ATE238285T1 - Pyrimidin-derivate - Google Patents
Pyrimidin-derivateInfo
- Publication number
- ATE238285T1 ATE238285T1 AT95940471T AT95940471T ATE238285T1 AT E238285 T1 ATE238285 T1 AT E238285T1 AT 95940471 T AT95940471 T AT 95940471T AT 95940471 T AT95940471 T AT 95940471T AT E238285 T1 ATE238285 T1 AT E238285T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- derivative
- salt
- present
- pyrimidine derivatives
- Prior art date
Links
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 102000002045 Endothelin Human genes 0.000 abstract 1
- 108050009340 Endothelin Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
- 230000003639 vasoconstrictive effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/69—Benzenesulfonamido-pyrimidines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP32732994 | 1994-12-28 | ||
| JP16945495 | 1995-07-05 | ||
| PCT/JP1995/002605 WO1996020177A1 (en) | 1994-12-28 | 1995-12-19 | Pyrimidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE238285T1 true ATE238285T1 (de) | 2003-05-15 |
Family
ID=26492784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95940471T ATE238285T1 (de) | 1994-12-28 | 1995-12-19 | Pyrimidin-derivate |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6008224A (de) |
| EP (1) | EP0801062B1 (de) |
| CN (1) | CN1171785A (de) |
| AT (1) | ATE238285T1 (de) |
| CA (1) | CA2207100C (de) |
| DE (1) | DE69530516T2 (de) |
| ES (1) | ES2196090T3 (de) |
| FI (1) | FI972795A7 (de) |
| HU (1) | HUT77534A (de) |
| NO (1) | NO973001L (de) |
| PT (1) | PT801062E (de) |
| WO (1) | WO1996020177A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69630799T2 (de) * | 1995-09-06 | 2004-08-12 | Kowa Co., Ltd., Nagoya | Pyrimidinderivate |
| US7566452B1 (en) | 1999-05-04 | 2009-07-28 | New York University | Cancer treatment with endothelin receptor antagonists |
| CA2315614C (en) * | 1999-07-29 | 2004-11-02 | Pfizer Inc. | Pyrazoles |
| MXPA02007192A (es) * | 2000-01-25 | 2002-12-09 | Hoffmann La Roche | Preparacion de sulfonamidas. |
| US6387915B2 (en) | 2000-05-31 | 2002-05-14 | Pfizer Inc. | Isoxazole-sulfonamide endothelin antagonists |
| US6670362B2 (en) | 2000-09-20 | 2003-12-30 | Pfizer Inc. | Pyridazine endothelin antagonists |
| CN112770760A (zh) | 2018-08-14 | 2021-05-07 | 托斯克公司 | 降低辐射诱发的毒性的方法和组合物 |
| CN112789048A (zh) | 2018-08-14 | 2021-05-11 | 托斯克公司 | 用于治疗粘膜炎的方法和组合物 |
| CN112839663A (zh) | 2018-08-14 | 2021-05-25 | 托斯克公司 | 降低氟尿嘧啶诱发的毒性的方法和组合物 |
| US11446303B2 (en) | 2019-06-21 | 2022-09-20 | Tosk, Inc. | Uridine phosphorylase (UPase) inhibitors for treatment of liver conditions |
| IL299703A (en) | 2020-07-07 | 2023-03-01 | Tosk Inc | Uridine phosphorylase inhibitors for the treatment or prevention of lung disease |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2086544C1 (ru) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
| TW394761B (en) * | 1993-06-28 | 2000-06-21 | Hoffmann La Roche | Novel Sulfonylamino Pyrimidines |
| IL111959A (en) * | 1993-12-17 | 2000-07-16 | Tanabe Seiyaku Co | N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them |
| DE69630799T2 (de) | 1995-09-06 | 2004-08-12 | Kowa Co., Ltd., Nagoya | Pyrimidinderivate |
-
1995
- 1995-12-19 PT PT95940471T patent/PT801062E/pt unknown
- 1995-12-19 ES ES95940471T patent/ES2196090T3/es not_active Expired - Lifetime
- 1995-12-19 US US08/849,725 patent/US6008224A/en not_active Expired - Fee Related
- 1995-12-19 WO PCT/JP1995/002605 patent/WO1996020177A1/ja not_active Ceased
- 1995-12-19 CN CN95197129.8A patent/CN1171785A/zh active Pending
- 1995-12-19 AT AT95940471T patent/ATE238285T1/de not_active IP Right Cessation
- 1995-12-19 HU HU9800062A patent/HUT77534A/hu unknown
- 1995-12-19 EP EP95940471A patent/EP0801062B1/de not_active Expired - Lifetime
- 1995-12-19 CA CA002207100A patent/CA2207100C/en not_active Expired - Fee Related
- 1995-12-19 FI FI972795A patent/FI972795A7/fi unknown
- 1995-12-19 DE DE69530516T patent/DE69530516T2/de not_active Expired - Fee Related
-
1997
- 1997-06-27 NO NO973001A patent/NO973001L/no unknown
-
1999
- 1999-11-05 US US09/434,474 patent/US6337334B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NO973001L (no) | 1997-08-27 |
| PT801062E (pt) | 2003-08-29 |
| WO1996020177A1 (en) | 1996-07-04 |
| DE69530516T2 (de) | 2003-12-24 |
| US6008224A (en) | 1999-12-28 |
| CA2207100C (en) | 2008-02-19 |
| EP0801062B1 (de) | 2003-04-23 |
| AU696216B2 (en) | 1998-09-03 |
| HUT77534A (hu) | 1998-05-28 |
| DE69530516D1 (de) | 2003-05-28 |
| AU4190096A (en) | 1996-07-19 |
| FI972795L (fi) | 1997-06-27 |
| EP0801062A1 (de) | 1997-10-15 |
| CA2207100A1 (en) | 1996-07-04 |
| US6337334B1 (en) | 2002-01-08 |
| FI972795A0 (fi) | 1997-06-27 |
| EP0801062A4 (de) | 1998-04-29 |
| ES2196090T3 (es) | 2003-12-16 |
| FI972795A7 (fi) | 1997-06-27 |
| CN1171785A (zh) | 1998-01-28 |
| NO973001D0 (no) | 1997-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |