ATE239722T1 - Benzofurylpiperazine als serotonin-agonisten - Google Patents

Benzofurylpiperazine als serotonin-agonisten

Info

Publication number: ATE239722T1
Authority: AT; Austria
Prior art keywords: benzofurylpiperazine; serotonin agonists; serotonin; agonists; benzofurans
Prior art date: 1999-07-29

Application number

AT00948746T

Other languages

English (en)

Inventor

Karin Briner

Timothy Paul Burkholder

Mark Louis Heiman

David Lloyd Garver Nelson

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-29

Filing date

2000-07-21

Publication date

2003-05-15

2000-07-21 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2003-05-15 Application granted granted Critical

2003-05-15 Publication of ATE239722T1 publication Critical patent/ATE239722T1/de

Links

LFWCEWLQBGZAGG-UHFFFAOYSA-N 1-(1-benzofuran-2-yl)piperazine Chemical compound C1CNCCN1C1=CC2=CC=CC=C2O1 LFWCEWLQBGZAGG-UHFFFAOYSA-N 0.000 title 1
239000000952 serotonin receptor agonist Substances 0.000 title 1
239000002253 acid Substances 0.000 abstract 1
150000001907 coumarones Chemical class 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000000862 serotonergic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT00948746T 1999-07-29 2000-07-21 Benzofurylpiperazine als serotonin-agonisten ATE239722T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US14628799P	1999-07-29	1999-07-29
US17216999P	1999-12-17	1999-12-17
PCT/US2000/019545 WO2001009123A1 (en)	1999-07-29	2000-07-21	Benzofurylpiperazine serotonin agonists

Publications (1)

Publication Number	Publication Date
ATE239722T1 true ATE239722T1 (de)	2003-05-15

Family

ID=26843756

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00948746T ATE239722T1 (de)	1999-07-29	2000-07-21	Benzofurylpiperazine als serotonin-agonisten

Country Status (11)

Country	Link
US (1)	US6638936B1 (de)
EP (1)	EP1204658B1 (de)
JP (1)	JP2003506370A (de)
AT (1)	ATE239722T1 (de)
AU (1)	AU6220300A (de)
CA (1)	CA2380531A1 (de)
DE (1)	DE60002583T2 (de)
DK (1)	DK1204658T3 (de)
ES (1)	ES2198329T3 (de)
PT (1)	PT1204658E (de)
WO (1)	WO2001009123A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BR0012752A (pt) *	1999-07-29	2002-04-02	Lilly Co Eli	Benzofuril piperazinas e benzofuril homopiperazinas: agonistas de serotonina
SE0004245D0 (sv)	2000-11-20	2000-11-20	Pharmacia Ab	Novel compounds and their use
IL155875A0 (en)	2000-11-20	2003-12-23	Biovitrum Ab	Piperazinylpyrazines compounds as antagonists of serotonin 5-ht2 receptor
ATE424825T1 (de)	2001-07-20	2009-03-15	Psychogenics Inc	Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten
CN100484933C (zh)	2002-06-19	2009-05-06	比奥维特罗姆股份公开公司	新的吡嗪化合物及其在制备用于治疗与5-羟色胺相关的疾病的药物中的用途
EP2248524A3 (de)	2004-08-25	2011-03-09	Takeda Pharmaceutical Company Limited	Mittel zur prävention/behandlung von stressbedingter harninkontinenz und vorsorgeuntersuchungsverfahren dafür
EP2742936A1 (de)	2006-05-16	2014-06-18	Takeda Pharmaceutical Company Limited	Kondensierte heterocyclische Verbindung und ihre Verwendung
TW200823187A (en) *	2006-10-24	2008-06-01	Wyeth Corp	Benzodioxane derivatives and uses thereof
EP2789338A3 (de)	2007-11-15	2015-01-14	Takeda Pharmaceutical Company Limited	Kondensiertes Pyridinderivat und seine Verwendung
JPWO2011071136A1 (ja)	2009-12-11	2013-04-22	アステラス製薬株式会社	線維筋痛症治療剤
WO2015066344A1 (en)	2013-11-01	2015-05-07	Arena Pharmaceuticals, Inc.	5-ht2c receptor agonists and compositions and methods of use
EP3733204A4 (de)	2017-12-27	2021-09-15	Takeda Pharmaceutical Company Limited	Therapeutikum für belastungsinkontinenz und stuhlinkontinenz
CN112773898A (zh) *	2019-11-11	2021-05-11	广州华真医药科技有限公司	磷酸二酯酶5抑制剂在制备抗纤维化疾病药物中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0006524A1 (de) *	1978-06-22	1980-01-09	Ciba-Geigy Ag	Neue Tetrahydropyridin- und Piperidinderivate und deren Säureadditionssalze, Verfahren zu deren Herstellung und solche enthaltende pharmazeutische Zusammensetzungen
DE3586794T2 (de) *	1984-12-21	1993-05-27	Duphar Int Res	Arzneimittel mit psychotroper wirkung.
WO1995011243A1 (en) *	1993-10-19	1995-04-27	Smithkline Beecham Plc	Benzanilide derivatives as 5ht-1d receptor antagonists
US5698766A (en) *	1995-04-05	1997-12-16	The Regents Of The University Of California	Transgenic animal model for testing drugs for treating eating disorders and epilepsy
GB9517559D0 (en) *	1995-08-26	1995-10-25	Smithkline Beecham Plc	Novel compounds
DE69736704T2 (de)	1996-03-29	2007-09-13	Duphar International Research B.V.	Piperazin- und piperidin- derivate
US6132538A (en)	1998-07-30	2000-10-17	Autoliv Development Ab	High gas yield generant compositions
GB0012165D0 (en)	2000-05-20	2000-07-12	Team Consulting Ltd	Portable device with consistent power output

2000
- 2000-07-21 CA CA002380531A patent/CA2380531A1/en not_active Abandoned
- 2000-07-21 WO PCT/US2000/019545 patent/WO2001009123A1/en not_active Ceased
- 2000-07-21 DE DE60002583T patent/DE60002583T2/de not_active Expired - Fee Related
- 2000-07-21 EP EP00948746A patent/EP1204658B1/de not_active Expired - Lifetime
- 2000-07-21 ES ES00948746T patent/ES2198329T3/es not_active Expired - Lifetime
- 2000-07-21 PT PT00948746T patent/PT1204658E/pt unknown
- 2000-07-21 AT AT00948746T patent/ATE239722T1/de not_active IP Right Cessation
- 2000-07-21 DK DK00948746T patent/DK1204658T3/da active
- 2000-07-21 US US10/031,310 patent/US6638936B1/en not_active Expired - Fee Related
- 2000-07-21 JP JP2001514326A patent/JP2003506370A/ja not_active Withdrawn
- 2000-07-21 AU AU62203/00A patent/AU6220300A/en not_active Abandoned

Also Published As

Publication number	Publication date
ES2198329T3 (es)	2004-02-01
DE60002583D1 (de)	2003-06-12
JP2003506370A (ja)	2003-02-18
CA2380531A1 (en)	2001-02-08
AU6220300A (en)	2001-02-19
US6638936B1 (en)	2003-10-28
EP1204658A1 (de)	2002-05-15
EP1204658B1 (de)	2003-05-07
DK1204658T3 (da)	2003-09-01
PT1204658E (pt)	2003-08-29
DE60002583T2 (de)	2004-03-25
WO2001009123A1 (en)	2001-02-08

Legal Events

Date

Code

Title

Description

2004-03-15

UEP

Publication of translation of european patent specification

Ref document number: 1204658

Country of ref document: EP

2006-04-15

REN

Ceased due to non-payment of the annual fee

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