ATE238771T1 - Herstellungsverfahren von löslichen verabreichungssystemen unter verwendung von flüchtigen salzen - Google Patents

Herstellungsverfahren von löslichen verabreichungssystemen unter verwendung von flüchtigen salzen

Info

Publication number
ATE238771T1
ATE238771T1 AT97904515T AT97904515T ATE238771T1 AT E238771 T1 ATE238771 T1 AT E238771T1 AT 97904515 T AT97904515 T AT 97904515T AT 97904515 T AT97904515 T AT 97904515T AT E238771 T1 ATE238771 T1 AT E238771T1
Authority
AT
Austria
Prior art keywords
tablets
production
distribution systems
volatile salts
soluble
Prior art date
Application number
AT97904515T
Other languages
English (en)
Inventor
Bruce Joseph Roser
Julian Blair
Original Assignee
Elan Drug Delivery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Drug Delivery Ltd filed Critical Elan Drug Delivery Ltd
Application granted granted Critical
Publication of ATE238771T1 publication Critical patent/ATE238771T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2095Tabletting processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fats And Perfumes (AREA)
AT97904515T 1996-02-09 1997-02-10 Herstellungsverfahren von löslichen verabreichungssystemen unter verwendung von flüchtigen salzen ATE238771T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/599,277 US5762961A (en) 1996-02-09 1996-02-09 Rapidly soluble oral solid dosage forms, methods of making same, and compositions thereof
PCT/GB1997/000368 WO1997028789A1 (en) 1996-02-09 1997-02-10 Process to prepare soluble delivery systems using volatile salts

Publications (1)

Publication Number Publication Date
ATE238771T1 true ATE238771T1 (de) 2003-05-15

Family

ID=24398981

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97904515T ATE238771T1 (de) 1996-02-09 1997-02-10 Herstellungsverfahren von löslichen verabreichungssystemen unter verwendung von flüchtigen salzen

Country Status (7)

Country Link
US (1) US5762961A (de)
EP (1) EP0879049B1 (de)
JP (1) JP2000505429A (de)
AT (1) ATE238771T1 (de)
AU (1) AU1729397A (de)
DE (1) DE69721489T2 (de)
WO (1) WO1997028789A1 (de)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6509146B1 (en) * 1996-05-29 2003-01-21 Universal Preservation Technologies, Inc. Scalable long-term shelf preservation of sensitive biological solutions and suspensions
AU3214597A (en) * 1996-05-29 1998-01-05 Universal Preservation Technologies, Inc. Long-term shelf preservation by vitrification
US8071128B2 (en) 1996-06-14 2011-12-06 Kyowa Hakko Kirin Co., Ltd. Intrabuccally rapidly disintegrating tablet and a production method of the tablets
GB9705588D0 (en) 1997-03-18 1997-05-07 Anglia Research Foundation Stable particle in liquid formulations
US6423345B2 (en) 1998-04-30 2002-07-23 Acusphere, Inc. Matrices formed of polymer and hydrophobic compounds for use in drug delivery
US6730322B1 (en) 1998-04-30 2004-05-04 Acusphere, Inc. Matrices formed of polymer and hydrophobic compounds for use in drug delivery
SE9803240D0 (sv) * 1998-09-24 1998-09-24 Diabact Ab A pharmaceutical composition having a rapid action
EP1128817A1 (de) * 1998-10-27 2001-09-05 Biovail Technologies Ltd Mikropartikel enthaltend peg und/oder peg glycerylestern
US7815937B2 (en) * 1998-10-27 2010-10-19 Biovail Laboratories International Srl Quick dissolve compositions and tablets based thereon
GB9904049D0 (en) * 1999-02-22 1999-04-14 Quadrant Holdings Cambridge Rapidly-soluble compositions
AU3957400A (en) 1999-04-16 2000-11-02 Novo Nordisk A/S Dry, mouldable drug formulation
GB9910505D0 (en) 1999-05-06 1999-07-07 Electrosols Ltd A method and apparatus for manufacturing consumable tablets
GB2350046B (en) * 1999-05-20 2002-12-18 British Sugar Plc Edible compositions containing trehalose
US6395300B1 (en) 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
KR100883477B1 (ko) * 1999-05-27 2009-02-16 아쿠스피어 인코포레이티드. 다공성 약물 매트릭스의 약제 조성물
US6610317B2 (en) 1999-05-27 2003-08-26 Acusphere, Inc. Porous paclitaxel matrices and methods of manufacture thereof
US7919119B2 (en) * 1999-05-27 2011-04-05 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
JP4903334B2 (ja) 1999-10-13 2012-03-28 ノヴォ ノルディスク アー/エス 細長の剤形を製造する方法
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
US7678387B2 (en) * 2000-06-06 2010-03-16 Capricorn Pharma, Inc. Drug delivery systems
US20100196466A1 (en) * 2000-06-06 2010-08-05 Capricorn Pharma Inc. Drug delivery system
US20070059367A1 (en) * 2000-06-06 2007-03-15 Cherukuri S R Drug Delivery System and Associated Methods
EP1313425B1 (de) * 2000-07-14 2007-03-07 Novo Nordisk A/S Verfahren zum formen einer pharmazeutischen zusammensetzung in einem verpackungsmaterial
JP5007417B2 (ja) * 2000-09-19 2012-08-22 株式会社林原 会合物形成剤
US7799342B2 (en) * 2000-12-06 2010-09-21 Wyeth Llc Fast dissolving tablet
US6733781B2 (en) 2000-12-06 2004-05-11 Wyeth Fast dissolving tablet
US6544552B2 (en) 2001-01-11 2003-04-08 Particle And Coating Technologies, Inc. Method of producing porous tablets with improved dissolution properties
MXPA03007081A (es) * 2001-02-08 2004-10-15 Pharmacia Corp Medicamento de accion rapida para el tratamiento de disfuncion sexual.
CA2440770C (en) * 2001-03-22 2010-07-13 Battelle Memorial Institute Manufacturing dissolvable dosage forms
JP4340151B2 (ja) * 2001-08-10 2009-10-07 株式会社林原生物化学研究所 トレハロース又はマルチトールと金属イオン化合物との会合物
CA2461042A1 (en) * 2001-09-25 2003-04-03 Ashish Madan Process for the preparation of fast dissolving dosage form
US9358214B2 (en) * 2001-10-04 2016-06-07 Adare Pharmaceuticals, Inc. Timed, sustained release systems for propranolol
WO2003041637A2 (en) * 2001-11-09 2003-05-22 Centocor, Inc. Lyophilized monoclonal antibody compositions
US8454997B2 (en) 2001-12-18 2013-06-04 Novo Nordisk A/S Solid dose micro implant
US20030017208A1 (en) * 2002-07-19 2003-01-23 Francis Ignatious Electrospun pharmaceutical compositions
WO2004032853A2 (en) * 2002-10-04 2004-04-22 Pharmacia Corporation Compositions and methods for treating sexual dysfunction
WO2004047810A1 (en) * 2002-11-25 2004-06-10 Purdue Research Foundation Mannose-based fast dissolving tablets
MXPA05005528A (es) * 2002-11-26 2006-04-05 Alk Abello As Producto farmaceutico de alergeno.
US8367111B2 (en) * 2002-12-31 2013-02-05 Aptalis Pharmatech, Inc. Extended release dosage forms of propranolol hydrochloride
AU2004238321B2 (en) * 2003-05-07 2009-08-27 Samyang Biopharmaceuticals Corporation Highly plastic granules for making fast melting tablets
RS51934B (sr) * 2003-08-08 2012-02-29 Biovail Laboratories International Srl. Tableta bupropion hidrohlorida sa modifikovanim otpuštanjem
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
US7282217B1 (en) 2003-08-29 2007-10-16 Kv Pharmaceutical Company Rapidly disintegrable tablets
GB0320854D0 (en) * 2003-09-05 2003-10-08 Arrow No 7 Ltd Buccal drug delivery
US7507396B2 (en) * 2003-10-17 2009-03-24 Amerilab Technologies, Inc. Effervescent composition and method of making an effervescent composition including a viscous component
EP1750760B1 (de) 2004-06-02 2017-06-28 Universal Stabilization Technologies, Inc. Konservierung mittels verdampfung
US8747895B2 (en) 2004-09-13 2014-06-10 Aptalis Pharmatech, Inc. Orally disintegrating tablets of atomoxetine
US9884014B2 (en) 2004-10-12 2018-02-06 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions
NZ589750A (en) 2004-10-21 2012-07-27 Aptalis Pharmatech Inc Taste-masked pharmaceutical compositions with gastrosoluble pore-formers
US20060105038A1 (en) * 2004-11-12 2006-05-18 Eurand Pharmaceuticals Limited Taste-masked pharmaceutical compositions prepared by coacervation
ITMI20042356A1 (it) * 2004-12-10 2005-03-10 Acraf Composizione farmaceutica orodisperdibile e procedimento per prepararla
US20060134036A1 (en) * 2004-12-20 2006-06-22 Scancarella Neil D Antiperspirant/deodorant compositions and methods
WO2006115770A2 (en) * 2005-04-22 2006-11-02 Teva Pharmaceuticals Usa, Inc. Orally disintegrating pharmaceutical tablet formulations of olanzapine
US9161918B2 (en) 2005-05-02 2015-10-20 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
GB0516604D0 (en) * 2005-08-12 2005-09-21 Sandoz Ag Rapidly dispersing/disintegrating compositions
GB0517688D0 (en) * 2005-08-31 2005-10-05 Cambridge Biostability Ltd Improvements in the stabilisation of biological materials
US20080305168A1 (en) * 2006-02-10 2008-12-11 Kyo-Tae Moon In-Situ Melting and Gelling Tablet Composition For Oral Care
US7826288B2 (en) * 2007-03-09 2010-11-02 International Business Machines Corporation Device threshold calibration through state dependent burn-in
US20080260823A1 (en) * 2007-04-20 2008-10-23 Sciele Pharma, Inc. Orally disintegrating tablet comprising glycopyrrolate for treating sialorrhea
DE102008047910A1 (de) 2008-09-19 2010-03-25 Molkerei Meggle Wasserburg Gmbh & Co. Kg Tablettierhilfsstoff auf Laktose- und Cellulosebasis
SG10201407965XA (en) 2009-12-02 2015-02-27 Aptalis Pharma Ltd Fexofenadine microcapsules and compositions containing them
US20110212171A1 (en) * 2010-01-08 2011-09-01 Eurand, Inc. Taste masked topiramate composition and an orally disintegrating tablet comprising the same
JP6195848B2 (ja) 2012-01-27 2017-09-13 ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、カリフォルニアThe Regents Of The University Of California 糖ポリマーを用いた生体分子の安定化
WO2015160595A1 (en) 2014-04-14 2015-10-22 Abbott Molecular, Inc. Medium used for blood sample collection and transport
CN116832004A (zh) * 2023-07-28 2023-10-03 安徽贝克生物制药有限公司 一种奈玛特韦、利托那韦复方片及其制备方法

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3557717A (en) * 1968-05-17 1971-01-26 Gen Mills Inc Process for making candy floss
US3619294A (en) * 1968-07-15 1971-11-09 Penick & Ford Ltd Method of combining crystalline sugar with impregnating agents and products produced thereby
US3632357A (en) * 1969-07-29 1972-01-04 Standard Brands Inc Method of producing hard candy
US3655442A (en) * 1969-08-27 1972-04-11 California & Hawaiian Sugar Method of making sugar and sugar products
DE2246013A1 (de) * 1972-09-20 1974-03-28 Boehringer Mannheim Gmbh Verfahren zur herstellung von poroesen tabletten
US4127502A (en) * 1977-06-10 1978-11-28 Eastman Kodak Company Stabilizers for reconstituted, lyophilized samples
US4158544A (en) * 1978-07-17 1979-06-19 Beckman Instruments, Inc. Process for preparing a biological composition for use as a reference control in diagnostic analysis
US4588744A (en) * 1978-09-19 1986-05-13 Mchugh John E Method of forming an aqueous solution of 3-3-Bis(p-hydroxyphenyl)-phthalide
US4327076A (en) * 1980-11-17 1982-04-27 Life Savers, Inc. Compressed chewable antacid tablet and method for forming same
US4327077A (en) * 1981-05-29 1982-04-27 Life Savers, Inc. Compressed chewable antacid tablet and method for forming same
JPS58216695A (ja) * 1982-06-07 1983-12-16 Otsuka Shokuhin Kogyo Kk トレハロ−スの製造方法
US4883762A (en) * 1983-06-06 1989-11-28 Ciba Corning Diagnostics Corp. Stabilized isoenzyme control products
US4865871A (en) * 1983-08-23 1989-09-12 Board Of Regents The University Of Texas System Method for cryopreparing biological tissue
WO1987000196A1 (en) * 1985-07-09 1987-01-15 Quadrant Bioresources Limited Protection of proteins and the like
DE3445010A1 (de) * 1984-12-10 1986-06-19 Boehringer Mannheim Gmbh Kontroll- bzw. eichserum fuer die lipid-diagnostik
US4678812A (en) * 1986-05-30 1987-07-07 E. I. Du Pont De Nemours And Company Trehalose as stabilizer and tableting excipient
US4762857A (en) * 1986-05-30 1988-08-09 E. I. Du Pont De Nemours And Company Trehalose as stabilizer and tableting excipient
GB8715238D0 (en) * 1987-06-29 1987-08-05 Quadrant Bioresources Ltd Food process
GB8801338D0 (en) * 1988-01-21 1988-02-17 Quadrant Bioresources Ltd Preservation of viruses
US5045446A (en) * 1988-08-26 1991-09-03 Cryopharm Corporation Lyophilization of cells
US5112616A (en) * 1988-11-30 1992-05-12 Schering Corporation Fast dissolving buccal tablet
GB8917470D0 (en) * 1989-07-31 1989-09-13 Quadrant Bioresources Ltd Composition and method
IT1246350B (it) * 1990-07-11 1994-11-17 Eurand Int Metodo per ottenere una rapida sospensione in acqua di farmaci insolubili
WO1992002133A1 (en) * 1990-08-10 1992-02-20 Analytical Control Systems, Inc. Improved diagnostic and therapeutic compositions
US5200399A (en) * 1990-09-14 1993-04-06 Boyce Thompson Institute For Plant Research, Inc. Method of protecting biological materials from destructive reactions in the dry state
ATE126115T1 (de) * 1991-07-31 1995-08-15 Blatter Farros Ag Schleifgerät zum schleifen einer zylindrischen oder sphärischen oberfläche einer walze, insbesondere einer walze einer papiermaschine.
GB9125695D0 (en) * 1991-12-03 1992-01-29 Mastavac Limited Medical preparations
ES2090714T3 (es) * 1991-12-05 1996-10-16 Mallinckrodt Veterinary Inc Matriz de vidrio de carbohidrato para la liberacion prolongada de un agente terapeutico.
EP0553777B1 (de) * 1992-01-29 2002-04-24 Takeda Chemical Industries, Ltd. Schnellösliche Tablette und ihre Herstellung
US5422384A (en) * 1992-11-25 1995-06-06 Battelle Memorial Institute Glass/polymer composites and methods of making
DE69332781T2 (de) * 1992-12-28 2004-02-12 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Reinigung von Trehalose
DK0686045T3 (da) * 1993-02-23 2001-03-05 Genentech Inc Stabilisering af med organisk opløsningsmiddel behandlede polypeptider med et hjælpestof
US5424077A (en) * 1993-07-13 1995-06-13 Church & Dwight Co., Inc. Co-micronized bicarbonate salt compositions
JP3633648B2 (ja) * 1993-07-20 2005-03-30 株式会社林原生物化学研究所 マルトース・トレハロース変換酵素とその製造方法並びに用途
AU4953393A (en) * 1993-08-24 1995-03-21 Mogen International N.V. Production of trehalose in plants
CN1188171C (zh) * 1994-06-02 2005-02-09 廓德伦特控股剑桥有限公司 防止各种特质在再水化或熔化时聚集的方法以及由此获得的组合物
US5482720A (en) * 1994-10-11 1996-01-09 Church & Dwight Co., Inc. Encapsulated co-micronized bicarbonate salt compositions
US5512547A (en) * 1994-10-13 1996-04-30 Wisconsin Alumni Research Foundation Pharmaceutical composition of botulinum neurotoxin and method of preparation
JPH08157491A (ja) * 1994-11-30 1996-06-18 Hayashibara Biochem Lab Inc トレハロース誘導体の製造方法

Also Published As

Publication number Publication date
US5762961A (en) 1998-06-09
JP2000505429A (ja) 2000-05-09
DE69721489T2 (de) 2004-05-06
DE69721489D1 (de) 2003-06-05
AU1729397A (en) 1997-08-28
EP0879049A1 (de) 1998-11-25
WO1997028789A1 (en) 1997-08-14
EP0879049B1 (de) 2003-05-02

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