medical devices with improved properties
DE59604255D1 (de) Wasserabsorbierende, schaumförmige, vernetzte hydrogel-polymere
ATE320238T1 (de) Superabsorbierende carboxylhaltige polymere mit geruchseindämmenden eigenschaften und verfahren zu ihrer herstellung
BR9814680A (pt) Gels superabsorventes com base em poli (vinilamina), e método para manufaturar o mesmo
EP0940447A3 (de) Siliconhydrogelpolymere
DK1168934T3 (da) Hydrogeldannende system med hydrofobe og hydrofile komponenter
NO20021862D0 (no) Katalysatorsammensetninger, fremgangsmåter for polymerisasjon og polymerer derfra
WO2001044307A3 (en) Degradable poly(vinyl alcohol) hydrogels
WO2003086316A3 (en) Degradable crosslinkers, and degradable crosslinked hydrogels comprising them
ATE424789T1 (de) Bandscheibenimplantate und methoden zu deren herstellung
BR0000015B1 (pt) processo de preparaÇço de polÍmeros diÊnicos amina-funcionalizados, sistema catalÍtico, polÍmero diÊnico amina-funcionalizado, composiÇço de borracha vulcanizÁvel com enxofre, e, invàlucro de pneumÁtico.
AU2004697A (en) Biodegradable poly (amino acid)s, derivatized amino acid polymers and methods for making same
AU2474592A (en) Utilisation of cross-linked collagen for the fabrication of a stitchable, biocompatible, slow resorption membrane
AU2003224926A1 (en) Hydrogel with controllable mechanical chemical and biological properties and method for making same
EP1098382A3 (de) Polyelektrolytgel
WO2004029137A3 (en) Cross-linked polymer matrices, and methods of making and using same
BR0005413B1 (pt) processo para preparar uma plataforma polimÉrica porosa, biodegradÁvel e biocompatÍvel para engenharia de tecidos.
AU1823700A (en) Silyl-functional initiator for living cationic polymerization
NO20012982D0 (no) Olefinpolymerisasjonskatalysatorsystem, polymerisasjonsprosess og polymer derfra
ES8404392A1 (es) Un procedimiento para preparar un copolielectrolito biopolimero hidrofilo.
AU2003237321A1 (en) Monomer compound comprising several cationic groups, process for making the same, and polymers comprising units deriving therefrom

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0910412

Country of ref document: EP

REN Ceased due to non-payment of the annual fee