ATE238264T1 - Verwendung v0n 1,3,4,6-tetrahydroxy-helianthron und derivaten in der photodynamischen therapie und derivate - Google Patents

Verwendung v0n 1,3,4,6-tetrahydroxy-helianthron und derivaten in der photodynamischen therapie und derivate

Info

Publication number
ATE238264T1
ATE238264T1 AT98933874T AT98933874T ATE238264T1 AT E238264 T1 ATE238264 T1 AT E238264T1 AT 98933874 T AT98933874 T AT 98933874T AT 98933874 T AT98933874 T AT 98933874T AT E238264 T1 ATE238264 T1 AT E238264T1
Authority
AT
Austria
Prior art keywords
derivatives
tetrahydroxy
photodynamic therapy
helianthron
helianthrone
Prior art date
Application number
AT98933874T
Other languages
English (en)
Inventor
Yehuda Mazur
Gad Lavie
Original Assignee
Yeda Res & Dev
Univ New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev, Univ New York filed Critical Yeda Res & Dev
Application granted granted Critical
Publication of ATE238264T1 publication Critical patent/ATE238264T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/36—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/95—Esters of quinone carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/54—Ortho- or ortho- and peri-condensed systems containing more than five condensed rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT98933874T 1997-07-31 1998-07-27 Verwendung v0n 1,3,4,6-tetrahydroxy-helianthron und derivaten in der photodynamischen therapie und derivate ATE238264T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL12144097A IL121440A0 (en) 1997-07-31 1997-07-31 The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives
PCT/IL1998/000346 WO1999006347A1 (en) 1997-07-31 1998-07-27 The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives

Publications (1)

Publication Number Publication Date
ATE238264T1 true ATE238264T1 (de) 2003-05-15

Family

ID=11070450

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98933874T ATE238264T1 (de) 1997-07-31 1998-07-27 Verwendung v0n 1,3,4,6-tetrahydroxy-helianthron und derivaten in der photodynamischen therapie und derivate

Country Status (8)

Country Link
US (1) US6229048B1 (de)
EP (1) EP1001924B1 (de)
AT (1) ATE238264T1 (de)
AU (1) AU8355598A (de)
CA (1) CA2298820C (de)
DE (1) DE69813828T2 (de)
IL (1) IL121440A0 (de)
WO (1) WO1999006347A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794518B1 (en) 1998-12-18 2004-09-21 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
WO2001056558A1 (en) * 2000-01-31 2001-08-09 Yeda Research And Development Co. Ltd. Polycyclic dianthraquinones as anti-cancer and anti-angiogenic agents
CA2413957A1 (en) * 2000-06-21 2001-12-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals for use in combination therapy
US20030068319A1 (en) * 2001-03-23 2003-04-10 Menashe Bar-Eli Methods for inhibition of angiogenesis, tumor growth and metastasis by fully human anti-IL8 and anti-MUC18 in diverse types of tumors
US6838074B2 (en) 2001-08-08 2005-01-04 Bristol-Myers Squibb Company Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
DE60226499D1 (de) * 2001-12-28 2008-06-19 Amgen Fremont Inc Verwendung von antikörpern gegen das muc18-antigen
JP2005516965A (ja) * 2001-12-28 2005-06-09 アブジェニックス・インコーポレーテッド 抗ｍｕｃ１８抗体を使用する方法
US20100048728A1 (en) * 2006-08-03 2010-02-25 Hy Biopharma Inc. Polycyclic dianthraquinones as inhibitors of inflammatory cytokines
DK2571507T3 (en) 2010-05-04 2017-04-03 Soligenix Inc Formulations and methods for treating skin conditions
RU2719582C1 (ru) 2016-03-01 2020-04-21 Солидженикс, Инк. Системы и способы для получения синтетического гиперицина

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL79661A (en) 1986-08-08 1991-01-31 Yeda Res & Dev Antiviral composition containing hypericin or pseudohypericin
IL93682A (en) 1989-03-16 1996-06-18 Yeda Res & Dev Polycyclic compounds with antigypical activity are used in the manufacture of medicines and pharmaceutical preparations containing them
JP2735609B2 (ja) * 1989-03-31 1998-04-02 協和醗酵工業株式会社 Ｕｃｎ―１０２８ｄ誘導体
IL92315A (en) 1989-11-15 1996-12-05 Yeda Res & Dev Preparation of Hypericin from Amodin Enron
US5466468A (en) 1990-04-03 1995-11-14 Ciba-Geigy Corporation Parenterally administrable liposome formulation comprising synthetic lipids
US5514714A (en) 1990-08-23 1996-05-07 New York University Methods and polycyclic aromatic compound containing compositions for treating T-cell-mediated diseases
IL104693A0 (en) 1992-02-14 1993-06-10 Yeda Res & Dev Hypericin derivatives and pharmaceutical compositions comprising them
TW235298B (de) 1992-02-27 1994-12-01 Ciba Geigy
JPH08505054A (ja) * 1992-12-23 1996-06-04 アイオア ステート ユニバーシティー リサーチ ファンデーション インコーポレーテッド 分子フラッシュ
US6576784B1 (en) * 1993-05-27 2003-06-10 Yeda Research And Development Co. Ltd. Antiviral agents
US5824654A (en) * 1994-09-02 1998-10-20 New York University Method for delivery of nucleic acids to cells using hypericin polyamine complexes
US5556992A (en) 1994-09-02 1996-09-17 Universite De Montreal Novel rhodamine derivatives for photodynamic therapy of cancer and in vitro purging of the leukemias

Also Published As

Publication number Publication date
US6229048B1 (en) 2001-05-08
DE69813828D1 (de) 2003-05-28
EP1001924B1 (de) 2003-04-23
EP1001924A1 (de) 2000-05-24
CA2298820C (en) 2008-06-03
IL121440A0 (en) 1998-01-04
WO1999006347A1 (en) 1999-02-11
AU8355598A (en) 1999-02-22
CA2298820A1 (en) 1999-02-11
DE69813828T2 (de) 2004-03-04

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties