ATE239008T1 - Verfahren zur herstellung von (+/-) calanolide a und zwischenprodukte dafür - Google Patents
Verfahren zur herstellung von (+/-) calanolide a und zwischenprodukte dafürInfo
- Publication number
- ATE239008T1 ATE239008T1 AT95929365T AT95929365T ATE239008T1 AT E239008 T1 ATE239008 T1 AT E239008T1 AT 95929365 T AT95929365 T AT 95929365T AT 95929365 T AT95929365 T AT 95929365T AT E239008 T1 ATE239008 T1 AT E239008T1
- Authority
- AT
- Austria
- Prior art keywords
- calanolide
- producing
- intermediate products
- products therefor
- therefor
- Prior art date
Links
- NIDRYBLTWYFCFV-FMTVUPSXSA-N (+)-calanolide A Chemical compound C1=CC(C)(C)OC2=C1C(O[C@H](C)[C@@H](C)[C@@H]1O)=C1C1=C2C(CCC)=CC(=O)O1 NIDRYBLTWYFCFV-FMTVUPSXSA-N 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- QZHPTGXQGDFGEN-UHFFFAOYSA-N chromene Chemical compound C1=CC=C2C=C[CH]OC2=C1 QZHPTGXQGDFGEN-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/285,655 US5489697A (en) | 1994-08-03 | 1994-08-03 | Method for the preparation of (+)-calanolide A and intermediates thereof |
| PCT/US1995/009804 WO1996004263A1 (en) | 1994-08-03 | 1995-08-02 | Method for the preparation of (±)-calanolide a and intermediates thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE239008T1 true ATE239008T1 (de) | 2003-05-15 |
Family
ID=23095160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95929365T ATE239008T1 (de) | 1994-08-03 | 1995-08-02 | Verfahren zur herstellung von (+/-) calanolide a und zwischenprodukte dafür |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5489697A (de) |
| EP (3) | EP0775130B1 (de) |
| JP (1) | JP3043813B2 (de) |
| AT (1) | ATE239008T1 (de) |
| AU (1) | AU704247B2 (de) |
| CA (1) | CA2196656C (de) |
| DE (1) | DE69530592T2 (de) |
| MY (1) | MY118279A (de) |
| WO (1) | WO1996004263A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6774141B1 (en) | 1992-03-31 | 2004-08-10 | The United States Of America As Represented By The Secretary Of Health And Human Services | Calanolide and related antiviral compounds, compositions, and uses thereof |
| US5723631A (en) * | 1992-12-23 | 1998-03-03 | Smithkline Beecham Corporation | Coumarin derivatives as retroviral inhibitors |
| US6277879B1 (en) | 1994-08-03 | 2001-08-21 | Sarawak Medichem Pharmaceuticals, Inc. | Calanolide analogues and methods of their use |
| US6303652B1 (en) | 1998-08-21 | 2001-10-16 | Hughes Institute | BTK inhibitors and methods for their identification and use |
| AU3653099A (en) * | 1998-04-17 | 1999-11-08 | Parker Hughes Institute | Btk inhibitors and methods for their identification and use |
| US6306897B1 (en) | 1999-03-19 | 2001-10-23 | Parker Hughes Institute | Calanolides for inhibiting BTK |
| AU4491800A (en) | 1999-04-26 | 2000-11-10 | Sarawak Medichem Pharmaceuticals, Inc. | Methods for preparing antiviral calanolide compounds |
| JP2002193971A (ja) * | 2000-12-22 | 2002-07-10 | Kuraray Co Ltd | カラノリドａおよびその中間体の製造方法 |
| US6670383B2 (en) | 2001-03-16 | 2003-12-30 | Advanced Life Sciences, Inc. | Pyranocoumarin compounds as a novel pharmacophore with anti-TB activity |
| US20030176494A1 (en) * | 2001-11-16 | 2003-09-18 | Ze-Qi Xu | Novel coumarin and chromene compounds and methods of preparation and use thereof for treating or preventing viral infections |
| WO2003076444A1 (fr) * | 2002-03-08 | 2003-09-18 | Kuraray Co., Ltd. | Intermediaires destines a la production de (+) calanolide a, procedes de production de ces intermediaires, et procede de production de (+) calanolide a a l'aide de ceux-ci |
| US6777562B1 (en) | 2003-02-19 | 2004-08-17 | Dow Global Technologies Inc. | Preparation of a trans-calanolide ketone intermediate and chiral separation of calanolide alcohols to give racemic calanolide A |
| WO2004085406A1 (en) | 2003-03-24 | 2004-10-07 | F. Hoffmann-La Roche Ag | Benzyl-pyridazinons as reverse transcriptase inhibitors |
| JP2005314260A (ja) * | 2004-04-28 | 2005-11-10 | Japan Science & Technology Agency | フラボンｃ配糖体の製法 |
| EP1773802A1 (de) * | 2004-07-23 | 2007-04-18 | Pharmacia & Upjohn Company LLC | Enantioselektives verfahren zur trennung substituierter 2-trifluormethyl-2h-chromen-3-carbonsäurederivate |
| EP1940781A1 (de) | 2005-10-19 | 2008-07-09 | F.Hoffmann-La Roche Ag | Phenylacetamid-nnrt-inhibitoren |
| DE602007013573D1 (de) | 2006-08-16 | 2011-05-12 | Hoffmann La Roche | Nicht-nukleosidische reverse-transkriptase-hemmer |
| ES2550152T3 (es) | 2006-12-13 | 2015-11-04 | F. Hoffmann-La Roche Ag | Derivados de 2-(piperidin-4-il)-4-fenoxi-o fenilamino-pirimidina como inhibidores no nucleósidos de transcriptasa inversa |
| BRPI0811645A2 (pt) | 2007-05-30 | 2014-11-11 | Hoffmann La Roche | Inibidores de transcriptase reversa de não-nucleosídeo |
| AU2007361257A1 (en) * | 2007-11-05 | 2009-05-14 | Institute Of Mataria Medica, Chinese Academy Of Medical Sciences | Tetriacyclodipyranyl coumarins and the anti-HIV and anti-tuberculosis uses thereof |
| AU2008340422B2 (en) | 2007-12-21 | 2014-06-19 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
| WO2011077100A1 (en) | 2009-12-24 | 2011-06-30 | Cipla Limited | Antiretroviral composition |
| RU2458944C1 (ru) * | 2011-03-15 | 2012-08-20 | Государственное образовательное учреждение высшего профессионального образования Кемеровский технологический институт пищевой промышленности | Способ получения коллодиевой пленки центробежным методом |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU671827B2 (en) | 1992-03-31 | 1996-09-12 | United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The | Calanolide antiviral compounds, compositions and uses thereof |
| US5723631A (en) * | 1992-12-23 | 1998-03-03 | Smithkline Beecham Corporation | Coumarin derivatives as retroviral inhibitors |
-
1994
- 1994-08-03 US US08/285,655 patent/US5489697A/en not_active Expired - Lifetime
-
1995
- 1995-08-02 EP EP95929365A patent/EP0775130B1/de not_active Expired - Lifetime
- 1995-08-02 EP EP00112868A patent/EP1054007A3/de not_active Withdrawn
- 1995-08-02 EP EP03000557A patent/EP1308448A1/de not_active Withdrawn
- 1995-08-02 WO PCT/US1995/009804 patent/WO1996004263A1/en not_active Ceased
- 1995-08-02 DE DE69530592T patent/DE69530592T2/de not_active Expired - Lifetime
- 1995-08-02 AT AT95929365T patent/ATE239008T1/de not_active IP Right Cessation
- 1995-08-02 JP JP8506741A patent/JP3043813B2/ja not_active Expired - Fee Related
- 1995-08-02 CA CA2196656A patent/CA2196656C/en not_active Expired - Fee Related
- 1995-08-02 AU AU32746/95A patent/AU704247B2/en not_active Expired
-
1997
- 1997-01-31 MY MYPI97000394A patent/MY118279A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU3274695A (en) | 1996-03-04 |
| AU704247B2 (en) | 1999-04-15 |
| DE69530592T2 (de) | 2004-03-18 |
| JPH09512829A (ja) | 1997-12-22 |
| JP3043813B2 (ja) | 2000-05-22 |
| EP0775130B1 (de) | 2003-05-02 |
| CA2196656A1 (en) | 1996-02-15 |
| DE69530592D1 (de) | 2003-06-05 |
| MX9700782A (es) | 1997-09-30 |
| EP1308448A1 (de) | 2003-05-07 |
| EP1054007A2 (de) | 2000-11-22 |
| US5489697A (en) | 1996-02-06 |
| WO1996004263A1 (en) | 1996-02-15 |
| MY118279A (en) | 2004-09-30 |
| EP0775130A1 (de) | 1997-05-28 |
| CA2196656C (en) | 2010-03-23 |
| EP1054007A3 (de) | 2000-11-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |