ATE238429T1 - Enzymatisches verfahren zur herstellung von ascorbinsäure,2-keto-l-gulonsäure und 2-keto-l- gulonsäure-estern - Google Patents

Enzymatisches verfahren zur herstellung von ascorbinsäure,2-keto-l-gulonsäure und 2-keto-l- gulonsäure-estern

Info

Publication number: ATE238429T1
Authority: AT; Austria
Prior art keywords: keto; gulonic acid; acid; gulonic; enzymatic process
Prior art date: 1996-05-17

Application number

AT97925690T

Other languages

English (en)

Inventor

John Clark Hubbs

Original Assignee

Eastman Chem Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-17

Filing date

1997-05-16

Publication date

2003-05-15

1997-05-16 Application filed by Eastman Chem Co filed Critical Eastman Chem Co

2003-05-15 Application granted granted Critical

2003-05-15 Publication of ATE238429T1 publication Critical patent/ATE238429T1/de

Links

VBUYCZFBVCCYFD-NUNKFHFFSA-N 2-dehydro-L-idonic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)C(=O)C(O)=O VBUYCZFBVCCYFD-NUNKFHFFSA-N 0.000 title abstract 4
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 title abstract 4
VBUYCZFBVCCYFD-UHFFFAOYSA-N D-arabino-2-Hexulosonic acid Natural products OCC(O)C(O)C(O)C(=O)C(O)=O VBUYCZFBVCCYFD-UHFFFAOYSA-N 0.000 title abstract 3
229960005070 ascorbic acid Drugs 0.000 title abstract 2
235000010323 ascorbic acid Nutrition 0.000 title abstract 2
239000011668 ascorbic acid Substances 0.000 title abstract 2
230000002255 enzymatic effect Effects 0.000 title 1
108700023418 Amidases Proteins 0.000 abstract 1
108090000371 Esterases Proteins 0.000 abstract 1
108090000604 Hydrolases Proteins 0.000 abstract 1
102000004157 Hydrolases Human genes 0.000 abstract 1
108090001060 Lipase Proteins 0.000 abstract 1
239000004367 Lipase Substances 0.000 abstract 1
102000004882 Lipase Human genes 0.000 abstract 1
108091005804 Peptidases Proteins 0.000 abstract 1
239000004365 Protease Substances 0.000 abstract 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
102000005922 amidase Human genes 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
235000019421 lipase Nutrition 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/58—Aldonic, ketoaldonic or saccharic acids
- C12P7/60—2-Ketogulonic acid
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/832—Bacillus
- Y10S435/836—Bacillus licheniformis
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/847—Erwinia
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/913—Aspergillus
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/921—Candida
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/933—Penicillium

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Furan Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT97925690T 1996-05-17 1997-05-16 Enzymatisches verfahren zur herstellung von ascorbinsäure,2-keto-l-gulonsäure und 2-keto-l- gulonsäure-estern ATE238429T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US1787996P	1996-05-17	1996-05-17
US08/845,295 US5817490A (en)	1996-05-17	1997-04-25	Enzymatic process for the manufacture of ascorbic acid 2-keto-L-gulonic acid and esters of 2-keto-L-gulonic acid
PCT/US1997/008668 WO1997043433A1 (en)	1996-05-17	1997-05-16	Enzymatic process for the manufacture of ascorbic acid, 2-keto-l-gulonic acid and esters of 2-keto-l-gulonic acid

Publications (1)

Publication Number	Publication Date
ATE238429T1 true ATE238429T1 (de)	2003-05-15

Family

ID=26690448

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97925690T ATE238429T1 (de)	1996-05-17	1997-05-16	Enzymatisches verfahren zur herstellung von ascorbinsäure,2-keto-l-gulonsäure und 2-keto-l- gulonsäure-estern

Country Status (10)

Country	Link
US (4)	US5817490A (de)
EP (1)	EP0938582B1 (de)
JP (1)	JP3759621B2 (de)
CN (3)	CN1181206C (de)
AT (1)	ATE238429T1 (de)
AU (1)	AU3075697A (de)
BR (1)	BR9709099A (de)
DE (1)	DE69721292T2 (de)
MY (1)	MY134224A (de)
WO (1)	WO1997043433A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5817490A (en) *	1996-05-17	1998-10-06	Eastman Chemical Company	Enzymatic process for the manufacture of ascorbic acid 2-keto-L-gulonic acid and esters of 2-keto-L-gulonic acid
ATE323172T1 (de) *	1999-01-18	2006-04-15	Dsm Ip Assets Bv	Herstellung von l-ascorbinsäure und d- erythorbinsäure
EP1026257B1 (de) *	1999-01-18	2006-04-12	DSM IP Assets B.V.	Herstellung von L-Ascorbinsäure und D-Erythorbinsäure
DE19938980A1 (de) *	1999-08-19	2001-02-22	Basf Ag	Verfahren zur Herstellung von 2-Keto-L-gulonsäureestern
US6720168B2 (en)	2000-08-04	2004-04-13	Genencor International, Inc.	2,5-DKG permeases
EP1305422B1 (de) *	2000-08-04	2011-05-18	Microgenomics, Inc.	2,5-dkg-permeasen
AU781277B2 (en) *	2000-08-23	2005-05-12	Dsm Ip Assets B.V.	Microbial production of L-ascorbic acid and D-erythorbic acid
EP1182262A1 (de) *	2000-08-23	2002-02-27	Roche Vitamins AG	Mikrobielle Herstellung von L-Ascorbinsäure und D-Erythorbinsäure
US6642035B2 (en) *	2001-01-26	2003-11-04	The Scripps Research Institute	Synthesis of B-keto esters
US20070298474A1 (en) *	2001-08-03	2007-12-27	Manoj Kumar	Enhanced 2-Keto-L-Gulonic acid production
US7229811B2 (en) *	2001-08-03	2007-06-12	Genencor International, Inc.	2,5-diketo-D-gluconic acid (2,5-DKG) permeases
CN1318600C (zh) *	2001-11-09	2007-05-30	Dsmip资产有限公司	生产l－抗坏血酸和d－异抗坏血酸的酶方法
AU2003293666A1 (en) *	2002-11-11	2004-06-03	Basf Aktiengesellschaft	Method for the production of 2-keto-l-gulonic acid-c4-c10 alkyl esters
BRPI0608223A2 (pt) *	2005-02-11	2009-11-24	Dsm Ip Assets Bv	gene sms 05
AT502990A1 (de) *	2005-12-27	2007-07-15	Dsm Fine Chem Austria Gmbh	Neues polypeptid mit esteraseaktivität, und rekombinante esterase sowie deren verwendung
WO2007109247A2 (en) *	2006-03-20	2007-09-27	Duramed Pharmaceuticals, Inc.	Flexible, compressed intravaginal rings, methods of making and using the same, and apparatus for making the same
JP5438259B2 (ja) *	2006-04-13	2014-03-12	Ｂｉｏ−ｅｎｅｒｇｙ株式会社	カンジダ・アンタークティカ由来リパーゼｂを細胞表層に提示する酵母
US8765425B2 (en)	2011-03-23	2014-07-01	Butamax Advanced Biofuels Llc	In situ expression of lipase for enzymatic production of alcohol esters during fermentation
US8759044B2 (en)	2011-03-23	2014-06-24	Butamax Advanced Biofuels Llc	In situ expression of lipase for enzymatic production of alcohol esters during fermentation
US20140017741A1 (en) *	2011-03-30	2014-01-16	Novozymes A/S	Esterification Process
CN103344719B (zh) *	2013-06-27	2015-04-15	东北制药集团股份有限公司	一种可同时检测古龙酸、古龙酸甲酯、甲醇和乙醇的高效液相方法
CN111377543A (zh) *	2018-12-27	2020-07-07	南京百斯杰生物工程有限公司	脂肪酶在降低黄水酸度中的应用
KR102357426B1 (ko) *	2019-12-10	2022-01-28	건국대학교 산학협력단	신규 에스터 가수분해효소를 이용한 베타 아미노산의 효소적 생산방법
CN119876086B (zh) *	2025-01-08	2026-07-14	浙江工业大学	一种脂肪酶突变体及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES135896A1 (es) *	1933-10-25	1934-12-16	Hoffmann La Roche	PROCEDIMIENTO PARA LA FABRICACIoN DEL áCIDO 2-CETO-1-GULoNICO
GB466548A (en) *	1935-11-26	1937-05-31	Tadeus Reichstein	Process for the manufacture of laevo-ascorbic acid (vitamin-c)
US4760025A (en) *	1984-05-29	1988-07-26	Genencor, Inc.	Modified enzymes and methods for making same
US4595659A (en) *	1983-10-20	1986-06-17	Kraft, Inc.	Fermentation production of ascorbic acid from L-galactonic substrate
US5008193A (en) *	1984-06-14	1991-04-16	Genentech, Inc.	Ascorbic acid intermediates and process enzymes
US5001059A (en) *	1985-07-01	1991-03-19	Bio-Technical Resources, Inc.	L-ascorbic acid production in microorganisms
CN86105960A (zh) *	1985-08-09	1987-05-13	鲁布里佐尔公司	在基本无水条件下从2-酮-l-古洛糖酸制备l-抗坏血酸
US5079153A (en) *	1989-06-03	1992-01-07	Mitsubishi Rayon Co., Ltd.	Process for the preparation of organic esters of ascorbic acid or erythorbic acid using ester hydralases in organic solvents containing 100-10,000 ppm of water
JPH04141093A (ja) *	1990-10-03	1992-05-14	Mitsubishi Rayon Co Ltd	有機酸エステルの製造法
JPH04335893A (ja) *	1991-05-07	1992-11-24	Mitsubishi Rayon Co Ltd	固定化酵素を用いるエステル合成方法
EP0514694B1 (de) *	1991-05-18	1997-07-23	Mitsubishi Rayon Co., Ltd	Verfahren zur Herstellung von Ascorbinsäure-Estern oder Erythorbinsäure-Estern
JPH061783A (ja) *	1992-06-17	1994-01-11	Mitsubishi Rayon Co Ltd	有機酸エステルの製造法
US5817490A (en) *	1996-05-17	1998-10-06	Eastman Chemical Company	Enzymatic process for the manufacture of ascorbic acid 2-keto-L-gulonic acid and esters of 2-keto-L-gulonic acid

1997
- 1997-04-25 US US08/845,295 patent/US5817490A/en not_active Expired - Lifetime
- 1997-05-15 MY MYPI97002120A patent/MY134224A/en unknown
- 1997-05-16 CN CNB021199671A patent/CN1181206C/zh not_active Expired - Fee Related
- 1997-05-16 BR BR9709099A patent/BR9709099A/pt not_active Application Discontinuation
- 1997-05-16 EP EP97925690A patent/EP0938582B1/de not_active Expired - Lifetime
- 1997-05-16 JP JP54120797A patent/JP3759621B2/ja not_active Expired - Fee Related
- 1997-05-16 CN CN97196510A patent/CN1113100C/zh not_active Expired - Fee Related
- 1997-05-16 WO PCT/US1997/008668 patent/WO1997043433A1/en not_active Ceased
- 1997-05-16 AT AT97925690T patent/ATE238429T1/de not_active IP Right Cessation
- 1997-05-16 CN CNB021199698A patent/CN1182250C/zh not_active Expired - Fee Related
- 1997-05-16 AU AU30756/97A patent/AU3075697A/en not_active Abandoned
- 1997-05-16 DE DE69721292T patent/DE69721292T2/de not_active Expired - Fee Related
1998
- 1998-08-27 US US09/140,933 patent/US6022719A/en not_active Expired - Fee Related
- 1998-09-03 US US09/146,661 patent/US6136575A/en not_active Expired - Fee Related
- 1998-09-09 US US09/150,515 patent/US6271006B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2001505042A (ja)	2001-04-17
CN1225686A (zh)	1999-08-11
US6271006B1 (en)	2001-08-07
US5817490A (en)	1998-10-06
CN1412315A (zh)	2003-04-23
AU3075697A (en)	1997-12-05
EP0938582A1 (de)	1999-09-01
CN1412316A (zh)	2003-04-23
BR9709099A (pt)	1999-08-03
MY134224A (en)	2007-11-30
CN1182250C (zh)	2004-12-29
DE69721292D1 (de)	2003-05-28
CN1181206C (zh)	2004-12-22
JP3759621B2 (ja)	2006-03-29
US6022719A (en)	2000-02-08
WO1997043433A1 (en)	1997-11-20
CN1113100C (zh)	2003-07-02
DE69721292T2 (de)	2003-11-13
US6136575A (en)	2000-10-24
EP0938582B1 (de)	2003-04-23

Legal Events

Date	Code	Title	Description
2003-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69721292D1 (de)	2003-05-28	Enzymatisches verfahren zur herstellung von ascorbinsäure,2-keto-l-gulonsäure und 2-keto-l-gulonsäure-estern
DE68925002D1 (de)	1996-01-18	Verfahren zur Herstellung von optisch-aktiven alpha-substituierten organischen Säuren und Mikroorganismen und Enzyme, die dafür verwendet werden.
DE3750982D1 (de)	1995-02-23	Positionsmässig nicht spezifische lipase von candida-arten; verfahren für ihre herstellung und ihre verwendung.
WO1997040141A3 (en)	1998-01-08	Isolation of enzymes
DE69110952D1 (de)	1995-08-10	Penicillin-G-Acylase, dafür kodierendes Gen und Verfahren zur Herstellung von diesem Enzym.
DE69508987D1 (de)	1999-05-20	Enzymatische Hydrolyse zur Umwandlung von C7-Zucker in C-7-Hydroxyl-Taxanen
ATE219039T1 (de)	2002-06-15	Verfahren zur herstellung von tetrahydrofuran, gammabutyrolacton un butandiol
ATE103637T1 (de)	1994-04-15	Verfahren zur herstellung von fokirestriktionsendonuklease und -methylase.
DE69425801D1 (de)	2000-10-12	Enzymatisches Hydroxylierungsverfahren zur Herstellung von HMG-CoA-Reduktaseinhibitoren und Intermediate hiervon
DE68906904D1 (de)	1993-07-15	Verfahren zur herstellung von optisch aktiven 2-arylalkansaeuren.
BR9204797A (pt)	1993-08-03	Processo de caleira e mordentagem enzimaticamente apoiados
ATE283348T1 (de)	2004-12-15	Verfahren zur herstellung von aminoalkoholen und derivaten davon
EP0896057A3 (de)	2000-06-28	D-Aminoacylase
HUT59727A (en)	1992-06-29	Improved enzymatic oxidizing process for producing glutaryl-7-amino-cephalosporanic acid from cephalosporin c
UA48953C2 (uk)	2002-09-16	СПОСІБ ОДЕРЖАННЯ <font face="Symbol">a</font>-ЗАМІЩЕНИХ РАЦЕМІЧНИХ 4-МЕТИЛТІО-БУТАНОВИХ КИСЛОТ
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DE69901388D1 (de)	2002-06-06	Verfahren zur herstellung von zwischenprodukten für synthese
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ATE360087T1 (de)	2007-05-15	Verfahren zur racematspaltung von arylalkylcarbonsäureestern
AR007181A1 (es)	1999-10-13	Proceso enzimatico para la fabricacion de acido ascorbico, acido 2-ceto- l-gulonico y esteres de acido 2-ceto-l-gulonico
ATE239695T1 (de)	2003-05-15	Stereoselektive verfahren zur herstellung von gabapentinanalogen
ATE275193T1 (de)	2004-09-15	Gereinigte säurestabile alpha-amylase von schimmeliger herkunft
ATE103325T1 (de)	1994-04-15	Verfahren zur steigerung von enzym-aktivitaeten und der syntheseleistung von mikroorganismen und hoeheren pflanzen.
ATE4326T1 (de)	1983-08-15	Verfahren zur gewinnung von cholesterinesterase.
DE50204211D1 (de)	2005-10-20	Verfahren zur enzymatischen Herstellung von enantiomerenreinen 1,3-Dioxolan-4-on- und 1,3-Oxathiolan-5-on-Derivaten