ATE254607T1 - Pyrimidinderivate - Google Patents

Pyrimidinderivate

Info

Publication number: ATE254607T1
Authority: AT; Austria
Prior art keywords: group; substituent; derivative; salt; lower alkyl
Prior art date: 1995-09-06

Application number

AT96929512T

Other languages

English (en)

Inventor

Mitsuteru Hirata

Takeo Deushi

Yoshio Takahashi

Masahiro Tamura

Takeshi Ohshima

Toshiaki Oda

Tetsuya Ishikawa

Hiroyuki Sonoki

Masami Shiratsuchi

Original Assignee

Kowa Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-06

Filing date

1996-09-04

Publication date

2003-12-15

1996-09-04 Application filed by Kowa Co filed Critical Kowa Co

2003-12-15 Application granted granted Critical

2003-12-15 Publication of ATE254607T1 publication Critical patent/ATE254607T1/de

Links

CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
125000001424 substituent group Chemical group 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
102000002045 Endothelin Human genes 0.000 abstract 1
108050009340 Endothelin Proteins 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
-1 phenyloxy group Chemical group 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
150000003230 pyrimidines Chemical class 0.000 abstract 1
230000003639 vasoconstrictive effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT96929512T 1995-09-06 1996-09-04 Pyrimidinderivate ATE254607T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP22890795		1995-09-06
PCT/JP1996/002494 WO1997009318A1 (en)	1995-09-06	1996-09-04	Pyrimidine derivatives

Publications (1)

Publication Number	Publication Date
ATE254607T1 true ATE254607T1 (de)	2003-12-15

Family

ID=16883731

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96929512T ATE254607T1 (de)	1995-09-06	1996-09-04	Pyrimidinderivate

Country Status (14)

Country	Link
US (1)	US5883092A (de)
EP (1)	EP0852226B1 (de)
KR (1)	KR100453097B1 (de)
CN (1)	CN1105711C (de)
AT (1)	ATE254607T1 (de)
AU (1)	AU703892B2 (de)
CA (1)	CA2230516C (de)
DE (1)	DE69630799T2 (de)
ES (1)	ES2210384T3 (de)
HU (1)	HUP9903526A3 (de)
NO (1)	NO310235B1 (de)
PT (1)	PT852226E (de)
RU (1)	RU2170734C2 (de)
WO (1)	WO1997009318A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT801062E (pt) *	1994-12-28	2003-08-29	Kowa Co	Derivados de pirimidina
EP1066831A4 (de) *	1998-03-31	2002-03-06	Tanabe Seiyaku Co	Prophylaktische/therapeutische mittel für harnerkrankungen
CA2315614C (en) *	1999-07-29	2004-11-02	Pfizer Inc.	Pyrazoles
MXPA02007192A (es) *	2000-01-25	2002-12-09	Hoffmann La Roche	Preparacion de sulfonamidas.
US6387915B2 (en)	2000-05-31	2002-05-14	Pfizer Inc.	Isoxazole-sulfonamide endothelin antagonists
US6670362B2 (en)	2000-09-20	2003-12-30	Pfizer Inc.	Pyridazine endothelin antagonists
EP1507756B1 (de) *	2002-05-24	2015-07-22	Millennium Pharmaceuticals, Inc.	Ccr9-inhibitoren und verfahren zu deren verwendung
WO2011078143A1 (ja) *	2009-12-22	2011-06-30	塩野義製薬株式会社	ピリミジン誘導体およびそれらを含有する医薬組成物
US9682942B2 (en)	2013-05-31	2017-06-20	Kowa Company, Ltd.	Form of pyrimidine compound having dibenzylamine structure

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU751007A1 (ru) *	1979-02-05	1990-11-07	Институт биохимии АН ЛитССР	2- @ N-[4-(3,3-Диметилтриазено)-бензолсульфонил]-амидо @ -4,6-диметилпиримидин, про вл ющий противовоспалительное действие
HU177184B (en) *	1979-05-11	1981-08-28	Chinoin Gyogyszer Es Vegyeszet	Process for producing 2,3- and 3,4-disubstituted-hexahydro-pyrimido-square bracket-1,2-a-square bracket closed-asepines
FI64367C (fi) *	1980-02-26	1986-08-05	Orion Yhtymae Oy	Foerfarande foer framstaellning av alfa-form av prazosinhydroklorid
US4490374A (en) *	1982-09-30	1984-12-25	Ortho Pharmaceutical Corporation	5,6-Dialkoxy-3,4-optionally substituted-2(1H)quinazolinones, composition and method of use
US4612376A (en) *	1983-03-25	1986-09-16	Fujisawa Pharmaceutical Co., Ltd.	Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent
SU1433958A1 (ru) *	1985-07-26	1988-10-30	Институт Органического Синтеза Ан Латвсср	2-Оксо-4-(о-дифторметилтиофенил)-5-метоксикарбонил-6-метил-1,2,3,4-тетрагидропиримидин, обладающий коронарорасшир ющим действием
SU1533693A1 (ru) *	1987-05-14	1990-01-07	1-Й Московский Медицинский Институт Им.И.М.Сеченова	Способ лечени больных инфарктом миокарда
TW270116B (de) *	1991-04-25	1996-02-11	Hoffmann La Roche
RU2086544C1 (ru) *	1991-06-13	1997-08-10	Хоффманн-Ля Рош АГ	Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
DE4128116C1 (de) *	1991-08-24	1993-02-25	Schmidt Reuter Ingenieurgesellschaft Mbh & Partner Kg, 5000 Koeln, De
TW287160B (de) *	1992-12-10	1996-10-01	Hoffmann La Roche
TW394761B (en) *	1993-06-28	2000-06-21	Hoffmann La Roche	Novel Sulfonylamino Pyrimidines
IL111959A (en) *	1993-12-17	2000-07-16	Tanabe Seiyaku Co	N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them
PT801062E (pt) *	1994-12-28	2003-08-29	Kowa Co	Derivados de pirimidina

1996
- 1996-09-04 DE DE69630799T patent/DE69630799T2/de not_active Expired - Lifetime
- 1996-09-04 CN CN96196812A patent/CN1105711C/zh not_active Expired - Fee Related
- 1996-09-04 AT AT96929512T patent/ATE254607T1/de not_active IP Right Cessation
- 1996-09-04 US US09/029,244 patent/US5883092A/en not_active Expired - Fee Related
- 1996-09-04 HU HU9903526A patent/HUP9903526A3/hu unknown
- 1996-09-04 PT PT96929512T patent/PT852226E/pt unknown
- 1996-09-04 RU RU98106104/04A patent/RU2170734C2/ru not_active IP Right Cessation
- 1996-09-04 AU AU68890/96A patent/AU703892B2/en not_active Ceased
- 1996-09-04 KR KR10-1998-0701163A patent/KR100453097B1/ko not_active Expired - Fee Related
- 1996-09-04 CA CA002230516A patent/CA2230516C/en not_active Expired - Fee Related
- 1996-09-04 ES ES96929512T patent/ES2210384T3/es not_active Expired - Lifetime
- 1996-09-04 WO PCT/JP1996/002494 patent/WO1997009318A1/ja not_active Ceased
- 1996-09-04 EP EP96929512A patent/EP0852226B1/de not_active Expired - Lifetime
1998
- 1998-03-05 NO NO19980959A patent/NO310235B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO980959D0 (no)	1998-03-05
HUP9903526A3 (en)	2000-07-28
NO310235B1 (no)	2001-06-11
KR100453097B1 (ko)	2004-12-31
EP0852226A1 (de)	1998-07-08
CA2230516A1 (en)	1997-03-13
HK1016591A1 (en)	1999-11-05
EP0852226B1 (de)	2003-11-19
NO980959L (no)	1998-03-05
US5883092A (en)	1999-03-16
CA2230516C (en)	2008-11-18
DE69630799D1 (en)	2003-12-24
ES2210384T3 (es)	2004-07-01
RU2170734C2 (ru)	2001-07-20
KR19990037684A (ko)	1999-05-25
CN1105711C (zh)	2003-04-16
AU6889096A (en)	1997-03-27
AU703892B2 (en)	1999-04-01
WO1997009318A1 (en)	1997-03-13
HUP9903526A2 (hu)	2000-06-28
EP0852226A4 (de)	1998-09-02
DE69630799T2 (de)	2004-08-12
PT852226E (pt)	2004-03-31
CN1196051A (zh)	1998-10-14

Legal Events

Date	Code	Title	Description
2004-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DK0418845T3 (da)	1995-09-18	Pyrazolderivater, fremgangsmåder til fremstilling deraf og farmaceutisk præparat omfattende samme
DE60017115D1 (de)	2005-02-03	Amid-derivate und deren medizinische verwendung
MX9306831A (es)	1995-01-31	Nuevos compuestos heterociclicos.
BR9812364A (pt)	2000-09-19	Composto, uso do mesmo, composição farmacêutica, derivado de amida, e, processo para a preparação de um derivado de amida ou de um sal farmaceuticamente aceitável ou éster clivável in vivo deste
NO882036D0 (no)	1988-05-10	Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske ketoner.
ATE226574T1 (de)	2002-11-15	4,6-diarylpyrimidin-derivate und deren salze
ES2096073T3 (es)	1997-03-01	Derivado de benzamida.
ATE254607T1 (de)	2003-12-15	Pyrimidinderivate
KR960022486A (ko)	1996-07-18	신규 티아졸리딘-4-온 유도체
ES2011427A4 (es)	1990-01-16	Derivados de oxina de octahidronaftaleno para inhibicion de la sintesis del colesterol, procesos para su preparacion y composiciones que los contienen.
MY141488A (en)	2010-04-30	Hydroximic acid derivatives, processes for their preparation, and compositions comprising them
ATE238285T1 (de)	2003-05-15	Pyrimidin-derivate
DK0882728T3 (da)	2003-01-06	1-methylcarbapenemderivater
EP1252890A4 (de)	2003-05-07	Heilmittel und vorbeugende mittel für verdauungserkrankungen die diaminotrifluoromethylpyridinverbindungen enthalten
ATE342266T1 (de)	2006-11-15	1-methylcarbapenemderivate
ATE504572T1 (de)	2011-04-15	Derivate von aromatische heterocyclen enthaltende integraseinhibitoren
PT1209166E (pt)	2004-06-30	Novos derivados de a-500359
DK0501354T3 (da)	1995-10-16	Antikataraktmiddel
NO20004798L (no)	2000-11-20	Barbitursyrederivat og forebyggende og terapeutisk middel for ben og brusk inneholdende det samme
ATE241985T1 (de)	2003-06-15	Therapeutisches mittel zur behandlung von nierenerkrankungen