ATE238068T1 - Hydrolysierbare hydrogele zur gesteuerten freisetzung - Google Patents

Hydrolysierbare hydrogele zur gesteuerten freisetzung

Info

Publication number
ATE238068T1
ATE238068T1 AT97929571T AT97929571T ATE238068T1 AT E238068 T1 ATE238068 T1 AT E238068T1 AT 97929571 T AT97929571 T AT 97929571T AT 97929571 T AT97929571 T AT 97929571T AT E238068 T1 ATE238068 T1 AT E238068T1
Authority
AT
Austria
Prior art keywords
hydrolyzable
hydrogels
controlled release
hydrogel
physiological conditions
Prior art date
Application number
AT97929571T
Other languages
English (en)
Inventor
Wilhelmus Everhardus Hennink
Dijk-Wolthuis Wendelmoed N Van
Original Assignee
Univ Utrecht
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Utrecht filed Critical Univ Utrecht
Application granted granted Critical
Publication of ATE238068T1 publication Critical patent/ATE238068T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Lubricants (AREA)
  • Catalysts (AREA)
  • Soft Magnetic Materials (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Colloid Chemistry (AREA)
AT97929571T 1996-07-01 1997-07-01 Hydrolysierbare hydrogele zur gesteuerten freisetzung ATE238068T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP96201821 1996-07-01
US3167196P 1996-11-22 1996-11-22
PCT/NL1997/000374 WO1998000170A1 (en) 1996-07-01 1997-07-01 Hydrolysable hydrogels for controlled release

Publications (1)

Publication Number Publication Date
ATE238068T1 true ATE238068T1 (de) 2003-05-15

Family

ID=26142938

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97929571T ATE238068T1 (de) 1996-07-01 1997-07-01 Hydrolysierbare hydrogele zur gesteuerten freisetzung

Country Status (10)

Country Link
US (2) US6497903B1 (de)
EP (1) EP0910412B1 (de)
JP (1) JP4625548B2 (de)
AT (1) ATE238068T1 (de)
AU (1) AU3360197A (de)
DE (1) DE69721265T2 (de)
DK (1) DK0910412T3 (de)
ES (1) ES2198579T3 (de)
PT (1) PT910412E (de)
WO (1) WO1998000170A1 (de)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080131512A1 (en) * 1996-07-01 2008-06-05 Wilhelmus Everhardus Hennink Biodegradable hydrogels
EP0927214B2 (de) † 1996-09-23 2014-03-12 Genzyme Corporation Polymerisierbare biologisch abbaubare polymere mit carbonat-oder dioxanonbindungen
DE69837903T2 (de) * 1997-08-11 2008-02-14 Pfizer Products Inc., Groton Feste pharmazeutische Dispersionen mit erhöhter Bioverfügbarkeit
JP4865947B2 (ja) * 1999-02-19 2012-02-01 ウニフェルシテイト ユトレヒト ステレオコンプレックスヒドロゲル
US7425581B2 (en) * 1999-07-30 2008-09-16 Universiteit Utrecht Temperature sensitive polymers
US7008635B1 (en) 1999-09-10 2006-03-07 Genzyme Corporation Hydrogels for orthopedic repair
DE60040411D1 (de) * 1999-11-19 2008-11-13 Nof Corp Gerter freigabe und verfahren zu ihrer herstellung
US6961765B2 (en) 2000-04-06 2005-11-01 Bbx Technologies, Inc. System and method for real time monitoring and control of networked computers
US6800298B1 (en) * 2000-05-11 2004-10-05 Clemson University Biological lubricant composition and method of applying lubricant composition
US6805879B2 (en) 2000-06-23 2004-10-19 Biopharm Solutions Inc. Stable polymer aqueous/aqueous emulsion system and uses thereof
US20040018228A1 (en) * 2000-11-06 2004-01-29 Afmedica, Inc. Compositions and methods for reducing scar tissue formation
US7943067B2 (en) * 2001-08-16 2011-05-17 Polytechnic Institute Of New York University Nanogels and their production using liposomes as reactors
ATE381963T1 (de) 2001-10-26 2008-01-15 Octoplus Technologies B V Verfahren zur herstellung von gereinigten partikeln
US8545830B2 (en) * 2003-03-24 2013-10-01 University Of Tennessee Research Foundation Multi-functional polymeric materials and their uses
ES2404682T3 (es) 2003-12-11 2013-05-28 Isto Technologies Inc. Sistema de cartílago particulado
EP1576952A1 (de) * 2004-03-18 2005-09-21 OctoPlus Technologies B.V. Hydrogel-Mikrosphären mit verbessertem Freisetzungsprofil
EP1595534A1 (de) 2004-05-13 2005-11-16 Universiteit Utrecht Holding B.V. Gelzusammensetzung enthaltend geladenepolymere
US7968085B2 (en) * 2004-07-05 2011-06-28 Ascendis Pharma A/S Hydrogel formulations
US7235592B2 (en) * 2004-10-12 2007-06-26 Zimmer Gmbh PVA hydrogel
ITTO20040918A1 (it) * 2004-12-29 2005-03-29 Luigi Ambrosio Idrogel polimerici superassorbenti biodegradabili e procedimento per la loro preparazione
US8017139B2 (en) 2005-02-23 2011-09-13 Zimmer Technology, Inc. Blend hydrogels and methods of making
WO2007016622A2 (en) * 2005-08-02 2007-02-08 Wright Medical Technolody, Inc. Gel composition for inhibiting cellular adhesion
US7571295B2 (en) * 2005-08-04 2009-08-04 Intel Corporation Memory manager for heterogeneous memory control
AU2006282754A1 (en) 2005-08-26 2007-03-01 Zimmer, Inc. Implants and methods for repair, replacement and treatment of joint disease
EP1931311A4 (de) * 2005-08-29 2010-12-08 Tuo Jin Polysaccharid-mikroteilchen mit biologischen mitteln: ihre herstellung und verwendungen
EP1764117A1 (de) * 2005-09-20 2007-03-21 Zimmer GmbH Implantat zur Wiederherstellung von Knorpeldefekten und Verfahren zu seiner Herstellung
WO2007043973A1 (en) * 2005-10-13 2007-04-19 Dso National Laboratories Method of enhancing a fluorescent signal
US20070098799A1 (en) * 2005-10-28 2007-05-03 Zimmer, Inc. Mineralized Hydrogels and Methods of Making and Using Hydrogels
AU2006321809A1 (en) * 2005-12-07 2007-06-14 Zimmer, Inc. Methods of bonding or modifying hydrogels using irradiation
US20070141108A1 (en) * 2005-12-20 2007-06-21 Zimmer, Inc. Fiber-reinforced water-swellable articles
EP1801135B1 (de) * 2005-12-22 2010-09-29 Zimmer Inc. Perfluorcyclobutanvernetzte Hydrogele
US8110242B2 (en) * 2006-03-24 2012-02-07 Zimmer, Inc. Methods of preparing hydrogel coatings
EP1891941A1 (de) * 2006-08-11 2008-02-27 OctoPlus Technologies B.V. Wässrige Gele enthaltend Mikrokügelchen
US20080114096A1 (en) * 2006-11-09 2008-05-15 Hydromer, Inc. Lubricious biopolymeric network compositions and methods of making same
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
EP1985284A1 (de) * 2007-04-25 2008-10-29 OctoPlus Sciences B.V. Impfstoffformulierung
WO2008100142A2 (en) * 2007-02-12 2008-08-21 Octoplus Sciences B.V. Vaccine formulation
AU2008240191B2 (en) 2007-04-12 2013-09-19 Zimmer, Inc. Compositions and methods for tissue repair
US7731988B2 (en) 2007-08-03 2010-06-08 Zimmer, Inc. Multi-polymer hydrogels
US20090043398A1 (en) * 2007-08-09 2009-02-12 Zimmer, Inc. Method of producing gradient articles by centrifugation molding or casting
US8062739B2 (en) * 2007-08-31 2011-11-22 Zimmer, Inc. Hydrogels with gradient
CN101808624A (zh) * 2007-09-26 2010-08-18 帝斯曼知识产权资产管理有限公司 包含交联聚合物的微粒
US7947784B2 (en) * 2007-11-16 2011-05-24 Zimmer, Inc. Reactive compounding of hydrogels
US8034362B2 (en) 2008-01-04 2011-10-11 Zimmer, Inc. Chemical composition of hydrogels for use as articulating surfaces
US20090202642A1 (en) * 2008-02-08 2009-08-13 Xiao Huang Drug Delivery System Comprising Microparticles and Gelation System
US20110182957A1 (en) * 2008-06-19 2011-07-28 Nicoll Steven B Cellulosics for tissue replacement
US9193948B2 (en) 2008-11-12 2015-11-24 The Trustees Of The University Of Pennsylvania Biomaterials for tissue replacement
US8685458B2 (en) 2009-03-05 2014-04-01 Bend Research, Inc. Pharmaceutical compositions of dextran polymer derivatives
US9724664B2 (en) 2009-03-27 2017-08-08 Bend Research, Inc. Spray-drying process
JP5864429B2 (ja) 2009-11-09 2016-02-17 スポットライト テクノロジー パートナーズ エルエルシーＳｐｏｔｌｉｇｈｔ Ｔｅｃｈｎｏｌｏｇｙ Ｐａｒｔｎｅｒｓ Ｌｌｃ 架橋ヒドロゲル組成物、ヒドロゲル組成物の形成方法、及びキット
JP2013509963A (ja) 2009-11-09 2013-03-21 スポットライト テクノロジー パートナーズ エルエルシー 断片化ヒドロゲル
US20120003192A1 (en) * 2010-07-02 2012-01-05 Zimmer Orthobiologics, Inc. Hydrogel-forming composition comprising protein and non-protein segments
EP2611529B1 (de) 2010-09-03 2019-01-23 Bend Research, Inc. Sprühtrocknungsverfahren
US8815294B2 (en) 2010-09-03 2014-08-26 Bend Research, Inc. Pharmaceutical compositions of dextran polymer derivatives and a carrier material
PT2611530T (pt) 2010-09-03 2019-05-09 Bend Res Inc Aparelho de secagem por pulverização e métodos de utilização do mesmo
US9248584B2 (en) 2010-09-24 2016-02-02 Bend Research, Inc. High-temperature spray drying process and apparatus
US9084727B2 (en) 2011-05-10 2015-07-21 Bend Research, Inc. Methods and compositions for maintaining active agents in intra-articular spaces
WO2014034884A1 (ja) * 2012-08-31 2014-03-06 国立大学法人北陸先端科学技術大学院大学 凍結保存可能な細胞足場材料
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
AU2014260024B2 (en) * 2013-04-30 2016-09-15 Massachusetts Institute Of Technology Injectable nano-network gels for diabetes treatment
ES2908479T3 (es) 2015-08-26 2022-04-29 Achillion Pharmaceuticals Inc Compuestos para el tratamiento de trastornos inmunitarios e inflamatorios
AR106018A1 (es) 2015-08-26 2017-12-06 Achillion Pharmaceuticals Inc Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos
US10712240B2 (en) 2016-04-19 2020-07-14 Ariana Schanzer Contaminant monitor system and method
EP3939591A1 (de) 2016-06-27 2022-01-19 Achillion Pharmaceuticals, Inc. Chinazolin- und indolverbindungen zur behandlung von medizinischen leiden
US10220096B2 (en) * 2016-10-13 2019-03-05 The Board Of Trustees Of The Leland Stanford Junior University Injectable and stable hydrogels with dynamic properties modulated by biocompatible catalysts
AU2018227849B2 (en) 2017-03-01 2022-04-28 Achillion Pharmaceuticals, Inc. Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders
EP3581168A1 (de) * 2018-06-15 2019-12-18 Universiteit Utrecht Holding B.V. Zusammensetzung mit verzögerter freisetzung
JP7538113B2 (ja) 2018-08-20 2024-08-21 アキリオン ファーマシューティカルズ，インコーポレーテッド 補体ｄ因子の医学的障害の治療のための医薬化合物
WO2020051532A2 (en) 2018-09-06 2020-03-12 Achillion Pharmaceuticals, Inc. Macrocyclic compounds for the treatment of medical disorders
WO2020081723A1 (en) 2018-10-16 2020-04-23 Georgia State University Research Foundation, Inc. Carbon monoxide prodrugs for the treatment of medical disorders
US20230105108A1 (en) 2019-12-19 2023-04-06 Georgia State University Research Foundation, Inc. Compounds for the treatment of bacterial infections and potentiation of antibiotics
CN110897997B (zh) * 2019-12-31 2023-02-28 广州贝奥吉因生物科技股份有限公司 一种葡聚糖接枝甲基丙烯酸水凝胶微针及其制备方法
CN115362162A (zh) 2020-02-20 2022-11-18 艾其林医药公司 用于治疗补体因子d介导的障碍的杂芳基化合物
JP7787164B2 (ja) 2020-09-23 2025-12-16 アキリオン ファーマシューティカルズ， インコーポレーテッド 補体媒介性障害の治療のための医薬化合物
CN116832213B (zh) * 2023-07-11 2024-07-30 杭州帕莱拉医疗科技有限公司 一种可注射右旋糖苷/聚左旋乳酸互穿网络微球复合水凝胶填充剂的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2370589A (en) * 1944-02-29 1945-02-27 Pittsburgh Plate Glass Co Unsaturated carbonate esters
US4024073A (en) * 1972-01-08 1977-05-17 Toray Industries, Inc. Hydrogel and production thereof
US5356883A (en) * 1989-08-01 1994-10-18 Research Foundation Of State University Of N.Y. Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
WO1993009176A2 (en) 1991-10-29 1993-05-13 Clover Consolidated, Limited Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release
BR9306038A (pt) 1992-02-28 1998-01-13 Univ Texas Hidrogéis biodegradáveis fotopolimerizáveis como materiais de contato de tecidos e condutores de liberação controlada
DE4209160A1 (de) * 1992-03-20 1993-09-30 Bauer Kurt Heinz Prof Dr Vernetzte Polysaccharide, Verfahren zu ihrer Herstellung und ihre Verwendung
DK89592D0 (da) * 1992-07-07 1992-07-07 Helle Broendsted Laegemiddelafgivelsesindretning samt fremgangsmaade til fremstilling deraf

Also Published As

Publication number Publication date
EP0910412A1 (de) 1999-04-28
DE69721265T2 (de) 2004-05-06
AU3360197A (en) 1998-01-21
US6497903B1 (en) 2002-12-24
DE69721265D1 (de) 2003-05-28
DK0910412T3 (da) 2003-08-11
JP2000515853A (ja) 2000-11-28
WO1998000170A1 (en) 1998-01-08
EP0910412B1 (de) 2003-04-23
PT910412E (pt) 2003-09-30
JP4625548B2 (ja) 2011-02-02
ES2198579T3 (es) 2004-02-01
US7060296B2 (en) 2006-06-13
US20020131952A1 (en) 2002-09-19

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