ATE238803T1 - Pphospholipidkomplexe von proanthocyanidin a2 als antiatherosklerotische mittel - Google Patents

Pphospholipidkomplexe von proanthocyanidin a2 als antiatherosklerotische mittel

Info

Publication number: ATE238803T1
Authority: AT; Austria
Prior art keywords: proanthocyanidin; complexes; pphospholipide; antiatherosclerotic agents; phospholipids
Prior art date: 1998-12-18

Application number

AT99966956T

Other languages

English (en)

Inventor

Ezio Bombardelli

Paolo Morazzoni

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-18

Filing date

1999-12-13

Publication date

2003-05-15

1999-12-13 Application filed by Indena Spa filed Critical Indena Spa

2003-05-15 Application granted granted Critical

2003-05-15 Publication of ATE238803T1 publication Critical patent/ATE238803T1/de

Links

NSEWTSAADLNHNH-TXZJYACMSA-N Proanthocyanidin A-2 Natural products C1([C@H]2OC3=C4[C@H]5C6=C(O)C=C(O)C=C6O[C@]([C@@H]5O)(OC4=CC(O)=C3C[C@@H]2O)C=2C=C(O)C(O)=CC=2)=CC=C(O)C(O)=C1 NSEWTSAADLNHNH-TXZJYACMSA-N 0.000 title abstract 4
229920002982 Procyanidin A2 Polymers 0.000 title abstract 4
NSEWTSAADLNHNH-UHFFFAOYSA-N pavetannin A-2 Natural products OC1CC2=C(O)C=C3OC(C4O)(C=5C=C(O)C(O)=CC=5)OC5=CC(O)=CC(O)=C5C4C3=C2OC1C1=CC=C(O)C(O)=C1 NSEWTSAADLNHNH-UHFFFAOYSA-N 0.000 title abstract 4
NSEWTSAADLNHNH-LSBOWGMISA-N proanthocyanidin A2 Chemical compound C1([C@H]2OC3=C4[C@H]5C6=C(O)C=C(O)C=C6O[C@]([C@@H]5O)(OC4=CC(O)=C3C[C@H]2O)C=2C=C(O)C(O)=CC=2)=CC=C(O)C(O)=C1 NSEWTSAADLNHNH-LSBOWGMISA-N 0.000 title abstract 4
230000000879 anti-atherosclerotic effect Effects 0.000 title 1
150000003904 phospholipids Chemical class 0.000 abstract 3
201000001320 Atherosclerosis Diseases 0.000 abstract 1
206010008118 cerebral infarction Diseases 0.000 abstract 1
208000026106 cerebrovascular disease Diseases 0.000 abstract 1
230000002107 myocardial effect Effects 0.000 abstract 1
208000010125 myocardial infarction Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Diabetes (AREA)
Obesity (AREA)
Biophysics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Plant Substances (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT99966956T 1998-12-18 1999-12-13 Pphospholipidkomplexe von proanthocyanidin a2 als antiatherosklerotische mittel ATE238803T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT1998MI002732A IT1304183B1 (it)	1998-12-18	1998-12-18	Complessi di proantocianidina a2 con fosfolipidi come agentiantiaterosclerotici.
PCT/EP1999/009854 WO2000037062A2 (en)	1998-12-18	1999-12-13	Phospholipid complexes of proanthocyanidin a2 as antiatherosclerotic agents

Publications (1)

Publication Number	Publication Date
ATE238803T1 true ATE238803T1 (de)	2003-05-15

Family

ID=11381268

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99966956T ATE238803T1 (de)	1998-12-18	1999-12-13	Pphospholipidkomplexe von proanthocyanidin a2 als antiatherosklerotische mittel

Country Status (22)

Country	Link
US (1)	US6429202B1 (de)
EP (1)	EP1140115B1 (de)
JP (1)	JP4842436B2 (de)
KR (1)	KR100694907B1 (de)
CN (1)	CN1146429C (de)
AT (1)	ATE238803T1 (de)
AU (1)	AU763907B2 (de)
CA (1)	CA2355776C (de)
CZ (1)	CZ301495B6 (de)
DE (1)	DE69907509T2 (de)
DK (1)	DK1140115T3 (de)
ES (1)	ES2197708T3 (de)
HK (1)	HK1042430B (de)
HU (1)	HU228928B1 (de)
IL (2)	IL143751A0 (de)
IT (1)	IT1304183B1 (de)
NO (1)	NO328733B1 (de)
PL (1)	PL197153B1 (de)
PT (1)	PT1140115E (de)
RU (1)	RU2248798C2 (de)
SK (1)	SK284884B6 (de)
WO (1)	WO2000037062A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8507018B2 (en)	1998-03-12	2013-08-13	Mars, Incorporated	Products containing polyphenol(s) and L-arginine and methods of use thereof
ES2297176T5 (es) *	2002-02-12	2011-12-07	HUNZA DI PISTOLESI ELVIRA & C. S.A.S.	Composiciones que contienen n-acil-fosfatidil-etanolaminas y/o mezclas de n-acil-etanolaminas con ácidos fosfatídicos o ácidos lisofosfatídicos.
ITMI20020756A1 (it) *	2002-04-09	2003-10-09	Sinclair Pharma S R L	Composizioni farmaceutiche topiche per il trattamento delle dermatiti
GB0321996D0 (en) *	2003-09-19	2003-10-22	Novartis Nutrition Ag	Organic compounds
JP5456955B2 (ja) *	2004-01-28	2014-04-02	マースインコーポレーテッド	Ａタイプのプロシアニジンを含有する組成物およびその使用方法
EP1837030A1 (de)	2006-03-09	2007-09-26	INDENA S.p.A.	Curcumin-phospholipid-Komplexe mit verbesserter Bioverfügbarkeit
WO2009104556A1 (ja) *	2008-02-19	2009-08-27	株式会社岐阜セラツク製造所	組成物
IT1398624B1 (it) *	2009-02-02	2013-03-08	Dermogyn S R L	Uso cosmetico della proantocianidina a2
RU2456674C1 (ru) *	2011-05-31	2012-07-20	Тагир Уралович Гафаров	Способ моделирования атрофического рубца кожи
CN102688501A (zh) *	2012-06-20	2012-09-26	浙江萧山医院	原花青素b2磷脂复合物及其制备方法和用途
CN103120798A (zh) *	2013-01-10	2013-05-29	施冬云	一种具有抗氧化应激作用的磷脂复合物制备方法及其应用
CN103467778B (zh) *	2013-09-06	2015-09-30	天津大学	细菌纤维素/卵磷脂复合材料及制备和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4698360B1 (en) *	1985-04-09	1997-11-04	D Investigations Pharmacologiq	Plant extract with a proanthocyanidins content as therapeutic agent having radical scavenger effect and use thereof
GB8518289D0 (en) *	1985-07-19	1985-08-29	Inverni Della Beffa Spa	Obtaining proanthocyanidine a2
IT1201149B (it) *	1987-01-14	1989-01-27	Indena Spa	Complessi di bioflavonoidi con fosfolipidi,loro preparazione,uso e composizioni farmaceutici e cosmetiche
IT1201151B (it) *	1987-01-14	1989-01-27	Indena Spa	Complessi fosfolipidici con estratti da vitis vinifera,procedimento per la loro preparazione e composizioni che li cntengono
DE59103442D1 (de) *	1990-08-20	1994-12-08	Ohlenschlaeger Gerhard	Therapeutisch wirksames stoffgemisch aus glutathion- und anthocyan-verbindungen.
IT1265312B1 (it) *	1993-12-21	1996-10-31	Indena Spa	Formulazioni contenenti carotenoidi e procarotenoidi associati a polifenoli nella prevenzione dei danni da abnorme produzione di
US5648377A (en)	1993-12-21	1997-07-15	Indena S.P.A.	Formulations containing carotenoids an procarotenoids combined with polyphenols in the prevention of the damages due to an abnormal production of free radicals
IT1270999B (it) *	1994-07-26	1997-05-26	Indena Spa	Formulazioni a base di cumarine e loro uso in campo farmaceutico e cosmetico
FI955691A7 (fi) *	1994-11-28	1996-05-29	Suntory Ltd	Lipoproteiini(a):ta alentava aine, kolesterolia alentava aine ja näitä aineita sisältävät lääkkeet
IT1296920B1 (it) *	1997-12-04	1999-08-03	Indena Spa	Uso di complessi di estratti vitis vinifera con fosfolipidi come agenti anti-aterosclerotici
CN1373950A (zh)	1999-09-08	2002-10-09	西门子公司	用于光信息传输的装置和方法

1998
- 1998-12-18 IT IT1998MI002732A patent/IT1304183B1/it active
1999
- 1999-12-13 AT AT99966956T patent/ATE238803T1/de active
- 1999-12-13 CN CNB998144460A patent/CN1146429C/zh not_active Expired - Fee Related
- 1999-12-13 CA CA002355776A patent/CA2355776C/en not_active Expired - Fee Related
- 1999-12-13 JP JP2000589173A patent/JP4842436B2/ja not_active Expired - Fee Related
- 1999-12-13 CZ CZ20012134A patent/CZ301495B6/cs not_active IP Right Cessation
- 1999-12-13 WO PCT/EP1999/009854 patent/WO2000037062A2/en not_active Ceased
- 1999-12-13 PL PL349534A patent/PL197153B1/pl unknown
- 1999-12-13 ES ES99966956T patent/ES2197708T3/es not_active Expired - Lifetime
- 1999-12-13 HU HU0104665A patent/HU228928B1/hu not_active IP Right Cessation
- 1999-12-13 AU AU22830/00A patent/AU763907B2/en not_active Ceased
- 1999-12-13 DE DE69907509T patent/DE69907509T2/de not_active Expired - Lifetime
- 1999-12-13 US US09/857,804 patent/US6429202B1/en not_active Expired - Lifetime
- 1999-12-13 RU RU2001116085/15A patent/RU2248798C2/ru not_active IP Right Cessation
- 1999-12-13 PT PT99966956T patent/PT1140115E/pt unknown
- 1999-12-13 SK SK860-2001A patent/SK284884B6/sk not_active IP Right Cessation
- 1999-12-13 HK HK02103200.8A patent/HK1042430B/zh not_active IP Right Cessation
- 1999-12-13 EP EP99966956A patent/EP1140115B1/de not_active Expired - Lifetime
- 1999-12-13 KR KR1020017007374A patent/KR100694907B1/ko not_active Expired - Fee Related
- 1999-12-13 IL IL14375199A patent/IL143751A0/xx active IP Right Grant
- 1999-12-13 DK DK99966956T patent/DK1140115T3/da active
2001
- 2001-06-13 IL IL143751A patent/IL143751A/en not_active IP Right Cessation
- 2001-06-14 NO NO20012944A patent/NO328733B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
HU228928B1 (en)	2013-06-28
PT1140115E (pt)	2003-08-29
US6429202B1 (en)	2002-08-06
IL143751A0 (en)	2002-04-21
CN1330548A (zh)	2002-01-09
SK284884B6 (sk)	2006-02-02
WO2000037062A2 (en)	2000-06-29
CA2355776A1 (en)	2000-06-29
JP4842436B2 (ja)	2011-12-21
CZ301495B6 (cs)	2010-03-24
CN1146429C (zh)	2004-04-21
RU2248798C2 (ru)	2005-03-27
HUP0104665A3 (en)	2003-01-28
ES2197708T3 (es)	2004-01-01
WO2000037062A3 (en)	2000-08-03
AU2283000A (en)	2000-07-12
EP1140115B1 (de)	2003-05-02
PL197153B1 (pl)	2008-03-31
JP2002532543A (ja)	2002-10-02
NO20012944L (no)	2001-06-14
EP1140115A2 (de)	2001-10-10
HK1042430B (zh)	2004-10-08
AU763907B2 (en)	2003-08-07
KR20010093826A (ko)	2001-10-29
CZ20012134A3 (cs)	2001-12-12
NO328733B1 (no)	2010-05-03
IT1304183B1 (it)	2001-03-08
NO20012944D0 (no)	2001-06-14
SK8602001A3 (en)	2001-12-03
HUP0104665A2 (hu)	2002-04-29
DK1140115T3 (da)	2003-08-25
DE69907509T2 (de)	2004-04-08
HK1042430A1 (en)	2002-08-16
DE69907509D1 (en)	2003-06-05
ITMI982732A1 (it)	2000-06-18
KR100694907B1 (ko)	2007-03-14
CA2355776C (en)	2008-03-18
IL143751A (en)	2006-07-05

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2003-09-15

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