ATE239020T1 - Tricyclische verbindungen als ras-fpt inhibitoren - Google Patents

Tricyclische verbindungen als ras-fpt inhibitoren

Info

Publication number: ATE239020T1
Authority: AT; Austria
Prior art keywords: hydrogen; lower alkyl; group; ras; alkyl
Prior art date: 1996-10-09

Application number

AT97911596T

Other languages

English (en)

Inventor

Adriano Afonso

Joseph M Kelly

Stuart Rosenblum

Ronald L Wolin

Jay Weinstein

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-09

Filing date

1997-10-07

Publication date

2003-05-15

1997-10-07 Application filed by Schering Corp filed Critical Schering Corp

2003-05-15 Application granted granted Critical

2003-05-15 Publication of ATE239020T1 publication Critical patent/ATE239020T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 7
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
150000002431 hydrogen Chemical class 0.000 abstract 3
229910052760 oxygen Inorganic materials 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
230000002401 inhibitory effect Effects 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
230000002159 abnormal effect Effects 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
238000007792 addition Methods 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
230000010261 cell growth Effects 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
230000002062 proliferating effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT97911596T 1996-10-09 1997-10-07 Tricyclische verbindungen als ras-fpt inhibitoren ATE239020T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US72810496A	1996-10-09	1996-10-09
PCT/US1997/017314 WO1998015556A1 (en)	1996-10-09	1997-10-07	TRICYCLIC COMPOUNDS HAVING ACTIVITY AS Ras-FPT INHIBITORS

Publications (1)

Publication Number	Publication Date
ATE239020T1 true ATE239020T1 (de)	2003-05-15

Family

ID=24925436

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97911596T ATE239020T1 (de)	1996-10-09	1997-10-07	Tricyclische verbindungen als ras-fpt inhibitoren

Country Status (8)

Country	Link
EP (1)	EP1021448B1 (de)
JP (1)	JP2001505189A (de)
AT (1)	ATE239020T1 (de)
AU (1)	AU4892297A (de)
CA (1)	CA2267800C (de)
DE (1)	DE69721588T2 (de)
ES (1)	ES2192671T3 (de)
WO (1)	WO1998015556A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2335115C (en) *	1998-06-16	2009-01-27	The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Fused azepinone cyclin dependent kinase inhibitors
US6740406B2 (en) *	2000-12-15	2004-05-25	Kimberly-Clark Worldwide, Inc.	Coated activated carbon
WO2005017160A2 (en)	2003-08-13	2005-02-24	Children's Hospital Medical Center	Mobilization of hematopoietic cells
JP2008523104A (ja) *	2004-12-13	2008-07-03	シェーリングコーポレイション	癌を治療するための新規なファルネシルタンパク質トランスフェラーゼ阻害剤およびその使用
JP5503877B2 (ja) *	2009-01-30	2014-05-28	住友化学株式会社	ジベンゾオキセピン化合物の製造方法
CN118638053B (zh) *	2024-08-09	2024-10-22	浙江弘盛药业有限公司	一种8-氯-5，6-二氢-11H-苯并[5，6]环庚烷并-[1，2-b]吡啶-11-酮的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995010515A1 (en) *	1993-10-15	1995-04-20	Schering Corporation	Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5712280A (en) *	1995-04-07	1998-01-27	Schering Corporation	Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases

1997
- 1997-10-07 EP EP97911596A patent/EP1021448B1/de not_active Expired - Lifetime
- 1997-10-07 CA CA002267800A patent/CA2267800C/en not_active Expired - Fee Related
- 1997-10-07 ES ES97911596T patent/ES2192671T3/es not_active Expired - Lifetime
- 1997-10-07 DE DE69721588T patent/DE69721588T2/de not_active Expired - Fee Related
- 1997-10-07 AU AU48922/97A patent/AU4892297A/en not_active Abandoned
- 1997-10-07 JP JP51757098A patent/JP2001505189A/ja not_active Ceased
- 1997-10-07 AT AT97911596T patent/ATE239020T1/de not_active IP Right Cessation
- 1997-10-07 WO PCT/US1997/017314 patent/WO1998015556A1/en not_active Ceased

Also Published As

Publication number	Publication date
JP2001505189A (ja)	2001-04-17
DE69721588T2 (de)	2004-05-19
CA2267800A1 (en)	1998-04-16
EP1021448B1 (de)	2003-05-02
EP1021448A1 (de)	2000-07-26
DE69721588D1 (de)	2003-06-05
WO1998015556A1 (en)	1998-04-16
ES2192671T3 (es)	2003-10-16
AU4892297A (en)	1998-05-05
CA2267800C (en)	2003-12-23

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Legal Events

Date	Code	Title	Description
2003-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties