ATE239020T1 - Tricyclische verbindungen als ras-fpt inhibitoren - Google Patents

Tricyclische verbindungen als ras-fpt inhibitoren

Info

Publication number
ATE239020T1
ATE239020T1 AT97911596T AT97911596T ATE239020T1 AT E239020 T1 ATE239020 T1 AT E239020T1 AT 97911596 T AT97911596 T AT 97911596T AT 97911596 T AT97911596 T AT 97911596T AT E239020 T1 ATE239020 T1 AT E239020T1
Authority
AT
Austria
Prior art keywords
hydrogen
lower alkyl
group
ras
alkyl
Prior art date
Application number
AT97911596T
Other languages
English (en)
Inventor
Adriano Afonso
Joseph M Kelly
Stuart Rosenblum
Ronald L Wolin
Jay Weinstein
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE239020T1 publication Critical patent/ATE239020T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT97911596T 1996-10-09 1997-10-07 Tricyclische verbindungen als ras-fpt inhibitoren ATE239020T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72810496A 1996-10-09 1996-10-09
PCT/US1997/017314 WO1998015556A1 (en) 1996-10-09 1997-10-07 TRICYCLIC COMPOUNDS HAVING ACTIVITY AS Ras-FPT INHIBITORS

Publications (1)

Publication Number Publication Date
ATE239020T1 true ATE239020T1 (de) 2003-05-15

Family

ID=24925436

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97911596T ATE239020T1 (de) 1996-10-09 1997-10-07 Tricyclische verbindungen als ras-fpt inhibitoren

Country Status (8)

Country Link
EP (1) EP1021448B1 (de)
JP (1) JP2001505189A (de)
AT (1) ATE239020T1 (de)
AU (1) AU4892297A (de)
CA (1) CA2267800C (de)
DE (1) DE69721588T2 (de)
ES (1) ES2192671T3 (de)
WO (1) WO1998015556A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4555476B2 (ja) * 1998-06-16 2010-09-29 ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ， アズ レプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ 縮合アゼピノン型サイクリン依存性キナーゼ阻害物質
US6740406B2 (en) * 2000-12-15 2004-05-25 Kimberly-Clark Worldwide, Inc. Coated activated carbon
WO2005017160A2 (en) 2003-08-13 2005-02-24 Children's Hospital Medical Center Mobilization of hematopoietic cells
CN101115486A (zh) * 2004-12-13 2008-01-30 先灵公司 新的法呢基蛋白转移酶抑制剂及其治疗癌症的用途
JP5503877B2 (ja) * 2009-01-30 2014-05-28 住友化学株式会社 ジベンゾオキセピン化合物の製造方法
CN118638053B (zh) * 2024-08-09 2024-10-22 浙江弘盛药业有限公司 一种8-氯-5，6-二氢-11H-苯并[5，6]环庚烷并-[1，2-b]吡啶-11-酮的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2875393B2 (ja) * 1993-10-15 1999-03-31 シェーリング コーポレイション Ｇ−タンパク質機能の阻害および増殖性疾患の治療に有用な三環式カルバメート化合物
US5712280A (en) * 1995-04-07 1998-01-27 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases

Also Published As

Publication number Publication date
EP1021448B1 (de) 2003-05-02
DE69721588T2 (de) 2004-05-19
WO1998015556A1 (en) 1998-04-16
DE69721588D1 (de) 2003-06-05
CA2267800A1 (en) 1998-04-16
AU4892297A (en) 1998-05-05
ES2192671T3 (es) 2003-10-16
EP1021448A1 (de) 2000-07-26
CA2267800C (en) 2003-12-23
JP2001505189A (ja) 2001-04-17

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Legal Events

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