ATE239722T1 - Benzofurylpiperazine als serotonin-agonisten - Google Patents

Benzofurylpiperazine als serotonin-agonisten

Info

Publication number: ATE239722T1
Authority: AT; Austria
Prior art keywords: benzofurylpiperazine; serotonin agonists; serotonin; agonists; benzofurans
Prior art date: 1999-07-29

Application number

AT00948746T

Other languages

English (en)

Inventor

Karin Briner

Timothy Paul Burkholder

Mark Louis Heiman

David Lloyd Garver Nelson

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-29

Filing date

2000-07-21

Publication date

2003-05-15

2000-07-21 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2003-05-15 Application granted granted Critical

2003-05-15 Publication of ATE239722T1 publication Critical patent/ATE239722T1/de

Links

LFWCEWLQBGZAGG-UHFFFAOYSA-N 1-(1-benzofuran-2-yl)piperazine Chemical compound C1CNCCN1C1=CC2=CC=CC=C2O1 LFWCEWLQBGZAGG-UHFFFAOYSA-N 0.000 title 1
239000000952 serotonin receptor agonist Substances 0.000 title 1
239000002253 acid Substances 0.000 abstract 1
150000001907 coumarones Chemical class 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000000862 serotonergic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT00948746T 1999-07-29 2000-07-21 Benzofurylpiperazine als serotonin-agonisten ATE239722T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US14628799P	1999-07-29	1999-07-29
US17216999P	1999-12-17	1999-12-17
PCT/US2000/019545 WO2001009123A1 (en)	1999-07-29	2000-07-21	Benzofurylpiperazine serotonin agonists

Publications (1)

Publication Number	Publication Date
ATE239722T1 true ATE239722T1 (de)	2003-05-15

Family

ID=26843756

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00948746T ATE239722T1 (de)	1999-07-29	2000-07-21	Benzofurylpiperazine als serotonin-agonisten

Country Status (11)

Country	Link
US (1)	US6638936B1 (de)
EP (1)	EP1204658B1 (de)
JP (1)	JP2003506370A (de)
AT (1)	ATE239722T1 (de)
AU (1)	AU6220300A (de)
CA (1)	CA2380531A1 (de)
DE (1)	DE60002583T2 (de)
DK (1)	DK1204658T3 (de)
ES (1)	ES2198329T3 (de)
PT (1)	PT1204658E (de)
WO (1)	WO2001009123A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1204654B1 (de) *	1999-07-29	2003-07-23	Eli Lilly And Company	Benzofurylpiperazine: 5-ht2c serotoninrezeptor agonisten
SE0004245D0 (sv)	2000-11-20	2000-11-20	Pharmacia Ab	Novel compounds and their use
NZ525699A (en)	2000-11-20	2005-03-24	Biovitrum Ab	Piperazinylpyrazines compounds as antagonists of serotonin 5-HT2 receptor
ES2323451T7 (es)	2001-07-20	2011-08-01	Psychogenics Inc.	Tratamiento para el trastorno de hiperactividad con deficit de atencion.
JP4460450B2 (ja)	2002-06-19	2010-05-12	ビオヴィトルム・アクチボラゲット（プブリクト）	新規化合物、その使用および製造法
JP5173190B2 (ja)	2004-08-25	2013-03-27	武田薬品工業株式会社	腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法
EP2727585A1 (de)	2006-05-16	2014-05-07	Takeda Pharmaceutical Company Limited	In-vivo Screening-Methode
WO2008052086A1 (en) *	2006-10-24	2008-05-02	Wyeth	Benzodioxane derivatives and uses thereof
EP2789338A3 (de)	2007-11-15	2015-01-14	Takeda Pharmaceutical Company Limited	Kondensiertes Pyridinderivat und seine Verwendung
EP2510949A4 (de)	2009-12-11	2013-11-13	Astellas Pharma Inc	Therapeutikum für fibromyalgie
WO2015066344A1 (en)	2013-11-01	2015-05-07	Arena Pharmaceuticals, Inc.	5-ht2c receptor agonists and compositions and methods of use
US20210052600A1 (en)	2017-12-27	2021-02-25	Takeda Pharmaceutical Company Limited	Therapeutic agents for stress urinary incontinence and incotinence of feces
CN112773898A (zh) *	2019-11-11	2021-05-11	广州华真医药科技有限公司	磷酸二酯酶5抑制剂在制备抗纤维化疾病药物中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0006524A1 (de) *	1978-06-22	1980-01-09	Ciba-Geigy Ag	Neue Tetrahydropyridin- und Piperidinderivate und deren Säureadditionssalze, Verfahren zu deren Herstellung und solche enthaltende pharmazeutische Zusammensetzungen
EP0189612B1 (de) *	1984-12-21	1992-11-04	Duphar International Research B.V	Arzneimittel mit psychotroper Wirkung
WO1995011243A1 (en)	1993-10-19	1995-04-27	Smithkline Beecham Plc	Benzanilide derivatives as 5ht-1d receptor antagonists
US5698766A (en)	1995-04-05	1997-12-16	The Regents Of The University Of California	Transgenic animal model for testing drugs for treating eating disorders and epilepsy
GB9517559D0 (en)	1995-08-26	1995-10-25	Smithkline Beecham Plc	Novel compounds
JP3989554B2 (ja)	1996-03-29	2007-10-10	デユフアー・インターナシヨナル・リサーチ・ベー・ブイ	ピペラジンおよびピペリジン化合物
US6132538A (en)	1998-07-30	2000-10-17	Autoliv Development Ab	High gas yield generant compositions
GB0012165D0 (en)	2000-05-20	2000-07-12	Team Consulting Ltd	Portable device with consistent power output

2000
- 2000-07-21 ES ES00948746T patent/ES2198329T3/es not_active Expired - Lifetime
- 2000-07-21 AU AU62203/00A patent/AU6220300A/en not_active Abandoned
- 2000-07-21 DE DE60002583T patent/DE60002583T2/de not_active Expired - Fee Related
- 2000-07-21 EP EP00948746A patent/EP1204658B1/de not_active Expired - Lifetime
- 2000-07-21 CA CA002380531A patent/CA2380531A1/en not_active Abandoned
- 2000-07-21 WO PCT/US2000/019545 patent/WO2001009123A1/en not_active Ceased
- 2000-07-21 PT PT00948746T patent/PT1204658E/pt unknown
- 2000-07-21 DK DK00948746T patent/DK1204658T3/da active
- 2000-07-21 US US10/031,310 patent/US6638936B1/en not_active Expired - Fee Related
- 2000-07-21 AT AT00948746T patent/ATE239722T1/de not_active IP Right Cessation
- 2000-07-21 JP JP2001514326A patent/JP2003506370A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
WO2001009123A1 (en)	2001-02-08
DK1204658T3 (da)	2003-09-01
ES2198329T3 (es)	2004-02-01
EP1204658B1 (de)	2003-05-07
EP1204658A1 (de)	2002-05-15
AU6220300A (en)	2001-02-19
DE60002583T2 (de)	2004-03-25
DE60002583D1 (de)	2003-06-12
CA2380531A1 (en)	2001-02-08
JP2003506370A (ja)	2003-02-18
PT1204658E (pt)	2003-08-29
US6638936B1 (en)	2003-10-28

Legal Events

Date

Code

Title

Description

2004-03-15

UEP

Publication of translation of european patent specification

Ref document number: 1204658

Country of ref document: EP

2006-04-15

REN

Ceased due to non-payment of the annual fee

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