ATE238301T1 - Interleukin-5 hemmende 6-azauracil derivate - Google Patents
Interleukin-5 hemmende 6-azauracil derivateInfo
- Publication number
- ATE238301T1 ATE238301T1 AT99947336T AT99947336T ATE238301T1 AT E238301 T1 ATE238301 T1 AT E238301T1 AT 99947336 T AT99947336 T AT 99947336T AT 99947336 T AT99947336 T AT 99947336T AT E238301 T1 ATE238301 T1 AT E238301T1
- Authority
- AT
- Austria
- Prior art keywords
- interleukin
- inhibiting
- azauracil derivatives
- azauracil
- derivatives
- Prior art date
Links
- SSPYSWLZOPCOLO-UHFFFAOYSA-N 6-azauracil Chemical class O=C1C=NNC(=O)N1 SSPYSWLZOPCOLO-UHFFFAOYSA-N 0.000 title 1
- 102000000743 Interleukin-5 Human genes 0.000 title 1
- 108010002616 Interleukin-5 Proteins 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 229940100602 interleukin-5 Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98203148A EP0987265A1 (de) | 1998-09-18 | 1998-09-18 | Interleukin-5 hemmende 6-Azauracil Derivate |
| PCT/EP1999/006776 WO2000017195A1 (en) | 1998-09-18 | 1999-09-14 | Interleukin-5 inhibiting 6-azauracil derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE238301T1 true ATE238301T1 (de) | 2003-05-15 |
Family
ID=8234138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99947336T ATE238301T1 (de) | 1998-09-18 | 1999-09-14 | Interleukin-5 hemmende 6-azauracil derivate |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6894046B2 (de) |
| EP (2) | EP0987265A1 (de) |
| JP (1) | JP2002526495A (de) |
| AR (1) | AR021491A1 (de) |
| AT (1) | ATE238301T1 (de) |
| AU (1) | AU769133B2 (de) |
| CA (1) | CA2344390A1 (de) |
| DE (1) | DE69907233T2 (de) |
| ES (1) | ES2198958T3 (de) |
| WO (1) | WO2000017195A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0987265A1 (de) | 1998-09-18 | 2000-03-22 | Janssen Pharmaceutica N.V. | Interleukin-5 hemmende 6-Azauracil Derivate |
| EA004740B1 (ru) * | 1999-08-06 | 2004-08-26 | Янссен Фармацевтика Н.В. | Интерлейкин-5 ингибирующие производные 6-азаурацила |
| US7183276B2 (en) | 2002-02-28 | 2007-02-27 | Takeda Pharmaceutical Company Limited | Azole compounds |
| EP1758874A1 (de) * | 2004-05-29 | 2007-03-07 | 7TM Pharma A/S | Substituierte thiazolessigsäuren als crth2-liganden |
| AU2011292285A1 (en) * | 2010-08-16 | 2013-01-31 | Boehringer Ingelheim International Gmbh | Oxadiazole inhibitors of leukotriene production |
| EP2633855A1 (de) | 2012-03-01 | 2013-09-04 | Veterinärmedizinische Universität Wien | Proteaseinhibitoren zur Behandlung von Infektionen mit Trichomonas gallinae |
| JP2020100564A (ja) * | 2017-04-03 | 2020-07-02 | 京都薬品工業株式会社 | リードスルー誘導剤およびその医薬用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1244024A (en) | 1984-08-01 | 1988-11-01 | Gustaaf M. Boeckx | .alpha.- ARYL-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN- 2(3H)-YL)BENZENEACETONITRILES |
| US4631278A (en) | 1984-08-01 | 1986-12-23 | Janssen Pharmaceutica N.V. | Anti-protozoal α-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-benzeneacetonitrile derivatives, pharmaceutical compositions, and method of use therefor |
| GB8602342D0 (en) | 1986-01-30 | 1986-03-05 | Janssen Pharmaceutica Nv | 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones |
| DE69615601T2 (de) * | 1995-04-14 | 2002-07-11 | Takeda Schering-Plough Animal Health K.K., Osaka | Verfahren zur Herstellung von Triazinderivate |
| CN1128141C (zh) * | 1996-08-30 | 2003-11-19 | 武田舍林-普劳动物保健株式会社 | 1,2,4－三嗪－3,5－二酮衍生物,其制备和用途 |
| BR9811678A (pt) * | 1997-07-10 | 2000-09-19 | Janssen Pharmaceutica Nv | Derivados de 6-azauracila de inibição de il-5 |
| HRP990333A2 (en) * | 1997-07-10 | 2000-04-30 | Janssen Pharmaceutica Nv | 6-azauracil derivatives as il-5 inhibitors |
| EP0987265A1 (de) | 1998-09-18 | 2000-03-22 | Janssen Pharmaceutica N.V. | Interleukin-5 hemmende 6-Azauracil Derivate |
-
1998
- 1998-09-18 EP EP98203148A patent/EP0987265A1/de not_active Withdrawn
-
1999
- 1999-09-14 EP EP99947336A patent/EP1114046B1/de not_active Expired - Lifetime
- 1999-09-14 AU AU60825/99A patent/AU769133B2/en not_active Ceased
- 1999-09-14 WO PCT/EP1999/006776 patent/WO2000017195A1/en not_active Ceased
- 1999-09-14 CA CA002344390A patent/CA2344390A1/en not_active Abandoned
- 1999-09-14 AT AT99947336T patent/ATE238301T1/de not_active IP Right Cessation
- 1999-09-14 JP JP2000574104A patent/JP2002526495A/ja not_active Withdrawn
- 1999-09-14 ES ES99947336T patent/ES2198958T3/es not_active Expired - Lifetime
- 1999-09-14 DE DE69907233T patent/DE69907233T2/de not_active Expired - Fee Related
- 1999-09-17 AR ARP990104679A patent/AR021491A1/es not_active Application Discontinuation
-
2001
- 2001-03-19 US US09/812,731 patent/US6894046B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1114046A1 (de) | 2001-07-11 |
| ES2198958T3 (es) | 2004-02-01 |
| EP1114046B1 (de) | 2003-04-23 |
| CA2344390A1 (en) | 2000-03-30 |
| WO2000017195A1 (en) | 2000-03-30 |
| US20020010177A1 (en) | 2002-01-24 |
| AR021491A1 (es) | 2002-07-24 |
| DE69907233D1 (de) | 2003-05-28 |
| US6894046B2 (en) | 2005-05-17 |
| AU6082599A (en) | 2000-04-10 |
| JP2002526495A (ja) | 2002-08-20 |
| EP0987265A1 (de) | 2000-03-22 |
| DE69907233T2 (de) | 2004-04-01 |
| AU769133B2 (en) | 2004-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |