ATE238346T1 - Rho-conotoxin peptide mit selektiver antagonistischer aktivität auf den alpha-1- adrenozeptor - Google Patents

Rho-conotoxin peptide mit selektiver antagonistischer aktivität auf den alpha-1- adrenozeptor

Info

Publication number: ATE238346T1
Authority: AT; Austria
Prior art keywords: adrenoceptor; alpha; rho; antagonistic activity; conotoxin peptides
Prior art date: 1998-10-02

Application number

AT99950405T

Other languages

English (en)

Inventor

Richard James Lewis

Paul Francis Alewood

Iain Andrew Sharpe

Original Assignee

Univ Queensland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-02

Filing date

1999-10-01

Publication date

2003-05-15

1999-10-01 Application filed by Univ Queensland filed Critical Univ Queensland

2003-05-15 Application granted granted Critical

2003-05-15 Publication of ATE238346T1 publication Critical patent/ATE238346T1/de

Links

108020004102 alpha-1 Adrenergic Receptor Proteins 0.000 title abstract 3
102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
102000030619 alpha-1 Adrenergic Receptor Human genes 0.000 title 1
230000003042 antagnostic effect Effects 0.000 title 1
239000000556 agonist Substances 0.000 abstract 3
SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 abstract 2
102000015009 alpha1-adrenergic receptor activity proteins Human genes 0.000 abstract 2
230000002401 inhibitory effect Effects 0.000 abstract 2
229960002748 norepinephrine Drugs 0.000 abstract 2
SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 abstract 2
239000005557 antagonist Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Tropical Medicine & Parasitology (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

AT99950405T 1998-10-02 1999-10-01 Rho-conotoxin peptide mit selektiver antagonistischer aktivität auf den alpha-1- adrenozeptor ATE238346T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AUPP6273A AUPP627398A0 (en)	1998-10-02	1998-10-02	Novel peptides - II
PCT/AU1999/000843 WO2000020443A1 (en)	1998-10-02	1999-10-01	Novel peptides

Publications (1)

Publication Number	Publication Date
ATE238346T1 true ATE238346T1 (de)	2003-05-15

Family

ID=3810491

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99950405T ATE238346T1 (de)	1998-10-02	1999-10-01	Rho-conotoxin peptide mit selektiver antagonistischer aktivität auf den alpha-1- adrenozeptor

Country Status (10)

Country	Link
US (1)	US6849601B1 (de)
EP (1)	EP1117681B1 (de)
JP (1)	JP4512273B2 (de)
AT (1)	ATE238346T1 (de)
AU (1)	AUPP627398A0 (de)
CA (1)	CA2344551A1 (de)
DE (1)	DE69907239T2 (de)
ES (1)	ES2200558T3 (de)
NZ (1)	NZ510812A (de)
WO (1)	WO2000020443A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0612669D0 (en) *	2006-06-27	2006-08-09	Univ Leeds	Biomarkers for preeclampsia
WO2016191200A1 (en) *	2015-05-22	2016-12-01	Clemson University	Conotoxin peptides for use in biofouling deterrence
CN110981967B (zh) *	2019-11-22	2022-10-14	中国海洋大学	α-芋螺毒素Mr1.1的二聚体、合成方法及应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5514774A (en)	1993-06-29	1996-05-07	University Of Utah Research Foundation	Conotoxin peptides
US5780433A (en)	1996-12-06	1998-07-14	University Of Utah Research Foundation	Use of α-conotoxin MII to treat disorders resulting from nicotine stimulated dopamine release
EP1032588A4 (de)	1997-10-24	2001-11-28	Univ Utah Res Found	Wechselwirkung von alpha-conotoxinpeptiden mit neuronalen nikotinischen acetylcholin rezeptoren
WO1999033482A1 (en)	1997-12-31	1999-07-08	University Of Utah Research Foundation	Uses of alpha-conotoxin peptides

1998
- 1998-10-02 AU AUPP6273A patent/AUPP627398A0/en not_active Abandoned
1999
- 1999-10-01 AT AT99950405T patent/ATE238346T1/de not_active IP Right Cessation
- 1999-10-01 NZ NZ510812A patent/NZ510812A/xx not_active IP Right Cessation
- 1999-10-01 ES ES99950405T patent/ES2200558T3/es not_active Expired - Lifetime
- 1999-10-01 DE DE69907239T patent/DE69907239T2/de not_active Expired - Lifetime
- 1999-10-01 WO PCT/AU1999/000843 patent/WO2000020443A1/en not_active Ceased
- 1999-10-01 CA CA002344551A patent/CA2344551A1/en not_active Abandoned
- 1999-10-01 US US09/806,376 patent/US6849601B1/en not_active Expired - Fee Related
- 1999-10-01 JP JP2000574554A patent/JP4512273B2/ja not_active Expired - Fee Related
- 1999-10-01 EP EP99950405A patent/EP1117681B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP1117681B1 (de)	2003-04-23
DE69907239T2 (de)	2004-04-01
AUPP627398A0 (en)	1998-10-22
ES2200558T3 (es)	2004-03-01
JP4512273B2 (ja)	2010-07-28
WO2000020443A1 (en)	2000-04-13
NZ510812A (en)	2004-02-27
US6849601B1 (en)	2005-02-01
EP1117681A4 (de)	2002-01-02
CA2344551A1 (en)	2000-04-13
JP2002526097A (ja)	2002-08-20
DE69907239D1 (de)	2003-05-28
EP1117681A1 (de)	2001-07-25

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Legal Events

Date	Code	Title	Description
2003-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties